View source for Epstein-Barr virus-associated smooth muscle tumour

'''[[Epstein-Barr virus]]-associated smooth muscle tumour''', abbreviated '''EBV-SMT''', is a very uncommon [[soft tissue lesions|soft tissue lesion]].<ref name=pmid16330945>{{Cite journal  | last1 = Deyrup | first1 = AT. | last2 = Lee | first2 = VK. | last3 = Hill | first3 = CE. | last4 = Cheuk | first4 = W. | last5 = Toh | first5 = HC. | last6 = Kesavan | first6 = S. | last7 = Chan | first7 = EW. | last8 = Weiss | first8 = SW. | title = Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 75-82 | month = Jan | year = 2006 | doi =  | PMID = 16330945 }}</ref>

==General==
*Immunosuppressed individuals, e.g. individuals with [[HIV]].
*Caused by [[Epstein-Barr virus]].

==Microscopic==
Features:<ref name=pmid16330945/>
*Smooth muscle lesion:
**Spindle cells in a [[fascicular]] arrangement.
**Usually minimal nuclear atypia and few mitoses.
*Lymphocytes.

DDx:
*[[Gastrointestinal stromal tumour]].
*[[Leiomyosarcoma]].
*[[Leiomyoma]].

Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig2/ EBV-EMT (nih.gov)].<ref name=pmid20690046>{{Cite journal  | last1 = Huang | first1 = J. | last2 = Loh | first2 = KS. | last3 = Petersson | first3 = F. | title = Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma. | journal = Head Neck Pathol | volume = 4 | issue = 4 | pages = 300-4 | month = Dec | year = 2010 | doi = 10.1007/s12105-010-0201-7 | PMID = 20690046 }}
</ref>

==IHC==
*SMA +ve 
*Desmin +ve/-ve.
*CD34 -ve.
*CD117 -ve.

Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig4/ EBV-SMT (nih.gov)].

==Molecular==
*[[EBER]] +ve.<ref name=pmid20690046/>

==References==
{{Reflist|1}}

[[Category:Soft tissue lesions]]
[[Category:Diagnosis]]