ABCC2 - Revision history

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2026-07-08T17:28:28Z

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← Older revision		Revision as of 17:28, 8 July 2026
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	1. Histopathology. 2023 Dec;83(6):949-958. doi: 10.1111/his.15042.		1. Histopathology. 2023 Dec;83(6):949-958. doi: 10.1111/his.15042.
	</~~rep~~>		</pre>

	===Negative===		===Negative===

Michael at 17:28, 8 July 2026

2026-07-08T17:28:20Z

← Older revision		Revision as of 17:28, 8 July 2026
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	*Brush border staining suggests response to immunotherapy.<ref>{{cite journal \|authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R \|title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy \|journal=J Pathol \|volume=268 \|issue=2 \|pages=188–199 \|date=February 2026 \|pmid=41259021 \|doi=10.1002/path.70001 \|url=}}</ref>		*Brush border staining suggests response to immunotherapy.<ref>{{cite journal \|authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R \|title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy \|journal=J Pathol \|volume=268 \|issue=2 \|pages=188–199 \|date=February 2026 \|pmid=41259021 \|doi=10.1002/path.70001 \|url=}}</ref>

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			===Positive===
			<pre>
			ABCC2 brush border staining in the tumour is PRESENT, patchy and estimated as >50%; the presence of significant ABCC2 staining suggests a more aggressive disease.[1]

			The findings are in keeping with papillary renal cell carcinoma; the diagnosis is not changed.

			1. Histopathology. 2023 Dec;83(6):949-958. doi: 10.1111/his.15042.
			</rep>

			===Negative===
			<pre>
			Significant ABCC2 brush border staining in the tumour is ABSENT (<50%).
			</pre>

	==References==		==References==

Michael at 22:59, 18 May 2026

2026-05-18T22:59:55Z

← Older revision		Revision as of 22:59, 18 May 2026
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	==Papillary renal cell carcinoma==		==Papillary renal cell carcinoma==
	ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]]~~; when brush~~ border staining ~~is present it~~ is associated with a worse survival.<ref name=pmid37680023>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>		ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]]:
			*Brush border staining is associated with a worse survival.<ref name=pmid37680023>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>
			*Brush border staining suggests response to immunotherapy.<ref>{{cite journal \|authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R \|title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy \|journal=J Pathol \|volume=268 \|issue=2 \|pages=188–199 \|date=February 2026 \|pmid=41259021 \|doi=10.1002/path.70001 \|url=}}</ref>

Michael at 22:54, 18 May 2026

2026-05-18T22:54:12Z

← Older revision		Revision as of 22:54, 18 May 2026
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	==Papillary renal cell carcinoma==		==Papillary renal cell carcinoma==
	ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]].<ref name=pmid37680023>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>		ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]]; when brush border staining is present it is associated with a worse survival.<ref name=pmid37680023>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>

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2026-05-18T22:52:05Z

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'''ABCC2''' is an [[immunostain]].

==Papillary renal cell carcinoma==
ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]].<ref name=pmid37680023>{{cite journal |authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM |title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases |journal=Histopathology |volume=83 |issue=6 |pages=949–958 |date=December 2023 |pmid=37680023 |doi=10.1111/his.15042 |url=}}</ref>

==References==
{{Reflist|1}}

[[Category:Immunohistochemistry]]