Michael: fix

2025-09-26T21:50:50Z

fix

← Older revision		Revision as of 21:50, 26 September 2025
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	It may be abbreviated ''ALK-RCC''.		It may be abbreviated ''ALK-RCC''.

	~~==General==~~
	*Extremely rare.
	**One case was identified in 829 consecutively screened Korean patients.<ref name=pmid24255633>{{Cite journal \| last1 = Lee \| first1 = C. \| last2 = Park \| first2 = JW. \| last3 = Suh \| first3 = JH. \| last4 = Nam \| first4 = KH. \| last5 = Moon \| first5 = KC. \| title = ALK-Positive Renal Cell Carcinoma in a Large Series of Consecutively Resected Korean Renal Cell Carcinoma Patients. \| journal = Korean J Pathol \| volume = 47 \| issue = 5 \| pages = 452-7 \| month = Oct \| year = 2013 \| doi = 10.4132/KoreanJPathol.2013.47.5.452 \| PMID = 24255633 }}</ref>
	**A second series described 8 in 276 cases on a microarray.<ref name=pmid38039739>{{cite journal \|authors=Doğan K, Onder E \|title=ALK-rearranged renal cell carcinoma (ALK-RCC): Evaluation of histomorphological and immunohistochemical features by analysis of 276 renal cell carcinoma cases in Turkey \|journal=Pathol Res Pract \|volume=253 \|issue= \|pages=154951 \|date=January 2024 \|pmid=38039739 \|doi=10.1016/j.prp.2023.154951 \|url=}}</ref>
	**In 2016, less than 17 cases reported.<ref name=pmid27554841>{{Cite journal \| last1 = Jeanneau \| first1 = M. \| last2 = Gregoire \| first2 = V. \| last3 = Desplechain \| first3 = C. \| last4 = Escande \| first4 = F. \| last5 = Tica \| first5 = DP. \| last6 = Aubert \| first6 = S. \| last7 = Leroy \| first7 = X. \| title = ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult. \| journal = Pathol Res Pract \| volume = 212 \| issue = 11 \| pages = 1064-1066 \| month = Nov \| year = 2016 \| doi = 10.1016/j.prp.2016.07.015 \| PMID = 27554841 }}</ref>
	*May respond to [[ALK inhibitors]] such as alectinib<ref name=pmid29685646>{{Cite journal \| last1 = Pal \| first1 = SK. \| last2 = Bergerot \| first2 = P. \| last3 = Dizman \| first3 = N. \| last4 = Bergerot \| first4 = C. \| last5 = Adashek \| first5 = J. \| last6 = Madison \| first6 = R. \| last7 = Chung \| first7 = JH. \| last8 = Ali \| first8 = SM. \| last9 = Jones \| first9 = JO. \| title = Responses to Alectinib in ALK-rearranged Papillary Renal Cell Carcinoma. \| journal = Eur Urol \| volume = 74 \| issue = 1 \| pages = 124-128 \| month = 07 \| year = 2018 \| doi = 10.1016/j.eururo.2018.03.032 \| PMID = 29685646 }}</ref> or crizotinib.<ref name=pmid27554841>{{Cite journal \| last1 = Jeanneau \| first1 = M. \| last2 = Gregoire \| first2 = V. \| last3 = Desplechain \| first3 = C. \| last4 = Escande \| first4 = F. \| last5 = Tica \| first5 = DP. \| last6 = Aubert \| first6 = S. \| last7 = Leroy \| first7 = X. \| title = ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult. \| journal = Pathol Res Pract \| volume = 212 \| issue = 11 \| pages = 1064-1066 \| month = Nov \| year = 2016 \| doi = 10.1016/j.prp.2016.07.015 \| PMID = 27554841 }}</ref>

	~~==Microscopic==~~
	~~Features:~~
	*Mix of morphologies - including:
	**[[Papillary renal cell carcinoma]].<ref name=pmid24255633/>
	**[[Renal cell carcinoma with rhabdoid morphology\|Rhabdoid change]].<ref name=pmid26017874>{{Cite journal \| last1 = Kuroda \| first1 = N. \| last2 = Karashima \| first2 = T. \| last3 = Inoue \| first3 = K. \| last4 = Kasajima \| first4 = A. \| last5 = Ohe \| first5 = C. \| last6 = Kawakami \| first6 = F. \| last7 = Mikami \| first7 = S. \| last8 = Matsuura \| first8 = K. \| last9 = Moriyama \| first9 = M. \| title = Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects. \| journal = Pol J Pathol \| volume = 66 \| issue = 1 \| pages = 3-8 \| month = Mar \| year = 2015 \| doi = \| PMID = 26017874 }}</ref>
	**[[Renal cell carcinoma with sarcomatoid differentiation\|Sarcomatoid change]].
	**"[[Unclassified renal cell carcinoma]]".

	~~DDx:~~
	*[[Papillary renal cell carcinoma]] - especially what used to be known as "type 2".<ref name=pmid24255633/>
	*[[Unclassified renal cell carcinoma]]
	*[[Renal medullary carcinoma]].
	*[[Clear cell renal cell carcinoma]].<ref name=pmid38039739/>
	*[[Renal mucinous tubular and spindle cell carcinoma]].<ref>{{cite journal \|authors=Kai K, Tobu S, Kido S, Mikami S, Takeuchi K, Dobashi A, Togashi Y, Noguchi M, Aishima S \|title=ALK rearrangement-associated renal cell carcinoma morphologically mimicking mucinous tubular and spindle cell carcinoma: a case report \|journal=Diagn Pathol \|volume=17 \|issue=1 \|pages=52 \|date=June 2022 \|pmid=35718773 \|pmc=9206751 \|doi=10.1186/s13000-022-01238-z \|url=}}</ref>

	~~==IHC==~~
	Features:<ref>{{Cite journal \| last1 = Jeanneau \| first1 = M. \| last2 = Gregoire \| first2 = V. \| last3 = Desplechain \| first3 = C. \| last4 = Escande \| first4 = F. \| last5 = Tica \| first5 = DP. \| last6 = Aubert \| first6 = S. \| last7 = Leroy \| first7 = X. \| title = ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult. \| journal = Pathol Res Pract \| volume = 212 \| issue = 11 \| pages = 1064-1066 \| month = Nov \| year = 2016 \| doi = 10.1016/j.prp.2016.07.015 \| PMID = 27554841 }}</ref>
	*L-ALK +ve. ‡
	*PAX8 +ve.
	*Vimentin +ve (diffuse).
	*CK7 +ve (focal).
	*[[SMARCB1]] normal nuclear staining.{{fact}}

	‡ There are different clones for ALK; they may be called ''ALK1'' (used in lymphoma) and ''L-ALK'' (used in lung cancer). In the context of RCC, the ALK clone for lung cancer (e.g. D5F3) should be used.<ref>{{cite journal \|authors=Kai K, Tobu S, Kido S, Mikami S, Takeuchi K, Dobashi A, Togashi Y, Noguchi M, Aishima S \|title=ALK rearrangement-associated renal cell carcinoma morphologically mimicking mucinous tubular and spindle cell carcinoma: a case report \|journal=Diagn Pathol \|volume=17 \|issue=1 \|pages=52 \|date=June 2022 \|pmid=35718773 \|pmc=9206751 \|doi=10.1186/s13000-022-01238-z \|url=}}</ref>

	~~==Molecular==~~
	*ALK rearrangement.

	~~==See also==~~
	*[[Vancouver classification]].
	*[[Kidney tumours]].
	*[[Lung carcinoma with ALK rearrangement]].

	~~==References==~~
	~~{{Reflist\|2}}~~

	~~[[Category:Kidney tumours]]~~
	~~[[Category:Diagnosis]]~~

	~~Summary:~~
	~~This is a minor edit~~
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	~~{{ Infobox diagnosis~~
	~~\| Name = {{PAGENAME}}~~
	~~\| Image =~~
	~~\| Width =~~
	~~\| Caption =~~
	~~\| Synonyms =~~
	~~\| Micro = mixed morphology, +/-papillae, +/-myxoid change~~
	~~\| Subtypes =~~
	\| LMDDx = [[papillary renal cell carcinoma]], [[unclassified renal cell carcinoma]], [[clear cell renal cell carcinoma]], [[SMARCB1-deficient renal medullary carcinoma]], [[renal mucinous tubular and spindle cell carcinoma]]
	~~\| Stains =~~
	~~\| IHC = ALK +ve~~
	~~\| EM =~~
	~~\| Molecular = ALK rearranagement~~
	~~\| IF =~~
	~~\| Gross =~~
	~~\| Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]]~~
	~~\| Staging = [[kidney cancer staging]]~~
	~~\| Site = [[kidney]] - see ''[[kidney tumours]]''~~
	~~\| Assdx =~~
	~~\| Syndromes =~~
	~~\| Clinicalhx =~~
	~~\| Signs =~~
	~~\| Symptoms =~~
	~~\| Prevalence = very rare~~
	~~\| Bloodwork =~~
	~~\| Rads =~~
	~~\| Endoscopy =~~
	~~\| Prognosis =~~
	~~\| Other =~~
	~~\| ClinDDx =~~
	~~\| Tx = may respond to ALK inhibitors~~
	}}
	'''ALK-rearranged renal cell carcinoma''', also '''ALK translocation renal cell carcinoma''' and '''ALK-positive renal cell carcinoma''', is a type of [[renal cell carcinoma]] recognized by the World Health Organization (WHO).

	==General==		==General==

Michael at 21:49, 26 September 2025

2025-09-26T21:49:45Z

← Older revision		Revision as of 21:49, 26 September 2025
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	}}		}}
	'''ALK-rearranged renal cell carcinoma''', also '''ALK translocation renal cell carcinoma''' and '''ALK-positive renal cell carcinoma''', is a type of [[renal cell carcinoma]] recognized by the WHO.		'''ALK-rearranged renal cell carcinoma''', also '''ALK translocation renal cell carcinoma''' and '''ALK-positive renal cell carcinoma''', is a type of [[renal cell carcinoma]] recognized by the WHO.

			It may be abbreviated ''ALK-RCC''.

	==General==		==General==

Michael: reorder

2025-09-26T21:47:25Z

reorder

← Older revision		Revision as of 21:47, 26 September 2025
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	\| Tx = may respond to ALK inhibitors		\| Tx = may respond to ALK inhibitors
	}}		}}
	'''ALK ~~translocation~~ renal cell carcinoma''', also '''ALK~~-rearranged~~ renal cell carcinoma''' and '''ALK-positive renal cell carcinoma''', is a type of [[renal cell carcinoma]] recognized by the WHO.		'''ALK-rearranged renal cell carcinoma''', also '''ALK translocation renal cell carcinoma''' and '''ALK-positive renal cell carcinoma''', is a type of [[renal cell carcinoma]] recognized by the WHO.

	==General==		==General==

Michael: tweak

2025-09-26T21:46:05Z

tweak

← Older revision		Revision as of 21:46, 26 September 2025
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	~~Editing ALK translocation renal cell carcinoma~~
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}

Michael: change name of article

2025-09-26T21:45:12Z

change name of article

Show changes

Michael: redirect

2019-04-04T15:09:30Z

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#redirect [[ALK translocation renal cell carcinoma]]

ALK-rearranged renal cell carcinoma - Revision history

Michael: fix

Michael at 21:49, 26 September 2025

Michael: reorder

Michael: tweak

Michael: change name of article

Michael: redirect