Michael: split out

2014-12-10T05:33:15Z

split out

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	~~#redirect~~ [[Neuropathology~~#Acute_disseminated_encephalomyelitis~~]]		'''Acute disseminated encephalomyelitis''', abbreviated '''ADEM''', is an uncommon [[neuropathology]] with some similarities with [[multiple sclerosis]].

			==General==
			*Thought to be autoimmune; often associated with/preceded by viral illness.<ref name=pmid17438235>{{cite journal \|author=Tenembaum S, Chitnis T, Ness J, Hahn JS \|title=Acute disseminated encephalomyelitis \|journal=Neurology \|volume=68 \|issue=16 Suppl 2 \|pages=S23–36 \|year=2007 \|month=April \|pmid=17438235 \|doi=10.1212/01.wnl.0000259404.51352.7f \|url=}}</ref>
			*May mimic [[multiple sclerosis]].

			Treatment:
			*Steroids.
			*Plasmapheresis.

			Diagnosis:
			*Need to r/o infection (with lumbar puncture).
			*No old plaques on imaging (MRI).

			An acute form exists known as ''acute hemorrhagic leukoencephalitis''<ref>URL: [http://path.upmc.edu/cases/case102/dx.html http://path.upmc.edu/cases/case102/dx.html]. Accessed on: 2 January 2012.</ref> (AKA ''acute necrotizing hemorrhagic encephalomyelitis'').

			==Microscopic==
			Features:<ref>{{Ref PBoD8\|1312}}</ref>
			*Myelin loss with sparing of axons.
			*Inflammation:
			**Early: [[neutrophil]]s.
			**Late: mononuclear cells (lymphocytes, plasma cells).
			*Lipid-laden macrophages.

			DDx:
			*[[Multiple sclerosis]].
			**Tend to be larger, more lymphocytes,<ref>{{Ref APBR\|423}}</ref> age of the lesions differ.
			*Acute necrotizing hemorrhagic encephalomyelitis (ANHE) - if one considers this a separate entity.
			*Acute necrotizing encephalopathy.<ref>URL: [http://path.upmc.edu/cases/case619/dx.html http://path.upmc.edu/cases/case619/dx.html]. Accessed on: 26 January 2012.</ref>

			==See also==
			*[[Neuropathology]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology]]

Michael: redirect w/ cat

2011-11-26T22:35:42Z

redirect w/ cat

New page

#redirect [[Neuropathology#Acute_disseminated_encephalomyelitis]]

[[Category:Diagnosis]]

Acute disseminated encephalomyelitis - Revision history

Michael: split out

Michael: redirect w/ cat