Acute myeloid leukemia - Revision history

Michael at 23:48, 27 May 2018

2018-05-27T23:48:42Z

← Older revision		Revision as of 23:48, 27 May 2018
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			[[Image:Auer_rods.PNG\|thumb\|right\|Auer rods characterize ''acute myeloid leukemia''.]]
	'''Acute myeloid leukemia''', abbreviated '''AML''', is a group of [[cancer\|malignancies]].		'''Acute myeloid leukemia''', abbreviated '''AML''', is a group of [[cancer\|malignancies]].

Michael at 23:44, 27 May 2018

2018-05-27T23:44:46Z

← Older revision		Revision as of 23:44, 27 May 2018
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	'''Acute myeloid leukemia''', abbreviated '''AML''', is a group of [[cancer\|malignancies]].		'''Acute myeloid leukemia''', abbreviated '''AML''', is a group of [[cancer\|malignancies]].

			=Overview=
			*Group of malignancies.
			*Defined by the cytogenetic abnormalities.

	=No recurrent cytogenetic abnormalities=		=No recurrent cytogenetic abnormalities=

Michael: /* Acute myeloid leukemia with t(15;17) */

2018-05-27T23:35:18Z

Acute myeloid leukemia with t(15;17)

← Older revision		Revision as of 23:35, 27 May 2018
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	*Associated with [[DIC]].		*Associated with [[DIC]].
	*Treatment: all-trans retinoic acid (ATRA).		*Treatment: all-trans retinoic acid (ATRA).

	~~Variants:~~
	*t(11;17) -- ATRA doesn't work.<ref>{{Ref APBR\|623 Q2}}</ref>
	*t(17;17) -- ATRA doesn't work.
	*t(5;17). (???)

	===Microscopic===		===Microscopic===
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	*CD34 -ve, HLA-DR -ve.		*CD34 -ve, HLA-DR -ve.
	*CD33 +ve, CD13 +ve/-ve, CD117 +ve (weak), CD56 +ve/-ve.		*CD33 +ve, CD13 +ve/-ve, CD117 +ve (weak), CD56 +ve/-ve.

			===Molecular===
			Variants:
			*t(11;17) -- ATRA doesn't work.<ref>{{Ref APBR\|623 Q2}}</ref>
			*t(17;17) -- ATRA doesn't work.
			*t(5;17). (???)

	==Acute myeloid leukemia with t(9;11)==		==Acute myeloid leukemia with t(9;11)==

Michael: /* Acute myeloid leukemia with t(8;21) */

2018-05-27T23:34:04Z

Acute myeloid leukemia with t(8;21)

← Older revision		Revision as of 23:34, 27 May 2018
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	=AML with recurrent cytogenetic abnormalities=		=AML with recurrent cytogenetic abnormalities=
	==Acute myeloid leukemia with t(8;21)==		==Acute myeloid leukemia with t(8;21)==
	*t(8;21)(q22;q22).<ref>{{Cite journal \| last1 = Berger \| first1 = R. \| title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. \| journal = Nouv Rev Fr Hematol \| volume = 36 Suppl 1 \| issue = \| pages = S67-9 \| month = \| year = 1994 \| doi = \| PMID = 8177719 }}</ref>

	===IHC===		===IHC===
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	Images:		Images:
	*[http://path.upmc.edu/cases/case712.html AML with t(8;21) (upmc.edu)].		*[http://path.upmc.edu/cases/case712.html AML with t(8;21) (upmc.edu)].

			===Molecular===
			*t(8;21)(q22;q22).<ref>{{Cite journal \| last1 = Berger \| first1 = R. \| title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. \| journal = Nouv Rev Fr Hematol \| volume = 36 Suppl 1 \| issue = \| pages = S67-9 \| month = \| year = 1994 \| doi = \| PMID = 8177719 }}</ref>

	==Acute myeloid leukemia with inv(16)==		==Acute myeloid leukemia with inv(16)==

Michael: /* AML with recurrent cytogenetic abnormalities */

2018-05-27T23:33:06Z

AML with recurrent cytogenetic abnormalities

← Older revision		Revision as of 23:33, 27 May 2018
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	*t(8;21)(q22;q22).<ref>{{Cite journal \| last1 = Berger \| first1 = R. \| title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. \| journal = Nouv Rev Fr Hematol \| volume = 36 Suppl 1 \| issue = \| pages = S67-9 \| month = \| year = 1994 \| doi = \| PMID = 8177719 }}</ref>		*t(8;21)(q22;q22).<ref>{{Cite journal \| last1 = Berger \| first1 = R. \| title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. \| journal = Nouv Rev Fr Hematol \| volume = 36 Suppl 1 \| issue = \| pages = S67-9 \| month = \| year = 1994 \| doi = \| PMID = 8177719 }}</ref>

	IHC:		===IHC===
	*CD34+, CD13+, MPO+ (cytoplasm), CD33+ (weak).		*CD34+, CD13+, MPO+ (cytoplasm), CD33+ (weak).
	*[[CD56]]+, CD117+.		*[[CD56]]+, CD117+.
	**Usu. assoc. with a bad prognosis.		**Usu. assoc. with a bad prognosis.

	Flow cytometry:		===Flow cytometry===
	*CD19+, PAX5+, CD79a +/-.		*CD19+, PAX5+, CD79a +/-.

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	*Associated with [[myeloid sarcoma]].		*Associated with [[myeloid sarcoma]].

	Microscopic:		===Microscopic===
	*Blast count usu. ~20% (low).		*Blast count usu. ~20% (low).
	*Eosinophilic granules.		*Eosinophilic granules.
	**Used to be classified as "M4" with eosinophilia.		**Used to be classified as "M4" with eosinophilia.

	IHC:		===IHC===
	*CD2+ -- common.		*CD2+ -- common.

Michael: /* Acute myeloid leukemia with t(9;11) */

2018-05-27T23:31:30Z

Acute myeloid leukemia with t(9;11)

← Older revision		Revision as of 23:31, 27 May 2018
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	==Acute myeloid leukemia with t(9;11)==		==Acute myeloid leukemia with t(9;11)==
	*~~t(9;11)~~.		===General===
			Clinical:
			*+/-[[DIC]].
			*Usu. children.

	Microscopic:		===Microscopic===
	*Monoblastic morphology. (???)		*Monoblastic morphology. (???)
	*Myelomonocytic morphology. (???)		*Myelomonocytic morphology. (???)

	~~Clinical:~~		===IHC===
	*+/-[[DIC]].
	*Usu. children.

	IHC:
	*CD33+, CD65+, CD4+, HLA-DR+.		*CD33+, CD65+, CD4+, HLA-DR+.
	*CD34+. (???)		*CD34+. (???)
	*CD13+. (???)		*CD13+. (???)

			===Molecular===
			*t(9;11).

	=See also=		=See also=

Michael: /* Microscopic */

2018-05-27T23:28:58Z

Microscopic

← Older revision		Revision as of 23:28, 27 May 2018
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	*t(5;17). (???)		*t(5;17). (???)

	==Microscopic==		===Microscopic===
	Comes in two flavours.		Comes in two flavours.

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	*Absence of granules on light microscopy.		*Absence of granules on light microscopy.

	===Images===		====Images====
	<gallery>		<gallery>
	Image:Faggot cell in AML-M3.jpg \|Faggot cell in AML-M3. (WC)		Image:Faggot cell in AML-M3.jpg \|Faggot cell in AML-M3. (WC)

Michael: /* General */

2018-05-27T23:28:33Z

General

← Older revision		Revision as of 23:28, 27 May 2018
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	**Fusion transcripts: PML<ref name=omim102578>{{OMIM\|102578}}</ref>-RARA.<ref name=omim180240>{{OMIM\|180240}}</ref>		**Fusion transcripts: PML<ref name=omim102578>{{OMIM\|102578}}</ref>-RARA.<ref name=omim180240>{{OMIM\|180240}}</ref>

	==General==		===General===
	Clinical:		Clinical:
	*Associated with [[DIC]].		*Associated with [[DIC]].

Michael: tweak

2018-05-27T23:28:18Z

tweak

← Older revision		Revision as of 23:28, 27 May 2018
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	~~Abbreviated~~ ''[[~~AML~~]]''.		'''Acute myeloid leukemia''', abbreviated '''AML''', is a group of [[cancer\|malignancies]].

			=No recurrent cytogenetic abnormalities=
			==Acute myeloid leukemia without recurrent cytogenetic abnormalities==
	===General===		===General===
	*Adults.		*Adults.
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	*May be classified by morphology, using the (old) French-American-British (FAB) classification (M0-M7).		*May be classified by morphology, using the (old) French-American-British (FAB) classification (M0-M7).

	====Image====		===Image===
	<gallery>		<gallery>
	Image:Auer_rods.PNG \| Auer rods in an AML. (WC)		Image:Auer_rods.PNG \| Auer rods in an AML. (WC)
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	*Must exclude all the recurrent cytogenetic abnormalities - see below.		*Must exclude all the recurrent cytogenetic abnormalities - see below.

	==AML with recurrent cytogenetic abnormalities==		=AML with recurrent cytogenetic abnormalities=
	===Acute myeloid leukemia with t(8;21)===		==Acute myeloid leukemia with t(8;21)==
	*t(8;21)(q22;q22).<ref>{{Cite journal \| last1 = Berger \| first1 = R. \| title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. \| journal = Nouv Rev Fr Hematol \| volume = 36 Suppl 1 \| issue = \| pages = S67-9 \| month = \| year = 1994 \| doi = \| PMID = 8177719 }}</ref>		*t(8;21)(q22;q22).<ref>{{Cite journal \| last1 = Berger \| first1 = R. \| title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. \| journal = Nouv Rev Fr Hematol \| volume = 36 Suppl 1 \| issue = \| pages = S67-9 \| month = \| year = 1994 \| doi = \| PMID = 8177719 }}</ref>

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	*[http://path.upmc.edu/cases/case712.html AML with t(8;21) (upmc.edu)].		*[http://path.upmc.edu/cases/case712.html AML with t(8;21) (upmc.edu)].

	===Acute myeloid leukemia with inv(16)===		==Acute myeloid leukemia with inv(16)==
	*inv(16)(p13.1q22).<ref name=pmid16917916>{{Cite journal \| last1 = Lu \| first1 = CM. \| last2 = Murata-Collins \| first2 = JL. \| last3 = Wang \| first3 = E. \| last4 = Siddiqi \| first4 = I. \| last5 = Lawrence \| first5 = HJ. \| title = Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases. \| journal = Am J Hematol \| volume = 81 \| issue = 12 \| pages = 963-8 \| month = Dec \| year = 2006 \| doi = 10.1002/ajh.20716 \| PMID = 16917916 }}		*inv(16)(p13.1q22).<ref name=pmid16917916>{{Cite journal \| last1 = Lu \| first1 = CM. \| last2 = Murata-Collins \| first2 = JL. \| last3 = Wang \| first3 = E. \| last4 = Siddiqi \| first4 = I. \| last5 = Lawrence \| first5 = HJ. \| title = Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases. \| journal = Am J Hematol \| volume = 81 \| issue = 12 \| pages = 963-8 \| month = Dec \| year = 2006 \| doi = 10.1002/ajh.20716 \| PMID = 16917916 }}
	</ref>		</ref>
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	*CD2+ -- common.		*CD2+ -- common.

	===Acute myeloid leukemia with t(15;17)===		==Acute myeloid leukemia with t(15;17)==
	*[[AKA]] ''acute promyelocytic leukemia''		*[[AKA]] ''acute promyelocytic leukemia''
	**Abbreviated ''APL''.		**Abbreviated ''APL''.
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	**Fusion transcripts: PML<ref name=omim102578>{{OMIM\|102578}}</ref>-RARA.<ref name=omim180240>{{OMIM\|180240}}</ref>		**Fusion transcripts: PML<ref name=omim102578>{{OMIM\|102578}}</ref>-RARA.<ref name=omim180240>{{OMIM\|180240}}</ref>

	====General====		==General==
	Clinical:		Clinical:
	*Associated with [[DIC]].		*Associated with [[DIC]].
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	*t(5;17). (???)		*t(5;17). (???)

	====Microscopic====		==Microscopic==
	Comes in two flavours.		Comes in two flavours.

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	*Absence of granules on light microscopy.		*Absence of granules on light microscopy.

	=====Images=====		===Images===
	<gallery>		<gallery>
	Image:Faggot cell in AML-M3.jpg \|Faggot cell in AML-M3. (WC)		Image:Faggot cell in AML-M3.jpg \|Faggot cell in AML-M3. (WC)
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	*[http://path.upmc.edu/cases/case705.html APML - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case705.html APML - several images (upmc.edu)].

	====IHC====		===IHC===
	*CD2 +ve, CD34 +ve/-ve, CD56 +ve/-ve.		*CD2 +ve, CD34 +ve/-ve, CD56 +ve/-ve.

	====[[Flow cytometry]]====		===[[Flow cytometry]]===
	*CD34 -ve, HLA-DR -ve.		*CD34 -ve, HLA-DR -ve.
	*CD33 +ve, CD13 +ve/-ve, CD117 +ve (weak), CD56 +ve/-ve.		*CD33 +ve, CD13 +ve/-ve, CD117 +ve (weak), CD56 +ve/-ve.

	===Acute myeloid leukemia with t(9;11)===		==Acute myeloid leukemia with t(9;11)==
	*t(9;11).		*t(9;11).

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	*CD34+. (???)		*CD34+. (???)
	*CD13+. (???)		*CD13+. (???)

			=See also=
			*[[Leukemia]].

			=References=
			{{Reflist\|1}}

	[[Category: Hematopathology]]		[[Category: Hematopathology]]

Mark: hive off from Leukemia page

2018-05-26T18:48:32Z

hive off from Leukemia page

← Older revision		Revision as of 18:48, 26 May 2018
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	~~#redirect~~ [[~~Leukemia#Acute_myeloid_leukemia~~]]		Abbreviated ''[[AML]]''.

	[[Category:~~Diagnosis~~]]		===General===
			*Adults.

			Exclusions for this diagnosis:
			*Prior [[MDS]].
			*[[Down syndrome]].

			===Microscopic===
			Features:
			*[[Auer rods]] present
			*Cytoplasmic granularity.
			*Large cells.

			Note:
			*May be classified by morphology, using the (old) French-American-British (FAB) classification (M0-M7).

			====Image====
			<gallery>
			Image:Auer_rods.PNG \| Auer rods in an AML. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case344.html AML - several images (upmc.edu)].

			===Molecular===
			*Must exclude all the recurrent cytogenetic abnormalities - see below.

			==AML with recurrent cytogenetic abnormalities==
			===Acute myeloid leukemia with t(8;21)===
			*t(8;21)(q22;q22).<ref>{{Cite journal \| last1 = Berger \| first1 = R. \| title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. \| journal = Nouv Rev Fr Hematol \| volume = 36 Suppl 1 \| issue = \| pages = S67-9 \| month = \| year = 1994 \| doi = \| PMID = 8177719 }}</ref>

			IHC:
			*CD34+, CD13+, MPO+ (cytoplasm), CD33+ (weak).
			*[[CD56]]+, CD117+.
			**Usu. assoc. with a bad prognosis.

			Flow cytometry:
			*CD19+, PAX5+, CD79a +/-.

			Images:
			*[http://path.upmc.edu/cases/case712.html AML with t(8;21) (upmc.edu)].

			===Acute myeloid leukemia with inv(16)===
			*inv(16)(p13.1q22).<ref name=pmid16917916>{{Cite journal \| last1 = Lu \| first1 = CM. \| last2 = Murata-Collins \| first2 = JL. \| last3 = Wang \| first3 = E. \| last4 = Siddiqi \| first4 = I. \| last5 = Lawrence \| first5 = HJ. \| title = Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases. \| journal = Am J Hematol \| volume = 81 \| issue = 12 \| pages = 963-8 \| month = Dec \| year = 2006 \| doi = 10.1002/ajh.20716 \| PMID = 16917916 }}
			</ref>

			*Associated with [[myeloid sarcoma]].

			Microscopic:
			*Blast count usu. ~20% (low).
			*Eosinophilic granules.
			**Used to be classified as "M4" with eosinophilia.

			IHC:
			*CD2+ -- common.

			===Acute myeloid leukemia with t(15;17)===
			*[[AKA]] ''acute promyelocytic leukemia''
			**Abbreviated ''APL''.
			*t(15;17)(q22;q12).
			**Fusion transcripts: PML<ref name=omim102578>{{OMIM\|102578}}</ref>-RARA.<ref name=omim180240>{{OMIM\|180240}}</ref>

			====General====
			Clinical:
			*Associated with [[DIC]].
			*Treatment: all-trans retinoic acid (ATRA).

			Variants:
			*t(11;17) -- ATRA doesn't work.<ref>{{Ref APBR\|623 Q2}}</ref>
			*t(17;17) -- ATRA doesn't work.
			*t(5;17). (???)

			====Microscopic====
			Comes in two flavours.

			Microscopic (Hypergranular ''or'' typical APL):
			*Bean-shaped nucleus ''or'' bilobed nucleus.
			*Buddles of Auer rods - known as "Faggot cells".

			Microscopic (Microgranular ''or'' hypogranular APL):
			*Bilobed nuclei with nuclear overlap. (???)
			*Absence of granules on light microscopy.

			=====Images=====
			<gallery>
			Image:Faggot cell in AML-M3.jpg \|Faggot cell in AML-M3. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case457/images/fig01.jpg AML - showing Auer rods (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case457.html http://path.upmc.edu/cases/case457.html]. Accessed on: 21 January 2012.</ref>
			*[http://path.upmc.edu/cases/case705.html APML - several images (upmc.edu)].

			====IHC====
			*CD2 +ve, CD34 +ve/-ve, CD56 +ve/-ve.

			====[[Flow cytometry]]====
			*CD34 -ve, HLA-DR -ve.
			*CD33 +ve, CD13 +ve/-ve, CD117 +ve (weak), CD56 +ve/-ve.

			===Acute myeloid leukemia with t(9;11)===
			*t(9;11).

			Microscopic:
			*Monoblastic morphology. (???)
			*Myelomonocytic morphology. (???)

			Clinical:
			*+/-[[DIC]].
			*Usu. children.

			IHC:
			*CD33+, CD65+, CD4+, HLA-DR+.
			*CD34+. (???)
			*CD13+. (???)

			[[Category: Hematopathology]]