Adenocarcinoma of the lung - Revision history

Michael: /* Lepidic pattern on biopsy */ tweak

2022-01-11T21:54:36Z

Lepidic pattern on biopsy: tweak

← Older revision		Revision as of 21:54, 11 January 2022
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	NEGATIVE: p40.		NEGATIVE: p40.

	The findings are in keeping with lepidic pattern adenocarcinoma; the differential diagnosis includes: (1) adenocarcinoma in situ, (2) ~~lepidic pattern~~ adenocarcinoma, and (3) invasive adenocarcinoma.		The findings are in keeping with lepidic pattern adenocarcinoma; the differential diagnosis includes: (1) adenocarcinoma in situ, (2) minimally invasive adenocarcinoma, and (3) invasive adenocarcinoma.

	Lung biomarkers (EGFR, ALK, PDL1, ROS1) have been ordered.		Lung biomarkers (EGFR, ALK, PDL1, ROS1) have been ordered.

2022-01-11T21:51:48Z

Lepidic pattern on biopsy

← Older revision		Revision as of 21:51, 11 January 2022
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	NEGATIVE: p40.		NEGATIVE: p40.

	The findings are in keeping with lepidic pattern adenocarcinoma~~. The~~ differential diagnosis includes: (1) adenocarcinoma in situ, (2) lepidic pattern adenocarcinoma, and (3) invasive adenocarcinoma.		The findings are in keeping with lepidic pattern adenocarcinoma; the differential diagnosis includes: (1) adenocarcinoma in situ, (2) lepidic pattern adenocarcinoma, and (3) invasive adenocarcinoma.

	Lung biomarkers (EGFR, ALK, PDL1, ROS1) have been ordered.		Lung biomarkers (EGFR, ALK, PDL1, ROS1) have been ordered.

2022-01-11T21:51:29Z

Microscopic

← Older revision		Revision as of 21:51, 11 January 2022
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	*[[Squamous cell carcinoma of the lung]].		*[[Squamous cell carcinoma of the lung]].
	*[[Small cell carcinoma of the lung]].		*[[Small cell carcinoma of the lung]].
	*[[Adenoid ~~Cystic Carcinoma~~]].		*[[Adenoid cystic carcinoma]].
	*[[Non-small cell lung carcinoma]] - diagnosis should be avoided if possible.		*[[Non-small cell lung carcinoma]] - diagnosis should be avoided if possible.
	*[[Malignant mesothelioma]].		*[[Malignant mesothelioma]].

2022-01-11T21:48:58Z

Microscopic

← Older revision		Revision as of 21:48, 11 January 2022
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	DDx:		DDx:
	*[[Atypical adenomatous hyperplasia of the lung]] - spaced [[hobnail]] cells, mild-to-moderate nuclear atypia, small lesion (< 5 mm).		*[[Atypical adenomatous hyperplasia of the lung]] - spaced [[hobnail]] cells, mild-to-moderate nuclear atypia, small lesion (must be <5 mm).
	*Adenocarcinoma in situ.		*Adenocarcinoma in situ.
	*[[Papillary thyroid carcinoma\|Papillary carcinoma of thyroid]].		*[[Papillary thyroid carcinoma\|Papillary carcinoma of thyroid]].

2022-01-11T21:47:14Z

Lepidic pattern on biopsy

← Older revision		Revision as of 21:47, 11 January 2022
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	====Lepidic pattern on biopsy====		====Lepidic pattern on biopsy====
	~~Note~~: ~~Lesion~~ must be >=5 mm.		Important note: lesion '''''must''''' be >=5 mm ''and'' <=30 mm.
	<pre>		<pre>
	Lung, Left Upper Lobe, Core Biopsy:		Lung, Left Upper Lobe, Core Biopsy:

2022-01-11T21:45:42Z

Lepidic pattern on biopsy

← Older revision		Revision as of 21:45, 11 January 2022
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	====Lepidic pattern on biopsy====		====Lepidic pattern on biopsy====
			Note: Lesion must be >=5 mm.
	<pre>		<pre>
	Lung, Left Upper Lobe, Core Biopsy:		Lung, Left Upper Lobe, Core Biopsy:

2022-01-11T21:42:53Z

Biopsy

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	The adenocarcinoma is positive for TTF-1 and napsin. EGFR/ALK testing was ordered.		The adenocarcinoma is positive for TTF-1 and napsin. EGFR/ALK testing was ordered.
	</pre>		</pre>

			====Lepidic pattern on biopsy====
			<pre>
			Lung, Left Upper Lobe, Core Biopsy:
			- ADENOCARCINOMA, lepidic pattern.

			Comment:
			The tumour is stains as follows:
			POSITIVE: TTF-1, napsin A, CK7.
			NEGATIVE: p40.

			The findings are in keeping with lepidic pattern adenocarcinoma. The differential diagnosis includes: (1) adenocarcinoma in situ, (2) lepidic pattern adenocarcinoma, and (3) invasive adenocarcinoma.

			Lung biomarkers (EGFR, ALK, PDL1, ROS1) have been ordered.
			</pre>


	=====Mucinous adenocarcinoma with noncontributory stains=====		=====Mucinous adenocarcinoma with noncontributory stains=====

2021-03-26T16:04:09Z

Classification

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	===Classification===		===Classification===
	Classification based on extent:<ref name=pmid21252716>{{cite journal \|author=Travis WD, Brambilla E, Noguchi M, ''et al.'' \|title=International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma \|journal=J Thorac Oncol \|volume=6 \|issue=2 \|pages=244–85 \|year=2011 \|month=February \|pmid=21252716 \|doi=10.1097/JTO.0b013e318206a221 \|url=}}</ref>		Classification based on extent:<ref name=pmid21252716>{{cite journal \|author=Travis WD, Brambilla E, Noguchi M, ''et al.'' \|title=International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma \|journal=J Thorac Oncol \|volume=6 \|issue=2 \|pages=244–85 \|year=2011 \|month=February \|pmid=21252716 \|doi=10.1097/JTO.0b013e318206a221 \|url=}}</ref>
	#Adenocarcinoma in situ (AIS) - previously known as [[BAC]].		#Adenocarcinoma in situ (AIS) - previously known as ''bronchioloalveolar carcinoma'' (abbreviated [[BAC]]).
	#*Subtypes: nonmucinous, mucinous, mixed mucinous/nonmucinous.		#*Subtypes: nonmucinous, mucinous, mixed mucinous/nonmucinous.
	#*Definition: lack of invasion into the stroma, vascular spaces and pleura.		#*Definition: lack of invasion into the stroma, vascular spaces and pleura.

2018-10-19T16:20:36Z

2018-09-24T23:50:20Z

Microscopic

← Older revision		Revision as of 23:50, 24 September 2018
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	***[[Invasive ductal carcinoma of the breast]].		***[[Invasive ductal carcinoma of the breast]].
	***[[Invasive lobular carcinoma]].		***[[Invasive lobular carcinoma]].
			***[[Bronchiolar metaplasia]].
	**Other carcinomas.		**Other carcinomas.
	*Carcinomas of the bronchial glands, e.g. [[adenoid cystic carcinoma]].		*Carcinomas of the bronchial glands, e.g. [[adenoid cystic carcinoma]].

← Older revision		Revision as of 16:20, 19 October 2018
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	*[[Metastasis]].		*[[Metastasis]].
	*[[Lung carcinoma with ALK rearrangement]].		*[[Lung carcinoma with ALK rearrangement]].
			*[[SMARCA4-deficient adenocarcinoma of the lung]].

	==References==		==References==