Adenocarcinoma of the uterine cervix - Revision history

Michael: /* IHC */

2016-06-23T20:34:04Z

IHC

← Older revision		Revision as of 20:34, 23 June 2016
Line 91:		Line 91:
	Uterus vs. cervix:<ref name=pmid20335127>{{Cite journal \| last1 = Hu \| first1 = WW. \| last2 = Tao \| first2 = JH. \| last3 = Li \| first3 = GM. \| last4 = Xu \| first4 = X. \| last5 = Yang \| first5 = XM. \| title = [Value of ER, VIM, CEA and p16 detection in the diagnosis and differential diagnosis of primary endocervical and endometrial adenocarcinomas]. \| journal = Nan Fang Yi Ke Da Xue Xue Bao \| volume = 30 \| issue = 3 \| pages = 526-8, 531 \| month = Mar \| year = 2010 \| doi = \| PMID = 20335127 }}</ref>		Uterus vs. cervix:<ref name=pmid20335127>{{Cite journal \| last1 = Hu \| first1 = WW. \| last2 = Tao \| first2 = JH. \| last3 = Li \| first3 = GM. \| last4 = Xu \| first4 = X. \| last5 = Yang \| first5 = XM. \| title = [Value of ER, VIM, CEA and p16 detection in the diagnosis and differential diagnosis of primary endocervical and endometrial adenocarcinomas]. \| journal = Nan Fang Yi Ke Da Xue Xue Bao \| volume = 30 \| issue = 3 \| pages = 526-8, 531 \| month = Mar \| year = 2010 \| doi = \| PMID = 20335127 }}</ref>
	*Cervix (typically): CEA +ve, p16 +ve.		*Cervix (typically): CEA +ve, p16 +ve.
	**ER -ve, PR -ve, vimentin -ve.		**[[ER]] -ve, PR -ve, vimentin -ve.
	*Uterus (typically): vimentin +ve, ER +ve, PR +ve.		*Uterus (typically): vimentin +ve, ER +ve, PR +ve.
	**CEA -ve, p16 -ve.		**CEA -ve, p16 -ve.

Michael: /* IHC */

2016-06-23T20:33:53Z

IHC

← Older revision		Revision as of 20:33, 23 June 2016
Line 89:		Line 89:
	*Ki-67 -- high.		*Ki-67 -- high.

	Uterus vs. cervix:~~<ref>LAE. 15 January 2009.</ref>~~<ref name=pmid20335127>{{Cite journal \| last1 = Hu \| first1 = WW. \| last2 = Tao \| first2 = JH. \| last3 = Li \| first3 = GM. \| last4 = Xu \| first4 = X. \| last5 = Yang \| first5 = XM. \| title = [Value of ER, VIM, CEA and p16 detection in the diagnosis and differential diagnosis of primary endocervical and endometrial adenocarcinomas]. \| journal = Nan Fang Yi Ke Da Xue Xue Bao \| volume = 30 \| issue = 3 \| pages = 526-8, 531 \| month = Mar \| year = 2010 \| doi = \| PMID = 20335127 }}</ref>		Uterus vs. cervix:<ref name=pmid20335127>{{Cite journal \| last1 = Hu \| first1 = WW. \| last2 = Tao \| first2 = JH. \| last3 = Li \| first3 = GM. \| last4 = Xu \| first4 = X. \| last5 = Yang \| first5 = XM. \| title = [Value of ER, VIM, CEA and p16 detection in the diagnosis and differential diagnosis of primary endocervical and endometrial adenocarcinomas]. \| journal = Nan Fang Yi Ke Da Xue Xue Bao \| volume = 30 \| issue = 3 \| pages = 526-8, 531 \| month = Mar \| year = 2010 \| doi = \| PMID = 20335127 }}</ref>
	*Cervix (typically): CEA +ve, p16 +ve.		*Cervix (typically): CEA +ve, p16 +ve.
	**ER -ve, PR -ve, vimentin -ve.		**ER -ve, PR -ve, vimentin -ve.

Michael at 23:16, 13 March 2016

2016-03-13T23:16:21Z

← Older revision		Revision as of 23:16, 13 March 2016
Line 33:		Line 33:

	It is also known as '''endocervical adenocarcinoma''' and '''cervical adenocarcinoma'''.		It is also known as '''endocervical adenocarcinoma''' and '''cervical adenocarcinoma'''.

			Very well-differentiated adenocarcinoma of the cervix is covered in ''[[minimal deviation adenocarcinoma of the uterine cervix]]''.
	==General==		==General==
	*Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix.		*Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix.

Michael: /* General */

2016-03-13T23:07:40Z

General

← Older revision		Revision as of 23:07, 13 March 2016
Line 36:		Line 36:
	*Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix.		*Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix.
	*Arises from the endocervical glands.		*Arises from the endocervical glands.
			*Usually [[HPV]] related.
			*Non-HPV related adenocarcinoma may be syndromic - [[Peutz-Jeghers syndrome]], [[Li-Fraumeni syndrome]].<ref name=pmid26457350>{{Cite journal \| last1 = Karamurzin \| first1 = YS. \| last2 = Kiyokawa \| first2 = T. \| last3 = Parkash \| first3 = V. \| last4 = Jotwani \| first4 = AR. \| last5 = Patel \| first5 = P. \| last6 = Pike \| first6 = MC. \| last7 = Soslow \| first7 = RA. \| last8 = Park \| first8 = KJ. \| title = Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 11 \| pages = 1449-57 \| month = Nov \| year = 2015 \| doi = 10.1097/PAS.0000000000000532 \| PMID = 26457350 }}</ref>

	==Microscopic==		==Microscopic==

Michael: /* Images */

2015-02-21T16:30:43Z

Images

← Older revision		Revision as of 16:30, 21 February 2015
Line 71:		Line 71:
	Image:Cervical_adenocarcinoma_-_intermed_mag.jpg \| Cervical adenocarcinoma - intermed. mag. (WC)		Image:Cervical_adenocarcinoma_-_intermed_mag.jpg \| Cervical adenocarcinoma - intermed. mag. (WC)
	Image:Cervical_adenocarcinoma_-_high_mag.jpg \| Cervical adenocarcinoma - high mag. (WC)		Image:Cervical_adenocarcinoma_-_high_mag.jpg \| Cervical adenocarcinoma - high mag. (WC)
			</gallery>
			<gallery>
			Image: Endocervical_adenocarcinoma_(1).jpg \| Endocervical adenocarcinoma. (WC/KGH)
			Image: Endocervical_adenocarcinoma_(2).jpg \| Endocervical adenocarcinoma. (WC/KGH)
			Image: Endocervical_adenocarcinoma_(3).jpg \| Endocervical adenocarcinoma. (WC/KGH)
			Image: Endocervical_adenocarcinoma_(4).jpg \| Endocervical adenocarcinoma. (WC/KGH)
	</gallery>		</gallery>

Michael: /* IHC */

2014-02-23T13:47:54Z

IHC

← Older revision		Revision as of 13:47, 23 February 2014
Line 79:		Line 79:
	*Ki-67 -- high.		*Ki-67 -- high.

	Uterus vs. cervix:<ref>LAE. 15 January 2009.</ref>		Uterus vs. cervix:<ref>LAE. 15 January 2009.</ref><ref name=pmid20335127>{{Cite journal \| last1 = Hu \| first1 = WW. \| last2 = Tao \| first2 = JH. \| last3 = Li \| first3 = GM. \| last4 = Xu \| first4 = X. \| last5 = Yang \| first5 = XM. \| title = [Value of ER, VIM, CEA and p16 detection in the diagnosis and differential diagnosis of primary endocervical and endometrial adenocarcinomas]. \| journal = Nan Fang Yi Ke Da Xue Xue Bao \| volume = 30 \| issue = 3 \| pages = 526-8, 531 \| month = Mar \| year = 2010 \| doi = \| PMID = 20335127 }}</ref>
	*Cervix (typically): CEA +ve, p16 +ve.		*Cervix (typically): CEA +ve, p16 +ve.
	**ER -ve, PR -ve, vimentin -ve.		**ER -ve, PR -ve, vimentin -ve.

Michael: /* IHC */

2014-02-23T13:44:32Z

IHC

← Older revision		Revision as of 13:44, 23 February 2014
Line 76:		Line 76:
	Features for diagnosis:		Features for diagnosis:
	*p16 +ve.		*p16 +ve.
			**May be negative ~25% of cases in one series.<ref name=pmid23626605>{{Cite journal \| last1 = Izadi-Mood \| first1 = N. \| last2 = Asadi \| first2 = K. \| last3 = Shojaei \| first3 = H. \| last4 = Sarmadi \| first4 = S. \| last5 = Ahmadi \| first5 = SA. \| last6 = Sani \| first6 = S. \| last7 = Chelavi \| first7 = LH. \| title = Potential diagnostic value of P16 expression in premalignant and malignant cervical lesions. \| journal = J Res Med Sci \| volume = 17 \| issue = 5 \| pages = 428-33 \| month = May \| year = 2012 \| doi = \| PMID = 23626605 }}</ref>
	*Ki-67 -- high.		*Ki-67 -- high.

Michael at 03:47, 22 February 2014

2014-02-22T03:47:42Z

← Older revision		Revision as of 03:47, 22 February 2014
Line 1:		Line 1:
	'''Adenocarcinoma of the uterine cervix''' is a relative uncommon form of cervical [[cancer]]. Like the more common [[squamous cell carcinoma of the cervix]], it is associated strongly with the [[human papilloma virus]].		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Cervical_adenocarcinoma_-_high_mag.jpg
			\| Width =
			\| Caption = Cervical adenocarcinoma. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[microglandular hyperplasia]], [[endocervical adenocarcinoma in situ]], metastatic [[adenocarcinoma]] (e.g. [[endometrioid endometrial carcinoma]], [[serous endometrial carcinoma]], [[colorectal adenocarcinoma]]), [[villoglandular adenocarcinoma]], [[glassy cell carcinoma]], [[clear cell carcinoma]] of the cervix
			\| Stains =
			\| IHC = p16 +ve, CEA +ve, vimentin -ve, ER -ve, PR -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[uterine cervix]] - endocervical canal
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = fairly good
			\| Other =
			\| ClinDDx = other cervical tumours
			\| Tx = radical trachelectomy or radical hysterectomy
			}}
			'''Adenocarcinoma of the uterine cervix''' is a relative uncommon form of cervical [[cancer]]. Like the more common [[squamous cell carcinoma of the uterine cervix\|squamous cell carcinoma]], it is associated strongly with the [[human papilloma virus]].

	It is also known as '''endocervical adenocarcinoma''' and '''cervical adenocarcinoma'''.		It is also known as '''endocervical adenocarcinoma''' and '''cervical adenocarcinoma'''.
Line 8:		Line 39:
	==Microscopic==		==Microscopic==
	Features:		Features:
			*Cells with moderate cytoplasm, typically with basally stratfied nuclei.
			*Cytologic changes:
			**Nuclear hyperchromasia.
			**Nuclear pseudostratification.
			**Nuclear enlargement.
	*Stromal changes - "[[desmoplastic stroma]]/[[desmoplastic reaction]]".		*Stromal changes - "[[desmoplastic stroma]]/[[desmoplastic reaction]]".
	**Fibrosis/streaming cells.		**Fibrosis/streaming cells.
	*Gland fusion.		*Abnormal architecture:
	*Glands too deep -- very fuzzy criterion.		**Gland fusion.
			**Glands too deep -- very fuzzy criterion.

	Notes:		Notes:

Michael at 03:38, 22 February 2014

2014-02-22T03:38:52Z

← Older revision		Revision as of 03:38, 22 February 2014
Line 1:		Line 1:
	~~#redirect~~ [[~~Uterine_cervix#Adenocarcinoma_of_the_uterine_cervix~~]]		'''Adenocarcinoma of the uterine cervix''' is a relative uncommon form of cervical [[cancer]]. Like the more common [[squamous cell carcinoma of the cervix]], it is associated strongly with the [[human papilloma virus]].

			It is also known as '''endocervical adenocarcinoma''' and '''cervical adenocarcinoma'''.
			==General==
			*Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix.
			*Arises from the endocervical glands.

			==Microscopic==
			Features:
			*Stromal changes - "[[desmoplastic stroma]]/[[desmoplastic reaction]]".
			**Fibrosis/streaming cells.
			*Gland fusion.
			*Glands too deep -- very fuzzy criterion.

			Notes:
			*AIS changes - similar to [[colon\|colonic]] dysplasia.
			*AIS may occur together with CIN.
			**Not infrequently they (AIS, CIN) occur together - both are due, indirectly, to HPV infection.
			*May be difficult to be certain of invasion.
			**A feature suggestive of invasion is ''cytoplasmic eosinophilia''.

			DDx:
			*[[Microglandular hyperplasia]] - [[NC ratio]] normal, no nuclear atypia.
			*[[Endocervical adenocarcinoma in situ]].
			*[[Villoglandular adenocarcinoma]].
			*[[Glassy cell carcinoma]].
			*Metastatic adenocarcinoma.
			**[[Endometrioid endometrial carcinoma]].
			**[[Serous endometrial carcinoma]].

			===Images===
			<gallery>
			Image:Cervical_adenocarcinoma_-_low_mag.jpg \| Cervical adenocarcinoma - low mag. (WC)
			Image:Cervical_adenocarcinoma_-_intermed_mag.jpg \| Cervical adenocarcinoma - intermed. mag. (WC)
			Image:Cervical_adenocarcinoma_-_high_mag.jpg \| Cervical adenocarcinoma - high mag. (WC)
			</gallery>

			==IHC==
			Features for diagnosis:
			*p16 +ve.
			*Ki-67 -- high.

			Uterus vs. cervix:<ref>LAE. 15 January 2009.</ref>
			*Cervix (typically): CEA +ve, p16 +ve.
			**ER -ve, PR -ve, vimentin -ve.
			*Uterus (typically): vimentin +ve, ER +ve, PR +ve.
			**CEA -ve, p16 -ve.

			==See also==
			*[[Uterine cervix]].
			*[[Gynecologic cytopathology]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Uterine cervix]]

Michael: redirect w/ cat.

2012-06-26T03:25:48Z

redirect w/ cat.

New page

#redirect [[Uterine_cervix#Adenocarcinoma_of_the_uterine_cervix]]

[[Category:Diagnosis]]