Adenosarcoma of the uterus - Revision history

Michael at 19:16, 21 September 2015

2015-09-21T19:16:35Z

← Older revision		Revision as of 19:16, 21 September 2015
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	*May prolapse through cervical os and thus present as [[cervical polyp]].		*May prolapse through cervical os and thus present as [[cervical polyp]].
	*Most commonly uterine corpus, occasionally cervix and ovary, rarely in the vagina, fallopian tube, peritoneal surfaces, intestine.		*Most commonly uterine corpus, occasionally cervix and ovary, rarely in the vagina, fallopian tube, peritoneal surfaces, intestine.
	*Large age range<name=pmid9625851/> - may be premenopausal ''or'' postmenopausal.		*Large age range<ref name=pmid9625851/> - may be premenopausal ''or'' postmenopausal.

	Clinical:<ref name=pmid17506376>{{Cite journal \| last1 = Abu \| first1 = J. \| last2 = Ireland \| first2 = D. \| last3 = Brown \| first3 = L. \| title = Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. \| journal = J Reprod Med \| volume = 52 \| issue = 4 \| pages = 326-8 \| month = Apr \| year = 2007 \| doi = \| PMID = 17506376 }}</ref>		Clinical:<ref name=pmid17506376>{{Cite journal \| last1 = Abu \| first1 = J. \| last2 = Ireland \| first2 = D. \| last3 = Brown \| first3 = L. \| title = Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. \| journal = J Reprod Med \| volume = 52 \| issue = 4 \| pages = 326-8 \| month = Apr \| year = 2007 \| doi = \| PMID = 17506376 }}</ref>

Michael at 19:15, 21 September 2015

2015-09-21T19:15:30Z

← Older revision		Revision as of 19:15, 21 September 2015
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = ~~typically 30-40 years old~~		\| Clinicalhx = large age range
	\| Signs = vaginal bleeding, mass lesion		\| Signs = vaginal bleeding, mass lesion
	\| Symptoms =		\| Symptoms =
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	*May prolapse through cervical os and thus present as [[cervical polyp]].		*May prolapse through cervical os and thus present as [[cervical polyp]].
	*Most commonly uterine corpus, occasionally cervix and ovary, rarely in the vagina, fallopian tube, peritoneal surfaces, intestine.		*Most commonly uterine corpus, occasionally cervix and ovary, rarely in the vagina, fallopian tube, peritoneal surfaces, intestine.
	*~~Typically 30~~-~~40 years old~~.		*Large age range<name=pmid9625851/> - may be premenopausal ''or'' postmenopausal.

	Clinical:<ref name=pmid17506376>{{Cite journal \| last1 = Abu \| first1 = J. \| last2 = Ireland \| first2 = D. \| last3 = Brown \| first3 = L. \| title = Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. \| journal = J Reprod Med \| volume = 52 \| issue = 4 \| pages = 326-8 \| month = Apr \| year = 2007 \| doi = \| PMID = 17506376 }}</ref>		Clinical:<ref name=pmid17506376>{{Cite journal \| last1 = Abu \| first1 = J. \| last2 = Ireland \| first2 = D. \| last3 = Brown \| first3 = L. \| title = Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. \| journal = J Reprod Med \| volume = 52 \| issue = 4 \| pages = 326-8 \| month = Apr \| year = 2007 \| doi = \| PMID = 17506376 }}</ref>

Michael: +infoboxes

2014-11-24T02:52:00Z

+infoboxes

← Older revision		Revision as of 02:52, 24 November 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Uterine_adenosarcoma_-_high_mag.jpg
			\| Width =
			\| Caption = Uterine adenosarcoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = "Malignant stroma" (stromal with nuclear pleomorphism - typically low grade), benign glands with an abnormal shape and "cambium layer" (increased cellularity around the epithelial elements)
			\| Subtypes =
			\| LMDDx = [[benign endometrial polyp]], [[uterine adenofibroma]], [[endometrial stromal sarcoma]]
			\| Stains =
			\| IHC = CD10 +ve, ER +ve, PR +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[uterus]] - see ''[[uterine tumours]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = typically 30-40 years old
			\| Signs = vaginal bleeding, mass lesion
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = other causes of [[AUB]]
			\| Tx = TAH-BSO
			}}
	'''Adenosarcoma of the uterus''' is an uncommon tumour that arises from the [[uterus]] with benign glands and [[malignant]] mesenchymal elements.		'''Adenosarcoma of the uterus''' is an uncommon tumour that arises from the [[uterus]] with benign glands and [[malignant]] mesenchymal elements.

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	*[[Benign endometrial polyp]].		*[[Benign endometrial polyp]].
	*[[Uterine adenofibroma]].		*[[Uterine adenofibroma]].
			*[[Endometrial stromal sarcoma]].

	===Images===		===Images===

Michael: split out

2014-11-24T02:27:35Z

split out

← Older revision		Revision as of 02:27, 24 November 2014
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	~~#redirect~~ [[~~Uterine_tumours#Adenosarcoma_of_the_uterus~~]]		'''Adenosarcoma of the uterus''' is an uncommon tumour that arises from the [[uterus]] with benign glands and [[malignant]] mesenchymal elements.

			==General==
			Features:<ref name=pmid20179434>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| title = Mullerian adenosarcoma of the female genital tract. \| journal = Adv Anat Pathol \| volume = 17 \| issue = 2 \| pages = 122-9 \| month = Mar \| year = 2010 \| doi = 10.1097/PAP.0b013e3181cfe732 \| PMID = 20179434 }}</ref>
			*Uncommon.
			*May prolapse through cervical os and thus present as [[cervical polyp]].
			*Most commonly uterine corpus, occasionally cervix and ovary, rarely in the vagina, fallopian tube, peritoneal surfaces, intestine.
			*Typically 30-40 years old.

			Clinical:<ref name=pmid17506376>{{Cite journal \| last1 = Abu \| first1 = J. \| last2 = Ireland \| first2 = D. \| last3 = Brown \| first3 = L. \| title = Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. \| journal = J Reprod Med \| volume = 52 \| issue = 4 \| pages = 326-8 \| month = Apr \| year = 2007 \| doi = \| PMID = 17506376 }}</ref>
			*Most common presentations of Müllerian adenosarcoma (percentages based on series of 41 individuals<ref name=pmid9625851>{{Cite journal \| last1 = Verschraegen \| first1 = CF. \| last2 = Vasuratna \| first2 = A. \| last3 = Edwards \| first3 = C. \| last4 = Freedman \| first4 = R. \| last5 = Kudelka \| first5 = AP. \| last6 = Tornos \| first6 = C. \| last7 = Kavanagh \| first7 = JJ. \| title = Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience. \| journal = Oncol Rep \| volume = 5 \| issue = 4 \| pages = 939-44 \| month = \| year = \| doi = \| PMID = 9625851 }}</ref>):
			**Vaginal bleeding ~ 70%.
			**Pelvic mass ~ 40%.
			**Uterine polyp ~ 30%.
			*Prognosis (based on series of ~500 individuals<ref name=pmid20688363>{{Cite journal \| last1 = Arend \| first1 = R. \| last2 = Bagaria \| first2 = M. \| last3 = Lewin \| first3 = SN. \| last4 = Sun \| first4 = X. \| last5 = Deutsch \| first5 = I. \| last6 = Burke \| first6 = WM. \| last7 = Herzog \| first7 = TJ. \| last8 = Wright \| first8 = JD. \| title = Long-term outcome and natural history of uterine adenosarcomas. \| journal = Gynecol Oncol \| volume = 119 \| issue = 2 \| pages = 305-8 \| month = Nov \| year = 2010 \| doi = 10.1016/j.ygyno.2010.07.001 \| PMID = 20688363 }}</ref>):
			**Favourable outcome - most detected at an early stage.
			***~80% five year survival for stage I tumours.
			**Outcome better than [[uterine carcinosarcoma\|carcinosarcoma]].

			Treatment:
			*TAH-BSO.
			**Tumours are estrogen responsive.
			*Chemotherapy (platin-based).<ref name=pmid9625851/>

			==Microscopic==
			Features:<ref name=Ref_PBoD1089>{{Ref PBoD\|1089}}</ref><ref name=pmid20179434/>
			*"Malignant stroma" - '''key feature'''.
			**Stromal nuclear pleomorphism - usually low grade.
			**WHO criteria: 2+ mitoses / 10 HPF -- definition suffers from [[HPFitis]].
			***Mitotic rate criteria often ignored as mitotically inactive tumours metastasize.<ref name=pmid20179434/>
			*Benign glands with an abnormal shape.
			*"Cambium layer" = increased cellularity around the epithelial elements.<ref name=pmid20179434/><ref name=medilexicon_cambium/>

			Notes:
			*Tumour may vaguely resemble a [[phyllodes tumour]].<ref name=pmid20179434/>
			*''Cambium layer'' - seen in: adenosarcoma, botryoid [[RMS]].<ref name=medilexicon_cambium>URL: [http://www.medilexicon.com/medicaldictionary.php?t=48297 http://www.medilexicon.com/medicaldictionary.php?t=48297]. Accessed on: 9 August 2011.</ref>

			DDx:
			*[[Benign endometrial polyp]].
			*[[Uterine adenofibroma]].

			===Images===
			<gallery>
			Image:Uterine_adenosarcoma_-_low_mag.jpg \| Uterine adenosarcoma - low mag. (WC)
			Image:Uterine_adenosarcoma_-_intermed_mag.jpg \| Uterine adenosarcoma - intermed. mag. (WC)
			Image:Uterine_adenosarcoma_-_high_mag.jpg \| Uterine adenosarcoma - high mag. (WC)
			</gallery>

			==IHC==
			*CD10 +ve.<ref name=pmid20179434/>
			*ER +ve.
			*PR +ve.

			==See also==
			*[[Uterine tumours]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Gynecologic pathology]]

Michael: redirect w/ cat.

2012-03-10T22:13:35Z

redirect w/ cat.

New page

#redirect [[Uterine_tumours#Adenosarcoma_of_the_uterus]]

[[Category:Diagnosis]]