Adenosis of the prostate gland - Revision history

Michael: +images

2015-06-17T17:09:19Z

+images

← Older revision		Revision as of 17:09, 17 June 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Adenosis of prostate -- low mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Adenosis of prostate gland. [[H&E stain]].
	\| Synonyms = atypical adenomatous hyperplasia		\| Synonyms = atypical adenomatous hyperplasia
	\| Micro = glandular crowding, bland nuclear features (lack prominent nucleoli, lack nuclear enlargement)		\| Micro = glandular crowding, bland nuclear features (lack prominent nucleoli, lack nuclear enlargement)
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	*[[Bulbourethral gland]] - at apex of prostate.		*[[Bulbourethral gland]] - at apex of prostate.
	*Atypical sclerosing adenosis of the prostate.<ref name=pmid20459573>{{Cite journal \| last1 = Cheng \| first1 = L. \| last2 = Bostwick \| first2 = DG. \| title = Atypical sclerosing adenosis of the prostate: a rare mimic of adenocarcinoma. \| journal = Histopathology \| volume = 56 \| issue = 5 \| pages = 627-31 \| month = Apr \| year = 2010 \| doi = 10.1111/j.1365-2559.2010.03525.x \| PMID = 20459573 }}</ref>		*Atypical sclerosing adenosis of the prostate.<ref name=pmid20459573>{{Cite journal \| last1 = Cheng \| first1 = L. \| last2 = Bostwick \| first2 = DG. \| title = Atypical sclerosing adenosis of the prostate: a rare mimic of adenocarcinoma. \| journal = Histopathology \| volume = 56 \| issue = 5 \| pages = 627-31 \| month = Apr \| year = 2010 \| doi = 10.1111/j.1365-2559.2010.03525.x \| PMID = 20459573 }}</ref>

			===Images===
			<gallery>
			Image: Adenosis of prostate -- very low mag.jpg \| Adenosis - very low mag.
			Image: Adenosis of prostate -- low mag.jpg \| Adenosis - low mag.
			Image: Adenosis of prostate -- intermed mag.jpg \| Adenosis - intermed. mag.
			Image: Adenosis of prostate -- high mag.jpg \| Adenosis - high mag.
			Image: Adenosis of prostate - alt -- intermed mag.jpg \| Adenosis - intermed. mag.
			Image: Adenosis of prostate - alt -- high mag.jpg \| Adenosis - high mag.
			</gallery>

	==IHC==		==IHC==
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	Notes:		Notes:
	*‡ Often patchy - some glands in a group may lack basal cells.		*‡ Often patchy - some glands in a group may lack basal cells.

			===Images===
			<gallery>
			Image: Adenosis of prostate - amacr-ck5 6 -- very low mag.jpg \| Adenosis - very low mag.
			Image: Adenosis of prostate - amacr-ck5 6 -- low mag.jpg \| Adenosis - low mag.
			Image: Adenosis of prostate - amacr-ck5 6 -- intermed mag.jpg \| Adenosis - intermed. mag.
			Image: Adenosis of prostate - amacr-ck5 6 -- high mag.jpg \| Adenosis - high mag.
			Image: Adenosis of prostate - amacr-ck5 6 - alt -- intermed mag.jpg \| Adenosis - intermed. mag.
			Image: Adenosis of prostate - amacr-ck5 6- alt -- high mag.jpg \| Adenosis - high mag.
			</gallery>

	==Sign out==		==Sign out==

Michael at 21:52, 8 June 2015

2015-06-08T21:52:53Z

← Older revision		Revision as of 21:52, 8 June 2015
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	Notes:		Notes:
	*‡ Often patchy - some glands in a group may lack basal cells.		*‡ Often patchy - some glands in a group may lack basal cells.

			==Sign out==
			*Typically not reported explicitly.
			*IHC should be reported if done.

	==See also==		==See also==

Michael: /* Microscopic */

2015-06-08T21:50:36Z

Microscopic

← Older revision		Revision as of 21:50, 8 June 2015
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	**[[Foamy gland adenocarcinoma]] - typically has intraluminal crystalloids.		**[[Foamy gland adenocarcinoma]] - typically has intraluminal crystalloids.
	*[[Bulbourethral gland]] - at apex of prostate.		*[[Bulbourethral gland]] - at apex of prostate.
			*Atypical sclerosing adenosis of the prostate.<ref name=pmid20459573>{{Cite journal \| last1 = Cheng \| first1 = L. \| last2 = Bostwick \| first2 = DG. \| title = Atypical sclerosing adenosis of the prostate: a rare mimic of adenocarcinoma. \| journal = Histopathology \| volume = 56 \| issue = 5 \| pages = 627-31 \| month = Apr \| year = 2010 \| doi = 10.1111/j.1365-2559.2010.03525.x \| PMID = 20459573 }}</ref>

	==IHC==		==IHC==

Michael: tweak

2015-06-08T21:47:43Z

tweak

← Older revision		Revision as of 21:47, 8 June 2015
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	\| LMDDx = [[prostatic adenocarcinoma]] (esp. [[foamy gland adenocarcinoma]]), [[bulbourethral gland]]		\| LMDDx = [[prostatic adenocarcinoma]] (esp. [[foamy gland adenocarcinoma]]), [[bulbourethral gland]]
	\| Stains =		\| Stains =
	\| IHC = patchy basal cell markers (e.g. p63 +ve, CK5/6 +ve), AMACR -ve		\| IHC = patchy basal cell markers (e.g. p63 +ve, CK5/6 +ve), AMACR -ve, ERG -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 21:47, 8 June 2015

2015-06-08T21:47:15Z

← Older revision		Revision as of 21:47, 8 June 2015
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	\| Molecular =		\| Molecular =
	\| IF =		\| IF =
	\| Gross = ~~note~~ evident		\| Gross = not evident
	\| Grossing =		\| Grossing =
	\| Site = [[prostate gland]] - transistion zone		\| Site = [[prostate gland]] - transistion zone

Michael at 21:46, 8 June 2015

2015-06-08T21:46:49Z

← Older revision		Revision as of 21:46, 8 June 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms = atypical adenomatous hyperplasia
			\| Micro = glandular crowding, bland nuclear features (lack prominent nucleoli, lack nuclear enlargement)
			\| Subtypes =
			\| LMDDx = [[prostatic adenocarcinoma]] (esp. [[foamy gland adenocarcinoma]]), [[bulbourethral gland]]
			\| Stains =
			\| IHC = patchy basal cell markers (e.g. p63 +ve, CK5/6 +ve), AMACR -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = note evident
			\| Grossing =
			\| Site = [[prostate gland]] - transistion zone
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx = none
			}}
	'''Adenosis of the prostate gland''', also '''adenosis of the prostate''', is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) [[prostatic adenocarcinoma]].<ref name=pmid7793471>{{Cite journal \| last1 = Gaudin \| first1 = PB. \| last2 = Epstein \| first2 = JI. \| title = Adenosis of the prostate. Histologic features in needle biopsy specimens. \| journal = Am J Surg Pathol \| volume = 19 \| issue = 7 \| pages = 737-47 \| month = Jul \| year = 1995 \| doi = \| PMID = 7793471 }}</ref>		'''Adenosis of the prostate gland''', also '''adenosis of the prostate''', is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) [[prostatic adenocarcinoma]].<ref name=pmid7793471>{{Cite journal \| last1 = Gaudin \| first1 = PB. \| last2 = Epstein \| first2 = JI. \| title = Adenosis of the prostate. Histologic features in needle biopsy specimens. \| journal = Am J Surg Pathol \| volume = 19 \| issue = 7 \| pages = 737-47 \| month = Jul \| year = 1995 \| doi = \| PMID = 7793471 }}</ref>

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	*May be mistaken for [[prostatic adenocarcinoma]].<ref name=pmid22212076>{{Cite journal \| last1 = Epstein \| first1 = JI. \| title = Diagnosis of limited adenocarcinoma of the prostate. \| journal = Histopathology \| volume = 60 \| issue = 1 \| pages = 28-40 \| month = Jan \| year = 2012 \| doi = 10.1111/j.1365-2559.2011.03990.x \| PMID = 22212076 }}</ref>		*May be mistaken for [[prostatic adenocarcinoma]].<ref name=pmid22212076>{{Cite journal \| last1 = Epstein \| first1 = JI. \| title = Diagnosis of limited adenocarcinoma of the prostate. \| journal = Histopathology \| volume = 60 \| issue = 1 \| pages = 28-40 \| month = Jan \| year = 2012 \| doi = 10.1111/j.1365-2559.2011.03990.x \| PMID = 22212076 }}</ref>
	*Lesion of the transistion zone of the prostate.<ref name=pmid7793471>{{Cite journal \| last1 = Gaudin \| first1 = PB. \| last2 = Epstein \| first2 = JI. \| title = Adenosis of the prostate. Histologic features in needle biopsy specimens. \| journal = Am J Surg Pathol \| volume = 19 \| issue = 7 \| pages = 737-47 \| month = Jul \| year = 1995 \| doi = \| PMID = 7793471 }}</ref>		*Lesion of the transistion zone of the prostate.<ref name=pmid7793471>{{Cite journal \| last1 = Gaudin \| first1 = PB. \| last2 = Epstein \| first2 = JI. \| title = Adenosis of the prostate. Histologic features in needle biopsy specimens. \| journal = Am J Surg Pathol \| volume = 19 \| issue = 7 \| pages = 737-47 \| month = Jul \| year = 1995 \| doi = \| PMID = 7793471 }}</ref>
			*'''Not''' considered a precursor of [[prostatic adenocarcinoma]].<ref name=pmid23664537>{{Cite journal \| last1 = Green \| first1 = WM. \| last2 = Hicks \| first2 = JL. \| last3 = De Marzo \| first3 = A. \| last4 = Illei \| first4 = PP. \| last5 = Epstein \| first5 = JI. \| title = Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate. \| journal = Hum Pathol \| volume = 44 \| issue = 9 \| pages = 1895-901 \| month = Sep \| year = 2013 \| doi = 10.1016/j.humpath.2013.02.019 \| PMID = 23664537 }}</ref>

	==Microscopic==		==Microscopic==
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	*p63 +ve. ‡		*p63 +ve. ‡
	*AMACR -ve.		*AMACR -ve.
			*ERG -ve.<ref name=pmid23664537>{{Cite journal \| last1 = Green \| first1 = WM. \| last2 = Hicks \| first2 = JL. \| last3 = De Marzo \| first3 = A. \| last4 = Illei \| first4 = PP. \| last5 = Epstein \| first5 = JI. \| title = Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate. \| journal = Hum Pathol \| volume = 44 \| issue = 9 \| pages = 1895-901 \| month = Sep \| year = 2013 \| doi = 10.1016/j.humpath.2013.02.019 \| PMID = 23664537 }}</ref>

	Notes:		Notes:

Michael: /* Microscopic */

2015-06-08T21:30:55Z

Microscopic

← Older revision		Revision as of 21:30, 8 June 2015
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	==Microscopic==		==Microscopic==
	Features:		Features:
	*Glandular crowding.		*Glandular crowding - '''key feature'''.
	**Glands may be back-to-back.		**Glands may be back-to-back.
	*Lack of prominent [[nucleoli]].		*Lack of prominent [[nucleoli]].

Michael: /* Microscopic */

2015-06-08T21:29:24Z

Microscopic

← Older revision		Revision as of 21:29, 8 June 2015
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	DDx:		DDx:
	*[[Adenocarcinoma of the prostate]] - ~~esp~~. [[~~foamy~~ gland ~~adenocarcinoma~~]].		*[[Adenocarcinoma of the prostate]].
			**[[Foamy gland adenocarcinoma]] - typically has intraluminal crystalloids.
			*[[Bulbourethral gland]] - at apex of prostate.

	==IHC==		==IHC==

Michael: /* See also */

2015-06-08T21:27:09Z

Michael: expand

2015-06-08T21:24:40Z

expand

← Older revision		Revision as of 21:24, 8 June 2015
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	'''Adenosis of the prostate''', ~~formally~~ '''adenosis of the prostate ~~gland~~''', is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) [[prostatic adenocarcinoma]].<ref name=pmid7793471>{{Cite journal \| last1 = Gaudin \| first1 = PB. \| last2 = Epstein \| first2 = JI. \| title = Adenosis of the prostate. Histologic features in needle biopsy specimens. \| journal = Am J Surg Pathol \| volume = 19 \| issue = 7 \| pages = 737-47 \| month = Jul \| year = 1995 \| doi = \| PMID = 7793471 }}</ref>		'''Adenosis of the prostate gland''', also '''adenosis of the prostate''', is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) [[prostatic adenocarcinoma]].<ref name=pmid7793471>{{Cite journal \| last1 = Gaudin \| first1 = PB. \| last2 = Epstein \| first2 = JI. \| title = Adenosis of the prostate. Histologic features in needle biopsy specimens. \| journal = Am J Surg Pathol \| volume = 19 \| issue = 7 \| pages = 737-47 \| month = Jul \| year = 1995 \| doi = \| PMID = 7793471 }}</ref>

			It is also known as '''[[atypical adenomatous hyperplasia]]'''.<ref name=pmid22520603>{{Cite journal \| last1 = Molinié \| first1 = V. \| last2 = Vadrot \| first2 = J. \| last3 = Duchatelle \| first3 = V. \| last4 = Balaton \| first4 = A. \| last5 = Abbey-Tobby \| first5 = A. \| last6 = Baumert \| first6 = H. \| title = [Diagnostic issues of prostate biopsies. Case 2. Atypical adenomatous hyperplasia (adenosis)]. \| journal = Ann Pathol \| volume = 32 \| issue = 2 \| pages = 114-7 \| month = Apr \| year = 2012 \| doi = 10.1016/j.annpat.2012.02.003 \| PMID = 22520603 }}</ref><ref name=pmid23000851>{{Cite journal \| last1 = Humphrey \| first1 = PA. \| title = Atypical adenomatous hyperplasia (adenosis) of the prostate. \| journal = J Urol \| volume = 188 \| issue = 6 \| pages = 2371-2 \| month = Dec \| year = 2012 \| doi = 10.1016/j.juro.2012.09.058 \| PMID = 23000851 }}</ref>

			==General==
			*May be mistaken for [[prostatic adenocarcinoma]].<ref name=pmid22212076>{{Cite journal \| last1 = Epstein \| first1 = JI. \| title = Diagnosis of limited adenocarcinoma of the prostate. \| journal = Histopathology \| volume = 60 \| issue = 1 \| pages = 28-40 \| month = Jan \| year = 2012 \| doi = 10.1111/j.1365-2559.2011.03990.x \| PMID = 22212076 }}</ref>
			*Lesion of the transistion zone of the prostate.<ref name=pmid7793471>{{Cite journal \| last1 = Gaudin \| first1 = PB. \| last2 = Epstein \| first2 = JI. \| title = Adenosis of the prostate. Histologic features in needle biopsy specimens. \| journal = Am J Surg Pathol \| volume = 19 \| issue = 7 \| pages = 737-47 \| month = Jul \| year = 1995 \| doi = \| PMID = 7793471 }}</ref>

			==Microscopic==
			Features:
			*Glandular crowding.
			**Glands may be back-to-back.
			*Lack of prominent [[nucleoli]].

			DDx:
			*[[Adenocarcinoma of the prostate]] - esp. [[foamy gland adenocarcinoma]].

			==IHC==
			*CK5/6 +ve. ‡
			*p63 +ve. ‡
			*AMACR -ve.

			Notes:
			*‡ Often patchy - some glands in a group may lack basal cells.

	==See also==		==See also==
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Prostate gland]]		[[Category:Prostate gland]]

← Older revision		Revision as of 21:27, 8 June 2015
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	==See also==		==See also==
			*[[Prostate gland]].
	*[[Adenosis]].		*[[Adenosis]].