Adipocytic tumours - Revision history

Michael at 15:51, 22 April 2024

2024-04-22T15:51:30Z

← Older revision		Revision as of 15:51, 22 April 2024
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	*[[Soft tissue lesions]].		*[[Soft tissue lesions]].
	*[[Bone]].		*[[Bone]].
			*[[Brown fat]].

	=References=		=References=

Michael at 22:27, 9 October 2021

2021-10-09T22:27:17Z

← Older revision		Revision as of 22:27, 9 October 2021
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	===General===		===General===
	*May be syndromic - typically [[autosomal recessive]].<ref name=pmid25671454>{{cite journal \|~~vauthors~~=Garib G, Siegal GP, Andea AA \|title=Autosomal-dominant familial angiolipomatosis \|journal=Cutis \|volume=95 \|issue=1 \|pages=E26–9 \|date=January 2015 \|pmid=25671454 \|doi= \|url=}}</ref>		*May be syndromic - typically [[autosomal recessive]].<ref name=pmid25671454>{{cite journal \|authors=Garib G, Siegal GP, Andea AA \|title=Autosomal-dominant familial angiolipomatosis \|journal=Cutis \|volume=95 \|issue=1 \|pages=E26–9 \|date=January 2015 \|pmid=25671454 \|doi= \|url=}}</ref>
	*Can be seen in the context of [[Birt–Hogg–Dubé syndrome]].<ref name=pmid8734663>{{cite journal \|~~vauthors~~=Chung JY, Ramos-Caro FA, Beers B, Ford MJ, Flowers F \|title=Multiple lipomas, angiolipomas, and parathyroid adenomas in a patient with Birt-Hogg-Dube syndrome \|journal=Int J Dermatol \|volume=35 \|issue=5 \|pages=365–7 \|date=May 1996 \|pmid=8734663 \|doi=10.1111/j.1365-4362.1996.tb03642.x \|url=}}</ref>		*Can be seen in the context of [[Birt–Hogg–Dubé syndrome]].<ref name=pmid8734663>{{cite journal \|authors=Chung JY, Ramos-Caro FA, Beers B, Ford MJ, Flowers F \|title=Multiple lipomas, angiolipomas, and parathyroid adenomas in a patient with Birt-Hogg-Dube syndrome \|journal=Int J Dermatol \|volume=35 \|issue=5 \|pages=365–7 \|date=May 1996 \|pmid=8734663 \|doi=10.1111/j.1365-4362.1996.tb03642.x \|url=}}</ref>
	*[[Painful skin lesion]].		*[[Painful skin lesion]].

Michael: /* Angiolipoma */

2021-06-14T19:24:21Z

Angiolipoma

← Older revision		Revision as of 19:24, 14 June 2021
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	===General===		===General===
	*May be syndromic - typically [[autosomal recessive]].<ref name=pmid25671454>{{cite journal \|vauthors=Garib G, Siegal GP, Andea AA \|title=Autosomal-dominant familial angiolipomatosis \|journal=Cutis \|volume=95 \|issue=1 \|pages=E26–9 \|date=January 2015 \|pmid=25671454 \|doi= \|url=}}</ref>		*May be syndromic - typically [[autosomal recessive]].<ref name=pmid25671454>{{cite journal \|vauthors=Garib G, Siegal GP, Andea AA \|title=Autosomal-dominant familial angiolipomatosis \|journal=Cutis \|volume=95 \|issue=1 \|pages=E26–9 \|date=January 2015 \|pmid=25671454 \|doi= \|url=}}</ref>
	*Can be seen in the context of [[~~Birt-Hogg-Dube~~]].<ref>{{cite journal \|vauthors=Chung JY, Ramos-Caro FA, Beers B, Ford MJ, Flowers F \|title=Multiple lipomas, angiolipomas, and parathyroid adenomas in a patient with Birt-Hogg-Dube syndrome \|journal=Int J Dermatol \|volume=35 \|issue=5 \|pages=365–7 \|date=May 1996 \|pmid=8734663 \|doi=10.1111/j.1365-4362.1996.tb03642.x \|url=}}</ref>		*Can be seen in the context of [[Birt–Hogg–Dubé syndrome]].<ref name=pmid8734663>{{cite journal \|vauthors=Chung JY, Ramos-Caro FA, Beers B, Ford MJ, Flowers F \|title=Multiple lipomas, angiolipomas, and parathyroid adenomas in a patient with Birt-Hogg-Dube syndrome \|journal=Int J Dermatol \|volume=35 \|issue=5 \|pages=365–7 \|date=May 1996 \|pmid=8734663 \|doi=10.1111/j.1365-4362.1996.tb03642.x \|url=}}</ref>
	*[[Painful skin lesion]].		*[[Painful skin lesion]].

Michael: /* Angiolipoma */

2021-06-14T19:23:33Z

Angiolipoma

← Older revision		Revision as of 19:23, 14 June 2021
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	===General===		===General===
	*May be syndromic - typically [[autosomal recessive]].<ref name=pmid25671454>{{cite journal \|vauthors=Garib G, Siegal GP, Andea AA \|title=Autosomal-dominant familial angiolipomatosis \|journal=Cutis \|volume=95 \|issue=1 \|pages=E26–9 \|date=January 2015 \|pmid=25671454 \|doi= \|url=}}</ref>		*May be syndromic - typically [[autosomal recessive]].<ref name=pmid25671454>{{cite journal \|vauthors=Garib G, Siegal GP, Andea AA \|title=Autosomal-dominant familial angiolipomatosis \|journal=Cutis \|volume=95 \|issue=1 \|pages=E26–9 \|date=January 2015 \|pmid=25671454 \|doi= \|url=}}</ref>
			*Can be seen in the context of [[Birt-Hogg-Dube]].<ref>{{cite journal \|vauthors=Chung JY, Ramos-Caro FA, Beers B, Ford MJ, Flowers F \|title=Multiple lipomas, angiolipomas, and parathyroid adenomas in a patient with Birt-Hogg-Dube syndrome \|journal=Int J Dermatol \|volume=35 \|issue=5 \|pages=365–7 \|date=May 1996 \|pmid=8734663 \|doi=10.1111/j.1365-4362.1996.tb03642.x \|url=}}</ref>
	*[[Painful skin lesion]].		*[[Painful skin lesion]].

Michael: /* Liposarcoma */ +angiolipoma

2021-06-14T19:20:18Z

Liposarcoma: +angiolipoma

← Older revision		Revision as of 19:20, 14 June 2021
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	==Liposarcoma==		==Liposarcoma==
	{{Main\|Liposarcoma}}		{{Main\|Liposarcoma}}

			==Angiolipoma==

			===General===
			*May be syndromic - typically [[autosomal recessive]].<ref name=pmid25671454>{{cite journal \|vauthors=Garib G, Siegal GP, Andea AA \|title=Autosomal-dominant familial angiolipomatosis \|journal=Cutis \|volume=95 \|issue=1 \|pages=E26–9 \|date=January 2015 \|pmid=25671454 \|doi= \|url=}}</ref>
			*[[Painful skin lesion]].

			===Microscopic===
			Features:
			*Adipose tissue.
			*Small blood vessels (clustered).

			DDx:
			*[[Liposarcoma]].

	=See also=		=See also=

Mitchell: /* Lipoblastoma */ added section with lipoblastoma like tumor

2016-12-19T19:57:34Z

Lipoblastoma: added section with lipoblastoma like tumor

← Older revision		Revision as of 19:57, 19 December 2016
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	Images:		Images:
	*[http://www.sarcomaimages.com/index.php?v=Lipoblastoma Lipoblastoma (sarcomaimages.com)].		*[http://www.sarcomaimages.com/index.php?v=Lipoblastoma Lipoblastoma (sarcomaimages.com)].

			==Lipoblastoma like tumor==

			[[File: 5 22974716644038 sl 1.png\|Lipoblastoma like tumor]]
			[[File: 5 22974716644038 sl 2.png\|Lipoblastoma like tumor]]
			[[File: 5 22974716644038 sl 3.png\|Lipoblastoma like tumor]]
			[[File: 5 22974716644038 sl 4.png\|Lipoblastoma like tumor]]


			Lipoblastoma like tumor in 26 yo woman, tumor of pelvis. A. Lobulated appearance at low power. B. Cytologically bland lipoblasts with a myxoid stroma. C. Numerous thin-walled branching blood vessels. D. Loose collagenous stroma. The morphologic features, combined with molecular findings of negative DDI T3 gene rearrangement and lack of MDM2 amplification permit the diagnosis.

	==Lipoma==		==Lipoma==

Michael: /* Pleomorphic lipoma */ split out

2016-05-01T22:56:41Z

Pleomorphic lipoma: split out

← Older revision		Revision as of 22:56, 1 May 2016
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	==Pleomorphic lipoma==		==Pleomorphic lipoma==
	~~===General===~~		{{Main\|Pleomorphic lipoma}}
	*Rare.
	*May mimic a malignancy.<ref name=pmid15510605>{{~~Cite journal~~ \| last1 = Persichetti \| first1 = P. \| last2 = Di Lella \| first2 = F. \| last3 = Marangi \| first3 = GF. \| last4 = Cagli \| first4 = B. \| last5 = Simone \| first5 = P. \| last6 = Tenna \| first6 = S. \| last7 = Rabitri \| first7 = C. \| last8 = Cassandro \| first8 = R. \| last9 = Esposito \| first9 = V. \| title = Pleomorphic lipoma: a definite histopathological entity. \| journal = Anticancer Res \| volume = 24 \| issue = 5B \| pages = 3157-9 \| month = \| year = \| doi = \| PMID = 15510605 }}</ref>
	*Male > female.<ref name=pmid18181679>{{Cite journal \| last1 = Syed \| first1 = S. \| last2 = Martin \| first2 = AM. \| last3 = Haupt \| first3 = H. \| last4 = Podolski \| first4 = V. \| last5 = Brooks \| first5 = JJ. \| title = Frequent detection of androgen receptors in spindle cell lipomas: an explanation for this lesion's male predominance? \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 1 \| pages = 81-3 \| month = Jan \| year = 2008 \| doi = 10.1043/1543-2165(2008)132[81:FDOARI]2.0.CO;2 \| PMID = 18181679 }}</ref>

	~~===Gross===~~
	*Classically shoulder and neck region in adults.<ref>URL: [http://www.webpathology.com/image.asp?n=2&Case=435 http://www.webpathology.com/image.asp?n=2&Case=435]. Accessed on: 3 October 2011.</ref>

	~~DDx - shoulder lesions:~~
	*[[Elastofibroma]].
	*[[Desmoplastic fibroblastoma]].

	~~===Microscopic===~~
	~~Features:~~
	*Multinucleated cells - "floret cells" - '''key feature'''.
	**Solid eosinophilic cytoplasm.
	**Peripheral nuclei - impart a knobby border to the cells.
	*Fibrous septa.

	~~Notes:~~
	*May overlap with ''[[spindle cell lipoma]]''.<ref name=spc_stanford>URL: [http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/ http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/]. Accessed on: 4 December 2010.</ref>
	*Floret cell - may look similar to [[Touton giant cell]]s.

	~~Images:~~
	*[http://www.webpathology.com/image.asp?case=435&n=1 Pleomorphic lipoma ~~- low mag. (webpathology.com)].~~
	*[http://www.webpathology.com/image.asp?n=2&Case=435 Pleomorphic lipoma - high mag. (webpathology.com)].

	~~DDx:~~
	*[[Liposarcoma]].<ref name=pmid6884998>{{Cite journal \| last1 = Azzopardi \| first1 = JG. \| last2 = Iocco \| first2 = J. \| last3 = Salm \| first3 = R. \| title = Pleomorphic lipoma: a tumour simulating liposarcoma. \| journal = Histopathology \| volume = 7 \| issue = 4 \| pages = 511-23 \| month = Jul \| year = 1983 \| doi = \| PMID = 6884998 }}</ref>
	*Ancient [[neurofibroma]].
	*Ancient [[schwannoma]].

	~~===IHC===~~
	*AR +ve - ~95% in men, ~85% in women.<ref name=pmid18181679>{{Cite journal \| last1 = Syed \| first1 = S. \| last2 = Martin \| first2 = AM. \| last3 = Haupt \| first3 = H. \| last4 = Podolski \| first4 = V. \| last5 = Brooks \| first5 = JJ. \| title = Frequent detection of androgen receptors in spindle cell lipomas: an explanation for this lesion's male predominance? \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 1 \| pages = 81-3 \| month = Jan \| year = 2008 \| doi = 10.1043/1543-2165(2008)132[81:FDOARI]2.0.CO;2 \| PMID = 18181679 }}</ref>
	*CD34 +ve (26 +ve of 26 cases<ref name=pmid25219904>{{Cite journal \| last1 = Cheah \| first1 = A. \| last2 = Billings \| first2 = S. \| last3 = Goldblum \| first3 = J. \| last4 = Hornick \| first4 = J. \| last5 = Uddin \| first5 = N. \| last6 = Rubin \| first6 = B. \| title = Spindle cell/pleomorphic lipomas of the face: an under-recognized diagnosis. \| journal = Histopathology \| volume = 66 \| issue = 3 \| pages = 430-7 \| month = Feb \| year = 2015 \| doi = 10.1111/his.12548 \| PMID = 25219904 }}~~</ref>).~~
	*Desmin -ve (0 +ve of 20 cases<ref name=pmid25219904/>).
	*ER -ve/+ve (5 +ve of 21 cases<ref name=pmid25219904/>).

	==Spindle cell lipoma==		==Spindle cell lipoma==

Michael: /* Spindle cell lipoma */ split out

2016-05-01T22:51:13Z

Spindle cell lipoma: split out

← Older revision		Revision as of 22:51, 1 May 2016
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	==Spindle cell lipoma==		==Spindle cell lipoma==
	~~===General===~~		{{Main\|Spindle cell lipoma}}
	*Rare.
	*Predominantly men.<ref name=pmid15371618/>

	~~Note:~~
	*Spindle cell lipoma may immunohistochemically and histomorphologically overlap with ''mammary-type myofibroblastoma''<ref name=pmid11474286>{{Cite journal \| last1 = McMenamin \| first1 = ME. \| last2 = Fletcher \| first2 = CD. \| title = Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. \| journal = Am J Surg Pathol \| volume = 25 \| issue = 8 \| pages = 1022-9 \| month = Aug \| year = 2001 \| doi = \| PMID = 11474286 }}</ref> - see: ''[[mammary myofibroblastoma]]''.

	~~===Microscopic===~~
	Features:<ref name=pmid15371618>{{Cite journal \| last1 = Murphey \| first1 = MD. \| last2 = Carroll \| first2 = JF. \| last3 = Flemming \| first3 = DJ. \| last4 = Pope \| first4 = TL. \| last5 = Gannon \| first5 = FH. \| last6 = Kransdorf \| first6 = MJ. \| title = From the archives of the AFIP: benign musculoskeletal lipomatous lesions. \| journal = Radiographics \| volume = 24 \| issue = 5 \| pages = 1433-66 \| month = \| year = \| doi = 10.1148/rg.245045120 \| PMID = 15371618 }}</ref>
	*Aligned bland spindled cells adjacent to fat.
	*Rope-like collagen bundles - '''key feature'''.
	**May be described as "shreaded wheat".
	*+/-[[Myxoid]] component.
	*+/-[[staghorn vessels\|Staghorn-like vessels]].

	~~Notes:~~
	*May overlap with ''[[pleomorphic lipoma]]''.<ref name=spc_stanford>URL: [http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/ http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/]. Accessed on: 4 December 2010.</ref>

	~~DDx:~~
	*[[Neurofibroma]].
	*Spindle cell [[liposarcoma]] - extremely rare.<ref name=pmid8067512>{{Cite journal \| last1 = Dei Tos \| first1 = AP. \| last2 = Mentzel \| first2 = T. \| last3 = Newman \| first3 = PL. \| last4 = Fletcher \| first4 = CD. \| title = Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 9 \| pages = 913-21 \| month = Sep \| ~~year = 1994 \| doi = \| PMID = 8067512 }}</ref>~~

	~~====Image====~~
	~~www:~~
	*[http://www.sarcoma.org/pathology_review/round%20cell%20and%20soft%20tissue%20tumors/source/spindle_cell_lipoma3.html Spindle cell lipoma ~~(sarcoma.org)].~~

	~~===IHC===~~
	*CD34 +ve.<ref name=pmid20559119>{{Cite journal \| last1 = Wood \| first1 = L. \| last2 = Fountaine \| first2 = TJ. \| last3 = Rosamilia \| first3 = L. \| last4 = Helm \| first4 = KF. \| last5 = Clarke \| first5 = LE. \| title = Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. \| journal = Am J Dermatopathol \| volume = 32 \| issue = 8 \| pages = 764-8 \| month = Dec \| year = 2010 \| doi = 10.1097/DAD.0b013e3181d0c587 \| PMID = 20559119 }}</ref>
	*Desmin +ve.
	*S100 -ve. (???)

	~~Lipoma versus liposarcoma:~~
	*MDM2 -ve.<ref name=pmid23529275>{{Cite journal \| last1 = Alshenawy \| first1 = H. \| title = Can HMGI-C be used as an aid with MDM2 and CDK4 to differentiate liposarcoma subtypes from their mimics? \| journal = J Cancer Res Clin Oncol \| volume = 139 \| issue = 6 \| pages = 1073-81 \| month = Jun \| year = 2013 \| doi = 10.1007/s00432-013-1420-6 \| PMID = 23529275 }}</ref>
	*p16 -ve.<ref name=pmid24659226>{{Cite journal \| last1 = Creytens \| first1 = D. \| last2 = van Gorp \| first2 = J. \| last3 = Savola \| first3 = S. \| last4 = Ferdinande \| first4 = L. \| last5 = Mentzel \| first5 = T. \| last6 = Libbrecht \| first6 = L. \| title = Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. \| journal = Virchows Arch \| volume = 465 \| issue = 1 \| pages = 97-108 \| month = Jul \| year = 2014 \| doi = 10.1007/s00428-014-1568-8 \| PMID = 24659226 }}</ref>

	~~===Molecular===~~
	*Retinoblastoma (Rb) deletions.<ref name=pmid24659226>{{Cite journal \| last1 = Creytens \| first1 = D. \| last2 = van Gorp \| first2 = J. \| last3 = Savola \| first3 = S. \| last4 = Ferdinande \| first4 = L. \| last5 = Mentzel \| first5 = T. \| last6 = Libbrecht \| first6 = L. \| title = Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. \| journal = Virchows Arch \| volume = 465 \| issue = 1 \| pages = 97-108 \| month = Jul \| year = 2014 \| doi = 10.1007/s00428-014-1568-8 \| PMID = 24659226 }}~~</ref>~~
	*CDK4 no amplication ([[FISH]]).<ref name=pmid24659226/>

	==Hibernoma==		==Hibernoma==

Michael at 16:02, 4 November 2015

2015-11-04T16:02:40Z

← Older revision		Revision as of 16:02, 4 November 2015
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	===IHC===		===IHC===
	*~~S100~~ +ve.		*[[S-100]] +ve.

	==Lipoblastoma==		==Lipoblastoma==

Michael: /* Spindle cell lipoma */

2015-03-18T19:35:47Z

Spindle cell lipoma

← Older revision		Revision as of 19:35, 18 March 2015
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	DDx:		DDx:
	*[[Neurofibroma]].		*[[Neurofibroma]].
	*Spindle cell liposarcoma - extremely rare.<ref name=pmid8067512>{{Cite journal \| last1 = Dei Tos \| first1 = AP. \| last2 = Mentzel \| first2 = T. \| last3 = Newman \| first3 = PL. \| last4 = Fletcher \| first4 = CD. \| title = Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 9 \| pages = 913-21 \| month = Sep \| year = 1994 \| doi = \| PMID = 8067512 }}</ref>		*Spindle cell [[liposarcoma]] - extremely rare.<ref name=pmid8067512>{{Cite journal \| last1 = Dei Tos \| first1 = AP. \| last2 = Mentzel \| first2 = T. \| last3 = Newman \| first3 = PL. \| last4 = Fletcher \| first4 = CD. \| title = Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 9 \| pages = 913-21 \| month = Sep \| year = 1994 \| doi = \| PMID = 8067512 }}</ref>

	====Image====		====Image====