Alpha-methylacyl-CoA racemase - Revision history

Michael: /* General */ tweak

2018-04-14T12:32:50Z

General: tweak

← Older revision		Revision as of 12:32, 14 April 2018
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	==General==		==General==
	AMACR converts testosterone to hydrotestosterone.<ref name=pmid8626825>{{Cite journal \| last1 = Cai \| first1 = LQ. \| last2 = Zhu \| first2 = YS. \| last3 = Katz \| first3 = MD. \| last4 = Herrera \| first4 = C. \| last5 = Baéz \| first5 = J. \| last6 = DeFillo-Ricart \| first6 = M. \| last7 = Shackleton \| first7 = CH. \| last8 = Imperato-McGinley \| first8 = J. \| title = 5 alpha-reductase-2 gene mutations in the Dominican Republic. \| journal = J Clin Endocrinol Metab \| volume = 81 \| issue = 5 \| pages = 1730-5 \| month = May \| year = 1996 \| doi = 10.1210/jcem.81.5.8626825 \| PMID = 8626825 }}</ref>		AMACR converts [[testosterone]] to hydrotestosterone.<ref name=pmid8626825>{{Cite journal \| last1 = Cai \| first1 = LQ. \| last2 = Zhu \| first2 = YS. \| last3 = Katz \| first3 = MD. \| last4 = Herrera \| first4 = C. \| last5 = Baéz \| first5 = J. \| last6 = DeFillo-Ricart \| first6 = M. \| last7 = Shackleton \| first7 = CH. \| last8 = Imperato-McGinley \| first8 = J. \| title = 5 alpha-reductase-2 gene mutations in the Dominican Republic. \| journal = J Clin Endocrinol Metab \| volume = 81 \| issue = 5 \| pages = 1730-5 \| month = May \| year = 1996 \| doi = 10.1210/jcem.81.5.8626825 \| PMID = 8626825 }}</ref>

	==Positive==		==Positive==

Michael: /* Images */

2016-07-31T19:19:49Z

Images

← Older revision		Revision as of 19:19, 31 July 2016
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	==Images==		==Images==
	<gallery>		<gallery>
	Image: Prostate carcinoma with inflammation - ck5-6-amacr -- low mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - low mag. (WC)		Image: Prostate carcinoma with inflammation - ck5-6-amacr -- low mag.jpg \| [[Prostatic carcinoma]] - CK5/6-AMACR - low mag. (WC)
	Image: Prostate carcinoma with inflammation - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. mag. (WC)		Image: Prostate carcinoma with inflammation - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. mag. (WC)
	Image: Prostate carcinoma with inflammation - alt - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. (WC)		Image: Prostate carcinoma with inflammation - alt - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. (WC)

Michael: /* Images */

2016-07-31T19:19:16Z

Images

← Older revision		Revision as of 19:19, 31 July 2016
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	==Images==		==Images==
			<gallery>
	Image: Prostate carcinoma with inflammation - ck5-6-amacr -- low mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - low mag. (WC)		Image: Prostate carcinoma with inflammation - ck5-6-amacr -- low mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - low mag. (WC)
	Image: Prostate carcinoma with inflammation - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. mag. (WC)		Image: Prostate carcinoma with inflammation - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. mag. (WC)
	Image: Prostate carcinoma with inflammation - alt - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. (WC)		Image: Prostate carcinoma with inflammation - alt - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. (WC)
	Image: Prostate carcinoma with inflammation - ck5-6-amacr -- high mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - high mag. (WC)		Image: Prostate carcinoma with inflammation - ck5-6-amacr -- high mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - high mag. (WC)
			</gallery>

	==See also==		==See also==

Michael at 19:18, 31 July 2016

2016-07-31T19:18:46Z

← Older revision		Revision as of 19:18, 31 July 2016
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	==Negative==		==Negative==
	*[[Clear cell papillary renal cell carcinoma]].		*[[Clear cell papillary renal cell carcinoma]].

			==Images==
			Image: Prostate carcinoma with inflammation - ck5-6-amacr -- low mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - low mag. (WC)
			Image: Prostate carcinoma with inflammation - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. mag. (WC)
			Image: Prostate carcinoma with inflammation - alt - ck5-6-amacr -- intermed mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - intermed. (WC)
			Image: Prostate carcinoma with inflammation - ck5-6-amacr -- high mag.jpg \| Prostatic carcinoma - CK5/6-AMACR - high mag. (WC)

	==See also==		==See also==

Michael at 03:04, 22 September 2015

2015-09-22T03:04:06Z

← Older revision		Revision as of 03:04, 22 September 2015
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	[[Image:Atypical_small_acinar_proliferation_-_AMACR-CK34betaE12_-_alt_--_very_high_mag.jpg\|~~thumb\|right~~\|AMACR positivity in [[ASAP]]. CK5/6-AMACR immunostain.]]		{{ Infobox immunostain
			\| Name = {{PAGENAME}}
			\| Image = Atypical_small_acinar_proliferation_-_AMACR-CK34betaE12_-_alt_--_very_high_mag.jpg
			\| Width =
			\| Caption = AMACR positivity in [[ASAP]]. CK5/6-AMACR immunostain
			\| Abbrev = AMACR
			\| Synonyms = racemase
			\| Similar =
			\| Clones =
			\| Use =
			\| Subspecial = [[genitourinary pathology]]
			\| Pattern = cytoplasmic
			\| Positive = [[prostate carcinoma]] ~90%, [[high grade prostatic intraepithelial neoplasia]], [[urothelial carcinoma]] ~50%, [[papillary renal cell carcinoma]]
			\| Negative = [[clear cell papillary renal cell carcinoma]] (clear cell tubulopapillary RCC)
			\| Other =
			}}
	'''Alpha-methylacyl-CoA racemase''', abbreviated '''AMACR''', is a commonly used [[immunostain]] in [[genitourinary pathology]].		'''Alpha-methylacyl-CoA racemase''', abbreviated '''AMACR''', is a commonly used [[immunostain]] in [[genitourinary pathology]].

Michael at 03:00, 22 September 2015

2015-09-22T03:00:49Z

← Older revision		Revision as of 03:00, 22 September 2015
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	[[Image:Atypical_small_acinar_proliferation_-_AMACR-CK34betaE12_-_alt_--_very_high_mag.jpg\|thumb\|right\|AMACR positivity in [[ASAP]]. CK5/6-AMACR immunostain.]]		[[Image:Atypical_small_acinar_proliferation_-_AMACR-CK34betaE12_-_alt_--_very_high_mag.jpg\|thumb\|right\|AMACR positivity in [[ASAP]]. CK5/6-AMACR immunostain.]]
	'''Alpha-methylacyl-CoA racemase''', abbreviated '''AMACR''', is a commonly used [[immunostain]] in [[genitourinary pathology]].		'''Alpha-methylacyl-CoA racemase''', abbreviated '''AMACR''', is a commonly used [[immunostain]] in [[genitourinary pathology]].

			==General==
			AMACR converts testosterone to hydrotestosterone.<ref name=pmid8626825>{{Cite journal \| last1 = Cai \| first1 = LQ. \| last2 = Zhu \| first2 = YS. \| last3 = Katz \| first3 = MD. \| last4 = Herrera \| first4 = C. \| last5 = Baéz \| first5 = J. \| last6 = DeFillo-Ricart \| first6 = M. \| last7 = Shackleton \| first7 = CH. \| last8 = Imperato-McGinley \| first8 = J. \| title = 5 alpha-reductase-2 gene mutations in the Dominican Republic. \| journal = J Clin Endocrinol Metab \| volume = 81 \| issue = 5 \| pages = 1730-5 \| month = May \| year = 1996 \| doi = 10.1210/jcem.81.5.8626825 \| PMID = 8626825 }}</ref>

	==Positive==		==Positive==

Michael: /* Positive or negative */

2014-12-11T16:49:13Z

Positive or negative

← Older revision		Revision as of 16:49, 11 December 2014
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	==Positive or negative==		==Positive or negative==
	*[[Nephrogenic adenoma]].		*[[Nephrogenic adenoma]].
	*[[Urothelial carcinoma]] - not useful for ~~differentating ''~~prostate'' versus ''bladder''.		*[[Urothelial carcinoma]] - not useful for prostate versus bladder; it is positive in ~50% of [[UCC]].<ref name=pmid16315020>{{Cite journal \| last1 = Langner \| first1 = C. \| last2 = Rupar \| first2 = G. \| last3 = Leibl \| first3 = S. \| last4 = Hutterer \| first4 = G. \| last5 = Chromecki \| first5 = T. \| last6 = Hoefler \| first6 = G. \| last7 = Rehak \| first7 = P. \| last8 = Zigeuner \| first8 = R. \| title = Alpha-methylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression. \| journal = Virchows Arch \| volume = 448 \| issue = 3 \| pages = 325-30 \| month = Mar \| year = 2006 \| doi = 10.1007/s00428-005-0129-6 \| PMID = 16315020 }}</ref>

	==Negative==		==Negative==

Michael at 16:40, 11 December 2014

2014-12-11T16:40:23Z

← Older revision		Revision as of 16:40, 11 December 2014
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			[[Image:Atypical_small_acinar_proliferation_-_AMACR-CK34betaE12_-_alt_--_very_high_mag.jpg\|thumb\|right\|AMACR positivity in [[ASAP]]. CK5/6-AMACR immunostain.]]
	'''Alpha-methylacyl-CoA racemase''', abbreviated '''AMACR''', is a commonly used [[immunostain]] in [[genitourinary pathology]].		'''Alpha-methylacyl-CoA racemase''', abbreviated '''AMACR''', is a commonly used [[immunostain]] in [[genitourinary pathology]].

Michael: /* Positive */

2014-12-11T16:38:25Z

Positive

← Older revision		Revision as of 16:38, 11 December 2014
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	*[[Prostate adenocarcinoma]].<ref name=pmid23376124>{{Cite journal \| last1 = Lloyd \| first1 = MD. \| last2 = Yevglevskis \| first2 = M. \| last3 = Lee \| first3 = GL. \| last4 = Wood \| first4 = PJ. \| last5 = Threadgill \| first5 = MD. \| last6 = Woodman \| first6 = TJ. \| title = α-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S. \| journal = Prog Lipid Res \| volume = 52 \| issue = 2 \| pages = 220-30 \| month = Apr \| year = 2013 \| doi = 10.1016/j.plipres.2013.01.001 \| PMID = 23376124 }}</ref>		*[[Prostate adenocarcinoma]].<ref name=pmid23376124>{{Cite journal \| last1 = Lloyd \| first1 = MD. \| last2 = Yevglevskis \| first2 = M. \| last3 = Lee \| first3 = GL. \| last4 = Wood \| first4 = PJ. \| last5 = Threadgill \| first5 = MD. \| last6 = Woodman \| first6 = TJ. \| title = α-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S. \| journal = Prog Lipid Res \| volume = 52 \| issue = 2 \| pages = 220-30 \| month = Apr \| year = 2013 \| doi = 10.1016/j.plipres.2013.01.001 \| PMID = 23376124 }}</ref>
	*[[Papillary renal cell carcinoma]].<Ref name=pmid16733210>{{Cite journal \| last1 = Molinié \| first1 = V. \| last2 = Balaton \| first2 = A. \| last3 = Rotman \| first3 = S. \| last4 = Mansouri \| first4 = D. \| last5 = De Pinieux \| first5 = I. \| last6 = Homsi \| first6 = T. \| last7 = Guillou \| first7 = L. \| title = Alpha-methyl CoA racemase expression in renal cell carcinomas. \| journal = Hum Pathol \| volume = 37 \| issue = 6 \| pages = 698-703 \| month = Jun \| year = 2006 \| doi = 10.1016/j.humpath.2006.01.012 \| PMID = 16733210 }}</ref>		*[[Papillary renal cell carcinoma]].<Ref name=pmid16733210>{{Cite journal \| last1 = Molinié \| first1 = V. \| last2 = Balaton \| first2 = A. \| last3 = Rotman \| first3 = S. \| last4 = Mansouri \| first4 = D. \| last5 = De Pinieux \| first5 = I. \| last6 = Homsi \| first6 = T. \| last7 = Guillou \| first7 = L. \| title = Alpha-methyl CoA racemase expression in renal cell carcinomas. \| journal = Hum Pathol \| volume = 37 \| issue = 6 \| pages = 698-703 \| month = Jun \| year = 2006 \| doi = 10.1016/j.humpath.2006.01.012 \| PMID = 16733210 }}</ref>
			*[[High-grade prostatic intraepithelial neoplasia]].

	==Positive or negative==		==Positive or negative==

Michael: /* Positive or negative */

2014-12-11T16:38:00Z

Positive or negative

← Older revision		Revision as of 16:38, 11 December 2014
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	==Positive or negative==		==Positive or negative==
	*[[Nephrogenic adenoma]].		*[[Nephrogenic adenoma]].
			*[[Urothelial carcinoma]] - not useful for differentating ''prostate'' versus ''bladder''.

	==Negative==		==Negative==