Anal intraepithelial lesions - Revision history

Michael: Redirected page to Anal intraepithelial neoplasia

2016-05-06T14:49:47Z

Redirected page to Anal intraepithelial neoplasia

← Older revision		Revision as of 14:49, 6 May 2016
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	~~The article deals with '''anal intraepithelial lesions''', abbreviated '''AILs'''. They are now classified as either low grade or high grade, as in the uterine cervix.~~		#redirect [[Anal intraepithelial neoplasia]]

	'''Anal intraepithelial neoplasia''', abbreviated '''AIN''', is an older term that is still used.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref>

	~~Regardless of the name, they are considered to be the precursor of [[anal squamous cell carcinoma]].~~

	~~==General==~~
	*Precursor lesion of [[anal squamous cell carcinoma]].
	*Usually [[HPV]] associated.
	**May be prevented by HPV vaccine.
	**Strong association with [[HIV]] infection.<ref name=pmid26274593/>

	~~==Microscopic==~~
	~~DDx:~~
	*[[Anal ~~squamous cell carcinoma]].~~

	~~===Grading===~~
	AIN is graded much like [[cervix\|cervical intraepithelial neoplasia]]:<ref name=pmid25938361>{{Cite journal \| last1 = Roberts \| first1 = JM. \| last2 = Jin \| first2 = F. \| last3 = Thurloe \| first3 = JK. \| last4 = Biro \| first4 = C. \| last5 = Poynten \| first5 = IM. \| last6 = Tabrizi \| first6 = SN. \| last7 = Fairley \| first7 = CK. \| last8 = Templeton \| first8 = DJ. \| last9 = Carr \| first9 = AD. \| title = High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal. \| journal = Pathology \| volume = 47 \| issue = 4 \| pages = 308-13 \| month = Jun \| year = 2015 \| doi = 10.1097/PAT.0000000000000246 \| PMID = 25938361 }}</ref><ref name=pmid26688291>{{Cite journal \| last1 = Burgos \| first1 = J. \| last2 = Curran \| first2 = A. \| last3 = Landolfi \| first3 = S. \| last4 = Navarro \| first4 = J. \| last5 = Tallada \| first5 = N. \| last6 = Guelar \| first6 = A. \| last7 = Crespo \| first7 = M. \| last8 = Ocaña \| first8 = I. \| last9 = Ribera \| first9 = E. \| title = The effectiveness of electrocautery ablation for the treatment of high-grade anal intraepithelial neoplasia ~~in HIV-infected men who have sex with men. \| journal = HIV Med \| volume = \| issue = \| pages = \| month = Dec \| year = 2015 \| doi = 10.1111/hiv.12352 \| PMID = 26688291 }}</ref>~~
	*High-grade anal intraepithelial neoplasia (HGAIN).
	*Low-grade anal intraepithelial neoplasia (LGAIN).

	~~==Sign out==~~
	~~<pre>~~
	~~Anus (Submitted as "Anal Intraepithelial Neoplasia"), Biopsy:~~
	~~- HIGH GRADE SQUAMOUS INTRAEPITHIAL LESION (HSIL) of the anus.~~
	~~- Benign colorectal type mucosa.~~

	~~Comment:~~
	~~The HSIL is in keeping with AIN 3.~~
	~~</pre>~~

	~~===Block letters===~~
	~~<pre>~~
	~~ANAL CANAL, RIGHT UPPER QUADRANT, BIOPSY:~~
	~~- LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CONDYLOMA ACUMINATUM-LIKE).~~
	~~</pre>~~

	~~<pre>~~
	~~ANAL CANAL, LEFT UPPER QUADRANT, BIOPSY:~~
	~~- LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION.~~
	~~- RECTAL MUCOSA WITHIN NORMAL LIMITS.~~
	~~</pre>~~

	~~<pre>~~
	~~SKIN LESION, PERIANAL, BIOPSY:~~
	~~- ANAL INTRAEPITHELIAL NEOPLASIA 3 (SEVERE DYSPLASIA), WARTY-TYPE.~~
	~~- MARGIN POSITIVE FOR ANAL INTRAEPITHELIAL NEOPLASIA 3.~~
	~~</pre>~~

	~~===Micro===~~
	~~There is dysplastic squamous epithelium with coarse chromatin, nuclear hyperchromasia,~~
	~~nuclear enlargement, irregular nuclear membranes, and an increase nuclear-to-cytoplasmic~~
	~~ratio. Mitotic activity is abundant. Several atypical mitoses are identified.~~

	~~The dysplastic squamous epithelium shows minimal maturation toward the surface (AIN 3). A~~
	~~sizable portion of the lesion show some maturation to the surface (AIN 2).~~

	~~Inflammation at the dermal-epidermal interface is minimal and the dermal-epidermal~~
	~~interface is well-demarcated. Focal ulceration is present.~~

	~~The margin of the biopsy has severely dysplastic epithelium (AIN 3).~~

	~~==See also==~~
	*[[Anus]].
	*[[LSIL]].
	*[[HSIL]].

	~~==References==~~
	~~{{Reflist\|1}}~~
	~~[[Category:Diagnosis]]~~
	~~[[Category:Anus~~]].

Michael: /* Grading */

2016-05-06T14:43:43Z

Grading

← Older revision		Revision as of 14:43, 6 May 2016
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	===Grading===		===Grading===
	AIN is graded much like [[cervix\|cervical intraepithelial neoplasia]]:<ref name=pmid25938361>{{Cite journal \| last1 = Roberts \| first1 = JM. \| last2 = Jin \| first2 = F. \| last3 = Thurloe \| first3 = JK. \| last4 = Biro \| first4 = C. \| last5 = Poynten \| first5 = IM. \| last6 = Tabrizi \| first6 = SN. \| last7 = Fairley \| first7 = CK. \| last8 = Templeton \| first8 = DJ. \| last9 = Carr \| first9 = AD. \| title = High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal. \| journal = Pathology \| volume = 47 \| issue = 4 \| pages = 308-13 \| month = Jun \| year = 2015 \| doi = 10.1097/PAT.0000000000000246 \| PMID = 25938361 }}</ref>		AIN is graded much like [[cervix\|cervical intraepithelial neoplasia]]:<ref name=pmid25938361>{{Cite journal \| last1 = Roberts \| first1 = JM. \| last2 = Jin \| first2 = F. \| last3 = Thurloe \| first3 = JK. \| last4 = Biro \| first4 = C. \| last5 = Poynten \| first5 = IM. \| last6 = Tabrizi \| first6 = SN. \| last7 = Fairley \| first7 = CK. \| last8 = Templeton \| first8 = DJ. \| last9 = Carr \| first9 = AD. \| title = High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal. \| journal = Pathology \| volume = 47 \| issue = 4 \| pages = 308-13 \| month = Jun \| year = 2015 \| doi = 10.1097/PAT.0000000000000246 \| PMID = 25938361 }}</ref><ref name=pmid26688291>{{Cite journal \| last1 = Burgos \| first1 = J. \| last2 = Curran \| first2 = A. \| last3 = Landolfi \| first3 = S. \| last4 = Navarro \| first4 = J. \| last5 = Tallada \| first5 = N. \| last6 = Guelar \| first6 = A. \| last7 = Crespo \| first7 = M. \| last8 = Ocaña \| first8 = I. \| last9 = Ribera \| first9 = E. \| title = The effectiveness of electrocautery ablation for the treatment of high-grade anal intraepithelial neoplasia in HIV-infected men who have sex with men. \| journal = HIV Med \| volume = \| issue = \| pages = \| month = Dec \| year = 2015 \| doi = 10.1111/hiv.12352 \| PMID = 26688291 }}</ref>
	*High-grade anal intraepithelial neoplasia (HGAIN).		*High-grade anal intraepithelial neoplasia (HGAIN).
	*Low-grade anal intraepithelial neoplasia (LGAIN).		*Low-grade anal intraepithelial neoplasia (LGAIN).

Michael: /* References */

2016-05-06T14:42:25Z

References

← Older revision		Revision as of 14:42, 6 May 2016
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Anus]].		[[Category:Anus]].

Michael: /* Sign out */

2016-05-06T14:32:53Z

Sign out

← Older revision		Revision as of 14:32, 6 May 2016
Line 21:		Line 21:

	==Sign out==		==Sign out==
			<pre>
			Anus (Submitted as "Anal Intraepithelial Neoplasia"), Biopsy:
			- HIGH GRADE SQUAMOUS INTRAEPITHIAL LESION (HSIL) of the anus.
			- Benign colorectal type mucosa.

			Comment:
			The HSIL is in keeping with AIN 3.
			</pre>

			===Block letters===
	<pre>		<pre>
	ANAL CANAL, RIGHT UPPER QUADRANT, BIOPSY:		ANAL CANAL, RIGHT UPPER QUADRANT, BIOPSY:

Michael at 14:27, 6 May 2016

2016-05-06T14:27:53Z

← Older revision		Revision as of 14:27, 6 May 2016
Line 1:		Line 1:
	The article deals with '''anal intraepithelial lesions''', abbreviated '''AILs'''. They are now classified as either low grade or high grade, as in the uterine cervix.		The article deals with '''anal intraepithelial lesions''', abbreviated '''AILs'''. They are now classified as either low grade or high grade, as in the uterine cervix.

	~~In the past the term~~ '''~~anal~~ intraepithelial neoplasia''', abbreviated '''AIN''' ~~was~~ used. ~~This is still used frequently~~.		'''Anal intraepithelial neoplasia''', abbreviated '''AIN''', is an older term that is still used.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref>

	Regardless of the name, they are considered to be the precursor of [[anal squamous cell carcinoma]].		Regardless of the name, they are considered to be the precursor of [[anal squamous cell carcinoma]].
Line 9:		Line 9:
	*Usually [[HPV]] associated.		*Usually [[HPV]] associated.
	**May be prevented by HPV vaccine.		**May be prevented by HPV vaccine.
			**Strong association with [[HIV]] infection.<ref name=pmid26274593/>

	==Microscopic==		==Microscopic==

Michael at 14:23, 6 May 2016

2016-05-06T14:23:27Z

← Older revision		Revision as of 14:23, 6 May 2016
Line 1:		Line 1:
	'''~~Anal~~ intraepithelial neoplasia''', abbreviated '''AIN''', the precursor of [[anal squamous cell carcinoma]].		The article deals with '''anal intraepithelial lesions''', abbreviated '''AILs'''. They are now classified as either low grade or high grade, as in the uterine cervix.

			In the past the term '''anal intraepithelial neoplasia''', abbreviated '''AIN''' was used. This is still used frequently.

			Regardless of the name, they are considered to be the precursor of [[anal squamous cell carcinoma]].

	==General==		==General==
	*Precursor lesion of ~~anal~~ [[squamous cell carcinoma]].		*Precursor lesion of [[anal squamous cell carcinoma]].
	*Usually [[HPV]] associated.		*Usually [[HPV]] associated.
	**May be prevented by HPV vaccine.		**May be prevented by HPV vaccine.

Michael: Michael moved page Anal intraepithelial neoplasia to Anal intraepithelial lesions: going to LSIL/HSIL terminology

2016-05-06T14:20:20Z

Michael moved page Anal intraepithelial neoplasia to Anal intraepithelial lesions: going to LSIL/HSIL terminology

← Older revision	Revision as of 14:20, 6 May 2016
(No difference)

Michael: /* Grading */

2016-05-06T14:19:28Z

Grading

← Older revision		Revision as of 14:19, 6 May 2016
Line 11:		Line 11:

	===Grading===		===Grading===
	AIN is graded much like [[cervix\|cervical intraepithelial neoplasia]]:		AIN is graded much like [[cervix\|cervical intraepithelial neoplasia]]:<ref name=pmid25938361>{{Cite journal \| last1 = Roberts \| first1 = JM. \| last2 = Jin \| first2 = F. \| last3 = Thurloe \| first3 = JK. \| last4 = Biro \| first4 = C. \| last5 = Poynten \| first5 = IM. \| last6 = Tabrizi \| first6 = SN. \| last7 = Fairley \| first7 = CK. \| last8 = Templeton \| first8 = DJ. \| last9 = Carr \| first9 = AD. \| title = High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal. \| journal = Pathology \| volume = 47 \| issue = 4 \| pages = 308-13 \| month = Jun \| year = 2015 \| doi = 10.1097/PAT.0000000000000246 \| PMID = 25938361 }}</ref>
	*High-grade anal intraepithelial neoplasia (HGAIN).		*High-grade anal intraepithelial neoplasia (HGAIN).
	*Low-grade anal intraepithelial neoplasia (LGAIN).		*Low-grade anal intraepithelial neoplasia (LGAIN).

Michael: split out

2016-05-06T14:17:24Z

split out

← Older revision		Revision as of 14:17, 6 May 2016
Line 1:		Line 1:
	~~#redirect~~ [[~~Anus#~~Anal intraepithelial neoplasia]]		'''Anal intraepithelial neoplasia''', abbreviated '''AIN''', the precursor of [[anal squamous cell carcinoma]].

			==General==
			*Precursor lesion of anal [[squamous cell carcinoma]].
			*Usually [[HPV]] associated.
			**May be prevented by HPV vaccine.

			==Microscopic==
			DDx:
			*[[Anal squamous cell carcinoma]].

			===Grading===
			AIN is graded much like [[cervix\|cervical intraepithelial neoplasia]]:
			*High-grade anal intraepithelial neoplasia (HGAIN).
			*Low-grade anal intraepithelial neoplasia (LGAIN).

			==Sign out==
			<pre>
			ANAL CANAL, RIGHT UPPER QUADRANT, BIOPSY:
			- LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CONDYLOMA ACUMINATUM-LIKE).
			</pre>

			<pre>
			ANAL CANAL, LEFT UPPER QUADRANT, BIOPSY:
			- LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION.
			- RECTAL MUCOSA WITHIN NORMAL LIMITS.
			</pre>

			<pre>
			SKIN LESION, PERIANAL, BIOPSY:
			- ANAL INTRAEPITHELIAL NEOPLASIA 3 (SEVERE DYSPLASIA), WARTY-TYPE.
			- MARGIN POSITIVE FOR ANAL INTRAEPITHELIAL NEOPLASIA 3.
			</pre>

			===Micro===
			There is dysplastic squamous epithelium with coarse chromatin, nuclear hyperchromasia,
			nuclear enlargement, irregular nuclear membranes, and an increase nuclear-to-cytoplasmic
			ratio. Mitotic activity is abundant. Several atypical mitoses are identified.

			The dysplastic squamous epithelium shows minimal maturation toward the surface (AIN 3). A
			sizable portion of the lesion show some maturation to the surface (AIN 2).

			Inflammation at the dermal-epidermal interface is minimal and the dermal-epidermal
			interface is well-demarcated. Focal ulceration is present.

			The margin of the biopsy has severely dysplastic epithelium (AIN 3).

			==See also==
			*[[Anus]].
			*[[LSIL]].
			*[[HSIL]].

			==References==
			{{Reflist\|1}}

			[[Category:Diagnosis]]
			[[Category:Anus]].

Michael: redirect

2015-03-19T18:11:29Z

redirect

New page

#redirect [[Anus#Anal intraepithelial neoplasia]]