Anal intraepithelial neoplasia - Revision history

Michael: /* Microscopic */

2016-06-16T02:24:15Z

Microscopic

← Older revision		Revision as of 02:24, 16 June 2016
Line 13:		Line 13:
	==Microscopic==		==Microscopic==
	DDx:		DDx:
	*[[~~Squamous~~ metaplasia of the rectum]].		*[[Immature squamous metaplasia of the rectum]].
	*[[Anal squamous cell carcinoma]].		*[[Anal squamous cell carcinoma]].

Michael: /* Microscopic */

2016-06-16T02:22:44Z

Microscopic

← Older revision		Revision as of 02:22, 16 June 2016
Line 13:		Line 13:
	==Microscopic==		==Microscopic==
	DDx:		DDx:
			*[[Squamous metaplasia of the rectum]].
	*[[Anal squamous cell carcinoma]].		*[[Anal squamous cell carcinoma]].

Michael at 15:07, 6 May 2016

2016-05-06T15:07:40Z

← Older revision		Revision as of 15:07, 6 May 2016
Line 3:		Line 3:
	AIN is now usually classified as either low grade or high grade, as in the uterine cervix.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref> AIN is considered to be the precursor of [[anal squamous cell carcinoma]].		AIN is now usually classified as either low grade or high grade, as in the uterine cervix.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref> AIN is considered to be the precursor of [[anal squamous cell carcinoma]].

	''Anal intraepithelial lesions'' and ''anal intraepithelial lesion'' ~~redirects~~ here.		''Anal intraepithelial lesions'' and ''anal intraepithelial lesion'' redirect here.

	==General==		==General==

Michael at 15:07, 6 May 2016

2016-05-06T15:07:35Z

← Older revision		Revision as of 15:07, 6 May 2016
Line 3:		Line 3:
	AIN is now usually classified as either low grade or high grade, as in the uterine cervix.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref> AIN is considered to be the precursor of [[anal squamous cell carcinoma]].		AIN is now usually classified as either low grade or high grade, as in the uterine cervix.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref> AIN is considered to be the precursor of [[anal squamous cell carcinoma]].

	''Anal intraepithelial lesion'' redirects here.		''Anal intraepithelial lesions'' and ''anal intraepithelial lesion'' redirects here.

	==General==		==General==

Michael at 14:50, 6 May 2016

2016-05-06T14:50:29Z

← Older revision		Revision as of 14:50, 6 May 2016
Line 1:		Line 1:
	The article deals with '''anal intraepithelial neoplasia''', abbreviated '''AIN'''. ~~They are~~ now classified as either low grade or high grade, as in the uterine cervix.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref> AIN is considered to be the precursor of [[anal squamous cell carcinoma]].		The article deals with '''anal intraepithelial neoplasia''', abbreviated '''AIN'''.

			AIN is now usually classified as either low grade or high grade, as in the uterine cervix.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref> AIN is considered to be the precursor of [[anal squamous cell carcinoma]].

	''Anal intraepithelial lesion'' redirects here.		''Anal intraepithelial lesion'' redirects here.

Michael at 14:49, 6 May 2016

2016-05-06T14:49:08Z

← Older revision		Revision as of 14:49, 6 May 2016
Line 1:		Line 1:
	~~#REDIRECT~~ [[Anal intraepithelial lesions]]		The article deals with '''anal intraepithelial neoplasia''', abbreviated '''AIN'''. They are now classified as either low grade or high grade, as in the uterine cervix.<ref name=pmid26274593>{{Cite journal \| last1 = Dietrich \| first1 = A. \| last2 = Hermans \| first2 = C. \| last3 = Heppt \| first3 = MV. \| last4 = Ruzicka \| first4 = T. \| last5 = Schauber \| first5 = J. \| last6 = Reinholz \| first6 = M. \| title = Human papillomavirus status, anal cytology and histopathological outcome in HIV-positive patients. \| journal = J Eur Acad Dermatol Venereol \| volume = 29 \| issue = 10 \| pages = 2011-8 \| month = Oct \| year = 2015 \| doi = 10.1111/jdv.13205 \| PMID = 26274593 }}</ref> AIN is considered to be the precursor of [[anal squamous cell carcinoma]].

			''Anal intraepithelial lesion'' redirects here.

			==General==
			*Precursor lesion of [[anal squamous cell carcinoma]].
			*Usually [[HPV]] associated.
			**May be prevented by HPV vaccine.
			**Strong association with [[HIV]] infection.<ref name=pmid26274593/>

			==Microscopic==
			DDx:
			*[[Anal squamous cell carcinoma]].

			===Grading===
			AIN is graded much like [[cervix\|cervical intraepithelial neoplasia]]:<ref name=pmid25938361>{{Cite journal \| last1 = Roberts \| first1 = JM. \| last2 = Jin \| first2 = F. \| last3 = Thurloe \| first3 = JK. \| last4 = Biro \| first4 = C. \| last5 = Poynten \| first5 = IM. \| last6 = Tabrizi \| first6 = SN. \| last7 = Fairley \| first7 = CK. \| last8 = Templeton \| first8 = DJ. \| last9 = Carr \| first9 = AD. \| title = High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal. \| journal = Pathology \| volume = 47 \| issue = 4 \| pages = 308-13 \| month = Jun \| year = 2015 \| doi = 10.1097/PAT.0000000000000246 \| PMID = 25938361 }}</ref><ref name=pmid26688291>{{Cite journal \| last1 = Burgos \| first1 = J. \| last2 = Curran \| first2 = A. \| last3 = Landolfi \| first3 = S. \| last4 = Navarro \| first4 = J. \| last5 = Tallada \| first5 = N. \| last6 = Guelar \| first6 = A. \| last7 = Crespo \| first7 = M. \| last8 = Ocaña \| first8 = I. \| last9 = Ribera \| first9 = E. \| title = The effectiveness of electrocautery ablation for the treatment of high-grade anal intraepithelial neoplasia in HIV-infected men who have sex with men. \| journal = HIV Med \| volume = \| issue = \| pages = \| month = Dec \| year = 2015 \| doi = 10.1111/hiv.12352 \| PMID = 26688291 }}</ref>
			*High-grade anal intraepithelial neoplasia (HGAIN).
			*Low-grade anal intraepithelial neoplasia (LGAIN).

			==Sign out==
			<pre>
			Anus (Submitted as "Anal Intraepithelial Neoplasia"), Biopsy:
			- HIGH GRADE SQUAMOUS INTRAEPITHIAL LESION (HSIL) of the anus.
			- Benign colorectal type mucosa.

			Comment:
			The HSIL is in keeping with AIN 3.
			</pre>

			===Block letters===
			<pre>
			ANAL CANAL, RIGHT UPPER QUADRANT, BIOPSY:
			- LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CONDYLOMA ACUMINATUM-LIKE).
			</pre>

			<pre>
			ANAL CANAL, LEFT UPPER QUADRANT, BIOPSY:
			- LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION.
			- RECTAL MUCOSA WITHIN NORMAL LIMITS.
			</pre>

			<pre>
			SKIN LESION, PERIANAL, BIOPSY:
			- ANAL INTRAEPITHELIAL NEOPLASIA 3 (SEVERE DYSPLASIA), WARTY-TYPE.
			- MARGIN POSITIVE FOR ANAL INTRAEPITHELIAL NEOPLASIA 3.
			</pre>

			===Micro===
			There is dysplastic squamous epithelium with coarse chromatin, nuclear hyperchromasia,
			nuclear enlargement, irregular nuclear membranes, and an increase nuclear-to-cytoplasmic
			ratio. Mitotic activity is abundant. Several atypical mitoses are identified.

			The dysplastic squamous epithelium shows minimal maturation toward the surface (AIN 3). A
			sizable portion of the lesion show some maturation to the surface (AIN 2).

			Inflammation at the dermal-epidermal interface is minimal and the dermal-epidermal
			interface is well-demarcated. Focal ulceration is present.

			The margin of the biopsy has severely dysplastic epithelium (AIN 3).

			==See also==
			*[[Anus]].
			*[[LSIL]].
			*[[HSIL]].

			==References==
			{{Reflist\|1}}
			[[Category:Diagnosis]]
			[[Category:Anus]].

Michael: Michael moved page Anal intraepithelial neoplasia to Anal intraepithelial lesions: going to LSIL/HSIL terminology

2016-05-06T14:20:20Z

Michael moved page Anal intraepithelial neoplasia to Anal intraepithelial lesions: going to LSIL/HSIL terminology

New page

#REDIRECT [[Anal intraepithelial lesions]]