Anaplastic large cell lymphoma - Revision history

Mark: additional features

2023-09-29T19:00:25Z

additional features

← Older revision		Revision as of 19:00, 29 September 2023
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	ALK IHC - systemic form:		ALK IHC - systemic form:
	* +ve = good prognosis.		* +ve = good prognosis (generally a disease of children, teenagers and young adults)
	* -ve = bad prognosis.		* -ve = bad prognosis

	==Microscopic==		==Microscopic==
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	*''Hallmark cells'' = "horseshoe-shaped or [[donut cell\|donut-shaped nucleus]] + eosinophilic paranuclear region"<ref name=pmid17941004>{{Cite journal \| last1 = Rapkiewicz \| first1 = A. \| last2 = Wen \| first2 = H. \| last3 = Sen \| first3 = F. \| last4 = Das \| first4 = K. \| title = Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology. \| journal = Cancer \| volume = 111 \| issue = 6 \| pages = 499-507 \| month = Dec \| year = 2007 \| doi = 10.1002/cncr.23120 \| PMID = 17941004 \| url=http://onlinelibrary.wiley.com/doi/10.1002/cncr.23120/full}}</ref><ref name=pmid12419758>{{Cite journal \| last1 = Ponzoni \| first1 = M. \| last2 = Terreni \| first2 = MR. \| last3 = Ciceri \| first3 = F. \| last4 = Ferreri \| first4 = AJ. \| last5 = Gerevini \| first5 = S. \| last6 = Anzalone \| first6 = N. \| last7 = Valle \| first7 = M. \| last8 = Pizzolito \| first8 = S. \| last9 = Arrigoni \| first9 = G. \| title = Primary brain CD30+ ALK1+ anaplastic large cell lymphoma ('ALKoma'): the first case with a combination of 'not common' variants. \| journal = Ann Oncol \| volume = 13 \| issue = 11 \| pages = 1827-32 \| month = Nov \| year = 2002 \| doi = \| PMID = 12419758 }}</ref> - '''key feature'''.		*''Hallmark cells'' = "horseshoe-shaped or [[donut cell\|donut-shaped nucleus]] + eosinophilic paranuclear region"<ref name=pmid17941004>{{Cite journal \| last1 = Rapkiewicz \| first1 = A. \| last2 = Wen \| first2 = H. \| last3 = Sen \| first3 = F. \| last4 = Das \| first4 = K. \| title = Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology. \| journal = Cancer \| volume = 111 \| issue = 6 \| pages = 499-507 \| month = Dec \| year = 2007 \| doi = 10.1002/cncr.23120 \| PMID = 17941004 \| url=http://onlinelibrary.wiley.com/doi/10.1002/cncr.23120/full}}</ref><ref name=pmid12419758>{{Cite journal \| last1 = Ponzoni \| first1 = M. \| last2 = Terreni \| first2 = MR. \| last3 = Ciceri \| first3 = F. \| last4 = Ferreri \| first4 = AJ. \| last5 = Gerevini \| first5 = S. \| last6 = Anzalone \| first6 = N. \| last7 = Valle \| first7 = M. \| last8 = Pizzolito \| first8 = S. \| last9 = Arrigoni \| first9 = G. \| title = Primary brain CD30+ ALK1+ anaplastic large cell lymphoma ('ALKoma'): the first case with a combination of 'not common' variants. \| journal = Ann Oncol \| volume = 13 \| issue = 11 \| pages = 1827-32 \| month = Nov \| year = 2002 \| doi = \| PMID = 12419758 }}</ref> - '''key feature'''.
	**The donut-shaped version is also known as a "wreath cell"<ref>{{Cite journal \| last1 = Amin \| first1 = HM. \| last2 = Lai \| first2 = R. \| title = Pathobiology of ALK+ anaplastic large-cell lymphoma. \| journal = Blood \| volume = 110 \| issue = 7 \| pages = 2259-67 \| month = Oct \| year = 2007 \| doi = 10.1182/blood-2007-04-060715 \| PMID = 17519389 \| url=http://bloodjournal.hematologylibrary.org/content/110/7/2259.full.html}}</ref> - large (multi-nucleated) cells with (morphologically) one toroidal-shaped nucleus.		**The donut-shaped version is also known as a "wreath cell"<ref>{{Cite journal \| last1 = Amin \| first1 = HM. \| last2 = Lai \| first2 = R. \| title = Pathobiology of ALK+ anaplastic large-cell lymphoma. \| journal = Blood \| volume = 110 \| issue = 7 \| pages = 2259-67 \| month = Oct \| year = 2007 \| doi = 10.1182/blood-2007-04-060715 \| PMID = 17519389 \| url=http://bloodjournal.hematologylibrary.org/content/110/7/2259.full.html}}</ref> - large (multi-nucleated) cells with (morphologically) one toroidal-shaped nucleus.
			*ALK+ ALCL includes variants without the classical hallmark cells, e.g. small cell variant and lymphohistiocytic variant

	DDx:		DDx:
	*[[Hodgkin's lymphoma]].		*[[Hodgkin's lymphoma]]
	*Carcinoma.		*Anaplastic variants of other haematolymphoid malignancies, e.g. DLBCL or myeloma
			*Carcinoma
			*Melanoma

	===Images===		===Images===
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	==IHC==		==IHC==
	Features:		Features:
	*CD30 +ve.		*CD30 +ve (usually strong and diffuse)
	*ALK-1 -ve/+ve; strongly supports ALCL Dx if +ve.		*ALK-1 -ve/+ve; strongly supports ALCL Dx if +ve.
	*CD45 +ve.		*CD45 +ve.
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	*CD7 -ve/+ve.		*CD7 -ve/+ve.
	*EMA +ve.		*EMA +ve.
			*Cytotoxic markers (e.g. TIA, perforin)

	==Molecular==		==Molecular==
	*t(2,5)(p23;q35)<ref name=pmid8547653>{{cite journal \|author=Lamant L, Meggetto F, al Saati T, ''et al.'' \|title=High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining \|journal=Blood \|volume=87 \|issue=1 \|pages=284–91 \|year=1996 \|month=January \|pmid=8547653 \|doi= \|url=}}</ref> - ~~can be detected with [[FISH]]~~ break apart probe.		*In ALK+ ALCL, there is commonly an ALK1 rearrangement.
			**This may be ALK::NPM1, i.e. t(2,5)(p23;q35)<ref name=pmid8547653>{{cite journal \|author=Lamant L, Meggetto F, al Saati T, ''et al.'' \|title=High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining \|journal=Blood \|volume=87 \|issue=1 \|pages=284–91 \|year=1996 \|month=January \|pmid=8547653 \|doi= \|url=}}</ref> - combined nuclear and cytoplasmic ALK staining is a surrogate for this translocation.
			*Other non-NPM1 partners may occur. A ALK1 break-apart probe will detect these.

	==See also==		==See also==

Michael at 21:33, 25 September 2023

2023-09-25T21:33:50Z

← Older revision		Revision as of 21:33, 25 September 2023
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	*Usually appear cohesive.		*Usually appear cohesive.
	*May be subcapsular in a [[lymph node]] and mimic a carcinoma.		*May be subcapsular in a [[lymph node]] and mimic a carcinoma.
	*''Hallmark cells'' = "horseshoe-shaped or donut-shaped nucleus + eosinophilic paranuclear region"<ref name=pmid17941004>{{Cite journal \| last1 = Rapkiewicz \| first1 = A. \| last2 = Wen \| first2 = H. \| last3 = Sen \| first3 = F. \| last4 = Das \| first4 = K. \| title = Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology. \| journal = Cancer \| volume = 111 \| issue = 6 \| pages = 499-507 \| month = Dec \| year = 2007 \| doi = 10.1002/cncr.23120 \| PMID = 17941004 \| url=http://onlinelibrary.wiley.com/doi/10.1002/cncr.23120/full}}</ref><ref name=pmid12419758>{{Cite journal \| last1 = Ponzoni \| first1 = M. \| last2 = Terreni \| first2 = MR. \| last3 = Ciceri \| first3 = F. \| last4 = Ferreri \| first4 = AJ. \| last5 = Gerevini \| first5 = S. \| last6 = Anzalone \| first6 = N. \| last7 = Valle \| first7 = M. \| last8 = Pizzolito \| first8 = S. \| last9 = Arrigoni \| first9 = G. \| title = Primary brain CD30+ ALK1+ anaplastic large cell lymphoma ('ALKoma'): the first case with a combination of 'not common' variants. \| journal = Ann Oncol \| volume = 13 \| issue = 11 \| pages = 1827-32 \| month = Nov \| year = 2002 \| doi = \| PMID = 12419758 }}</ref> - '''key feature'''.		*''Hallmark cells'' = "horseshoe-shaped or [[donut cell\|donut-shaped nucleus]] + eosinophilic paranuclear region"<ref name=pmid17941004>{{Cite journal \| last1 = Rapkiewicz \| first1 = A. \| last2 = Wen \| first2 = H. \| last3 = Sen \| first3 = F. \| last4 = Das \| first4 = K. \| title = Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology. \| journal = Cancer \| volume = 111 \| issue = 6 \| pages = 499-507 \| month = Dec \| year = 2007 \| doi = 10.1002/cncr.23120 \| PMID = 17941004 \| url=http://onlinelibrary.wiley.com/doi/10.1002/cncr.23120/full}}</ref><ref name=pmid12419758>{{Cite journal \| last1 = Ponzoni \| first1 = M. \| last2 = Terreni \| first2 = MR. \| last3 = Ciceri \| first3 = F. \| last4 = Ferreri \| first4 = AJ. \| last5 = Gerevini \| first5 = S. \| last6 = Anzalone \| first6 = N. \| last7 = Valle \| first7 = M. \| last8 = Pizzolito \| first8 = S. \| last9 = Arrigoni \| first9 = G. \| title = Primary brain CD30+ ALK1+ anaplastic large cell lymphoma ('ALKoma'): the first case with a combination of 'not common' variants. \| journal = Ann Oncol \| volume = 13 \| issue = 11 \| pages = 1827-32 \| month = Nov \| year = 2002 \| doi = \| PMID = 12419758 }}</ref> - '''key feature'''.
	**The donut-shaped version is also known as a "wreath cell"<ref>{{Cite journal \| last1 = Amin \| first1 = HM. \| last2 = Lai \| first2 = R. \| title = Pathobiology of ALK+ anaplastic large-cell lymphoma. \| journal = Blood \| volume = 110 \| issue = 7 \| pages = 2259-67 \| month = Oct \| year = 2007 \| doi = 10.1182/blood-2007-04-060715 \| PMID = 17519389 \| url=http://bloodjournal.hematologylibrary.org/content/110/7/2259.full.html}}</ref> - large (multi-nucleated) cells with (morphologically) one toroidal-shaped nucleus.		**The donut-shaped version is also known as a "wreath cell"<ref>{{Cite journal \| last1 = Amin \| first1 = HM. \| last2 = Lai \| first2 = R. \| title = Pathobiology of ALK+ anaplastic large-cell lymphoma. \| journal = Blood \| volume = 110 \| issue = 7 \| pages = 2259-67 \| month = Oct \| year = 2007 \| doi = 10.1182/blood-2007-04-060715 \| PMID = 17519389 \| url=http://bloodjournal.hematologylibrary.org/content/110/7/2259.full.html}}</ref> - large (multi-nucleated) cells with (morphologically) one toroidal-shaped nucleus.

Michael: /* Images */ +image

2015-04-01T21:21:10Z

Images: +image

← Older revision		Revision as of 21:21, 1 April 2015
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	===Images===		===Images===
	<gallery>		<gallery>
			Image: Anaplastic large cell lymphoma - high mag.jpg \| ALCL - high mag. (WC)
	Image:Anaplastic_large_cell_lymphoma_-_very_high_mag.jpg \| ALCL - very high mag. (WC)		Image:Anaplastic_large_cell_lymphoma_-_very_high_mag.jpg \| ALCL - very high mag. (WC)
	Image:Anaplastic_large_cell_lymphoma_-_cropped_-_very_high_mag.jpg \| ALCL - cropped - very high mag. (WC)		Image:Anaplastic_large_cell_lymphoma_-_cropped_-_very_high_mag.jpg \| ALCL - cropped - very high mag. (WC)

Michael at 21:19, 1 April 2015

2015-04-01T21:19:36Z

← Older revision		Revision as of 21:19, 1 April 2015
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	\| Caption = Anaplastic large cell lymphoma. [[H&E stain]].		\| Caption = Anaplastic large cell lymphoma. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = large cells with eosinophilic cytoplasm, Hallmark cells ("horseshoe-shaped or donut-shaped nucleus + eosinophilic paranuclear region")
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[Hodgkin's lymphoma]], poorly differentiated [[carcinoma]]		\| LMDDx = [[Hodgkin's lymphoma]], poorly differentiated [[carcinoma]]

Michael: +infobox

2015-04-01T21:18:04Z

+infobox

← Older revision		Revision as of 21:18, 1 April 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Anaplastic_large_cell_lymphoma_-_cropped_-_very_high_mag.jpg
			\| Width =
			\| Caption = Anaplastic large cell lymphoma. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[Hodgkin's lymphoma]], poorly differentiated [[carcinoma]]
			\| Stains =
			\| IHC = CD30 +ve, ALK-1 -ve/+ve, CD45 +ve, CD4 +ve, CD3 -ve/+ve, CD7 -ve/+ve, EMA +ve
			\| EM =
			\| Molecular = t(2,5)(p23;q35)
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[skin]], [[lymph node]], other
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good to poor, dependent on ALK status and site
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Anaplastic large cell lymphoma''', abbreviated '''ALCL''', is an uncommon large cell [[lymphoma]].		'''Anaplastic large cell lymphoma''', abbreviated '''ALCL''', is an uncommon large cell [[lymphoma]].

Michael: split out

2014-03-09T03:56:55Z

split out

← Older revision		Revision as of 03:56, 9 March 2014
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	~~#redirect~~ [[~~Lymphoma#Anaplastic_large_cell_lymphoma~~]]		'''Anaplastic large cell lymphoma''', abbreviated '''ALCL''', is an uncommon large cell [[lymphoma]].

			==General==
			*May look a lot like a carcinoma.
			**Often subcapsular in LNs.
			*Usually T-cell derived.
			*May be isolated to the [[skin]] - good prognosis.

			Subtypes:
			* Systemic ALCL.
			* Cutaneous ALCL -- ALK -ve.

			ALK IHC - systemic form:
			* +ve = good prognosis.
			* -ve = bad prognosis.

			==Microscopic==
			Features:
			*Large cells with eosinophilic cytoplasm.
			*Usually appear cohesive.
			*May be subcapsular in a [[lymph node]] and mimic a carcinoma.
			*''Hallmark cells'' = "horseshoe-shaped or donut-shaped nucleus + eosinophilic paranuclear region"<ref name=pmid17941004>{{Cite journal \| last1 = Rapkiewicz \| first1 = A. \| last2 = Wen \| first2 = H. \| last3 = Sen \| first3 = F. \| last4 = Das \| first4 = K. \| title = Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology. \| journal = Cancer \| volume = 111 \| issue = 6 \| pages = 499-507 \| month = Dec \| year = 2007 \| doi = 10.1002/cncr.23120 \| PMID = 17941004 \| url=http://onlinelibrary.wiley.com/doi/10.1002/cncr.23120/full}}</ref><ref name=pmid12419758>{{Cite journal \| last1 = Ponzoni \| first1 = M. \| last2 = Terreni \| first2 = MR. \| last3 = Ciceri \| first3 = F. \| last4 = Ferreri \| first4 = AJ. \| last5 = Gerevini \| first5 = S. \| last6 = Anzalone \| first6 = N. \| last7 = Valle \| first7 = M. \| last8 = Pizzolito \| first8 = S. \| last9 = Arrigoni \| first9 = G. \| title = Primary brain CD30+ ALK1+ anaplastic large cell lymphoma ('ALKoma'): the first case with a combination of 'not common' variants. \| journal = Ann Oncol \| volume = 13 \| issue = 11 \| pages = 1827-32 \| month = Nov \| year = 2002 \| doi = \| PMID = 12419758 }}</ref> - '''key feature'''.
			**The donut-shaped version is also known as a "wreath cell"<ref>{{Cite journal \| last1 = Amin \| first1 = HM. \| last2 = Lai \| first2 = R. \| title = Pathobiology of ALK+ anaplastic large-cell lymphoma. \| journal = Blood \| volume = 110 \| issue = 7 \| pages = 2259-67 \| month = Oct \| year = 2007 \| doi = 10.1182/blood-2007-04-060715 \| PMID = 17519389 \| url=http://bloodjournal.hematologylibrary.org/content/110/7/2259.full.html}}</ref> - large (multi-nucleated) cells with (morphologically) one toroidal-shaped nucleus.

			DDx:
			*[[Hodgkin's lymphoma]].
			*Carcinoma.

			===Images===
			<gallery>
			Image:Anaplastic_large_cell_lymphoma_-_very_high_mag.jpg \| ALCL - very high mag. (WC)
			Image:Anaplastic_large_cell_lymphoma_-_cropped_-_very_high_mag.jpg \| ALCL - cropped - very high mag. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case363.html ALCL - several images (upmc.edu)].
			*[http://path.upmc.edu/cases/case557.html Small cell variant of ALCL - several images (upmc.edu)].

			==IHC==
			Features:
			*CD30 +ve.
			*ALK-1 -ve/+ve; strongly supports ALCL Dx if +ve.
			*CD45 +ve.
			*CD4 +ve.
			*CD3 -ve/+ve.
			*CD7 -ve/+ve.
			*EMA +ve.

			==Molecular==
			*t(2,5)(p23;q35)<ref name=pmid8547653>{{cite journal \|author=Lamant L, Meggetto F, al Saati T, ''et al.'' \|title=High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining \|journal=Blood \|volume=87 \|issue=1 \|pages=284–91 \|year=1996 \|month=January \|pmid=8547653 \|doi= \|url=}}</ref> - can be detected with [[FISH]] break apart probe.

			==See also==
			*[[Lymphoma]].
			*[[Diffuse large B-cell lymphoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Lymphoma]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: +cat.

2011-10-23T00:37:50Z

+cat.

← Older revision		Revision as of 00:37, 23 October 2011
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	#redirect [[Lymphoma#Anaplastic_large_cell_lymphoma]]		#redirect [[Lymphoma#Anaplastic_large_cell_lymphoma]]

			[[Category:Diagnosis]]

Michael: redirect for now

2011-03-03T15:52:34Z

redirect for now

New page

#redirect [[Lymphoma#Anaplastic_large_cell_lymphoma]]