Anaplastic thyroid carcinoma - Revision history

Michael: /* General */

2015-03-04T03:12:26Z

General

← Older revision		Revision as of 03:12, 4 March 2015
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	Epidemiology:		Epidemiology:
	*Very rare.		*Very rare.
	*Horrible prognosis.		*Horrible prognosis - median survival of 8 months in one series.<ref name=pmid24554064>{{Cite journal \| last1 = Mohebati \| first1 = A. \| last2 = Dilorenzo \| first2 = M. \| last3 = Palmer \| first3 = F. \| last4 = Patel \| first4 = SG. \| last5 = Pfister \| first5 = D. \| last6 = Lee \| first6 = N. \| last7 = Tuttle \| first7 = RM. \| last8 = Shaha \| first8 = AR. \| last9 = Shah \| first9 = JP. \| title = Anaplastic thyroid carcinoma: a 25-year single-institution experience. \| journal = Ann Surg Oncol \| volume = 21 \| issue = 5 \| pages = 1665-70 \| month = May \| year = 2014 \| doi = 10.1245/s10434-014-3545-5 \| PMID = 24554064 }}</ref>
	*Often presents with obstruction.		*Often presents with obstruction.
	*Typically there is a history of a thyroid mass.		*Typically there is a history of a thyroid mass.

2015-03-04T03:10:01Z

split out

← Older revision		Revision as of 03:10, 4 March 2015
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	~~#redirect~~ [[~~Thyroid_gland#Anaplastic_thyroid_carcinoma~~]]		'''Anaplastic thyroid carcinoma''' is a rare aggressive tumour of the [[thyroid gland]].

			==General==
			Epidemiology:
			*Very rare.
			*Horrible prognosis.
			*Often presents with obstruction.
			*Typically there is a history of a thyroid mass.

			==Microscopic==
			Features:
			*Cytologically malignant:
			**Huge [[NC ratio]].
			**Mitoses.
			*+/-[[Necrosis]].

			Notes:
			*May have features of other thyroid carcinomas, e.g. [[psammoma bodies]], papillae, nuclear changes of [[papillary thyroid carcinoma\|PTC]].

			DDx:
			*[[Poorly differentiated carcinoma of the thyroid\|Poorly differentiated thyroid carcinoma]].
			*[[Squamous cell carcinoma]].
			*[[Medullary thyroid carcinoma]].
			*[[Sarcoma]].

			===Images===
			<gallery>
			Image:Anaplastic_thyroid_carcinoma_low_mag.jpg \| Anaplastic thyroid carcinoma with a component of PTC. (WC)
			</gallery>

			==IHC==
			*Keratin (AE1/AE3) +ve.
			*Vimentin +ve, >90%.<ref name=pmid1712540>{{cite journal \|author=Ordóñez NG, El-Naggar AK, Hickey RC, Samaan NA \|title=Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases \|journal=Am. J. Clin. Pathol. \|volume=96 \|issue=1 \|pages=15–24 \|year=1991 \|month=July \|pmid=1712540 \|doi= \|url=}}</ref>
			*Thyroglobulin - rarely +ve (~15%).<ref name=pmid1712540/>
			*CEA -ve, calcitonin -ve; to r/o medullary.
			*p53 +ve.
			*[[TTF-1]] +ve.

			==See also==
			*[[Thyroid gland]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Thyroid gland]]

2011-11-10T13:23:57Z

redirect /w cat.

New page

#redirect [[Thyroid_gland#Anaplastic_thyroid_carcinoma]]

[[Category:Diagnosis]]