Arias-Stella reaction - Revision history

Michael: /* General */ tweak epi

2012-10-30T02:56:03Z

General: tweak epi

← Older revision		Revision as of 02:56, 30 October 2012
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	**May be seen in a normal pregnancy, [[hydatidiform mole]]s, others.		**May be seen in a normal pregnancy, [[hydatidiform mole]]s, others.
	*Historically it was diagnosed as [[endometrial cancer]].		*Historically it was diagnosed as [[endometrial cancer]].
			*Usually in premenopausal women - [[pregnancy\|pregnant]] or recently pregnant; however, it may be seen postmenopausal women.<ref name=pmid22885379>{{Cite journal \| last1 = Offman \| first1 = SL. \| last2 = Longacre \| first2 = TA. \| title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). \| journal = Adv Anat Pathol \| volume = 19 \| issue = 5 \| pages = 296-312 \| month = Sep \| year = 2012 \| doi = 10.1097/PAP.0b013e31826663b1 \| PMID = 22885379 }}</ref>

	Note:		Note:

Michael: /* Microscopic */ more

2012-06-26T04:27:11Z

Microscopic: more

← Older revision		Revision as of 04:27, 26 June 2012
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	*[[Choriocarcinoma]].		*[[Choriocarcinoma]].
	*[[Herpes simplex virus\|Herpetic]] [[endometritis]].		*[[Herpes simplex virus\|Herpetic]] [[endometritis]].
	*[[~~Endometrial clear~~ cell carcinoma]].		*[[Clear cell endometrial carcinoma]].
			*[[Serous endometrial carcinoma]].<ref name=pmid20173505>{{Cite journal \| last1 = Félix \| first1 = A. \| last2 = Nogales \| first2 = FF. \| last3 = Arias-Stella \| first3 = J. \| title = Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens. \| journal = Int J Gynecol Pathol \| volume = 29 \| issue = 2 \| pages = 185-8 \| month = Mar \| year = 2010 \| doi = 10.1097/PGP.0b013e3181b7015e \| PMID = 20173505 }}</ref>

	Images:		Images:

Michael: /* Microscopic */ wikify DDx

2012-06-26T04:21:04Z

Microscopic: wikify DDx

← Older revision		Revision as of 04:21, 26 June 2012
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	*[[Choriocarcinoma]].		*[[Choriocarcinoma]].
	*[[Herpes simplex virus\|Herpetic]] [[endometritis]].		*[[Herpes simplex virus\|Herpetic]] [[endometritis]].
	*~~Clear~~ cell carcinoma.		*[[Endometrial clear cell carcinoma]].

	Images:		Images:

Michael: create

2011-10-19T15:26:37Z

create

← Older revision		Revision as of 15:26, 19 October 2011
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	#~~redirect~~ [[~~Products_of_conception#Arias-Stella_reaction~~]]		The '''Arias-Stella reaction''' is a benign change.

			==General==
			*Benign atypical endometrial changes associated with chorionic tissue.<ref name=pmid11756756>{{Cite journal \| last1 = Arias-Stella \| first1 = J. \| title = The Arias-Stella reaction: facts and fancies four decades after. \| journal = Adv Anat Pathol \| volume = 9 \| issue = 1 \| pages = 12-23 \| month = Jan \| year = 2002 \| doi = \| PMID = 11756756 }}</ref>
			**May be seen in a normal pregnancy, [[hydatidiform mole]]s, others.
			*Historically it was diagnosed as [[endometrial cancer]].

			Note:
			*To the novice... the nuclei look really scary, i.e. they look like cancer.

			==Microscopic==
			Features:<ref name=pmid11756756/>
			*Epithelial component of endometrium with large nuclei - '''key feature'''.
			**+/-Nuclear hyperchromasia, i.e. dark nuclei.
			**+/-Irregular nuclear membrane.
			**+/-Nuclear clearing.<ref name=Ref_DCHH236-7>{{Ref DCHH\|236-7}}.</ref>
			**+/-[[Nuclear pseudoinclusions]].
			*[[NC ratio]] is preserved.<ref name=Ref_DCHH236-7>{{Ref DCHH\|236-7}}</ref>
			*Usually a focal change.
			*+/-Mitoses - uncommon.

			Notes:
			*No decidual reaction in the stroma.

			DDx:
			*[[Choriocarcinoma]].
			*[[Herpes simplex virus\|Herpetic]] [[endometritis]].
			*Clear cell carcinoma.

			Images:
			*[http://commons.wikimedia.org/wiki/File:Intermediate_trophoblast_3_-_low_mag.jpg Intermediate trophoblast reaction - low mag. (WC)].
			*[http://commons.wikimedia.org/wiki/File:Intermediate_trophoblast_3_-_high_mag.jpg Intermediate trophoblast - high mag. (WC)].

			===Subtypes===
			There are five subtypes:<ref name=pmid11756756/>
			#Minimal atypia.
			#*Usually early gestation.
			#Early secretory pattern.
			#*Mimics secretory endometrium: cytoplasmic vacuoles, central nucleus, palisading architecture.
			#Secretory or hypersecretory pattern.
			#Regenerative, proliferative or nonsecretory pattern.
			#Monstrous cell pattern.

			==See also==
			*[[Gynecologic pathology]].

			==References==
			{{Reflist\|2}}

			[[Category:Gynecologic pathology]]

Michael: redirect

2011-08-09T13:12:21Z

redirect

New page

#redirect [[Products_of_conception#Arias-Stella_reaction]]