Atrophic endometrium - Revision history

Michael: /* General */

2019-01-07T20:06:42Z

General

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	==General==		==General==
	*The most common pattern seen in postmenopausal women.<ref name=pmid1872332>{{Cite journal \| last1 = Archer \| first1 = DF. \| last2 = McIntyre-Seltman \| first2 = K. \| last3 = Wilborn \| first3 = WW. \| last4 = Dowling \| first4 = EA. \| last5 = Cone \| first5 = F. \| last6 = Creasy \| first6 = GW. \| last7 = Kafrissen \| first7 = ME. \| title = Endometrial morphology in asymptomatic postmenopausal women. \| journal = Am J Obstet Gynecol \| volume = 165 \| issue = 2 \| pages = 317-20; discussion 320-2 \| month = Aug \| year = 1991 \| doi = \| PMID = 1872332 }}</ref>		*The most common pattern seen in postmenopausal women.<ref name=pmid1872332>{{Cite journal \| last1 = Archer \| first1 = DF. \| last2 = McIntyre-Seltman \| first2 = K. \| last3 = Wilborn \| first3 = WW. \| last4 = Dowling \| first4 = EA. \| last5 = Cone \| first5 = F. \| last6 = Creasy \| first6 = GW. \| last7 = Kafrissen \| first7 = ME. \| title = Endometrial morphology in asymptomatic postmenopausal women. \| journal = Am J Obstet Gynecol \| volume = 165 \| issue = 2 \| pages = 317-20; discussion 320-2 \| month = Aug \| year = 1991 \| doi = \| PMID = 1872332 }}</ref>
	**Menopause typically happens at around 50 years old.		*Menopause typically happens at around 50 years old.
	*Very common diagnosis.		*Very common diagnosis.
	**Atrophy may be associated with bleeding and therefore biopsied to rule-out hyperplasia and malignancy.		**Atrophy may be associated with bleeding and therefore biopsied to rule-out hyperplasia and malignancy.

Michael: /* General */

2019-01-07T20:06:12Z

General

← Older revision		Revision as of 20:06, 7 January 2019
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	==General==		==General==
	*~~Endometrium of normal~~ postmenopausal women.		*The most common pattern seen in postmenopausal women.<ref name=pmid1872332>{{Cite journal \| last1 = Archer \| first1 = DF. \| last2 = McIntyre-Seltman \| first2 = K. \| last3 = Wilborn \| first3 = WW. \| last4 = Dowling \| first4 = EA. \| last5 = Cone \| first5 = F. \| last6 = Creasy \| first6 = GW. \| last7 = Kafrissen \| first7 = ME. \| title = Endometrial morphology in asymptomatic postmenopausal women. \| journal = Am J Obstet Gynecol \| volume = 165 \| issue = 2 \| pages = 317-20; discussion 320-2 \| month = Aug \| year = 1991 \| doi = \| PMID = 1872332 }}</ref>
	**Menopause typically happens at around 50 years old.		**Menopause typically happens at around 50 years old.
	*Very common diagnosis.		*Very common diagnosis.

Michael: fix ref

2016-11-30T20:00:02Z

fix ref

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	</gallery>		</gallery>
	www:		www:
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860448/figure/fig1/ Atrophic endometrium (nih.gov)].<ref name=pmid16873562>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| title = My approach to the interpretation of endometrial biopsies and curettings. \| journal = J Clin Pathol \| volume = 59 \| issue = 8 \| pages = 801-12 \| month = Aug \| year = 2006 \| doi = 10.1136/jcp.2005.029702 \| PMID = 16873562 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860448/figure/fig1/ Atrophic endometrium (nih.gov)].<ref name=pmid16873562>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| title = My approach to the interpretation of endometrial biopsies and curettings. \| journal = J Clin Pathol \| volume = 59 \| issue = 8 \| pages = 801-12 \| month = Aug \| year = 2006 \| doi = 10.1136/jcp.2005.029702 \| PMID = 16873562 \| PMC = 1860448 }}</ref>

	==Sign out==		==Sign out==

Michael at 19:58, 30 November 2016

2016-11-30T19:58:46Z

← Older revision		Revision as of 19:58, 30 November 2016
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	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860448/figure/fig1/ Atrophic endometrium (nih.gov)].<ref name=pmid16873562>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| title = My approach to the interpretation of endometrial biopsies and curettings. \| journal = J Clin Pathol \| volume = 59 \| issue = 8 \| pages = 801-12 \| month = Aug \| year = 2006 \| doi = 10.1136/jcp.2005.029702 \| PMID = 16873562 }}		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860448/figure/fig1/ Atrophic endometrium (nih.gov)].<ref name=pmid16873562>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| title = My approach to the interpretation of endometrial biopsies and curettings. \| journal = J Clin Pathol \| volume = 59 \| issue = 8 \| pages = 801-12 \| month = Aug \| year = 2006 \| doi = 10.1136/jcp.2005.029702 \| PMID = 16873562 }}</ref>
	</ref>

	==Sign out==		==Sign out==

Michael at 14:45, 11 March 2014

2014-03-11T14:45:15Z

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	COMMENT:		COMMENT:
	The sample is scant given the history of 'thickened endometrium'.		The sample is scant given the history of 'thickened endometrium'.
			</pre>

			===Polypoid===
			<pre>
			ENDOMETRIUM, CURETTAGE:
			- SMALL POLYPOID FRAGMENT OF ENDOMETRIUM WITH NONPROLIFERATIVE DILATED
			PSEUDOSTRATIFIED GLANDS WITH A MILDLY FIBROTIC STROMA AND SMALL BLOOD
			VESSELS, SEE COMMENT.
			- NO EVIDENCE OF HYPERPLASIA.
			- NO EVIDENCE OF MALIGNANCY.

			COMMENT:
			This is favored to represent endometrium with cystic atrophy. The differential
			diagnosis is a benign endometrial polyp.
	</pre>		</pre>

Michael: /* Images */

2013-12-20T00:38:09Z

Images

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	===Images===		===Images===
	<gallery>		<gallery>
	Image: Inactive endometrial epithelium -- intermed mag.jpg \| Inactive endometrium - intermed. mag.		Image: Inactive endometrial epithelium -- intermed mag.jpg \| Inactive endometrium - intermed. mag. (WC)
	Image: Inactive endometrial epithelium -- high mag.jpg \| Inactive endometrium - high mag.		Image: Inactive endometrial epithelium -- high mag.jpg \| Inactive endometrium - high mag. (WC)
			</gallery>
			<gallery>
			Image: Nonproliferative endometrial epithelium -- intermed mag.jpg \| IE - intermed. mag. (WC)
			Image: Nonproliferative endometrial epithelium -- high mag.jpg \| IE - high mag. (WC)
			Image: Nonproliferative endometrial epithelium - alt -- high mag.jpg \| IE - high mag. (WC)
			Image: Nonproliferative endometrial epithelium - alt 2 -- high mag.jpg \| IE - high mag. (WC)
			Image: Nonproliferative endometrial epithelium -- very high mag.jpg \| IE - very high mag. (WC)
	</gallery>		</gallery>
	www:		www:

Michael at 13:49, 16 December 2013

2013-12-16T13:49:54Z

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	It is also known as '''atrophy of the endometrium''' and '''endometrial atrophy'''.		It is also known as '''atrophy of the endometrium''' and '''endometrial atrophy'''.

			An introduction to the endometrium is found in the ''[[endometrium]]'' article.

	==General==		==General==

Michael: move

2013-12-16T02:37:14Z

move

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	~~#redirect~~ [[~~Endometrium#Atrophic_endometrium~~]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Inactive endometrial epithelium -- high mag.jpg
			\| Width =
			\| Caption = Inactive endometrial epithelium. [[H&E stain]].
			\| Micro = nonproliferative endometrial epithelium, +/-benign stroma with normal gland-to-stroma ratio, no nuclear atypia
			\| Subtypes =
			\| LMDDx = type 2 [[endometrial carcinoma]]s, esp. [[serous endometrial carcinoma]], [[proliferative phase endometrium]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[endometrium]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = postmenopausal
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other = normal postmenopausal finding
			\| ClinDDx = atrophy, [[endometrial hyperplasia]], [[endometrial carcinoma]], other gynecologic cancers
			}}
			'''Atrophic endometrium''', also '''inactive endometrium''', is the normal finding in postmenopausal women.

			It is also known as '''atrophy of the endometrium''' and '''endometrial atrophy'''.

			==General==
			*Endometrium of normal postmenopausal women.
			**Menopause typically happens at around 50 years old.
			*Very common diagnosis.
			**Atrophy may be associated with bleeding and therefore biopsied to rule-out hyperplasia and malignancy.

			==Gross==
			*Thin endometrium.

			==Microscopic==
			Features:
			*Glands - small columnar cells:
			**Moderate quantity of eosinophilic cytoplasm.
			**Ovoid (palisaded) nuclei +/- nuclear pseudostratification.<ref name=pmid16873562>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| title = My approach to the interpretation of endometrial biopsies and curettings. \| journal = J Clin Pathol \| volume = 59 \| issue = 8 \| pages = 801-12 \| month = Aug \| year = 2006 \| doi = 10.1136/jcp.2005.029702 \| PMID = 16873562 \| PMC = 1860448 }}</ref>
			**Eosinophilic cytoplasm.
			**No mitoses.
			*Architecture:
			**+/-Cystic dilation.

			Notes:
			*If a woman is truly postmenopausal, mitoses in the glandular epithelium is pathologic until demonstrated otherwise.
			**The exceptions are [[benign endometrial polyp]], [[uterine prolapse]], and possibly inflammation (e.g. the person has had several biopsy attempts and was seeded with pathogens).

			DDx:
			*[[Proliferative phase endometrium]] - esp. if there is pseudostratification.
			*[[Serous carcinoma of the endometrium]].

			===Images===
			<gallery>
			Image: Inactive endometrial epithelium -- intermed mag.jpg \| Inactive endometrium - intermed. mag.
			Image: Inactive endometrial epithelium -- high mag.jpg \| Inactive endometrium - high mag.
			</gallery>
			www:
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860448/figure/fig1/ Atrophic endometrium (nih.gov)].<ref name=pmid16873562>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| title = My approach to the interpretation of endometrial biopsies and curettings. \| journal = J Clin Pathol \| volume = 59 \| issue = 8 \| pages = 801-12 \| month = Aug \| year = 2006 \| doi = 10.1136/jcp.2005.029702 \| PMID = 16873562 }}
			</ref>

			==Sign out==
			<pre>
			ENDOMETRIUM, BIOPSY:
			- NON-PROLIFERATIVE ENDOMETRIUM.
			- BENIGN SQUAMOUS EPITHELIUM WITH METAPLASTIC CHANGE.
			- SCANT ENDOCERVICAL MUCOSA WITH REACTIVE CHANGES.
			</pre>

			<pre>
			ENDOMETRIUM, BIOPSY:
			- NON-PROLIFERATIVE ENDOMETRIUM.
			- BENIGN STRIPPED ENDOCERVICAL EPITHELIUM.
			- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.
			</pre>

			====Micro====
			The sections show small fragments of endometrium. The gland-to-stroma ratio is normal. The glands are small and round, and have a pseudostratified epithelium.

			Mitotic figures are not identified within the glands or stroma. No stromal condensation is apparent. No secretions are in the glands. No nuclear atypia is apparent.

			Scant benign endocervical tissue (stripped epithelium and mucosa) is present.

			===Limited stroma===
			<pre>
			ENDOMETRIUM, BIOPSY:
			- STRIPPED NONPROLIFERATIVE ENDOMETRIAL EPITHELIUM; NO APPRECIABLE STROMA PRESENT.
			- SCANT ENDOCERVICAL EPITHELIUM WITHIN NORMAL LIMITS.
			- MINUTE FRAGMENTS OF SQUAMOUS EPITHELIUM WITHOUT APPARENT PATHOLOGY.
			</pre>

			<pre>
			ENDOMETRIUM, BIOPSY:
			- SCANT STRIPPED NON-PROLIFERATIVE ENDOMETRIAL EPITHELIUM.
			- VERY SMALL FRAGMENT OF ENDOMETRIAL STROMA.
			- TUBAL METAPLASTIC EPITHELIUM.
			</pre>

			<pre>
			ENDOMETRIUM, ASPIRATION:
			- SMALL FRAGMENTS OF NONPROLIFERATIVE ENDOMETRIAL EPITHELIUM ATTACHED TO
			A VERY SMALL AMOUNT OF STROMA.
			- MINUTE BENIGN FRAGMENT OF SQUAMOUS EPITHELIUM.
			- MUCOUS AND INFLAMMATORY CELLS.

			COMMENT:
			The sample is scant given the history of 'thickened endometrium'.
			</pre>

			====Micro====
			The sections show stripped endometrial epithelium and stripped tubal-type epithelium.
			No mitotic activity is identified. No nuclear atypia is apparent. A small fragment of
			definite endometrial stroma is present. The gland-to-stroma ratio cannot be assessed due
			to the limited stroma.

			==See also==
			*[[Endometrium]].

			==References==
			{{Reflist\|1}}

			[[Category:Endometrium]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect w/ cat.

2011-11-06T12:35:52Z

redirect w/ cat.

New page

#redirect [[Endometrium#Atrophic_endometrium]]

[[Category:Diagnosis]]