Atypical lung carcinoid tumour - Revision history

Michael: tweak

2016-04-20T05:45:44Z

tweak

← Older revision		Revision as of 05:45, 20 April 2016
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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = moderate; poor vis-à-vis typical carcinoid
	\| Other =		\| Other =
	\| ClinDDx = other [[lung tumours]]		\| ClinDDx = other [[lung tumours]]
	\| Tx =		\| Tx = surgical resection +/-chemotherapy
	}}		}}
	'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours\|lung tumour]] with a poor outcome.		'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours\|lung tumour]] with a poor outcome.
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	==General==		==General==
	*Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal \| last1 = Naalsund \| first1 = A. \| last2 = Rostad \| first2 = H. \| last3 = Strøm \| first3 = EH. \| last4 = Lund \| first4 = MB. \| last5 = Strand \| first5 = TE. \| title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. \| journal = Eur J Cardiothorac Surg \| volume = 39 \| issue = 4 \| pages = 565-9 \| month = Apr \| year = 2011 \| doi = 10.1016/j.ejcts.2010.08.036 \| PMID = 20888248 }}</ref>		*Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal \| last1 = Naalsund \| first1 = A. \| last2 = Rostad \| first2 = H. \| last3 = Strøm \| first3 = EH. \| last4 = Lund \| first4 = MB. \| last5 = Strand \| first5 = TE. \| title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. \| journal = Eur J Cardiothorac Surg \| volume = 39 \| issue = 4 \| pages = 565-9 \| month = Apr \| year = 2011 \| doi = 10.1016/j.ejcts.2010.08.036 \| PMID = 20888248 }}</ref>

			Prognosis:
			*Significantly worse than for typical carcinoids; in one series,<ref name=pmid26195112>{{Cite journal \| last1 = Ayadi-Kaddour \| first1 = A. \| last2 = Marghli \| first2 = A. \| last3 = Zairi \| first3 = S. \| last4 = Zribi \| first4 = H. \| last5 = Ismail \| first5 = O. \| last6 = Braham \| first6 = E. \| last7 = Hantous-Zannad \| first7 = S. \| last8 = Kilani \| first8 = T. \| last9 = El Mezni \| first9 = F. \| title = [Bronchopulmonary carcinoid tumors: Tunisian experience with 115 surgically treated cases]. \| journal = Rev Pneumol Clin \| volume = 71 \| issue = 6 \| pages = 319-26 \| month = Dec \| year = 2015 \| doi = 10.1016/j.pneumo.2015.04.003 \| PMID = 26195112 }}</ref> the five year survival was 95% and 45% for typical carcinoid and atypical carcinoid respectively.

	Treatment:		Treatment:

Michael: tweak

2016-04-20T05:34:32Z

tweak

← Older revision		Revision as of 05:34, 20 April 2016
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	\| Width =		\| Width =
	\| Caption = Atypical lung carcinoid tumour. [[H&E stain]].		\| Caption = Atypical lung carcinoid tumour. [[H&E stain]].
	\| Synonyms = atypical carcinoid, atypical pulmonary ~~lung~~ carcinoid		\| Synonyms = atypical carcinoid, atypical lung carcinoid, atypical pulmonary carcinoid
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =

Michael: /* General */

2015-12-23T04:31:41Z

General

← Older revision		Revision as of 04:31, 23 December 2015
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	==General==		==General==
	*Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal \| last1 = Naalsund \| first1 = A. \| last2 = Rostad \| first2 = H. \| last3 = Strøm \| first3 = EH. \| last4 = Lund \| first4 = MB. \| last5 = Strand \| first5 = TE. \| title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. \| journal = Eur J Cardiothorac Surg \| volume = 39 \| issue = 4 \| pages = 565-9 \| month = Apr \| year = 2011 \| doi = 10.1016/j.ejcts.2010.08.036 \| PMID = 20888248 }}</ref>		*Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal \| last1 = Naalsund \| first1 = A. \| last2 = Rostad \| first2 = H. \| last3 = Strøm \| first3 = EH. \| last4 = Lund \| first4 = MB. \| last5 = Strand \| first5 = TE. \| title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. \| journal = Eur J Cardiothorac Surg \| volume = 39 \| issue = 4 \| pages = 565-9 \| month = Apr \| year = 2011 \| doi = 10.1016/j.ejcts.2010.08.036 \| PMID = 20888248 }}</ref>

			Treatment:
			*Surgery for diagnosis and treatment.
			*Chemotherapy for advanced/metastatic disease.<ref name=pmid25218177>{{Cite journal \| last1 = Chong \| first1 = CR. \| last2 = Wirth \| first2 = LJ. \| last3 = Nishino \| first3 = M. \| last4 = Chen \| first4 = AB. \| last5 = Sholl \| first5 = LM. \| last6 = Kulke \| first6 = MH. \| last7 = McNamee \| first7 = CJ. \| last8 = Jänne \| first8 = PA. \| last9 = Johnson \| first9 = BE. \| title = Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors. \| journal = Lung Cancer \| volume = 86 \| issue = 2 \| pages = 241-6 \| month = Nov \| year = 2014 \| doi = 10.1016/j.lungcan.2014.08.012 \| PMID = 25218177 }}</ref>

	==Microscopic==		==Microscopic==

Michael at 04:16, 23 December 2015

2015-12-23T04:16:23Z

← Older revision		Revision as of 04:16, 23 December 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Atypical lung carcinoid -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Atypical lung carcinoid tumour. [[H&E stain]].
	\| Synonyms =		\| Synonyms = atypical carcinoid, atypical pulmonary lung carcinoid
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =

Michael at 04:14, 23 December 2015

2015-12-23T04:14:43Z

← Older revision		Revision as of 04:14, 23 December 2015
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	*Metastatic [[small cell carcinoma]].		*Metastatic [[small cell carcinoma]].
	*[[Lung adenocarcinoma]].		*[[Lung adenocarcinoma]].

			===Images===
			<gallery>
			Image: Atypical lung carcinoid -- low mag.jpg \| ALC - low mag.
			Image: Atypical lung carcinoid -- intermed mag.jpg \| ALC - intermed. mag.
			Image: Atypical lung carcinoid -- high mag.jpg \| ALC - high mag.
			Image: Atypical lung carcinoid -- very high mag.jpg \| ALC - very high mag.

			Image: Atypical lung carcinoid - alt -- high mag.jpg \| ALC - high mag.
			Image: Atypical lung carcinoid - alt -- very high mag.jpg \| ALC - very high mag.
			Image: Atypical lung carcinoid - alt -- extremely high mag.jpg \| ALC - extremely high mag.
			</gallery>

	==IHC==		==IHC==

Michael at 03:58, 23 December 2015

2015-12-23T03:58:49Z

← Older revision		Revision as of 03:58, 23 December 2015
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	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[small cell carcinoma of the lung]], [[carcinoid lung tumour]], [[pulmonary carcinoid tumourlet]], [[lung adenocarcinoma]], metastatic [[small cell carcinoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = Ki-67 ~17% (range 10-26%)
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	*[[Typical carcinoid lung tumour]].		*[[Typical carcinoid lung tumour]].
	*[[Small cell carcinoma of the lung]].		*[[Small cell carcinoma of the lung]].
			*Metastatic [[small cell carcinoma]].
			*[[Lung adenocarcinoma]].

	==IHC==		==IHC==

Michael: +infobox

2015-12-23T03:56:31Z

+infobox

← Older revision		Revision as of 03:56, 23 December 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[lung]] - see ''[[lung tumours]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = other [[lung tumours]]
			\| Tx =
			}}
	'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours\|lung tumour]] with a poor outcome.		'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours\|lung tumour]] with a poor outcome.

Michael: /* General */

2015-12-23T03:54:23Z

General

← Older revision		Revision as of 03:54, 23 December 2015
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	==General==		==General==
	*Approximately 20% of lung ~~carcinoids~~.<ref name=pmid20888248>{{Cite journal \| last1 = Naalsund \| first1 = A. \| last2 = Rostad \| first2 = H. \| last3 = Strøm \| first3 = EH. \| last4 = Lund \| first4 = MB. \| last5 = Strand \| first5 = TE. \| title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. \| journal = Eur J Cardiothorac Surg \| volume = 39 \| issue = 4 \| pages = 565-9 \| month = Apr \| year = 2011 \| doi = 10.1016/j.ejcts.2010.08.036 \| PMID = 20888248 }}</ref>		*Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal \| last1 = Naalsund \| first1 = A. \| last2 = Rostad \| first2 = H. \| last3 = Strøm \| first3 = EH. \| last4 = Lund \| first4 = MB. \| last5 = Strand \| first5 = TE. \| title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. \| journal = Eur J Cardiothorac Surg \| volume = 39 \| issue = 4 \| pages = 565-9 \| month = Apr \| year = 2011 \| doi = 10.1016/j.ejcts.2010.08.036 \| PMID = 20888248 }}</ref>

	==Microscopic==		==Microscopic==

Michael: split out

2015-12-23T03:51:06Z

split out

← Older revision		Revision as of 03:51, 23 December 2015
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	~~#redirect~~ [[~~Lung~~ tumours~~#Atypical~~ carcinoid lung tumour]]		'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours\|lung tumour]] with a poor outcome.

			==General==
			*Approximately 20% of lung carcinoids.<ref name=pmid20888248>{{Cite journal \| last1 = Naalsund \| first1 = A. \| last2 = Rostad \| first2 = H. \| last3 = Strøm \| first3 = EH. \| last4 = Lund \| first4 = MB. \| last5 = Strand \| first5 = TE. \| title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. \| journal = Eur J Cardiothorac Surg \| volume = 39 \| issue = 4 \| pages = 565-9 \| month = Apr \| year = 2011 \| doi = 10.1016/j.ejcts.2010.08.036 \| PMID = 20888248 }}</ref>

			==Microscopic==
			Features:<ref name=Ref_WMSP115>{{Ref WMSP\|115}}</ref>
			*Nests of cells.
			**Stippled chromatin.
			**Mild-to-moderate amount of cytoplasm.
			*No necrosis/focal necrosis.
			*Moderate mitotic rate (2-10/[[HPF]] - definition suffers from [[HPFitis]]).

			DDx:
			*[[Typical carcinoid lung tumour]].
			*[[Small cell carcinoma of the lung]].

			==IHC==
			*Ki-67 ~17% (range 10-26%).<ref name=pmid25318848>{{Cite journal \| last1 = Liu \| first1 = SZ. \| last2 = Staats \| first2 = PN. \| last3 = Goicochea \| first3 = L. \| last4 = Alexiev \| first4 = BA. \| last5 = Shah \| first5 = N. \| last6 = Dixon \| first6 = R. \| last7 = Burke \| first7 = AP. \| title = Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung. \| journal = Diagn Pathol \| volume = 9 \| issue = \| pages = 174 \| month = \| year = 2014 \| doi = 10.1186/s13000-014-0174-z \| PMID = 25318848 }}</ref>

			Note:
			*[[Typical lung carcinoid tumour\|Typical carcinoid]] is considerably lower ~2% (range 0-7%) and large cell neuroendocrine considerable higher ~81% (range 63-92%).<ref name=pmid25318848/>

			==See also==
			*[[Lung tumours]].

			==References==
			{{Reflist\|2}}

			[[Category:Diagnosis]]
			[[Category:Pulmonary pathology]]

Michael: redirect

2012-01-22T22:27:16Z

redirect

New page

#redirect [[Lung tumours#Atypical carcinoid lung tumour]]