Autoimmune metaplastic atrophic gastritis - Revision history

Michael at 18:31, 22 April 2024

2024-04-22T18:31:13Z

← Older revision		Revision as of 18:31, 22 April 2024
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	These findings suggest an autoimmune (metaplastic atrophic) gastritis; correlation with blood work and clinical findings is recommended.		These findings suggest an autoimmune (metaplastic atrophic) gastritis; correlation with blood work and clinical findings is recommended.
	</pre>		</pre>

			====Listing the blood work====
			<pre>
			If not already done, correlation with blood work (anti-parietal cell antibody, intrinsic factor blocking antibody, gastrin) and clinical findings is recommended.
			</pre>

	===Block letters===		===Block letters===
	<pre>		<pre>

Michael at 18:22, 22 April 2024

2024-04-22T18:22:52Z

← Older revision		Revision as of 18:22, 22 April 2024
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	*Etiology: autoimmune.		*Etiology: autoimmune.

	Diagnosis based on serology for antibodies to:<ref name=pmid12643357>{{Cite journal \| last1 = Oh \| first1 = R. \| last2 = Brown \| first2 = DL. \| title = Vitamin B12 deficiency. \| journal = Am Fam Physician \| volume = 67 \| issue = 5 \| pages = 979-86 \| month = Mar \| year = 2003 \| doi = \| PMID = 12643357 }}</ref>		Diagnosis based on serology for antibodies to:<ref name=pmid12643357>{{Cite journal \| last1 = Oh \| first1 = R. \| last2 = Brown \| first2 = DL. \| title = Vitamin B12 deficiency. \| journal = Am Fam Physician \| volume = 67 \| issue = 5 \| pages = 979-86 \| month = Mar \| year = 2003 \| doi = \| PMID = 12643357 }}</ref><ref>{{cite journal \|authors=Salinas M, Flores E, López-Garrigós M, Leiva-Salinas C \|title=High frequency of anti-parietal cell antibody (APCA) and intrinsic factor blocking antibody (IFBA) in individuals with severe vitamin B12 deficiency - an observational study in primary care patients \|journal=Clin Chem Lab Med \|volume=58 \|issue=3 \|pages=424–429 \|date=February 2020 \|pmid=31714882 \|doi=10.1515/cclm-2019-0749 \|url=}}</ref>
	*Parietal cells.		*Parietal cells: anti-parietal cell antibody (APCA).
	*Intrinsic factor.		*Intrinsic factor: intrinsic factor blocking antibody (IFBA).

	Others:		Others:

Michael: /* Microscopic */

2024-03-26T00:08:30Z

Microscopic

← Older revision		Revision as of 00:08, 26 March 2024
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	*[[Gastric neuroendocrine tumour]].		*[[Gastric neuroendocrine tumour]].
	*[[Intestinal metaplasia of the stomach]] with chronic inflammation.		*[[Intestinal metaplasia of the stomach]] with chronic inflammation.
			*[[Chronic gastritis]].

	===Images===		===Images===

Michael: touch

2024-03-08T19:10:36Z

touch

← Older revision		Revision as of 19:10, 8 March 2024
Line 38:		Line 38:
	*Parietal cells.		*Parietal cells.
	*Intrinsic factor.		*Intrinsic factor.

	Others:		Others:
	*Gastrin level (increased).<ref name=pmid21947876>{{Cite journal \| last1 = Annibale \| first1 = B. \| last2 = Lahner \| first2 = E. \| last3 = Fave \| first3 = GD. \| title = Diagnosis and management of pernicious anemia. \| journal = Curr Gastroenterol Rep \| volume = 13 \| issue = 6 \| pages = 518-24 \| month = Dec \| year = 2011 \| doi = 10.1007/s11894-011-0225-5 \| PMID = 21947876 }}</ref>		*Gastrin level (increased).<ref name=pmid21947876>{{Cite journal \| last1 = Annibale \| first1 = B. \| last2 = Lahner \| first2 = E. \| last3 = Fave \| first3 = GD. \| title = Diagnosis and management of pernicious anemia. \| journal = Curr Gastroenterol Rep \| volume = 13 \| issue = 6 \| pages = 518-24 \| month = Dec \| year = 2011 \| doi = 10.1007/s11894-011-0225-5 \| PMID = 21947876 }}</ref>

Michael: /* Sign out */ +so example

2020-12-05T16:21:07Z

Sign out: +so example

← Older revision		Revision as of 16:21, 5 December 2020
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	==Sign out==		==Sign out==
			<pre>
			Stomach, Body, Biopsy:
			- Gastric mucosa with INTESTINAL METAPLASIA,
			moderate chronic inactive inflammation and atrophic features, SEE COMMENT.
			- NEGATIVE for apparent parietal cells, SEE COMMENT.
			- NEGATIVE for Helicobacter-like organisms.
			- NEGATIVE for dysplasia and NEGATIVE for malignancy.

			Comment:
			Immunostains show rows of Chromogranin A positive cells and a lack of gastrin staining.

			These findings suggest an autoimmune (metaplastic atrophic) gastritis; correlation with blood work and clinical findings is recommended.
			</pre>
			===Block letters===
	<pre>		<pre>
	STOMACH, BIOPSY:		STOMACH, BIOPSY:

Michael: /* Images */ sm fix

2020-05-24T17:48:58Z

Images: sm fix

← Older revision		Revision as of 17:48, 24 May 2020
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	===Images===		===Images===
			====Body====
	<gallery>		<gallery>
	~~====Body====~~
	Image: Metaplastic atrophic gastritis - body - chromogranin A -- very low mag.jpg \| MAG (body) - chromogranin A - very low mag.		Image: Metaplastic atrophic gastritis - body - chromogranin A -- very low mag.jpg \| MAG (body) - chromogranin A - very low mag.
	Image: Metaplastic atrophic gastritis - body - chromogranin A -- low mag.jpg \| MAG (body) - chromogranin A - low mag.		Image: Metaplastic atrophic gastritis - body - chromogranin A -- low mag.jpg \| MAG (body) - chromogranin A - low mag.
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	Image: Metaplastic atrophic gastritis - body - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.		Image: Metaplastic atrophic gastritis - body - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
	Image: Metaplastic atrophic gastritis - body - alt - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.		Image: Metaplastic atrophic gastritis - body - alt - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
			</gallery>
	====Antrum====		====Antrum====
			<gallery>
	Image: Metaplastic atrophic gastritis - antrum - gastrin -- low mag.jpg \| MAG (antrum) - gastrin - low mag.		Image: Metaplastic atrophic gastritis - antrum - gastrin -- low mag.jpg \| MAG (antrum) - gastrin - low mag.
	Image: Metaplastic atrophic gastritis - antrum - gastrin -- intermed mag.jpg \| MAG (antrum) - gastrin - intermed. mag.		Image: Metaplastic atrophic gastritis - antrum - gastrin -- intermed mag.jpg \| MAG (antrum) - gastrin - intermed. mag.

Michael: /* Images */ tweak

2020-05-24T17:38:32Z

Images: tweak

← Older revision		Revision as of 17:38, 24 May 2020
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	===Images===		===Images===
	<gallery>		<gallery>
			====Body====
	Image: Metaplastic atrophic gastritis - body - chromogranin A -- very low mag.jpg \| MAG (body) - chromogranin A - very low mag.		Image: Metaplastic atrophic gastritis - body - chromogranin A -- very low mag.jpg \| MAG (body) - chromogranin A - very low mag.
	Image: Metaplastic atrophic gastritis - body - chromogranin A -- low mag.jpg \| MAG (body) - chromogranin A - low mag.		Image: Metaplastic atrophic gastritis - body - chromogranin A -- low mag.jpg \| MAG (body) - chromogranin A - low mag.
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	Image: Metaplastic atrophic gastritis - body - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.		Image: Metaplastic atrophic gastritis - body - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
	Image: Metaplastic atrophic gastritis - body - alt - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.		Image: Metaplastic atrophic gastritis - body - alt - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
			====Antrum====
	Image: Metaplastic atrophic gastritis - antrum - gastrin -- low mag.jpg \| MAG (antrum) - gastrin - low mag.		Image: Metaplastic atrophic gastritis - antrum - gastrin -- low mag.jpg \| MAG (antrum) - gastrin - low mag.
	Image: Metaplastic atrophic gastritis - antrum - gastrin -- intermed mag.jpg \| MAG (antrum) - gastrin - intermed. mag.		Image: Metaplastic atrophic gastritis - antrum - gastrin -- intermed mag.jpg \| MAG (antrum) - gastrin - intermed. mag.

Michael: +caption, re-arrange imges

2020-05-24T17:37:01Z

+caption, re-arrange imges

← Older revision		Revision as of 17:37, 24 May 2020
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	\| Image = Metaplastic atrophic gastritis - body -- intermed mag.jpg		\| Image = Metaplastic atrophic gastritis - body -- intermed mag.jpg
	\| Width = Metaplastic atrophic gastritis - body of stomach. [[H&E stains]].		\| Width = Metaplastic atrophic gastritis - body of stomach. [[H&E stains]].
	\| Caption =		\| Caption = Atrophic gastritis (body) without appreciable parietal cells. [[H&E stain]].
	\| Micro = corpus predominant inflammation - usu. moderate or severe, loss of parietal cells, increased G cells in the antrum		\| Micro = corpus predominant inflammation - usu. moderate or severe, loss of parietal cells, increased G cells in the antrum
	\| Subtypes =		\| Subtypes =
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	Image: Metaplastic atrophic gastritis - body 2 - alt -- high mag.jpg \| MAG (body) - high mag.		Image: Metaplastic atrophic gastritis - body 2 - alt -- high mag.jpg \| MAG (body) - high mag.

	~~Image: Metaplastic atrophic gastritis - body - chromogranin A -- very low mag.jpg \| MAG - chromogranin A - very low mag.~~


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	Image: Metaplastic atrophic gastritis - antrum - alt -- intermed mag.jpg \| MAG - antrum - low mag.		Image: Metaplastic atrophic gastritis - antrum - alt -- intermed mag.jpg \| MAG - antrum - low mag.

	~~Image: Metaplastic atrophic gastritis - antrum - gastrin -- low mag.jpg \| MAG - antrum - gastrin - low mag.~~
	~~Image: Metaplastic atrophic gastritis - antrum - gastrin -- intermed mag.jpg \| MAG - antrum - gastrin - intermed. mag.~~
	</gallery>		</gallery>

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	===Images===		===Images===
	<gallery>		<gallery>
			Image: Metaplastic atrophic gastritis - body - chromogranin A -- very low mag.jpg \| MAG (body) - chromogranin A - very low mag.
	Image: Metaplastic atrophic gastritis - body - chromogranin A -- low mag.jpg \| MAG (body) - chromogranin A - low mag.		Image: Metaplastic atrophic gastritis - body - chromogranin A -- low mag.jpg \| MAG (body) - chromogranin A - low mag.
	Image: Metaplastic atrophic gastritis - body - chromogranin A -- intermed mag.jpg \| MAG (body) - chromogranin A - intermed. mag.		Image: Metaplastic atrophic gastritis - body - chromogranin A -- intermed mag.jpg \| MAG (body) - chromogranin A - intermed. mag.
Line 105:		Line 105:
	Image: Metaplastic atrophic gastritis - body - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.		Image: Metaplastic atrophic gastritis - body - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
	Image: Metaplastic atrophic gastritis - body - alt - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.		Image: Metaplastic atrophic gastritis - body - alt - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.

			Image: Metaplastic atrophic gastritis - antrum - gastrin -- low mag.jpg \| MAG (antrum) - gastrin - low mag.
			Image: Metaplastic atrophic gastritis - antrum - gastrin -- intermed mag.jpg \| MAG (antrum) - gastrin - intermed. mag.
	</gallery>		</gallery>

Michael: +images

2020-05-24T00:56:04Z

+images

← Older revision		Revision as of 00:56, 24 May 2020
Line 62:		Line 62:
	*[[Gastric neuroendocrine tumour]].		*[[Gastric neuroendocrine tumour]].
	*[[Intestinal metaplasia of the stomach]] with chronic inflammation.		*[[Intestinal metaplasia of the stomach]] with chronic inflammation.

			===Images===
			<gallery>
			Image: Metaplastic atrophic gastritis - body -- very low mag.jpg \| MAG (body) - very low mag.
			Image: Metaplastic atrophic gastritis - body -- low mag.jpg \| MAG (body) - low mag.
			Image: Metaplastic atrophic gastritis - body - alt -- low mag.jpg \| MAG (body) - low mag.
			Image: Metaplastic atrophic gastritis - body -- intermed mag.jpg \| MAG (body) - intermed. mag.
			Image: Metaplastic atrophic gastritis - body -- high mag.jpg \| MAG (body) - high mag.
			Image: Metaplastic atrophic gastritis - body - alt -- high mag.jpg \| MAG (body) - high mag.
			Image: Metaplastic atrophic gastritis - body -- very high mag.jpg \| MAG (body) - very high mag.

			Image: Metaplastic atrophic gastritis - body 2 -- very low mag.jpg \| MAG (body) - very low mag.
			Image: Metaplastic atrophic gastritis - body 2 -- low mag.jpg \| MAG (body) - low mag.
			Image: Metaplastic atrophic gastritis - body 2 - alt -- low mag.jpg \| MAG (body) - low mag.
			Image: Metaplastic atrophic gastritis - body 2 -- intermed mag.jpg \| MAG (body) - intermed. mag.
			Image: Metaplastic atrophic gastritis - body 2 -- high mag.jpg \| MAG (body) - high mag.
			Image: Metaplastic atrophic gastritis - body 2 - alt -- high mag.jpg \| MAG (body) - high mag.

			Image: Metaplastic atrophic gastritis - body - chromogranin A -- very low mag.jpg \| MAG - chromogranin A - very low mag.


			Image: Metaplastic atrophic gastritis - antrum -- low mag.jpg \| MAG - antrum - low mag.
			Image: Metaplastic atrophic gastritis - antrum -- intermed mag.jpg \| MAG - antrum - low mag.
			Image: Metaplastic atrophic gastritis - antrum - alt -- intermed mag.jpg \| MAG - antrum - low mag.

			Image: Metaplastic atrophic gastritis - antrum - gastrin -- low mag.jpg \| MAG - antrum - gastrin - low mag.
			Image: Metaplastic atrophic gastritis - antrum - gastrin -- intermed mag.jpg \| MAG - antrum - gastrin - intermed. mag.
			</gallery>

	==IHC==		==IHC==
Line 69:		Line 97:
	**+ve in antrum.		**+ve in antrum.

	Images:		===Images===
			<gallery>
			Image: Metaplastic atrophic gastritis - body - chromogranin A -- low mag.jpg \| MAG (body) - chromogranin A - low mag.
			Image: Metaplastic atrophic gastritis - body - chromogranin A -- intermed mag.jpg \| MAG (body) - chromogranin A - intermed. mag.
			Image: Metaplastic atrophic gastritis - body - chromogranin A -- high mag.jpg \| MAG (body) - chromogranin A - high mag.

			Image: Metaplastic atrophic gastritis - body - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
			Image: Metaplastic atrophic gastritis - body - alt - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
			</gallery>

			====www====
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575912/figure/f5/ Autoimmune gastritis - chromogranin A (nih.gov)].<ref name=pmid18719002>{{Cite journal \| last1 = Pritchard \| first1 = DM. \| last2 = Berry \| first2 = D. \| last3 = Przemeck \| first3 = SM. \| last4 = Campbell \| first4 = F. \| last5 = Edwards \| first5 = SW. \| last6 = Varro \| first6 = A. \| title = Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. \| journal = Am J Physiol Gastrointest Liver Physiol \| volume = 295 \| issue = 4 \| pages = G798-805 \| month = Oct \| year = 2008 \| doi = 10.1152/ajpgi.00015.2008 \| PMID = 18719002 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575912/figure/f5/ Autoimmune gastritis - chromogranin A (nih.gov)].<ref name=pmid18719002>{{Cite journal \| last1 = Pritchard \| first1 = DM. \| last2 = Berry \| first2 = D. \| last3 = Przemeck \| first3 = SM. \| last4 = Campbell \| first4 = F. \| last5 = Edwards \| first5 = SW. \| last6 = Varro \| first6 = A. \| title = Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. \| journal = Am J Physiol Gastrointest Liver Physiol \| volume = 295 \| issue = 4 \| pages = G798-805 \| month = Oct \| year = 2008 \| doi = 10.1152/ajpgi.00015.2008 \| PMID = 18719002 }}</ref>
	**Findings may be seen in hypergastrinemia and nodular enterochromaffin cell-like (ECL) hyperplasia.		**Findings may be seen in hypergastrinemia and nodular enterochromaffin cell-like (ECL) hyperplasia.

Michael at 00:53, 24 May 2020

2020-05-24T00:53:01Z

← Older revision		Revision as of 00:53, 24 May 2020
Line 1:		Line 1:
	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Metaplastic atrophic gastritis - body -- intermed mag.jpg
	\| Width =		\| Width = Metaplastic atrophic gastritis - body of stomach. [[H&E stains]].
	\| Caption =		\| Caption =
	\| Micro = corpus predominant inflammation - usu. moderate or severe, loss of parietal cells, increased G cells in the antrum		\| Micro = corpus predominant inflammation - usu. moderate or severe, loss of parietal cells, increased G cells in the antrum

← Older revision		Revision as of 00:56, 24 May 2020
Line 62:		Line 62:
	*[[Gastric neuroendocrine tumour]].		*[[Gastric neuroendocrine tumour]].
	*[[Intestinal metaplasia of the stomach]] with chronic inflammation.		*[[Intestinal metaplasia of the stomach]] with chronic inflammation.

			===Images===
			<gallery>
			Image: Metaplastic atrophic gastritis - body -- very low mag.jpg \| MAG (body) - very low mag.
			Image: Metaplastic atrophic gastritis - body -- low mag.jpg \| MAG (body) - low mag.
			Image: Metaplastic atrophic gastritis - body - alt -- low mag.jpg \| MAG (body) - low mag.
			Image: Metaplastic atrophic gastritis - body -- intermed mag.jpg \| MAG (body) - intermed. mag.
			Image: Metaplastic atrophic gastritis - body -- high mag.jpg \| MAG (body) - high mag.
			Image: Metaplastic atrophic gastritis - body - alt -- high mag.jpg \| MAG (body) - high mag.
			Image: Metaplastic atrophic gastritis - body -- very high mag.jpg \| MAG (body) - very high mag.

			Image: Metaplastic atrophic gastritis - body 2 -- very low mag.jpg \| MAG (body) - very low mag.
			Image: Metaplastic atrophic gastritis - body 2 -- low mag.jpg \| MAG (body) - low mag.
			Image: Metaplastic atrophic gastritis - body 2 - alt -- low mag.jpg \| MAG (body) - low mag.
			Image: Metaplastic atrophic gastritis - body 2 -- intermed mag.jpg \| MAG (body) - intermed. mag.
			Image: Metaplastic atrophic gastritis - body 2 -- high mag.jpg \| MAG (body) - high mag.
			Image: Metaplastic atrophic gastritis - body 2 - alt -- high mag.jpg \| MAG (body) - high mag.

			Image: Metaplastic atrophic gastritis - body - chromogranin A -- very low mag.jpg \| MAG - chromogranin A - very low mag.


			Image: Metaplastic atrophic gastritis - antrum -- low mag.jpg \| MAG - antrum - low mag.
			Image: Metaplastic atrophic gastritis - antrum -- intermed mag.jpg \| MAG - antrum - low mag.
			Image: Metaplastic atrophic gastritis - antrum - alt -- intermed mag.jpg \| MAG - antrum - low mag.

			Image: Metaplastic atrophic gastritis - antrum - gastrin -- low mag.jpg \| MAG - antrum - gastrin - low mag.
			Image: Metaplastic atrophic gastritis - antrum - gastrin -- intermed mag.jpg \| MAG - antrum - gastrin - intermed. mag.
			</gallery>

	==IHC==		==IHC==
Line 69:		Line 97:
	**+ve in antrum.		**+ve in antrum.

	Images:		===Images===
			<gallery>
			Image: Metaplastic atrophic gastritis - body - chromogranin A -- low mag.jpg \| MAG (body) - chromogranin A - low mag.
			Image: Metaplastic atrophic gastritis - body - chromogranin A -- intermed mag.jpg \| MAG (body) - chromogranin A - intermed. mag.
			Image: Metaplastic atrophic gastritis - body - chromogranin A -- high mag.jpg \| MAG (body) - chromogranin A - high mag.

			Image: Metaplastic atrophic gastritis - body - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
			Image: Metaplastic atrophic gastritis - body - alt - gastrin -- low mag.jpg \| MAG (body) - gastrin - low mag.
			</gallery>

			====www====
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575912/figure/f5/ Autoimmune gastritis - chromogranin A (nih.gov)].<ref name=pmid18719002>{{Cite journal \| last1 = Pritchard \| first1 = DM. \| last2 = Berry \| first2 = D. \| last3 = Przemeck \| first3 = SM. \| last4 = Campbell \| first4 = F. \| last5 = Edwards \| first5 = SW. \| last6 = Varro \| first6 = A. \| title = Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. \| journal = Am J Physiol Gastrointest Liver Physiol \| volume = 295 \| issue = 4 \| pages = G798-805 \| month = Oct \| year = 2008 \| doi = 10.1152/ajpgi.00015.2008 \| PMID = 18719002 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575912/figure/f5/ Autoimmune gastritis - chromogranin A (nih.gov)].<ref name=pmid18719002>{{Cite journal \| last1 = Pritchard \| first1 = DM. \| last2 = Berry \| first2 = D. \| last3 = Przemeck \| first3 = SM. \| last4 = Campbell \| first4 = F. \| last5 = Edwards \| first5 = SW. \| last6 = Varro \| first6 = A. \| title = Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. \| journal = Am J Physiol Gastrointest Liver Physiol \| volume = 295 \| issue = 4 \| pages = G798-805 \| month = Oct \| year = 2008 \| doi = 10.1152/ajpgi.00015.2008 \| PMID = 18719002 }}</ref>
	**Findings may be seen in hypergastrinemia and nodular enterochromaffin cell-like (ECL) hyperplasia.		**Findings may be seen in hypergastrinemia and nodular enterochromaffin cell-like (ECL) hyperplasia.