Benign clear cell clusters of the kidney - Revision history

Michael: vauthors

2021-03-25T17:21:49Z

vauthors

← Older revision		Revision as of 17:21, 25 March 2021
Line 31:		Line 31:
	\| Tx =		\| Tx =
	}}		}}
	'''Benign clear cell clusters of the kidney''' are a rare finding that may be confused for [[renal cell carcinoma]]<ref name=pmid33447899>{{cite journal \|~~vauthors~~=Ortiz-Rey JA, Fachal C, Juaneda-Magdalena L, Muñoz-Martín M, Repáraz-Andrade A, Teijeira S, Lamas-Barreiro JM, Almuster-Domínguez S, San Miguel-Fraile P, Gómez-de María C \|title=Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma \|journal=Virchows Arch \|volume= \|issue= \|pages= \|date=January 2021 \|pmid=33447899 \|doi=10.1007/s00428-021-03018-4 \|url=}}</ref> or may represent a precursor lesion of renal cell carcinoma.<ref>Ross J, He H, Lin X, Yang X, "Clear cell cluster in the kidney: Is this a precursor lesion of renal cell carcinoma?", USCAP Annual Meeting 2018, Abstrct ID# 1058.</ref>		'''Benign clear cell clusters of the kidney''' are a rare finding that may be confused for [[renal cell carcinoma]]<ref name=pmid33447899>{{cite journal \|authors=Ortiz-Rey JA, Fachal C, Juaneda-Magdalena L, Muñoz-Martín M, Repáraz-Andrade A, Teijeira S, Lamas-Barreiro JM, Almuster-Domínguez S, San Miguel-Fraile P, Gómez-de María C \|title=Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma \|journal=Virchows Arch \|volume= \|issue= \|pages= \|date=January 2021 \|pmid=33447899 \|doi=10.1007/s00428-021-03018-4 \|url=}}</ref> or may represent a precursor lesion of renal cell carcinoma.<ref>Ross J, He H, Lin X, Yang X, "Clear cell cluster in the kidney: Is this a precursor lesion of renal cell carcinoma?", USCAP Annual Meeting 2018, Abstrct ID# 1058.</ref>

	==General==		==General==

Michael: tweak

2021-01-31T22:10:48Z

tweak

← Older revision		Revision as of 22:10, 31 January 2021
Line 50:		Line 50:
	*[[Clear cell renal cell carcinoma]].		*[[Clear cell renal cell carcinoma]].
	*Other [[clear cell tumours]].		*Other [[clear cell tumours]].

			===Images===
			<gallery>
			Image: Benign clear cell clusters in the kidney -- very low mag.jpg \| BCCC - very low mag. (WC)
			Image: Benign clear cell clusters in the kidney -- low mag.jpg \| BCCC - low mag. (WC)
			Image: Benign clear cell clusters in the kidney -- intermed mag.jpg \| BCCC - intermed. mag. (WC)
			Image: Benign clear cell clusters in the kidney - alt -- intermed mag.jpg \| BCCC - intermed. mag. (WC)
			Image: Benign clear cell clusters in the kidney -- high mag.jpg \| BCCC - high mag. (WC)
			Image: Benign clear cell clusters in the kidney - alt -- high mag.jpg \| BCCC - high mag. (WC)
			Image: Benign clear cell clusters in the kidney -- very high mag.jpg \| BCCC - very high mag. (WC)
			</gallery>

	==IHC==		==IHC==
Line 68:		Line 79:
	*Melan A -ve.		*Melan A -ve.
	*HMB-45 -ve.		*HMB-45 -ve.


	~~===Images===~~
	~~<gallery>~~
	~~Image: Benign clear cell clusters in the kidney -- very low mag.jpg \| BCCC - very low mag. (WC)~~
	~~Image: Benign clear cell clusters in the kidney -- low mag.jpg \| BCCC - low mag. (WC)~~
	~~Image: Benign clear cell clusters in the kidney -- intermed mag.jpg \| BCCC - intermed. mag. (WC)~~
	~~Image: Benign clear cell clusters in the kidney - alt -- intermed mag.jpg \| BCCC - intermed. mag. (WC)~~
	~~Image: Benign clear cell clusters in the kidney -- high mag.jpg \| BCCC - high mag. (WC)~~
	~~Image: Benign clear cell clusters in the kidney - alt -- high mag.jpg \| BCCC - high mag. (WC)~~
	~~Image: Benign clear cell clusters in the kidney -- very high mag.jpg \| BCCC - very high mag. (WC)~~
	~~</gallery>~~

	==See also==		==See also==

Michael: tweak

2021-01-31T22:10:23Z

tweak

← Older revision		Revision as of 22:10, 31 January 2021
Line 9:		Line 9:
	\| LMDDx = [[chromophobe renal cell carcinoma]], other [[clear cell tumours]]		\| LMDDx = [[chromophobe renal cell carcinoma]], other [[clear cell tumours]]
	\| Stains =		\| Stains =
	\| IHC = PAX8 +ve, CK7 +ve, AMACR -ve, CD68 -ve, CD10 +ve/-ve, CD117 +ve/-ve		\| IHC = PAX8 +ve, CK7 +ve, AMACR -ve, CD68 -ve, CD10 +ve/-ve, CD117 +ve/-ve, vimentin -ve, CA9 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
Line 53:		Line 53:
	==IHC==		==IHC==
	Features:<ref name=pmid33447899/>		Features:<ref name=pmid33447899/>
	*PAX8 +ve.		*[[PAX8]] +ve.
	*AE1/AE3 +ve.		*AE1/AE3 +ve.
	*CK7 +ve.		*[[CK7]] +ve.
	*EMA +ve.		*EMA +ve.
	*CD10 typically focal.		*CD10 typically focal.
	*~~CA IX~~ -ve.
			Others:<ref name=pmid33447899/>
			*[[CA9]] -ve.
	*vimentin -ve.		*vimentin -ve.
	*AMACR -ve.		*AMACR -ve.

Michael: twak

2021-01-31T19:54:53Z

twak

← Older revision		Revision as of 19:54, 31 January 2021
Line 5:		Line 5:
	\| Caption = Benign clear cell clusters of the kidney. [[H&E stain]].		\| Caption = Benign clear cell clusters of the kidney. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = large cells in "small" nests with voluminous clear cytoplasm and small nuclei without prominent nucleoli
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[chromophobe renal cell carcinoma]], other [[clear cell tumours]]		\| LMDDx = [[chromophobe renal cell carcinoma]], other [[clear cell tumours]]

Michael: /* Microscopic */

2021-01-31T19:30:24Z

Microscopic

← Older revision		Revision as of 19:30, 31 January 2021
Line 40:		Line 40:
	*Large cells predominantly in "small" nests with:		*Large cells predominantly in "small" nests with:
	**Voluminous clear cytoplasm.		**Voluminous clear cytoplasm.
	**Small nuclei without prominent nucleoli.		**Small nuclei without prominent nucleoli ([[ISUP nucleolar grade]] 1 or 2).

	Notes:		Notes:
	*Tubules with narrow lumens may be present.		*Tubules with narrow lumens may be present.
	*"Small": typically less than 1.5 mm.		*"Small" nests: typically less than 1.5 mm.

	DDx:		DDx:

Michael: /* Microscopic */

2021-01-31T19:11:52Z

Microscopic

← Older revision		Revision as of 19:11, 31 January 2021
Line 47:		Line 47:

	DDx:		DDx:
			*[[Chromophobe renal cell carcinoma]].
	*[[Clear cell renal cell carcinoma]].		*[[Clear cell renal cell carcinoma]].
	*[[Chromophobe renal cell carcinoma]].
	*Other [[clear cell tumours]].		*Other [[clear cell tumours]].

Michael: /* General */

2021-01-31T19:11:29Z

General

← Older revision		Revision as of 19:11, 31 January 2021
Line 34:		Line 34:

	==General==		==General==
	*Associated with [[chronic renal ~~disease~~]].		*Associated with [[chronic renal failure\|chronic renal insufficiency]].

	==Microscopic==		==Microscopic==

Michael: /* General */

2021-01-31T19:09:47Z

General

← Older revision		Revision as of 19:09, 31 January 2021
Line 34:		Line 34:

	==General==		==General==
	*Associated with chronic renal disease.		*Associated with [[chronic renal disease]].

	==Microscopic==		==Microscopic==

Michael at 19:08, 31 January 2021

2021-01-31T19:08:52Z

← Older revision		Revision as of 19:08, 31 January 2021
Line 26:		Line 26:
	\| Rads = +/-renal mass		\| Rads = +/-renal mass
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = unknown		\| Prognosis = presumed benign based on limited data/unknown
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =

Michael: +infobox

2021-01-31T19:08:18Z

+infobox

← Older revision		Revision as of 19:08, 31 January 2021
Line 1:		Line 1:
			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Benign clear cell clusters in the kidney -- intermed mag.jpg
			\| Width =
			\| Caption = Benign clear cell clusters of the kidney. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[chromophobe renal cell carcinoma]], other [[clear cell tumours]]
			\| Stains =
			\| IHC = PAX8 +ve, CK7 +ve, AMACR -ve, CD68 -ve, CD10 +ve/-ve, CD117 +ve/-ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[kidney]] - see ''[[kidney tumours]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = chronic renal insufficiency
			\| Signs =
			\| Symptoms =
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads = +/-renal mass
			\| Endoscopy =
			\| Prognosis = unknown
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Benign clear cell clusters of the kidney''' are a rare finding that may be confused for [[renal cell carcinoma]]<ref name=pmid33447899>{{cite journal \|vauthors=Ortiz-Rey JA, Fachal C, Juaneda-Magdalena L, Muñoz-Martín M, Repáraz-Andrade A, Teijeira S, Lamas-Barreiro JM, Almuster-Domínguez S, San Miguel-Fraile P, Gómez-de María C \|title=Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma \|journal=Virchows Arch \|volume= \|issue= \|pages= \|date=January 2021 \|pmid=33447899 \|doi=10.1007/s00428-021-03018-4 \|url=}}</ref> or may represent a precursor lesion of renal cell carcinoma.<ref>Ross J, He H, Lin X, Yang X, "Clear cell cluster in the kidney: Is this a precursor lesion of renal cell carcinoma?", USCAP Annual Meeting 2018, Abstrct ID# 1058.</ref>		'''Benign clear cell clusters of the kidney''' are a rare finding that may be confused for [[renal cell carcinoma]]<ref name=pmid33447899>{{cite journal \|vauthors=Ortiz-Rey JA, Fachal C, Juaneda-Magdalena L, Muñoz-Martín M, Repáraz-Andrade A, Teijeira S, Lamas-Barreiro JM, Almuster-Domínguez S, San Miguel-Fraile P, Gómez-de María C \|title=Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma \|journal=Virchows Arch \|volume= \|issue= \|pages= \|date=January 2021 \|pmid=33447899 \|doi=10.1007/s00428-021-03018-4 \|url=}}</ref> or may represent a precursor lesion of renal cell carcinoma.<ref>Ross J, He H, Lin X, Yang X, "Clear cell cluster in the kidney: Is this a precursor lesion of renal cell carcinoma?", USCAP Annual Meeting 2018, Abstrct ID# 1058.</ref>