Bile duct adenoma - Revision history

Mitchell: /* Images */ added a case

2017-01-02T15:21:46Z

Images: added a case

← Older revision		Revision as of 15:21, 2 January 2017
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	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig1/ Bile duct adenoma - oncocytic - low mag. (nih.gov)].<ref name=pmid24592348/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig1/ Bile duct adenoma - oncocytic - low mag. (nih.gov)].<ref name=pmid24592348/>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig2/ Bile duct adenoma - oncocytic - high mag. (nih.gov)].<ref name=pmid24592348/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig2/ Bile duct adenoma - oncocytic - high mag. (nih.gov)].<ref name=pmid24592348/>


			[[File:5 2033397936391 sl 1.png\|Bile duct adenoma]]
			[[File:5 2033397936391 sl 2.png\|Bile duct adenoma]]
			[[File:5 2033397936391 sl 3.png\|Bile duct adenoma]]
			[[File:5 2033397936391 sl 4.png\|Bile duct adenoma]]
			[[File:5 2033397936391 sl 5.png\|Bile duct adenoma]]<br>
			Bile duct adenoma in a 67 yo man, not radiologically detected; this is important because cholangiocarcinomas are larger than bile duct adenomas. Bile duct adenomas are usually incidental findings, as in this case. These can be very difficult diagnosis; this case was evaluated by outside consultation. A. Glandular proliferation is seen. Note the curve indicated by the arrow, indicating a subcapsular location. B. The central scar, in other locations and with metastases, a finding associated with carcinoma, is in the liver a benign sign. The intense hyalin is also a benign sign, being that of a well-developed adenoma. C. Nuclear atypia in this case is modest near the region of scar, with tortuous glands. D. As the lesion progresses away from the scar, the atypia diminishes. Mitoses and outright necrosis were not identified. E. PAS-D stain shows the red rims about the glands, a benign sign, but also red cytoplasmic droplets, which is consistent with bile duct adenoma’s being known to produce mucin.

	==IHC==		==IHC==

Michael: /* Images */

2014-03-07T02:07:53Z

Images

← Older revision		Revision as of 02:07, 7 March 2014
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	===Images===		===Images===
	*[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)].		*[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)].
			*[http://www.surgpath4u.com/caseviewer.php?case_no=152 Bile duct adenoma (surgpath4u.com)].
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig1/ Bile duct adenoma - oncocytic - low mag. (nih.gov)].<ref name=pmid24592348/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig1/ Bile duct adenoma - oncocytic - low mag. (nih.gov)].<ref name=pmid24592348/>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig2/ Bile duct adenoma - oncocytic - high mag. (nih.gov)].<ref name=pmid24592348/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig2/ Bile duct adenoma - oncocytic - high mag. (nih.gov)].<ref name=pmid24592348/>

Michael: /* Microscopic */

2014-03-07T01:37:21Z

Microscopic

← Older revision		Revision as of 01:37, 7 March 2014
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	*Disordered bile ducts within in a fibrotic stroma.		*Disordered bile ducts within in a fibrotic stroma.
	**'''No''' (yellow) bile within, as these lesions do not have a connection to the biliary tree.		**'''No''' (yellow) bile within, as these lesions do not have a connection to the biliary tree.
	**+/-Lymphocytic cuff.		**+/-Lymphocytic cuff.<ref>URL: [http://www.surgpath4u.com/caseviewer.php?case_no=152 http://www.surgpath4u.com/caseviewer.php?case_no=152]. Accessed on: 6 March 2014.</ref>

	Negatives:		Negatives:

Michael: /* Images */

2014-03-07T01:32:23Z

Images

← Older revision		Revision as of 01:32, 7 March 2014
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	===Images===		===Images===
	*[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)].		*[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)].
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig1/ Bile duct adenoma - oncocytic - low mag. (nih.gov)].<ref name=pmid24592348/>
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926226/figure/fig2/ Bile duct adenoma - oncocytic - high mag. (nih.gov)].<ref name=pmid24592348/>

	==IHC==		==IHC==

Michael at 01:28, 7 March 2014

2014-03-07T01:28:02Z

← Older revision		Revision as of 01:28, 7 March 2014
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	==General==		==General==
	*Benign.		*Benign.
	*Important as it can be misdiagnosed as cancer.		*Important as it can be misdiagnosed as [[cancer]].

	==Microscopic==		==Microscopic==
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	DDx:		DDx:
	*[[Cholangiocarcinoma]].		*[[Cholangiocarcinoma]].
	*[[Pancreatic ductal adenocarcinoma]].<ref name=pmid15725808>{{Cite journal \| last1 = Hornick \| first1 = JL. \| last2 = Lauwers \| first2 = GY. \| last3 = Odze \| first3 = RD. \| title = Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. \| journal = Am J Surg Pathol \| volume = 29 \| issue = 3 \| pages = 381-9 \| month = Mar \| year = 2005 \| doi = \| PMID = 15725808 }}</ref>
	*Metastatic adenocarcinoma.		*Metastatic adenocarcinoma.
			**[[Pancreatic ductal adenocarcinoma]].<ref name=pmid15725808>{{Cite journal \| last1 = Hornick \| first1 = JL. \| last2 = Lauwers \| first2 = GY. \| last3 = Odze \| first3 = RD. \| title = Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. \| journal = Am J Surg Pathol \| volume = 29 \| issue = 3 \| pages = 381-9 \| month = Mar \| year = 2005 \| doi = \| PMID = 15725808 }}</ref>
	*[[Bile duct hamartoma]] (von Meyenburg complex).		*[[Bile duct hamartoma]] (von Meyenburg complex).

Michael: /* IHC */

2014-03-07T01:27:05Z

IHC

← Older revision		Revision as of 01:27, 7 March 2014
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	*HepPar-1 -ve.		*HepPar-1 -ve.
	*Ki-67 low.		*Ki-67 low.

			Others:<ref name=pmid15725808/>
			*p53 -ve.
			*mCEA -ve.

	==See also==		==See also==

Michael: /* Microscopic */

2014-03-07T01:26:20Z

Microscopic

← Older revision		Revision as of 01:26, 7 March 2014
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	DDx:		DDx:
	*[[Cholangiocarcinoma]].		*[[Cholangiocarcinoma]].
			*[[Pancreatic ductal adenocarcinoma]].<ref name=pmid15725808>{{Cite journal \| last1 = Hornick \| first1 = JL. \| last2 = Lauwers \| first2 = GY. \| last3 = Odze \| first3 = RD. \| title = Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. \| journal = Am J Surg Pathol \| volume = 29 \| issue = 3 \| pages = 381-9 \| month = Mar \| year = 2005 \| doi = \| PMID = 15725808 }}</ref>
	*Metastatic adenocarcinoma.		*Metastatic adenocarcinoma.
	*[[Bile duct hamartoma]] (von Meyenburg complex).		*[[Bile duct hamartoma]] (von Meyenburg complex).

Michael: /* IHC */

2014-03-07T01:22:45Z

IHC

← Older revision		Revision as of 01:22, 7 March 2014
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	*CK7 +ve.		*CK7 +ve.
	*HepPar-1 -ve.		*HepPar-1 -ve.
	*~~HMGA1~~ -~~ve/+ve~~.		*Ki-67 low.
	*HMGA2 -ve/+ve.

	~~Note:~~
	*HMGA1 & HMGA2 together may be useful for differentiating from adenocarcioma.<ref name=pmid23530587>{{Cite journal \| last1 = Zakharov \| first1 = V. \| last2 = Ren \| first2 = B. \| last3 = Ryan \| first3 = C. \| last4 = Cao \| first4 = W. \| title = Diagnostic value of HMGAs, p53 and β-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies. \| journal = Histopathology \| volume = 62 \| issue = 5 \| pages = 778-87 \| month = Apr \| year = 2013 \| doi = 10.1111/his.12084 \| PMID = 23530587 }}
	~~</ref>~~

	==See also==		==See also==

Michael at 01:20, 7 March 2014

2014-03-07T01:20:32Z

← Older revision		Revision as of 01:20, 7 March 2014
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	===Images===		===Images===
	*[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)].		*[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)].

			==IHC==
			*CK7 +ve.
			*HepPar-1 -ve.
			*HMGA1 -ve/+ve.
			*HMGA2 -ve/+ve.

			Note:
			*HMGA1 & HMGA2 together may be useful for differentiating from adenocarcioma.<ref name=pmid23530587>{{Cite journal \| last1 = Zakharov \| first1 = V. \| last2 = Ren \| first2 = B. \| last3 = Ryan \| first3 = C. \| last4 = Cao \| first4 = W. \| title = Diagnostic value of HMGAs, p53 and β-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies. \| journal = Histopathology \| volume = 62 \| issue = 5 \| pages = 778-87 \| month = Apr \| year = 2013 \| doi = 10.1111/his.12084 \| PMID = 23530587 }}
			</ref>

	==See also==		==See also==
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Liver neoplasms]]		[[Category:Liver neoplasms]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: split out

2014-03-07T01:12:48Z

split out

← Older revision		Revision as of 01:12, 7 March 2014
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	~~#redirect [[Liver_neoplasms#Bile_duct_adenoma]]~~		'''Bile duct adenoma''' is a benign liver lesion characterized composed of bile duct epithelium.

			It is also known as a '''benign bile duct proliferation'''.<ref name=pmid24592348>{{Cite journal \| last1 = Johannesen \| first1 = EJ. \| last2 = Wu \| first2 = Z. \| last3 = Holly \| first3 = JS. \| title = Bile duct adenoma with oncocytic features. \| journal = Case Rep Pathol \| volume = 2014 \| issue = \| pages = 282010 \| month = \| year = 2014 \| doi = 10.1155/2014/282010 \| PMID = 24592348 }}</ref>

			==General==
			*Benign.
			*Important as it can be misdiagnosed as cancer.

			==Microscopic==
			Features:
			*Disordered bile ducts within in a fibrotic stroma.
			**'''No''' (yellow) bile within, as these lesions do not have a connection to the biliary tree.
			**+/-Lymphocytic cuff.

			Negatives:
			*No mitotic activity.
			*No necrosis.

			DDx:
			*[[Cholangiocarcinoma]].
			*Metastatic adenocarcinoma.
			*[[Bile duct hamartoma]] (von Meyenburg complex).

			===Images===
			*[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)].

			==See also==
			*[[Liver neoplasms]].

			==References==
			{{Reflist\|1}}

			[[Category:Liver neoplasms]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]