Bizarre parosteal osteochondromatous proliferation - Revision history

Michael: /* External links */ +cat.

2014-11-30T02:43:44Z

External links: +cat.

← Older revision		Revision as of 02:43, 30 November 2014
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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Chondro-osseous tumours]]

Michael at 02:41, 30 November 2014

2014-11-30T02:41:34Z

← Older revision		Revision as of 02:41, 30 November 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Bone Bizzare Parosteal Osteochondromatous Proliferation MP2.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Bizarre parosteal osteochondromatous proliferation. [[H&E stain]].
	\| Synonyms = Nora lesion		\| Synonyms = Nora lesion
	\| Micro =		\| Micro = disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone, proliferation of fibroblasts surrounds the bone/cartilage and occupies the intertrabecular spaces
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = periosteal [[chondrosarcoma]], periosteal [[chondroma]], low grade parosteal [[osteosarcoma]], [[osteochondroma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = hands, feet		\| Site = [[bone]] (see ''[[chondro-osseous tumours]]'') - hands and feet
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = benign/locally aggressive
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
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	</gallery>		</gallery>
	www:		www:
	*~~BPOP - Web Pathology - radiology and histology~~[http://www.webpathology.com/slides-13/slides/Bone_BizarreParostealOsteochondromatousProlif_Xray.jpg]		*[http://www.webpathology.com/slides-13/slides/Bone_BizarreParostealOsteochondromatousProlif_Xray.jpg BPOP - radiology (webpathology.com)].
	*[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg BPOP]		*[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg BPOP (pathologyoutlines.com)].

	==Diagnostic categories==		==Diagnostic categories==

Michael at 02:31, 30 November 2014

2014-11-30T02:31:34Z

← Older revision		Revision as of 02:31, 30 November 2014
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	*Young adults.		*Young adults.
	*Typically age (years) 20s and 30s.<ref name=pmid19057740/>		*Typically age (years) 20s and 30s.<ref name=pmid19057740/>

			Prognosis:
			*Benign.
			*Locally aggressive.

	==Location==		==Location==
	Hands and feet		*Hands and feet.

	==Radiology==		==Radiology==
	*Marginated wide based bony growth projecting into the soft tissues.<ref>http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation</ref>		*Marginated wide based bony growth projecting into the soft tissues.<ref>URL: [http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation]. Accessed on: 29 November 2014.</ref>

	==Gross==		==Gross==
	*Nodule covered with glistening cartilage.		*Nodule covered with glistening [[cartilage]].

	==Microscopic==		==Microscopic==
	Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. ~~A proliferation~~ of fibroblasts surrounds the lesion and occupies intertrabecular spaces.		Features:
			Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. Proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.

	DDx:		DDx:
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	Image:Bone Bizzare Parosteal Osteochondromatous Proliferation HP.jpg\|High power		Image:Bone Bizzare Parosteal Osteochondromatous Proliferation HP.jpg\|High power
	</gallery>		</gallery>
	*BPOP[http:~~//www.webpathology.com/images/noimage.gif]~~		www:
	*BPOP - Web Pathology - radiology and histology[http://www.webpathology.com/slides-13/slides/Bone_BizarreParostealOsteochondromatousProlif_Xray.jpg]		*BPOP - Web Pathology - radiology and histology[http://www.webpathology.com/slides-13/slides/Bone_BizarreParostealOsteochondromatousProlif_Xray.jpg]
	*~~BPOP~~[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg]		*[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg BPOP]

	==~~Diangostic~~ categories==		==Diagnostic categories==
	*Cartilaginous neoplasms		*Cartilaginous neoplasms.
	*Osteocartilaginous neoplasms		*Osteocartilaginous neoplasms.

	==Molecular==		==Molecular==
	t(1:17)(q32;q21)<ref>{{Cite journal \| last1 = Kuruvilla \| first1 = S. \| last2 = Marco \| first2 = R. \| last3 = Raymond \| first3 = AK. \| last4 = Al-Ibraheemi \| first4 = A. \| last5 = Tatevian \| first5 = N. \| title = BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis. \| journal = Ann Clin Lab Sci \| volume = 41 \| issue = 3 \| pages = 285-7 \| month = \| year = 2011 \| doi = \| PMID = 22075515 }}</ref>		*t(1:17)(q32;q21).<ref>{{Cite journal \| last1 = Kuruvilla \| first1 = S. \| last2 = Marco \| first2 = R. \| last3 = Raymond \| first3 = AK. \| last4 = Al-Ibraheemi \| first4 = A. \| last5 = Tatevian \| first5 = N. \| title = BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis. \| journal = Ann Clin Lab Sci \| volume = 41 \| issue = 3 \| pages = 285-7 \| month = \| year = 2011 \| doi = \| PMID = 22075515 }}</ref>

	==Sign out==		==Sign out==
	*BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).		*BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).
	*APPROPRIATE MARGIN STATEMENT.		*APPROPRIATE MARGIN STATEMENT.

	~~==Prognosis==~~
	*Benign
	*Locally aggressive

	==See also==		==See also==
	*~~Pathology Outlines~~[~~http://www.pathologyoutlines~~.~~com/topic/bonebizarreparosteal.html]~~		*[[Chondro-osseous tumours]].

	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|1}}

			==External links==
			*[http://www.pathologyoutlines.com/topic/bonebizarreparosteal.html BPOP (pathologyoutlines.com)].

	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Sarah: /* See also */

2014-10-20T07:30:05Z

Sarah: /* See also */

2014-10-20T07:28:12Z

Sarah: /* Images */

2014-10-20T07:26:37Z

Images

← Older revision		Revision as of 07:26, 20 October 2014
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	</gallery>		</gallery>
	*BPOP[http://www.webpathology.com/images/noimage.gif]		*BPOP[http://www.webpathology.com/images/noimage.gif]
	*BPOP - Web Pathology - radiology[www.webpathology.com/slides-13/slides/Bone_BizarreParostealOsteochondromatousProlif_Xray.jpg]		*BPOP - Web Pathology - radiology and histology[http://www.webpathology.com/slides-13/slides/Bone_BizarreParostealOsteochondromatousProlif_Xray.jpg]
	*BPOP - Web Pathology[http://www.webpathology.com/image.asp?n=14&Case=328]
	*BPOP - Web Pathology{http://www.webpathology.com/image.asp?n=15&Case=328
	*BPOP[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg]		*BPOP[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg]
	~~http://~~

	==Diangostic categories==		==Diangostic categories==

Sarah: /* Images */

2014-10-20T07:25:37Z

Images

← Older revision		Revision as of 07:25, 20 October 2014
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	</gallery>		</gallery>
	*BPOP[http://www.webpathology.com/images/noimage.gif]		*BPOP[http://www.webpathology.com/images/noimage.gif]
	*BPOP[http://webpathology.com/~~images/noimage~~.~~gif~~]		*BPOP - Web Pathology - radiology[www.webpathology.com/slides-13/slides/Bone_BizarreParostealOsteochondromatousProlif_Xray.jpg]
	*BPOP[http://www.webpathology.com/~~images/noimage~~.~~gif]~~		*BPOP - Web Pathology[http://www.webpathology.com/image.asp?n=14&Case=328]
			*BPOP - Web Pathology{http://www.webpathology.com/image.asp?n=15&Case=328
	*BPOP[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg]		*BPOP[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg]
			http://

	==Diangostic categories==		==Diangostic categories==

Sarah: /* Images */

2014-10-20T06:28:27Z

Images

← Older revision		Revision as of 06:28, 20 October 2014
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	Image:Bone BizzareParostealOsteochondromatousProliferation PA (2).JPG \|Notice the disorganized blue tinted cartilage with partial ossification merging into mature bone.		Image:Bone BizzareParostealOsteochondromatousProliferation PA (2).JPG \|Notice the disorganized blue tinted cartilage with partial ossification merging into mature bone.
	Image:Bone BizzareParostealOsteochondromatousProliferation PA.JPG \|A loose proliferation of fibroblasts fills the spaces between the bony trabeculae.		Image:Bone BizzareParostealOsteochondromatousProliferation PA.JPG \|A loose proliferation of fibroblasts fills the spaces between the bony trabeculae.
			Image:Bone Bizzare Parosteal Osteochondromatous Proliferation MP.jpg\|Medium power
			Image:Bone Bizzare Parosteal Osteochondromatous Proliferation MP2.jpg\|Medium power
			Image:Bone Bizzare Parosteal Osteochondromatous Proliferation MP3.jpg\|Medium Power
			Image:Bone Bizzare Parosteal Osteochondromatous Proliferation HP.jpg\|High power
	</gallery>		</gallery>
	*BPOP[http://www.webpathology.com/images/noimage.gif]		*BPOP[http://www.webpathology.com/images/noimage.gif]

Sarah at 23:53, 18 October 2014

2014-10-18T23:53:26Z

← Older revision		Revision as of 23:53, 18 October 2014
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	\| Tx =		\| Tx =
	}}		}}
	'''Bizarre parosteal osteochondromatous proliferation''', also '''Nora lesion''', is a distinctive rare lesion of the hand or foot.<ref name=pmid19057740>{{Cite journal \| last1 = Gruber \| first1 = G. \| last2 = Giessauf \| first2 = C. \| last3 = Leithner \| first3 = A. \| last4 = Zacherl \| first4 = M. \| last5 = Clar \| first5 = H. \| last6 = Bodo \| first6 = K. \| last7 = Windhager \| first7 = R. \| title = Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature. \| journal = Can J Surg \| volume = 51 \| issue = 6 \| pages = 486-9 \| month = Dec \| year = 2008 \| doi = \| PMID = 19057740 }}</ref>		'''Bizarre parosteal osteochondromatous proliferation''', also known as '''Nora lesion''', is a distinctive rare lesion of the hand or foot.<ref name=pmid19057740>{{Cite journal \| last1 = Gruber \| first1 = G. \| last2 = Giessauf \| first2 = C. \| last3 = Leithner \| first3 = A. \| last4 = Zacherl \| first4 = M. \| last5 = Clar \| first5 = H. \| last6 = Bodo \| first6 = K. \| last7 = Windhager \| first7 = R. \| title = Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature. \| journal = Can J Surg \| volume = 51 \| issue = 6 \| pages = 486-9 \| month = Dec \| year = 2008 \| doi = \| PMID = 19057740 }}</ref>

	==General==		==General==

Michael: tweak a bit

2014-10-17T15:06:23Z

tweak a bit

← Older revision		Revision as of 15:06, 17 October 2014
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	\| Width =		\| Width =
	\| Caption =		\| Caption =
	\| Synonyms =Nora lesion		\| Synonyms = Nora lesion
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
Line 15:		Line 15:
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site =~~Hands~~, feet		\| Site = hands, feet
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
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	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
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	\| Tx =		\| Tx =
	}}		}}
			'''Bizarre parosteal osteochondromatous proliferation''', also '''Nora lesion''', is a distinctive rare lesion of the hand or foot.<ref name=pmid19057740>{{Cite journal \| last1 = Gruber \| first1 = G. \| last2 = Giessauf \| first2 = C. \| last3 = Leithner \| first3 = A. \| last4 = Zacherl \| first4 = M. \| last5 = Clar \| first5 = H. \| last6 = Bodo \| first6 = K. \| last7 = Windhager \| first7 = R. \| title = Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature. \| journal = Can J Surg \| volume = 51 \| issue = 6 \| pages = 486-9 \| month = Dec \| year = 2008 \| doi = \| PMID = 19057740 }}</ref>

	==General==		==General==
	A distinctive osteochondromatous proliferation of hands and feet.		A distinctive osteochondromatous proliferation of hands and feet.

	==Population==		Population:
	*Young adults		*Young adults.
	*20s-30s		*Typically age (years) 20s and 30s.<ref name=pmid19057740/>

	==Location==		==Location==
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	==Radiology==		==Radiology==
	Marginated wide based bony growth projecting into the soft tissues<ref>http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation</ref>		*Marginated wide based bony growth projecting into the soft tissues.<ref>http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation</ref>

	==Gross==		==Gross==
	*Nodule covered with glistening cartilage		*Nodule covered with glistening cartilage.

	==Microscopic==		==Microscopic==
	Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.		Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.

	==Images==		DDx:
	Image~~:[[File~~:Bone BizzareParostealOsteochondromatousProliferation PA (2).JPG~~\|thumb~~\|Notice the disorganized blue tinted cartilage with partial ossification merging into mature bone.]]		*Periosteal [[chondrosarcoma]].
	Image~~:[[File~~:Bone BizzareParostealOsteochondromatousProliferation PA.JPG~~\|thumb~~\|A loose proliferation of fibroblasts fills the spaces between the bony trabeculae.]]		*Periosteal [[chondroma]].
			*Low grade parosteal [[osteosarcoma]].
			*[[Osteochondroma]].

			===Images===
			<gallery>
			Image:Bone BizzareParostealOsteochondromatousProliferation PA (2).JPG \|Notice the disorganized blue tinted cartilage with partial ossification merging into mature bone.
			Image:Bone BizzareParostealOsteochondromatousProliferation PA.JPG \|A loose proliferation of fibroblasts fills the spaces between the bony trabeculae.
			</gallery>
	*BPOP[http://www.webpathology.com/images/noimage.gif]		*BPOP[http://www.webpathology.com/images/noimage.gif]
	*BPOP[http://webpathology.com/images/noimage.gif]		*BPOP[http://webpathology.com/images/noimage.gif]
	*BPOP[http://www.webpathology.com/images/noimage.gif]		*BPOP[http://www.webpathology.com/images/noimage.gif]
	*BPOP[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg]		*BPOP[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg]

	~~==DDX==~~
	*Periosteal chondrosarcoma
	*Periosteal chondroma
	*Low grade parosteal osteosarcoma
	*Osteochondroma

	==Diangostic categories==		==Diangostic categories==
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	==Molecular==		==Molecular==
	t(1:17)(q32;q21)<ref>{{Cite journal \| last1 = Kuruvilla \| first1 = S. \| last2 = Marco \| first2 = R. \| last3 = Raymond \| first3 = AK. \| last4 = Al-Ibraheemi \| first4 = A. \| last5 = Tatevian \| first5 = N. \| title = BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis. \| journal = Ann Clin Lab Sci \| volume = 41 \| issue = 3 \| pages = 285-7 \| month = \| year = 2011 \| doi = \| PMID = 22075515 }}		t(1:17)(q32;q21)<ref>{{Cite journal \| last1 = Kuruvilla \| first1 = S. \| last2 = Marco \| first2 = R. \| last3 = Raymond \| first3 = AK. \| last4 = Al-Ibraheemi \| first4 = A. \| last5 = Tatevian \| first5 = N. \| title = BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis. \| journal = Ann Clin Lab Sci \| volume = 41 \| issue = 3 \| pages = 285-7 \| month = \| year = 2011 \| doi = \| PMID = 22075515 }}</ref>
	</ref>

	==Sign out==		==Sign out==
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|1}}

			[[Category:Diagnosis]]

← Older revision		Revision as of 07:30, 20 October 2014
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	==See also==		==See also==
	*Pathology Outlines[http://www.pathologyoutlines.com/topic/bonebizarreparosteal.html]		*Pathology Outlines[http://www.pathologyoutlines.com/topic/bonebizarreparosteal.html]
	*Tumor Library[http://www.tumorlibrary.com/case/list.jsp?order=diagnosis+ASC&diagnosis=Chondroblastoma]

	==References==		==References==

← Older revision		Revision as of 07:28, 20 October 2014
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	==See also==		==See also==
	*Pathology Outlines[http://www.pathologyoutlines.com/topic/bonebizarreparosteal.html]		*Pathology Outlines[http://www.pathologyoutlines.com/topic/bonebizarreparosteal.html]
			*Tumor Library[http://www.tumorlibrary.com/case/list.jsp?order=diagnosis+ASC&diagnosis=Chondroblastoma]

	==References==		==References==