Breast calcifications - Revision history

Michael: /* General */

2017-02-05T17:10:10Z

General

← Older revision		Revision as of 17:10, 5 February 2017
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	==General==		==General==
	*Abnormal breast calcifications are considered a marker of [[malignancy]].		*Abnormal breast calcifications are considered a marker of [[malignancy]].
	*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition ~~one needs to find~~ calcifications this size.<ref>MUA. 1 October 2010.</ref>		*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition, the pathologist should be finding calcifications this size.<ref>MUA. 1 October 2010.</ref>
	**The large calcifications seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).		**The large calcifications seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).

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	*Calcium phosphate - typically purple.		*Calcium phosphate - typically purple.
	**Q. How to remember? A. '''P'''urple = '''P'''hosphate.		**Q. How to remember? A. '''P'''urple = '''P'''hosphate.
	*Calcium oxalate - not associated with malignancy.<ref name=pmid26769216>{{Cite journal \| last1 = Sharma \| first1 = T. \| last2 = Radosevich \| first2 = JA. \| last3 = Pachori \| first3 = G. \| last4 = Mandal \| first4 = CC. \| title = A Molecular View of Pathological Microcalcification in Breast Cancer. \| journal = J Mammary Gland Biol Neoplasia \| volume = \| issue = \| pages = \| month = Jan \| year = 2016 \| doi = 10.1007/s10911-015-9349-9 \| PMID = 26769216 }}</ref>		*Calcium oxalate - not associated with malignancy.<ref name=pmid26769216>{{Cite journal \| last1 = Sharma \| first1 = T. \| last2 = Radosevich \| first2 = JA. \| last3 = Pachori \| first3 = G. \| last4 = Mandal \| first4 = CC. \| title = A Molecular View of Pathological Microcalcification in Breast Cancer. \| journal = J Mammary Gland Biol Neoplasia \| volume = \| issue = \| pages = \| month = Jan \| year = 2016 \| doi = 10.1007/s10911-015-9349-9 \| PMID = 26769216 }}</ref>

	==Microscopic==		==Microscopic==

Michael: more formal

2016-09-08T09:30:19Z

more formal

← Older revision		Revision as of 09:30, 8 September 2016
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	==General==		==General==
	*Abnormal breast calcifications are considered a marker of [[malignancy]].		*Abnormal breast calcifications are considered a marker of [[malignancy]].
	*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find ~~calcs~~ this size.<ref>MUA. 1 October 2010.</ref>		*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcifications this size.<ref>MUA. 1 October 2010.</ref>
	**The large ~~calcs~~ seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).		**The large calcifications seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).

	Types:		Types:

Michael at 04:49, 17 June 2016

2016-06-17T04:49:52Z

← Older revision		Revision as of 04:49, 17 June 2016
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			[[Image:Calcification in breast benign -- high mag.jpg\|thumb\|right\|Calcification in benign breast tissue. [[H&E stain]]. (WC/Nephron)]]
	'''Breast calcifications''' may be found in benign or [[breast cancer\|malignant breast]] specimens.		'''Breast calcifications''' may be found in benign or [[breast cancer\|malignant breast]] specimens.

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	Note:		Note:
	*Calcium oxalate - visible with (light) [[polarization]].		*Calcium oxalate - visible with (light) [[polarization]].

			===Images===
			<gallery>
			Image: Calcification in breast benign -- intermed mag.jpg \| CBBT - intermed. mag.
			Image: Calcification in breast benign -- high mag.jpg \| CBBT - high mag.
			Image: Calcification in breast benign -- very high mag.jpg \| CBBT - very high mag.
			</gallery>

	==See also==		==See also==

Michael at 20:16, 23 April 2016

2016-04-23T20:16:38Z

← Older revision		Revision as of 20:16, 23 April 2016
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	Note:		Note:
	*Calcium oxalate - visible with (light) polarization.		*Calcium oxalate - visible with (light) [[polarization]].

	==See also==		==See also==

Michael at 16:14, 2 March 2016

2016-03-02T16:14:23Z

← Older revision		Revision as of 16:14, 2 March 2016
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	*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcs this size.<ref>MUA. 1 October 2010.</ref>		*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcs this size.<ref>MUA. 1 October 2010.</ref>
	**The large calcs seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).		**The large calcs seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).

			Types:
			*Calcium phosphate - typically purple.
			**Q. How to remember? A. '''P'''urple = '''P'''hosphate.
			*Calcium oxalate - not associated with malignancy.<ref name=pmid26769216>{{Cite journal \| last1 = Sharma \| first1 = T. \| last2 = Radosevich \| first2 = JA. \| last3 = Pachori \| first3 = G. \| last4 = Mandal \| first4 = CC. \| title = A Molecular View of Pathological Microcalcification in Breast Cancer. \| journal = J Mammary Gland Biol Neoplasia \| volume = \| issue = \| pages = \| month = Jan \| year = 2016 \| doi = 10.1007/s10911-015-9349-9 \| PMID = 26769216 }}</ref>

	==Microscopic==		==Microscopic==
	Features of calcification:		Features of calcification:
	*Purple globs (with concentric rings) on [[H&E stain\|H&E]] - represent calcium phosphate.		*Purple globs (with concentric rings) on [[H&E stain\|H&E]] - represent calcium phosphate.
	**Q. How to remember? A. '''P'''urple = '''P'''hosphate.
	*Often in the lumen of a gland, may be in the stroma.		*Often in the lumen of a gland, may be in the stroma.
	*Calcific material typically has a well-demarcated border +/- "sharp corners".		*Calcific material typically has a well-demarcated border +/- "sharp corners".

	Note:		Note:
	*Calcium oxalate is not associated with malignancy<ref name=pmid26769216>{{Cite journal \| last1 = Sharma \| first1 = T. \| last2 = Radosevich \| first2 = JA. \| last3 = Pachori \| first3 = G. \| last4 = Mandal \| first4 = CC. \| title = A Molecular View of Pathological Microcalcification in Breast Cancer. \| journal = J Mammary Gland Biol Neoplasia \| volume = \| issue = \| pages = \| month = Jan \| year = 2016 \| doi = 10.1007/s10911-015-9349-9 \| PMID = 26769216 }}</ref> - visible with (light) polarization.		*Calcium oxalate - visible with (light) polarization.

	==See also==		==See also==

Michael: /* See also */

2016-03-02T16:10:30Z

Michael: /* See also */

2016-03-02T16:10:24Z

Michael: create

2016-03-02T16:08:21Z

create

← Older revision		Revision as of 16:08, 2 March 2016
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	'''Breast calcifications''' may be found in benign or malignant breast specimens.		'''Breast calcifications''' may be found in benign or [[breast cancer\|malignant breast]] specimens.

	==General==		==General==
			*Abnormal breast calcifications are considered a marker of [[malignancy]].
	*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcs this size.<ref>MUA. 1 October 2010.</ref>		*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcs this size.<ref>MUA. 1 October 2010.</ref>
	**The large calcs seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).		**The large calcs seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).
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	==Microscopic==		==Microscopic==
	Features of calcification:		Features of calcification:
	*Purple globs (with concentric rings) on H&E - represent calcium phosphate.		*Purple globs (with concentric rings) on [[H&E stain\|H&E]] - represent calcium phosphate.
	**Q. How to remember? A. '''P'''urple = '''P'''hosphate.		**Q. How to remember? A. '''P'''urple = '''P'''hosphate.
	*Often in the lumen of a gland, may be in the stroma.		*Often in the lumen of a gland, may be in the stroma.
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	Note:		Note:
	*Calcium oxalate visible with (light) polarization ~~- not associated with malignancy~~.		*Calcium oxalate is not associated with malignancy<ref name=pmid26769216>{{Cite journal \| last1 = Sharma \| first1 = T. \| last2 = Radosevich \| first2 = JA. \| last3 = Pachori \| first3 = G. \| last4 = Mandal \| first4 = CC. \| title = A Molecular View of Pathological Microcalcification in Breast Cancer. \| journal = J Mammary Gland Biol Neoplasia \| volume = \| issue = \| pages = \| month = Jan \| year = 2016 \| doi = 10.1007/s10911-015-9349-9 \| PMID = 26769216 }}</ref> - visible with (light) polarization.

	==See also==		==See also==

Michael: Created page with "'''Breast calcifications''' may be found in benign or malignant breast specimens. ==General== *Radiologists can pick-up calcifications that are approximately 100 micrometers..."

2016-03-02T16:04:34Z

Created page with "'''Breast calcifications''' may be found in benign or malignant breast specimens. ==General== *Radiologists can pick-up calcifications that are approximately 100 micrometers..."

New page

'''Breast calcifications''' may be found in benign or malignant breast specimens.

==General==
*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcs this size.<ref>MUA. 1 October 2010.</ref>
**The large calcs seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).

==Microscopic==
Features of calcification:
*Purple globs (with concentric rings) on H&E - represent calcium phosphate.
**Q. How to remember? A. '''P'''urple = '''P'''hosphate.
*Often in the lumen of a gland, may be in the stroma.
*Calcific material typically has a well-demarcated border +/- "sharp corners".

Note:
*Calcium oxalate visible with (light) polarization - not associated with malignancy.

==See also==
*[[Medial calcific sclerosis]].

==References==
{{Reflist|1}}

[[Category:Breast pathology]]

← Older revision		Revision as of 16:10, 2 March 2016
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	==See also==		==See also==
	*[[Medial calcific sclerosis]].		*[[Medial calcific sclerosis]].
	*[[~~Calcifications~~]].		*[[Calcification]].

	==References==		==References==