Burkitt lymphoma - Revision history

Michael at 19:58, 26 December 2019

2019-12-26T19:58:47Z

← Older revision		Revision as of 19:58, 26 December 2019
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	\| LMDDx = [[DLBCL]], intermediate DLBCL/BL		\| LMDDx = [[DLBCL]], intermediate DLBCL/BL
	\| Stains =		\| Stains =
	\| IHC = [[CD20]]+, CD10+, BCL6+, EBER+, Ki-67 (100%)		\| IHC = [[CD20]]+, CD10+, BCL6+, [[EBER]]+, Ki-67 (100%)
	\| EM =		\| EM =
	\| Molecular = t(8;14) (q24;q32) + others		\| Molecular = t(8;14) (q24;q32) + others

Michael: /* IHC */

2019-12-26T19:58:33Z

IHC

← Older revision		Revision as of 19:58, 26 December 2019
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	*CD10 +ve.		*CD10 +ve.
	*BCL6 +ve.		*BCL6 +ve.
	*EBER +ve.		*[[EBER]] +ve.
	*Ki-67 ~100%.		*Ki-67 ~100%.

Mark: a few minor points

2018-05-12T17:34:52Z

a few minor points

← Older revision		Revision as of 17:34, 12 May 2018
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	==General==		==General==
	*Extremely high proliferative rate & rate of [[apoptosis]].		*Extremely high proliferative rate & rate of [[apoptosis]]
	*Rare in adults -- 1-2% of adult lymphomas.<ref name=omim113970>{{OMIM\|113970}}</ref>		*Rare in adults -- 1-2% of adult lymphomas.<ref name=omim113970>{{OMIM\|113970}}</ref>
	*Relatively common in children -- 30-50% of childhood lymphomas.<ref name=omim113970>{{OMIM\|113970}}</ref>		*Relatively common in children -- 30-50% of childhood lymphomas.<ref name=omim113970>{{OMIM\|113970}}</ref>
			*Although aggressive untreated, the high mitotic activity makes it relatively chemosensitive and complete remissions of 75-90% are described

	===Pathophysiology===		===Pathophysiology===
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	#*Found in Africa.		#*Found in Africa.
	#*EBV ([[Epstein-Barr virus]]) associated.<ref name=pmid12610094/>		#*EBV ([[Epstein-Barr virus]]) associated.<ref name=pmid12610094/>
	#Non-endemic:		#Non-endemic/sporadic:
	#*Typical of the BL seen in the western world; EBV negative.		#*Typical of the BL seen in the western world; EBV negative.
	#Immunodeficiency associated:		#Immunodeficiency associated:
	#*Associated with [[HIV]] infection.		#*Associated with [[HIV]] infection.
			#*Post-transplantation immunosuppression

	==Microscopic==		==Microscopic==
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	**Small nucleoli.		**Small nucleoli.
	**Relatively abundant cytoplasm.		**Relatively abundant cytoplasm.
	**Brisk mitotic rate.		**Brisk mitotic rate (near 100%).

	DDx:		DDx:
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	Others:		Others:
	*BCL2 -ve.		*BCL2 -ve (may show weak BCL2

	==Molecular pathology==		==Molecular pathology==
	*t(8;14) (q24;q32) ~~[[translocation]]~~.<ref name=pmid12610094/>		*Isolated CMYC-IGH [[translocation]] - t(8;14) (q24;q32).<ref name=pmid12610094/>
	*Several other variants -- involve MYC rearrangement.<ref name=pmid12610094/><ref name=omim113970>{{OMIM\|113970}}</ref>		*Several other variants -- involve MYC rearrangement with other partners.<ref name=pmid12610094/><ref name=omim113970>{{OMIM\|113970}}</ref>
			*Should not have CCND1, BCL6 or BCL2 translocations

	Note:		Note:

Michael at 15:50, 5 March 2017

2017-03-05T15:50:32Z

← Older revision		Revision as of 15:50, 5 March 2017
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	\| LMDDx = [[DLBCL]], intermediate DLBCL/BL		\| LMDDx = [[DLBCL]], intermediate DLBCL/BL
	\| Stains =		\| Stains =
	\| IHC = CD20+, CD10+, BCL6+, EBER+, Ki-67 (100%)		\| IHC = [[CD20]]+, CD10+, BCL6+, EBER+, Ki-67 (100%)
	\| EM =		\| EM =
	\| Molecular = t(8;14) (q24;q32) + others		\| Molecular = t(8;14) (q24;q32) + others
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	==IHC==		==IHC==
	Features:		Features:
	*CD20 +ve.		*[[CD20]] +ve.
	*CD10 +ve.		*CD10 +ve.
	*BCL6 +ve.		*BCL6 +ve.

Michael: touch

2016-10-17T16:16:22Z

touch

← Older revision		Revision as of 16:16, 17 October 2016
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Burkitt_lymphoma,_H%26E.jpg		\| Image = Burkitt_lymphoma,_H%26E.jpg
	\| Width =		\| Width =
	\| Caption = Starry-sky pattern. [[H&E stain]].		\| Caption = Starry-sky pattern. [[H&E stain]].

Michael: touch

2016-10-17T15:38:00Z

touch

← Older revision		Revision as of 15:38, 17 October 2016
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Burkitt_lymphoma,_H%26E.jpg		\| Image = Burkitt_lymphoma,_H%26E.jpg
	\| Width =		\| Width =
	\| Caption = Starry-sky pattern. [[H&E stain]].		\| Caption = Starry-sky pattern. [[H&E stain]].

Rudolf at 20:41, 5 July 2013

2013-07-05T20:41:29Z

← Older revision		Revision as of 20:41, 5 July 2013
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	\| Subtypes = endemic, non-endemic, immunodeficiency associated		\| Subtypes = endemic, non-endemic, immunodeficiency associated
	\| LMDDx = [[DLBCL]], intermediate DLBCL/BL		\| LMDDx = [[DLBCL]], intermediate DLBCL/BL
	\| Stains =		\| Stains =
	\| IHC = CD20+, CD10+, BCL6+, EBER+, Ki-67 (100%)		\| IHC = CD20+, CD10+, BCL6+, EBER+, Ki-67 (100%)
	\| EM =		\| EM =
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[~~Lymph~~ node]]		\| Site = [[lymph node]]
			\| Assdx = +/-[[EBV]] infection, +/-[[HIV]] infection
			\| Syndromes =
			\| Clinicalhx = very rapid growth
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence = ~~Uncommon~~		\| Prevalence = uncommon
	~~\| Assdx = +/-[[EBV]] infection, +/-[[HIV]] infection~~
	~~\| Syndromes =~~
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
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	\| ClinDDx =		\| ClinDDx =
	}}		}}

	'''Burkitt lymphoma''', abbreviated '''BL''', is an uncommon [[lymphoma]] with medium-sized cells.		'''Burkitt lymphoma''', abbreviated '''BL''', is an uncommon [[lymphoma]] with medium-sized cells.

Michael: more

2013-06-11T15:15:39Z

← Older revision		Revision as of 15:15, 11 June 2013
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	\| Symptoms =		\| Symptoms =
	\| Prevalence = Uncommon		\| Prevalence = Uncommon
	\| Assdx =		\| Assdx = +/-[[EBV]] infection, +/-[[HIV]] infection
	\| Syndromes =		\| Syndromes =
	\| Bloodwork =		\| Bloodwork =

Michael: more

2013-06-11T15:14:53Z

← Older revision		Revision as of 15:14, 11 June 2013
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	\| Symptoms =		\| Symptoms =
	\| Prevalence = Uncommon		\| Prevalence = Uncommon
			\| Assdx =
			\| Syndromes =
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =

Michael at 01:38, 4 June 2013

2013-06-04T01:38:52Z

← Older revision		Revision as of 01:38, 4 June 2013
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	\| Image = Burkitt_lymphoma,_H%26E.jpg		\| Image = Burkitt_lymphoma,_H%26E.jpg
	\| Width =		\| Width =
	\| Caption = Starry-sky pattern.		\| Caption = Starry-sky pattern. [[H&E stain]].
	\| Micro =		\| Micro = medium-sized lymphoid cells of uniform size with abundant cytoplasm, interspersed macrophages
	\| Subtypes =		\| Subtypes = endemic, non-endemic, immunodeficiency associated
	\| LMDDx = DLBCL, intermediate DLBCL/BL		\| LMDDx = [[DLBCL]], intermediate DLBCL/BL
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = CD20+, CD10+, BCL6+, EBER+, Ki-67 (100%)
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = t(8;14) (q24;q32) + others
	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site =		\| Site = [[Lymph node]]
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = Uncommon
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =