C-cell hyperplasia - Revision history

Michael: /* Gross */

2022-08-18T17:56:41Z

Gross

← Older revision		Revision as of 17:56, 18 August 2022
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	==Gross==		==Gross==
	*Not visible.		*Not visible on gross.

	Location:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf]. Accessed on: 7 April 2012.</ref>		Location:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf]. Accessed on: 7 April 2012.</ref>

Michael: tweak

2022-08-18T17:55:38Z

tweak

← Older revision		Revision as of 17:55, 18 August 2022
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	\| Molecular =		\| Molecular =
	\| IF =		\| IF =
	\| Gross = not apparent		\| Gross = not apparent; mid portion of lobe to upper third of lobe
	\| Grossing =		\| Grossing =
	\| Site = [[thyroid gland]]		\| Site = [[thyroid gland]]
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	==Gross==		==Gross==
	*Not visible.		*Not visible.

			Location:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf]. Accessed on: 7 April 2012.</ref>
			*Mid portion of lobe to upper third of lobe.
			**Not at the poles.
			**Not in the isthmus.

	==Microscopic==		==Microscopic==
	Features:		Features:
	*Location:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf]. Accessed on: 7 April 2012.</ref>
	**Mid portion of lobe to upper third of lobe.
	***Not at the poles.
	***Not in the isthmus.
	*Definitions vary.<ref>Raphael S. 17 January 2011.</ref>		*Definitions vary.<ref>Raphael S. 17 January 2011.</ref>
	**One definition - either of the following:<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>		**One definition - either of the following:<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>

Michael: /* IHC */

2016-01-02T05:26:25Z

IHC

← Older revision		Revision as of 05:26, 2 January 2016
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	==IHC==		==IHC==
	*Chromogranin A +ve.		*Chromogranin A +ve.
	*CEA +ve.		*[[CEA]] +ve.
	*Synaptophysin +ve.		*Synaptophysin +ve.

Michael at 06:49, 31 December 2015

2015-12-31T06:49:19Z

← Older revision		Revision as of 06:49, 31 December 2015
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	\| Site = [[thyroid gland]]		\| Site = [[thyroid gland]]
	\| Assdx =		\| Assdx =
	\| Syndromes = [[Multiple endocrine neoplasia type 2A]]		\| Syndromes = [[Multiple endocrine neoplasia type 2A]], [[Multiple endocrine neoplasia type 2B]]
	\| Clinicalhx =		\| Clinicalhx = +/-family history of thyroid cancer or MEN 2A or MEN 2B
	\| Signs =		\| Signs = +/-marfanoid habitus (seen in MEN 2B)
	\| Symptoms =		\| Symptoms =
	\| Prevalence = uncommon		\| Prevalence = uncommon
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	\| Prognosis = benign in itself		\| Prognosis = benign in itself
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
	\| Tx = prophylatic surgery		\| Tx = prophylatic surgery
	}}		}}

Michael at 06:46, 31 December 2015

2015-12-31T06:46:06Z

← Older revision		Revision as of 06:46, 31 December 2015
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	==General==		==General==
	*Screening for C-cell hyperplasia/[[medullary thyroid carcinoma]] done with ''serum calcitonin level''.<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>		*Screening for C-cell hyperplasia/[[medullary thyroid carcinoma]] done with ''serum calcitonin level''.<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>
	*Associated with [[~~multiple~~ endocrine neoplasia type 2A]].<ref name=pmid21134882>{{Cite journal \| last1 = Tyer \| first1 = NM. \| last2 = Braunstein \| first2 = GD. \| last3 = Frishberg \| first3 = D. \| title = Unusual case of multiple endocrine neoplasia type 2A syndrome without medullary thyroid carcinoma. \| journal = Endocr Pract \| volume = 17 \| issue = 2 \| pages = e4-7 \| month = \| year = \| doi = 10.4158/EP10157.CR \| PMID = 21134882 }}</ref>
	**May be found in specimen of a surgery done to exclude [[medullary thyroid carcinoma\|MTC]] in the context of [[MEN 2A]].<ref name=pmid18976013>{{Cite journal \| last1 = Etit \| first1 = D. \| last2 = Faquin \| first2 = WC. \| last3 = Gaz \| first3 = R. \| last4 = Randolph \| first4 = G. \| last5 = DeLellis \| first5 = RA. \| last6 = Pilch \| first6 = BZ. \| title = Histopathologic and clinical features of medullary microcarcinoma and C-cell hyperplasia in prophylactic thyroidectomies for medullary carcinoma: a study of 42 cases. \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 11 \| pages = 1767-73 \| month = Nov \| year = 2008 \| doi = 10.1043/1543-2165-132.11.1767 \| PMID = 18976013 }}</ref>		Associated with:
			*[[Multiple endocrine neoplasia type 2A]]<ref name=pmid21134882>{{Cite journal \| last1 = Tyer \| first1 = NM. \| last2 = Braunstein \| first2 = GD. \| last3 = Frishberg \| first3 = D. \| title = Unusual case of multiple endocrine neoplasia type 2A syndrome without medullary thyroid carcinoma. \| journal = Endocr Pract \| volume = 17 \| issue = 2 \| pages = e4-7 \| month = \| year = \| doi = 10.4158/EP10157.CR \| PMID = 21134882 }}</ref> - may be found in specimen of a surgery done to exclude [[medullary thyroid carcinoma\|MTC]] in the context of [[MEN 2A]].<ref name=pmid18976013>{{Cite journal \| last1 = Etit \| first1 = D. \| last2 = Faquin \| first2 = WC. \| last3 = Gaz \| first3 = R. \| last4 = Randolph \| first4 = G. \| last5 = DeLellis \| first5 = RA. \| last6 = Pilch \| first6 = BZ. \| title = Histopathologic and clinical features of medullary microcarcinoma and C-cell hyperplasia in prophylactic thyroidectomies for medullary carcinoma: a study of 42 cases. \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 11 \| pages = 1767-73 \| month = Nov \| year = 2008 \| doi = 10.1043/1543-2165-132.11.1767 \| PMID = 18976013 }}</ref>
			*[[Multiple endocrine neoplasia type 2B]].<ref name=pmid20301434>{{Cite journal \| last1 = Pagon \| first1 = RA. \| last2 = Adam \| first2 = MP. \| last3 = Ardinger \| first3 = HH. \| last4 = Wallace \| first4 = SE. \| last5 = Amemiya \| first5 = A. \| last6 = Bean \| first6 = LJH. \| last7 = Bird \| first7 = TD. \| last8 = Fong \| first8 = CT. \| last9 = Mefford \| first9 = HC. \| title = Multiple Endocrine Neoplasia Type 2 \| journal = \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301434 }}</ref>

	==Gross==		==Gross==

Michael at 06:42, 31 December 2015

2015-12-31T06:42:16Z

← Older revision		Revision as of 06:42, 31 December 2015
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	\| Tx = prophylatic surgery		\| Tx = prophylatic surgery
	}}		}}
	'''C-cell hyperplasia''' is a pathology of the [[thyroid gland]] and considered the precursor for [[medullary thyroid carcinoma]].		'''C-cell hyperplasia''', abbreviated '''CCH''', is a pathology of the [[thyroid gland]] and considered the precursor for [[medullary thyroid carcinoma]].

	==General==		==General==

Michael at 06:41, 31 December 2015

2015-12-31T06:41:17Z

← Older revision		Revision as of 06:41, 31 December 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = C-cell hyperplasia in MEN 2 -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = C-cell hyperplasia. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro =
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	\| LMDDx = [[medullary thyroid carcinoma]]		\| LMDDx = [[medullary thyroid carcinoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = CEA +ve, chromogranin A +ve, synaptophysin +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	===Images===		===Images===
			<gallery>
			Image: C-cell hyperplasia in MEN 2 -- very low mag.jpg \| CCH in MEN - very low mag. (WC)
			Image: C-cell hyperplasia in MEN 2 -- low mag.jpg \| CCH in MEN - low mag. (WC)
			Image: C-cell hyperplasia in MEN 2 - alt -- low mag.jpg \| CCH in MEN - low mag. (WC)
			Image: C-cell hyperplasia in MEN 2 -- intermed mag.jpg \| CCH in MEN - intermed. mag. (WC)
			Image: C-cell hyperplasia in MEN 2 -- high mag.jpg \| CCH in MEN - high mag. (WC)
			Image: C-cell hyperplasia in MEN 2 - alt -- high mag.jpg \| CCH in MEN - high mag. (WC)
			Image: C-cell hyperplasia in MEN 2 -- very high mag.jpg \| CCH in MEN - very high mag. (WC)
			Image: C-cell hyperplasia in MEN 2 - alt -- very high mag.jpg \| CCH in MEN - very high mag. (WC)
			</gallery>

			<gallery>
			Image: C-cell hyperplasia in MEN 2 - chromo A -- intermed mag.jpg \| CCH in MEN - chromo A - intermed. mag. (WC)
			Image: C-cell hyperplasia in MEN 2 - chromo A -- high mag.jpg \| CCH in MEN - chromo A - high mag. (WC)
			Image: C-cell hyperplasia in MEN 2 - chromo A -- very high mag.jpg \| CCH in MEN - chromo A - very high mag. (WC)

			Image: C-cell hyperplasia in MEN 2 - CEA -- low mag.jpg \| CCH in MEN - CEA - low mag. (WC)
			Image: C-cell hyperplasia in MEN 2 - CEA -- intermed mag.jpg \| CCH in MEN - CEA - intermed. mag. (WC)
			Image: C-cell hyperplasia in MEN 2 - CEA -- high mag.jpg \| CCH in MEN - CEA - high mag. (WC)
			Image: C-cell hyperplasia in MEN 2 - CEA -- very high mag.jpg \| CCH in MEN - CEA - very high mag. (WC)
			</gallery>

			====www====
	*[http://www.nature.com/modpathol/journal/v16/n8/fig_tab/3880836f2.html CCH - crappy B&W image (nature.com)].<ref>{{Cite journal \| last1 = Guyétant \| first1 = S. \| last2 = Josselin \| first2 = N. \| last3 = Savagner \| first3 = F. \| last4 = Rohmer \| first4 = V. \| last5 = Michalak \| first5 = S. \| last6 = Saint-André \| first6 = JP. \| title = C-cell hyperplasia and medullary thyroid carcinoma: clinicopathological and genetic correlations in 66 consecutive patients. \| journal = Mod Pathol \| volume = 16 \| issue = 8 \| pages = 756-63 \| month = Aug \| year = 2003 \| doi = 10.1097/01.MP.0000081727.75778.0C \| PMID = 12920219 }}</ref>		*[http://www.nature.com/modpathol/journal/v16/n8/fig_tab/3880836f2.html CCH - crappy B&W image (nature.com)].<ref>{{Cite journal \| last1 = Guyétant \| first1 = S. \| last2 = Josselin \| first2 = N. \| last3 = Savagner \| first3 = F. \| last4 = Rohmer \| first4 = V. \| last5 = Michalak \| first5 = S. \| last6 = Saint-André \| first6 = JP. \| title = C-cell hyperplasia and medullary thyroid carcinoma: clinicopathological and genetic correlations in 66 consecutive patients. \| journal = Mod Pathol \| volume = 16 \| issue = 8 \| pages = 756-63 \| month = Aug \| year = 2003 \| doi = 10.1097/01.MP.0000081727.75778.0C \| PMID = 12920219 }}</ref>
	*[http://www.nature.com/modpathol/journal/v16/n8/fig_tab/3880836f3.htm CCH - crappy B&W image (nature.com)].		*[http://www.nature.com/modpathol/journal/v16/n8/fig_tab/3880836f3.htm CCH - crappy B&W image (nature.com)].
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	*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=4849 CCH (unibas.ch)].		*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=4849 CCH (unibas.ch)].
	*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=10739 Nodular CCH (unibas.ch)].		*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=10739 Nodular CCH (unibas.ch)].

			==IHC==
			*Chromogranin A +ve.
			*CEA +ve.
			*Synaptophysin +ve.

	==See also==		==See also==

Michael: /* Microscopic */

2015-03-04T17:59:09Z

Microscopic

← Older revision		Revision as of 17:59, 4 March 2015
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	***Not at the poles.		***Not at the poles.
	***Not in the isthmus.		***Not in the isthmus.
	*Definitions vary.<ref>SR. 17 January 2011.</ref>		*Definitions vary.<ref>Raphael S. 17 January 2011.</ref>
	**One definition - either of the following:<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>		**One definition - either of the following:<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>
	**#>50 C-cells per low-power field (x100).		**#>50 C-cells per low-power field (x100).
	*#This part of the definition suffers from [[LPFitis]].		*#This part of the definition suffers from [[LPFitis]].
	**#~~Confined~~ to the thyroid gland and no larger than 10 mm in greatest dimension.		**#"[[Medullary thyroid carcinoma]] confined to the thyroid gland and no larger than 10 mm in greatest dimension."
	**Another definition:		**Another definition:
	***Invasion of the basement membrane with stromal reaction.		***Invasion of the basement membrane with stromal reaction.

Michael: /* Microscopic */

2015-03-04T17:49:50Z

Microscopic

← Older revision		Revision as of 17:49, 4 March 2015
Line 48:		Line 48:
	***Not in the isthmus.		***Not in the isthmus.
	*Definitions vary.<ref>SR. 17 January 2011.</ref>		*Definitions vary.<ref>SR. 17 January 2011.</ref>
	*One definition - either of the following:<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>		**One definition - either of the following:<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>
	*#>50 C-cells per low-power field (x100).		**#>50 C-cells per low-power field (x100).
	#This part of the definition suffers from [[LPFitis]].		*#This part of the definition suffers from [[LPFitis]].
	*#Confined to the thyroid gland and no larger than 10 mm in greatest dimension.		**#Confined to the thyroid gland and no larger than 10 mm in greatest dimension.
	*Another definition:		**Another definition:
	**Invasion of the basement membrane with stromal reaction.		***Invasion of the basement membrane with stromal reaction.
	*A third definition:		**A third definition:
	**"Several clusters" of more than six C cells.		***"Several clusters" of more than six C cells.

	===Images===		===Images===

Michael: /* Microscopic */

2015-03-04T17:49:17Z

Microscopic

← Older revision		Revision as of 17:49, 4 March 2015
Line 47:		Line 47:
	***Not at the poles.		***Not at the poles.
	***Not in the isthmus.		***Not in the isthmus.

	*Definitions vary.<ref>SR. 17 January 2011.</ref>		*Definitions vary.<ref>SR. 17 January 2011.</ref>
			*One definition - either of the following:<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>
	One definition - either of the following:<ref name=pmid19726541>{{cite journal \|author=Machens A, Hoffmann F, Sekulla C, Dralle H \|title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer \|journal=Endocr. Relat. Cancer \|volume=16 \|issue=4 \|pages=1291–8 \|year=2009 \|month=December \|pmid=19726541 \|doi=10.1677/ERC-09-0136 \|url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref>		*#>50 C-cells per low-power field (x100).
	#>50 C-cells per low-power field (x100).		#This part of the definition suffers from [[LPFitis]].
	#*This part of the definition suffers from [[LPFitis]]~~. The paper should have been rejected~~.		*#Confined to the thyroid gland and no larger than 10 mm in greatest dimension.
	#Confined to the thyroid gland and no larger than 10 mm in greatest dimension.		*Another definition:
			**Invasion of the basement membrane with stromal reaction.
	Another definition:		*A third definition:
	*Invasion of the basement membrane with stromal reaction.		**"Several clusters" of more than six C cells.

	A third definition:
	*"Several clusters" of more than six C cells.

	===Images===		===Images===