Case 116 - Revision history

Michael: /* Ask a colleague */

2015-09-27T03:17:05Z

Ask a colleague

← Older revision		Revision as of 03:17, 27 September 2015
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	====Ask a colleague====		====Ask a colleague====
	{{hidden\|Ask a colleague\|<center>~~COLLEAGUE'S ADVICE HERE~~</center>}}		{{hidden\|Ask a colleague\|<center>Did you check the history? I wonder whether this could be drug effect.</center>}}

	====Stains====		====Stains====

Michael at 02:51, 27 September 2015

2015-09-27T02:51:47Z

← Older revision		Revision as of 02:51, 27 September 2015
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	[[Image: Leiomyoma with changes secondary to tranexamic acid treatment low magnification.jpg \|500px\|link=\|center\|]]		[[Image: Leiomyoma with changes secondary to tranexamic acid treatment low magnification.jpg \|500px\|link=\|center\|]]
	<center>Low magnification. [[H&E stain]].</center>		<center>Low magnification. [[H&E stain]].</center>

	~~{{hidden\|Intermediate magnification\|[[Image: NAME OF IMAGE GOES HERE \|500px\|link=\|center\|]]~~
	~~<center>Intermediate magnification. [[H&E stain]].</center>}}~~

	{{hidden\|High magnification\|[[Image: Leiomyoma with changes secondary to tranexamic acid treatment high magnification.jpg \|500px\|link=\|center\|]]		{{hidden\|High magnification\|[[Image: Leiomyoma with changes secondary to tranexamic acid treatment high magnification.jpg \|500px\|link=\|center\|]]
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	===Differential diagnosis===		===Differential diagnosis===
	{{hidden\|Differential diagnosis\|<center>[[Smooth muscle tumour of uncertain malignant potential]] (STUMP), [[uterine leiomyosarcoma]] </center>}}		{{hidden\|Differential diagnosis\|<center>[[Smooth muscle tumour of uncertain malignant potential]] (STUMP), [[uterine leiomyosarcoma]]</center>}}

	===Additional tests===		===Additional tests===
	====More history====		====More history====
	{{hidden\|More history\|<center>Patient had received lysteda for control of bleeding </center>}}		{{hidden\|More history\|<center>Patient had received lysteda for control of bleeding.</center>}}

	====Ask a colleague====		====Ask a colleague====
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	===Diagnosis===		===Diagnosis===
	{{hidden\|Diagnosis\|<center>[[uterine leiomyoma\|LEIOMYOMA]] WITH TRANEXAMIC ACID ASSOCIATED MICROINFARCTION</center><br>		{{hidden\|Diagnosis\|<center>[[uterine leiomyoma\|LEIOMYOMA]] WITH TRANEXAMIC ACID ASSOCIATED MICROINFARCTION</center><br>
	This smooth muscle tumor depicts no atypia. When in this situation it is prudent to request detailed [[clinical history]]. Clinicians often do not inform of all agents given to patients to control uterine bleeding. <ref>{{Cite journal \| last1 = Ip \| first1 = PP. \| last2 = Lam \| first2 = KW. \| last3 = Cheung \| first3 = CL. \| last4 = Yeung \| first4 = MC. \| last5 = Pun \| first5 = TC. \| last6 = Chan \| first6 = QK. \| last7 = Cheung \| first7 = AN. \| title = Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 8 \| pages = 1215-24 \| month = Aug \| year = 2007 \| doi = 10.1097/PAS.0b013e318032125e \| PMID = 17667546 }}</ref>		This smooth muscle tumor depicts no atypia. When in this situation it is prudent to request detailed [[clinical history]]. Clinicians often do not inform of all agents given to patients to control uterine bleeding.<ref name=pmid17667546>{{Cite journal \| last1 = Ip \| first1 = PP. \| last2 = Lam \| first2 = KW. \| last3 = Cheung \| first3 = CL. \| last4 = Yeung \| first4 = MC. \| last5 = Pun \| first5 = TC. \| last6 = Chan \| first6 = QK. \| last7 = Cheung \| first7 = AN. \| title = Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 8 \| pages = 1215-24 \| month = Aug \| year = 2007 \| doi = 10.1097/PAS.0b013e318032125e \| PMID = 17667546 }}</ref>
	===References===		===References===
	{{Reflist\|1}}		{{Reflist\|1}}
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	[[Category:Cases]]		[[Category:Cases]]

	~~<!-- SELECT A CATEGORY~~
	[[Category:Cases in gynecologic pathology]]		[[Category:Cases in gynecologic pathology]]
	-->		[[Category:Cases in gynecologic pathology - fellow and expert]]

	[[Category:Cases difficulty 7]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->		[[Category:Cases difficulty 7]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->

Michael: /* Differential diagnosis */

2015-09-26T17:30:30Z

Differential diagnosis

← Older revision		Revision as of 17:30, 26 September 2015
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	===Differential diagnosis===		===Differential diagnosis===
	{{hidden\|Differential diagnosis\|<center>Smooth muscle ~~tumor~~ of ~~undetermined~~ malignant potential(STUMP), leiomyosarcoma </center>}}		{{hidden\|Differential diagnosis\|<center>[[Smooth muscle tumour of uncertain malignant potential]] (STUMP), [[uterine leiomyosarcoma]] </center>}}

	===Additional tests===		===Additional tests===

Michael: redo refs

2015-09-26T17:28:44Z

redo refs

← Older revision		Revision as of 17:28, 26 September 2015
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	===Diagnosis===		===Diagnosis===
	{{hidden\|Diagnosis\|<center>LEIOMYOMA WITH TRANEXAMIC ACID ASSOCIATED MICROINFARCTION. This smooth muscle tumor depicts no atypia. When in this situation it is prudent to request detailed clinical history. Clinicians often do not inform of all agents given to patients to control uterine bleeding. {{Cite journal \| last1 = Ip \| first1 = PP. \| last2 = Lam \| first2 = KW. \| last3 = Cheung \| first3 = CL. \| last4 = Yeung \| first4 = MC. \| last5 = Pun \| first5 = TC. \| last6 = Chan \| first6 = QK. \| last7 = Cheung \| first7 = AN. \| title = Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 8 \| pages = 1215-24 \| month = Aug \| year = 2007 \| doi = 10.1097/PAS.0b013e318032125e \| PMID = 17667546 }}</~~center~~>}}		{{hidden\|Diagnosis\|<center>[[uterine leiomyoma\|LEIOMYOMA]] WITH TRANEXAMIC ACID ASSOCIATED MICROINFARCTION</center><br>
			This smooth muscle tumor depicts no atypia. When in this situation it is prudent to request detailed [[clinical history]]. Clinicians often do not inform of all agents given to patients to control uterine bleeding. <ref>{{Cite journal \| last1 = Ip \| first1 = PP. \| last2 = Lam \| first2 = KW. \| last3 = Cheung \| first3 = CL. \| last4 = Yeung \| first4 = MC. \| last5 = Pun \| first5 = TC. \| last6 = Chan \| first6 = QK. \| last7 = Cheung \| first7 = AN. \| title = Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 8 \| pages = 1215-24 \| month = Aug \| year = 2007 \| doi = 10.1097/PAS.0b013e318032125e \| PMID = 17667546 }}</ref>
			===References===
			{{Reflist\|1}}
			}}
	<br>		<br>
	===Other cases===		===Other cases===

Vinita: Created page with "===Provided clinical history=== 45 year old woman, with intractable uterine bleeding unresponsive to hormone therapy. Mass lesion in the myometrium ===Site=== Uterus- myomet..."

2015-09-26T14:00:55Z

Created page with "===Provided clinical history=== 45 year old woman, with intractable uterine bleeding unresponsive to hormone therapy. Mass lesion in the myometrium ===Site=== Uterus- myomet..."

New page

===Provided clinical history===
45 year old woman, with intractable uterine bleeding unresponsive to hormone therapy. Mass lesion in the myometrium

===Site===
Uterus- myometrium

===Primary image===
[[Image: Leiomyoma with changes secondary to tranexamic acid treatment low magnification.jpg |500px|link=|center|]]
<center>Low magnification. [[H&E stain]].</center>

{{hidden|Intermediate magnification|[[Image: NAME OF IMAGE GOES HERE |500px|link=|center|]]
<center>Intermediate magnification. [[H&E stain]].</center>}}

{{hidden|High magnification|[[Image: Leiomyoma with changes secondary to tranexamic acid treatment high magnification.jpg |500px|link=|center|]]
<center>High magnification. [[H&E stain]].</center>}}

===Differential diagnosis===
{{hidden|Differential diagnosis|<center>Smooth muscle tumor of undetermined malignant potential(STUMP), leiomyosarcoma </center>}}

===Additional tests===
====More history====
{{hidden|More history|<center>Patient had received lysteda for control of bleeding </center>}}

====Ask a colleague====
{{hidden|Ask a colleague|<center>COLLEAGUE'S ADVICE HERE</center>}}

====Stains====
{{Case Stains
| blank=Dr Torres would ask why!
| alcpas=
| alc1=
| alc25=
| aur=
| biel=
| bili=
| iron=
| congored=
| cresylv=
| dieterle=
| diffquik=
| fontana=
| gallyas=
| giemsa=
| gms=
| gomori=
| gram=
| gremelius=
| jms=
| jones=
| kinyoun=
| luxol=
| masson=
| mmas=
| movat=
| mucicar=
| oilredo=
| orecein=
| pas=
| pasd=
| pasf=
| ptah=
| prussian=
| reticulin=
| sudanblackb=
| toluidine=
| verhoeff=
| vonkossa=
| warthinstarry=
| zn=
}}
====IHC====
{{Case IHC
| blank=Dr Torres would ask why!
| a1at=
| acth=
| ae1ae3=
| afp=
| alk1=
| amacr=
| ar=
| atrx=
| b2microglobulin=
| b72_3=
| bcatenin=
| bcl2=
| bcl6=
| bclxl=
| c3=
| ca9=
| calcitonin=
| calponin=
| calretinin=
| cam5p2=
| cathepsink=
| cd10=
| cd117=
| cd138=
| cd15=
| cd1a=
| cd20=
| cd21=
| cd23=
| cd3=
| cd30=
| cd31=
| cd34=
| cd35=
| cd4=
| cd43=
| cd45=
| cd5=
| cd56=
| cd57=
| cd68=
| cd7=
| cd79a=
| cd8=
| cd99=
| cdx2=
| cea=
| chromo=
| ck17=
| ck19=
| ck20=
| ck34be12=
| ck5_6=
| ck7=
| cmv=
| cmyc=
| cyclin_d1=
| d2_40=
| desmin=
| dog1=
| ebv=
| ema=
| erpr=
| f_viii=
| f_xiiia=
| fascin=
| fh=
| fsh=
| gastrin=
| gata3=
| gcdfp=
| gfap=
| gh=
| glucagon=
| glypican3=
| hbme1=
| hbv_core=
| hbv_surf=
| hcaldesmon=
| hcg=
| helicobacter=
| hepatocyte=
| her2=
| hhv8=
| hmb45=
| hnf1beta=
| hpv=
| hsv1=
| hsv2=
| Idh-1=
| inhibin=
| ini1=
| insulin=
| kappa=
| ki67=
| lambda=
| leu7=
| lga=
| lgg=
| lgm=
| lh=
| lysozyme=
| mammogl=
| map2=
| mcv=
| melanin_a=
| mitf=
| mum1=
| myleoperox=
| myo_d1=
| myog=
| napsin=
| nf=
| nkx3_1=
| nse=
| oct3_4=
| p16=
| p501s=
| p53=
| p57=
| p63=
| panker=
| pax2=
| pax5=
| pax8=
| pcna=
| pdgfr=
| plap=
| pnl-2c=
| prolactin=
| psa=
| psap=
| rcc=
| s100=
| sma=
| somatsatin=
| synapto=
| tdt=
| tfe3=
| tfeb=
| thyrogl=
| toxopl=
| tsh=
| ttf1=
| ubiquitin=
| uchl1=
| ulex_europe=
| vim=
| vip=
| vzv=
| wt1=
}}

====Molecular testing====
=====Chromosomal translocations=====
{{Case Translocations
| blank=Dr Torres would ask why!
| t1_13=
| t2_13=
| t8_14=
| t9_22bcr_abl=
| t9_22chn_ews=
| t11_14=
| t11_22dsrct=
| t11_22ews=
| t12_15=
| t12_16afh=
| t12_16liposar=
| t12_22=
| t14_18=
| t15_17=
| t16_21=
| t17_22=
| t21_22=
| tx_1=
| tx_17=
| tx_18=
}}
=====Other molecular tests=====
{{Case Molecular
| blank=Dr Torres would ask why!
| alk =
| b_cell_clone =
| bcl2 =
| braf =
| EBV_pcr =
| egrf =
| h3f3a =
| hhv8_pcr =
| identity_test =
| idh1_2 =
| jak2_v617f =
| kit =
| loh_1p19q =
| t_cell_clone =
}}

===Diagnosis===
{{hidden|Diagnosis|<center>LEIOMYOMA WITH TRANEXAMIC ACID ASSOCIATED MICROINFARCTION. This smooth muscle tumor depicts no atypia. When in this situation it is prudent to request detailed clinical history. Clinicians often do not inform of all agents given to patients to control uterine bleeding. {{Cite journal | last1 = Ip | first1 = PP. | last2 = Lam | first2 = KW. | last3 = Cheung | first3 = CL. | last4 = Yeung | first4 = MC. | last5 = Pun | first5 = TC. | last6 = Chan | first6 = QK. | last7 = Cheung | first7 = AN. | title = Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. | journal = Am J Surg Pathol | volume = 31 | issue = 8 | pages = 1215-24 | month = Aug | year = 2007 | doi = 10.1097/PAS.0b013e318032125e | PMID = 17667546 }}</center>}}
<br>
===Other cases===
{{Cases navigation}}

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[[Category:Cases difficulty 7]]