Cat scratch disease - Revision history

Michael at 01:56, 4 January 2014

2014-01-04T01:56:17Z

← Older revision		Revision as of 01:56, 4 January 2014
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	*Treatment: antibiotics.		*Treatment: antibiotics.

	==Clinical==		===Clinical===
	Features:<ref name=Ref_ILNP113>{{Ref ILNP\|113}}</ref>		Features:<ref name=Ref_ILNP113>{{Ref ILNP\|113}}</ref>
	*Usually unilateral.		*Usually unilateral lymphadenopathy.
	**May be disseminated in individuals with immune dysfunction.		**May be disseminated in individuals with immune dysfunction.
	*Contact with cats.		*Contact with cats.

			==Gross==
			*Lymphadenopathy - usu. unlitateral.
			**Typically axillary or cervical (like [[tularemia]]).<ref name=pmid22706525>{{Cite journal \| last1 = Asano \| first1 = S. \| title = Granulomatous lymphadenitis. \| journal = J Clin Exp Hematop \| volume = 52 \| issue = 1 \| pages = 1-16 \| month = \| year = 2012 \| doi = \| PMID = 22706525 }}</ref>

	==Micrograph==		==Micrograph==

Michael: /* Stains */ wikify

2014-01-04T01:37:40Z

Stains: wikify

← Older revision		Revision as of 01:37, 4 January 2014
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	==Stains==		==Stains==
	*Warthin-Starry stain +ve -- bacilli.		*[[Warthin-Starry stain]] +ve -- bacilli.
	*Gram stain -ve.		*[[Gram stain]] -ve.

	==IHC==		==IHC==

Michael: more

2014-01-04T01:36:59Z

← Older revision		Revision as of 01:36, 4 January 2014
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	\| Width =		\| Width =
	\| Caption = Cat scratch disease. [[H&E stain]].		\| Caption = Cat scratch disease. [[H&E stain]].
	\| Micro = necrotizing granulomas with neutrophils and star-shaped (stellate, +/-multinucleated giant cells, microorganisms consistent with ''B. henselae''		\| Micro = necrotizing granulomas with neutrophils and star-shaped (stellate), +/-multinucleated giant cells, microorganisms consistent with ''B. henselae''
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[sporotrichosis]], [[lymphogranuloma venereum]], [[tularemia]]		\| LMDDx = [[sporotrichosis]], [[lymphogranuloma venereum]], [[tularemia]]

Michael at 19:59, 14 December 2013

2013-12-14T19:59:46Z

← Older revision		Revision as of 19:59, 14 December 2013
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	\| Width =		\| Width =
	\| Caption = Cat scratch disease. [[H&E stain]].		\| Caption = Cat scratch disease. [[H&E stain]].
	\| Micro = necrotizing granulomas with neutrophils and star-shaped (stellate, +/-multinucleated giant cells, microorganisms consistent with B. henselae		\| Micro = necrotizing granulomas with neutrophils and star-shaped (stellate, +/-multinucleated giant cells, microorganisms consistent with ''B. henselae''
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[sporotrichosis]], [[lymphogranuloma venereum]], [[tularemia]]		\| LMDDx = [[sporotrichosis]], [[lymphogranuloma venereum]], [[tularemia]]
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	==General==		==General==
	*Infection caused ''[[Bartonella henselae]]'',<ref name=pmid19332922>{{Cite journal \| last1 = Jerris \| first1 = RC. \| last2 = Regnery \| first2 = RL. \| title = Will the real agent of cat-scratch disease please stand up? \| journal = Annu Rev Microbiol \| volume = 50 \| issue = \| pages = 707-25 \| month = \| year = 1996 \| doi = 10.1146/annurev.micro.50.1.707 \| PMID = 8905096 }}</ref> a gram-negative ~~bacilla~~ (0.3-1.0 x 0.6-3.0 micrometers) in chains, clumps, or singular.<ref name=Ref_ILNP110>{{Ref ILNP\|110}}</ref>		*Infection caused ''[[Bartonella henselae]]'',<ref name=pmid19332922>{{Cite journal \| last1 = Jerris \| first1 = RC. \| last2 = Regnery \| first2 = RL. \| title = Will the real agent of cat-scratch disease please stand up? \| journal = Annu Rev Microbiol \| volume = 50 \| issue = \| pages = 707-25 \| month = \| year = 1996 \| doi = 10.1146/annurev.micro.50.1.707 \| PMID = 8905096 }}</ref> a gram-negative bacillus (0.3-1.0 x 0.6-3.0 micrometers) in chains, clumps, or singular.<ref name=Ref_ILNP110>{{Ref ILNP\|110}}</ref>
	*Treatment: antibiotics.		*Treatment: antibiotics.

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	***Microabscesses often described as "stellate" (star-shaped).		***Microabscesses often described as "stellate" (star-shaped).
	*+/-Multinucleated giant cells.		*+/-Multinucleated giant cells.
			*Microorganism consistent with ''B. henselae''.

	Notes:		Notes:
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	==Stains==		==Stains==
	*Warthin-Starry stain +ve.		*Warthin-Starry stain +ve -- bacilli.
			*Gram stain -ve.

	==IHC==		==IHC==
	*B. henselae IHC stain +ve - '''diagnostic'''.		*B. henselae IHC stain +ve -- bacilli - '''diagnostic'''.

	==See also==		==See also==

Michael: +infobx

2013-12-14T19:56:57Z

+infobx

← Older revision		Revision as of 19:56, 14 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Cat_scratch_disease_-_low_mag.jpg
			\| Width =
			\| Caption = Cat scratch disease. [[H&E stain]].
			\| Micro = necrotizing granulomas with neutrophils and star-shaped (stellate, +/-multinucleated giant cells, microorganisms consistent with B. henselae
			\| Subtypes =
			\| LMDDx = [[sporotrichosis]], [[lymphogranuloma venereum]], [[tularemia]]
			\| Stains = [[Warthin-Starry stain]] +ve
			\| IHC = B. henselae +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[lymph node]] - see ''[[lymph node pathology]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = contact with cats
			\| Signs = fever, lymphadenopathy
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = other causes of lymphadenopathy, e.g. [[lymphoma]]
			}}
	'''Cat scratch disease''', also '''cat scratch fever''', is an uncommon [[lymph node pathology\|pathology of the lymph node]].		'''Cat scratch disease''', also '''cat scratch fever''', is an uncommon [[lymph node pathology\|pathology of the lymph node]].

Michael: split-out

2013-12-14T19:49:11Z

split-out

← Older revision		Revision as of 19:49, 14 December 2013
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	~~#redirect~~ [[~~Lymph_node_pathology#~~Cat-~~scratch_disease~~]]		'''Cat scratch disease''', also '''cat scratch fever''', is an uncommon [[lymph node pathology\|pathology of the lymph node]].

			==General==
			*Infection caused ''[[Bartonella henselae]]'',<ref name=pmid19332922>{{Cite journal \| last1 = Jerris \| first1 = RC. \| last2 = Regnery \| first2 = RL. \| title = Will the real agent of cat-scratch disease please stand up? \| journal = Annu Rev Microbiol \| volume = 50 \| issue = \| pages = 707-25 \| month = \| year = 1996 \| doi = 10.1146/annurev.micro.50.1.707 \| PMID = 8905096 }}</ref> a gram-negative bacilla (0.3-1.0 x 0.6-3.0 micrometers) in chains, clumps, or singular.<ref name=Ref_ILNP110>{{Ref ILNP\|110}}</ref>
			*Treatment: antibiotics.

			==Clinical==
			Features:<ref name=Ref_ILNP113>{{Ref ILNP\|113}}</ref>
			*Usually unilateral.
			**May be disseminated in individuals with immune dysfunction.
			*Contact with cats.

			==Micrograph==
			Features:<ref name=Ref_ILNP113>{{Ref ILNP\|113}}</ref>
			*Necrotizing granulomas with:
			**Neutrophils present in microabscess (necrotic debris) - '''key feature'''.
			***Microabscesses often described as "stellate" (star-shaped).
			*+/-Multinucleated giant cells.

			Notes:
			*May involve capsule or perinodal tissue.

			DDx of stellate abscess in lymph nodes - ''cat split'':<ref name=pmid>URL: [http://www.dermpathmd.com/mnemonics/mnemonics_dermatopathology.htm http://www.dermpathmd.com/mnemonics/mnemonics_dermatopathology.htm]. Accessed on: 23 September 2011.</ref>
			*Cat-scratch disease.
			*[[Sporotrichosis]].
			*[[Lymphogranuloma venereum]].
			*[[Tularemia]].

			===Images===
			www:
			*[http://www.webpathology.com/image.asp?case=386&n=1 Cat-scratch disease (webpathology.com)].
			*[http://www.webpathology.com/image.asp?n=2&Case=386 Cat-scratch disease - high mag. (webpathology.com)]
			<gallery>
			Image:Cat_scratch_disease_-_very_low_mag.jpg \| CSD - very low mag. - showing serpentine shaped microabscesses (WC)
			Image:Cat_scratch_disease_-_low_mag.jpg \| CSD - low mag. - showing serpentine shaped microabscesses (WC)
			Image:Cat_scratch_disease_-b-_high_mag.jpg \| CSD - high mag. - showing neutrophilic abscesses (WC)
			</gallery>

			==Stains==
			*Warthin-Starry stain +ve.

			==IHC==
			*B. henselae IHC stain +ve - '''diagnostic'''.

			==See also==
			*[[Lymph node pathology]].

			==References==
			{{Reflist\|2}}

			[[Category:Diagnosis]]
			[[Category:Lymph node pathology]]

Michael: redirect

2012-03-14T22:51:38Z

redirect

New page

#redirect [[Lymph_node_pathology#Cat-scratch_disease]]