Chondro-osseous tumours - Revision history

Michael: /* Bone tumours */

2016-06-20T01:46:57Z

Bone tumours

← Older revision		Revision as of 01:46, 20 June 2016
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	\| ?		\| ?
	\| no stains / may be assoc. with [[FAP]]		\| no stains / may be assoc. with [[FAP]]
	\| Image (~~???~~)		\| [[Image:Osteoma -- intermed mag.jpg \|thumb\|center\|150px\| Osteoma. (WC)]]
	\|-		\|-
	\| [[Osteoid osteoma]]		\| [[Osteoid osteoma]]

Michael: /* Bone tumours */

2016-02-23T21:07:03Z

Bone tumours

← Older revision		Revision as of 21:07, 23 February 2016
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	\| osteoblastic rimming		\| osteoblastic rimming
	\| anastomosing bony trabeculae		\| anastomosing bony trabeculae
	\| must be <2 cm, metaphysis		\| must be <2 cm,<ref name=pmid25224389>{{Cite journal \| last1 = Yalcinkaya \| first1 = U. \| last2 = Doganavsargil \| first2 = B. \| last3 = Sezak \| first3 = M. \| last4 = Kececi \| first4 = B. \| last5 = Argin \| first5 = M. \| last6 = Basdemir \| first6 = G. \| last7 = Oztop \| first7 = F. \| title = Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. \| journal = Ann Diagn Pathol \| volume = 18 \| issue = 6 \| pages = 319-25 \| month = Dec \| year = 2014 \| doi = 10.1016/j.anndiagpath.2014.08.006 \| PMID = 25224389 }}</ref> metaphysis
	\| painful, NSAIDs remove pain, young		\| painful, NSAIDs remove pain, young
	\| IHC / other		\| IHC / other
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	\| osteoblastic rimming		\| osteoblastic rimming
	\| anastomosing bony trabeculae		\| anastomosing bony trabeculae
	\| must be >1 cm, often >=2 cm, metaphysis		\| must be >1 cm,<ref name=pmid25224389/> often >=2 cm, metaphysis
	\| not painful		\| not painful
	\| IHC / other		\| IHC / other

Michael: /* Bone tumours */

2016-02-23T21:05:23Z

Bone tumours

← Older revision		Revision as of 21:05, 23 February 2016
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	\| osteoblastic rimming		\| osteoblastic rimming
	\| anastomosing bony trabeculae		\| anastomosing bony trabeculae
	\| <~~= 1.5~~ cm, metaphysis		\| must be <2 cm, metaphysis
	\| painful, NSAIDs remove pain, young		\| painful, NSAIDs remove pain, young
	\| IHC / other		\| IHC / other
Line 75:		Line 75:
	\| osteoblastic rimming		\| osteoblastic rimming
	\| anastomosing bony trabeculae		\| anastomosing bony trabeculae
	\| > 1.5 cm, metaphysis		\| must be >1 cm, often >=2 cm, metaphysis
	\| not painful		\| not painful
	\| IHC / other		\| IHC / other

Michael: /* Notochordal tumors */

2015-11-08T16:31:53Z

Notochordal tumors

← Older revision		Revision as of 16:31, 8 November 2015
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	Notochordal tumors arise from notochordal remnants and thus are seen in the clivus or sacrum.		Notochordal tumors arise from notochordal remnants and thus are seen in the clivus or sacrum.
	{{Main\|Chordoma}}		{{Main\|Chordoma}}


	==Osteochondroma==		==Osteochondroma==

Michael: /* Osteochondroma */ split out

2015-11-08T16:25:12Z

Osteochondroma: split out

← Older revision		Revision as of 16:25, 8 November 2015
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	==Osteochondroma==		==Osteochondroma==
	~~===General===~~		{{Main\|Osteochondroma}}
	*Benign.
	*Very common.
	*Abnormal outgrowth of bone and cartilage - associated with growth plate.
	*Usually present before age 20.<ref name=pmid12873205>{{~~Cite journal~~ \| ~~last1 = Parkin \| first1 = B. \| last2 = Bennett \| first2 = JC. \| last3 = Zaher \| first3 = A. \| title = Pathologic quiz case: an iliac mass in a 25-year-old woman.~~ Osteochondroma. \| journal = Arch Pathol Lab Med \| volume = 127 \| issue = 8 \| pages = e355-6 \| month = Aug \| year = 2003 \| doi = 10.1043/1543-2165(2003)127e355:PQCAIM2.0.CO;2 \| PMID = 12873205 \| URL = http://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282003%29127%3Ce355:PQCAIM%3E2.0.CO;2}}~~</ref>~~

	~~===Gross===~~
	~~Features:~~
	*Metasphyseal lesions.<ref name=medpath>URL: [http://www.medpath.info/MainContent/Skeletal/Bone_07.html http://www.medpath.info/MainContent/Skeletal/Bone_07.html]. Accessed on: 18 September 2012.</ref>
	**Often distal femur, proximal humerus or proximal tibia.<ref name=pmid12873205/>
	**Occasionally iliac mass.<ref name=pmid22217414>{{Cite journal \| last1 = Kokavec \| first1 = M. \| last2 = Gajdoš \| first2 = M. \| last3 = Džupa \| first3 = V. \| title = [Osteochondroma of the iliac crest: case report]. \| journal = Acta Chir Orthop Traumatol Cech \| volume = 78 \| issue = 6 \| pages = 583-5 \| month = \| year = 2011 \| doi = \| PMID = 22217414 }}
	~~</ref>~~
	*Mushroom-like shape - with broad or narrow base.

	~~Note:~~
	*Very unusual in craniofacial bones.<ref name=pmid12873205/>

	~~===Microscopic===~~
	~~Features:<ref name=pmid12873205/>~~
	*Bone - forms base of "mushroom".
	*Cartilage - layer usu. thinner in older individuals.
	**Lobular arrangement<ref name=upmc_case341>URL: [http://path.upmc.edu/cases/case341/dx.html http://path.upmc.edu/cases/case341/dx.html]. Accessed on: 19 September 2012.</ref> - clusters of 3-12 lacunae (separated by stroma).
	**May have mild atypia.
	**Nuclear enlargement - up to 5x normal.
	*[[Perichondrium]] - covers the cartilage.
	**Thin layer of cells - higher cellular density than cartilage.
	***Bland spindle cells in a fibrous (eosinophilic) stroma.

	~~Notes:~~
	*Benign cartilage - one chondrocyte per lacuna, small and round nucleus, no binucleation.

	~~DDx:~~
	*[[Chondrosarcoma]] - esp. in older individuals.

	~~Images:~~
	~~<gallery>~~
	~~Image:Bone Osteochondroma LP CTR.jpg\|Bone - Osteochondroma - low power (SKB)~~
	~~Image:Bone Osteochondroma LP CTR (2).jpg\|Bone - Osteochondroma - low power (SKB)~~
	~~Image:Bone Osteochondroma HP CTR.jpg\|Bone - Osteochondroma - high power (SKB)~~
	~~Image:Bone Osteochondroma LP PA.JPG\|Bone - Osteochondroma - low power (SKB)~~
	~~Image:Bone Osteochondroma MP PA.JPG\|Bone - Osteochondroma - medium power (SKB)~~
	~~Image:Bone Osteochondroma MP2 PA.JPG\|Bone - Osteochondroma - medium power (SKB)~~
	~~</gallery>~~
	*[http://path.upmc.edu/cases/case341.html Super rare intracranial mesenchymal osteochondroma - several images (upmc.edu)].<ref name=upmc_case341/>

	==Diffuse tenosynovial giant-cell tumour==		==Diffuse tenosynovial giant-cell tumour==

Michael: touch

2015-05-01T03:41:41Z

touch

← Older revision		Revision as of 03:41, 1 May 2015
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	[[Image:Osteosarcoma - very high mag.jpg\|thumb\|250px\|right\|A chondro-osseous tumour ([[osteosarcoma]]). [[H&E stain]].]]		[[Image:Osteosarcoma - very high mag.jpg\|thumb\|250px\|right\|A chondro-osseous tumour ([[osteosarcoma]]). [[H&E stain]].]]
	'''Chondro-osseous tumours''' occasionally cross the desk of the pathologist. They are grouped together as [[bone]] may develop from [[cartilage]].		'''Chondro-osseous tumours''' occasionally cross the desk of the pathologist. They are grouped together as [[bone]] may develop from [[cartilage]].

Jensflorian: /* Other */ +notochordal tumors

2015-04-16T14:15:52Z

Other: +notochordal tumors

← Older revision		Revision as of 14:15, 16 April 2015
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	=Other=		=Other=
	This section collects stuff that doesn't neatly fit into the ''bone'' or ''cartilage'' category.		This section collects stuff that doesn't neatly fit into the ''bone'' or ''cartilage'' category.

			==Notochordal tumors==
			Notochordal tumors arise from notochordal remnants and thus are seen in the clivus or sacrum.
			{{Main\|Chordoma}}


	==Osteochondroma==		==Osteochondroma==
	===General===		===General===

Sarah: /* Microscopic */

2015-04-16T09:41:46Z

Microscopic

← Older revision		Revision as of 09:41, 16 April 2015
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	Images:		Images:
	<gallery>		<gallery>
	Image:Bone Osteochondroma LP CTR.jpg~~\|thumb~~\|Bone - Osteochondroma - low power (SKB)		Image:Bone Osteochondroma LP CTR.jpg\|Bone - Osteochondroma - low power (SKB)
	Image:Bone Osteochondroma LP CTR (2).jpg~~\|thumb~~\|Bone - Osteochondroma - low power (SKB)		Image:Bone Osteochondroma LP CTR (2).jpg\|Bone - Osteochondroma - low power (SKB)
	Image:Bone Osteochondroma HP CTR.jpg~~\|thumb~~\|Bone - Osteochondroma - high power (SKB)		Image:Bone Osteochondroma HP CTR.jpg\|Bone - Osteochondroma - high power (SKB)
	Image:Bone Osteochondroma LP PA.JPG~~\|thumb~~\|Bone - Osteochondroma - low power (SKB)		Image:Bone Osteochondroma LP PA.JPG\|Bone - Osteochondroma - low power (SKB)
	Image:Bone Osteochondroma MP PA.JPG~~\|thumb~~\|Bone - Osteochondroma - medium power (SKB)		Image:Bone Osteochondroma MP PA.JPG\|Bone - Osteochondroma - medium power (SKB)
	Image:Bone Osteochondroma MP2 PA.JPG~~\|thumb~~\|Bone - Osteochondroma - medium power (SKB)		Image:Bone Osteochondroma MP2 PA.JPG\|Bone - Osteochondroma - medium power (SKB)
	</gallery>		</gallery>
	*[http://path.upmc.edu/cases/case341.html Super rare intracranial mesenchymal osteochondroma - several images (upmc.edu)].<ref name=upmc_case341/>		*[http://path.upmc.edu/cases/case341.html Super rare intracranial mesenchymal osteochondroma - several images (upmc.edu)].<ref name=upmc_case341/>

Sarah: /* Microscopic */

2015-04-16T09:32:38Z

Microscopic

← Older revision		Revision as of 09:32, 16 April 2015
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	Images:		Images:
			<gallery>
			Image:Bone Osteochondroma LP CTR.jpg\|thumb\|Bone - Osteochondroma - low power (SKB)
			Image:Bone Osteochondroma LP CTR (2).jpg\|thumb\|Bone - Osteochondroma - low power (SKB)
			Image:Bone Osteochondroma HP CTR.jpg\|thumb\|Bone - Osteochondroma - high power (SKB)
			Image:Bone Osteochondroma LP PA.JPG\|thumb\|Bone - Osteochondroma - low power (SKB)
			Image:Bone Osteochondroma MP PA.JPG\|thumb\|Bone - Osteochondroma - medium power (SKB)
			Image:Bone Osteochondroma MP2 PA.JPG\|thumb\|Bone - Osteochondroma - medium power (SKB)
			</gallery>
	*[http://path.upmc.edu/cases/case341.html Super rare intracranial mesenchymal osteochondroma - several images (upmc.edu)].<ref name=upmc_case341/>		*[http://path.upmc.edu/cases/case341.html Super rare intracranial mesenchymal osteochondroma - several images (upmc.edu)].<ref name=upmc_case341/>

Michael: /* Chondromyxoid fibroma */ split out

2014-11-09T05:21:18Z

Chondromyxoid fibroma: split out

← Older revision		Revision as of 05:21, 9 November 2014
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	==Chondromyxoid fibroma==		==Chondromyxoid fibroma==
	~~===General===~~		{{Main\|Chondromyxoid fibroma}}
	*Uncommon and benign.<ref name=pmid25217119>{{~~Cite journal~~ \| last1 = Bhamra \| first1 = JS. \| last2 = Al-Khateeb \| first2 = H. \| last3 = Dhinsa \| first3 = BS. \| last4 = Gikas \| first4 = PD. \| last5 = Tirabosco \| first5 = R. \| last6 = Pollock \| first6 = RC. \| last7 = Skinner \| first7 = JA. \| last8 = Aston \| first8 = WJ. \| last9 = Saifuddin \| first9 = A. \| title = Chondromyxoid fibroma management: a single institution experience of 22 cases. \| journal = World J Surg Oncol \| volume = 12 \| issue = \| pages = 283 \| month = \| year = 2014 \| doi = 10.1186/1477-7819-12-283 \| PMID = 25217119 }}</ref>
	*Teenagers or young adults.

	~~===Gross===~~
	*Metaphyseal lesion - classic location.<ref name=pmid18312923>{{Cite journal \| last1 = Budny \| first1 = AM. \| last2 = Ismail \| first2 = A. \| last3 = Osher \| first3 = L. \| title = Chondromyxoid fibroma~~. \| journal = J Foot Ankle Surg \| volume = 47 \| issue = 2 \| pages = 153-9 \| month = \| year = \| doi = 10.1053/j.jfas.2007.08.013 \| PMID = 18312923 }}</ref>~~
	*Well-circumscribed.

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP642>{{Ref WMSP\|642}}</ref>~~
	*Spindle cells or stellate cells in a myxoid or chondroid stroma.

	~~DDx:~~
	*[[Phosphaturic mesenchymal tumour]] - case report.<ref>{{Cite journal \| last1 = Suryawanshi \| first1 = P. \| last2 = Agarwal \| first2 = M. \| last3 = Dhake \| first3 = R. \| last4 = Desai \| first4 = S. \| last5 = Rekhi \| first5 = B. \| last6 = Reddy \| first6 = KB. \| last7 = Jambhekar \| first7 = NA. \| title = Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance. \| journal = Skeletal Radiol \| volume = 40 \| issue = 11 \| pages = 1481-5 \| month = Nov \| year = 2011 \| doi = 10.1007/s00256-011-1159-6 \| PMID = 21533894 }}~~</ref>~~

	~~Images:~~
	*[http://www.webpathology.com/image.asp?n=7&Case=331 Chondromyxoid fibroma - low mag. (webpathology.com)].
	*[http://www.webpathology.com/image.asp?case=331&n=8 Chondromyxoid fibroma - high mag. (webpathology.com)].

	==Chondrosarcoma==		==Chondrosarcoma==