Chromophobe renal cell carcinoma - Revision history

Michael at 15:04, 18 April 2024

2024-04-18T15:04:45Z

← Older revision		Revision as of 15:04, 18 April 2024
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	![[GATA3]]		![[GATA3]]
	\|-		\|-
	\| [[Renal ~~oncoctyoma~~]]		\| [[Renal oncocytoma]]
	\| -ve †		\| -ve †
	\| +ve		\| +ve

Michael at 15:04, 18 April 2024

2024-04-18T15:04:24Z

← Older revision		Revision as of 15:04, 18 April 2024
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	A panel:		A panel:
	*CK7, [[PAX8]], CD117, CD10, [[Mueller-Mowry stain]].		*CK7, [[PAX8]], CD117, CD10, [[Mueller-Mowry stain]].

			===Comparison between some renal tumours with eosinophilic cytoplasm===
			{\| class="wikitable sortable"
			!Tumour
			![[CK7]]
			![[CD117]]
			![[GATA3]]
			\|-
			\| [[Renal oncoctyoma]]
			\| -ve †
			\| +ve
			\| -ve/+ve
			\|-
			\| Chromophobe renal cell carcinoma
			\| +ve ‡
			\| +ve
			\| -ve
			\|-
			\| [[Low-grade oncocytic tumour]]
			\| +ve
			\| -ve
			\| +ve
			\|-
			\|}
			† may have scattered positive cells<br>
			‡ diffuse and strong

	==Molecular==		==Molecular==

Michael at 22:22, 12 February 2024

2024-02-12T22:22:57Z

← Older revision		Revision as of 22:22, 12 February 2024
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	===Micro===		===Micro===
			The sections show a sheeting tumour with abundant and eosinophilic cytoplasm. The tumour cell cell membranes are prominent and plant-like. Perinuclear clearing is present. Binucleation is frequent and the nuclear membranes moderately irregular. No definite papillae or macrophages are present. Nucleoli are not prominent. Small blood vessels are not prominent.

			====Alternate====
	The sections show a tumour composed of compact nests. The cytoplasm is abundant and eosinophilic. Perinuclear clearing is prominent. Binucleation is frequent and the nuclear membranes moderately irregular to round. No definite papillae or macrophages are present. Nucleoli are not prominent.		The sections show a tumour composed of compact nests. The cytoplasm is abundant and eosinophilic. Perinuclear clearing is prominent. Binucleation is frequent and the nuclear membranes moderately irregular to round. No definite papillae or macrophages are present. Nucleoli are not prominent.

Michael: /* Classic */ create

2021-01-31T19:37:32Z

Classic: create

← Older revision		Revision as of 19:37, 31 January 2021
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	**Perinuclear clearing is ''not'' seen in clear cell RCC.		**Perinuclear clearing is ''not'' seen in clear cell RCC.
	**ChRCC has wisps in the cytoplasm.		**ChRCC has wisps in the cytoplasm.
			*Other [[clear cell tumours]].
			*[[Benign clear cell clusters of the kidney]] - somewhat controversial.

	====Images====		====Images====

Michael: /* Sign out */

2017-06-01T18:28:30Z

Sign out

← Older revision		Revision as of 18:28, 1 June 2017
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	Negative: AMACR, CD10, CD68, RCC, vimentin.		Negative: AMACR, CD10, CD68, RCC, vimentin.
	</pre>		</pre>

			===Micro===
			The sections show a tumour composed of compact nests. The cytoplasm is abundant and eosinophilic. Perinuclear clearing is prominent. Binucleation is frequent and the nuclear membranes moderately irregular to round. No definite papillae or macrophages are present. Nucleoli are not prominent.

	==See also==		==See also==

Michael: /* IHC */

2017-05-29T20:32:19Z

IHC

← Older revision		Revision as of 20:32, 29 May 2017
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	*[[DOG1]] +ve (Swalchick ''et al.''<ref name=pmid26678977>{{Cite journal \| last1 = Swalchick \| first1 = W. \| last2 = Shamekh \| first2 = R. \| last3 = Bui \| first3 = MM. \| title = Is DOG1 Immunoreactivity Specific to Gastrointestinal Stromal Tumor? \| journal = Cancer Control \| volume = 22 \| issue = 4 \| pages = 498-504 \| month = Oct \| year = 2015 \| doi = \| PMID = 26678977 }}</ref> 32 +ve of 37 cases; Zhao ''et al.''<ref name=pmid25596994>{{Cite journal \| last1 = Zhao \| first1 = W. \| last2 = Tian \| first2 = B. \| last3 = Wu \| first3 = C. \| last4 = Peng \| first4 = Y. \| last5 = Wang \| first5 = H. \| last6 = Gu \| first6 = WL. \| last7 = Gao \| first7 = FH. \| title = DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. \| journal = Pathol Res Pract \| volume = 211 \| issue = 4 \| pages = 303-7 \| month = Apr \| year = 2015 \| doi = 10.1016/j.prp.2014.12.014 \| PMID = 25596994 }}</ref> 32 +ve of 32 cases).		*[[DOG1]] +ve (Swalchick ''et al.''<ref name=pmid26678977>{{Cite journal \| last1 = Swalchick \| first1 = W. \| last2 = Shamekh \| first2 = R. \| last3 = Bui \| first3 = MM. \| title = Is DOG1 Immunoreactivity Specific to Gastrointestinal Stromal Tumor? \| journal = Cancer Control \| volume = 22 \| issue = 4 \| pages = 498-504 \| month = Oct \| year = 2015 \| doi = \| PMID = 26678977 }}</ref> 32 +ve of 37 cases; Zhao ''et al.''<ref name=pmid25596994>{{Cite journal \| last1 = Zhao \| first1 = W. \| last2 = Tian \| first2 = B. \| last3 = Wu \| first3 = C. \| last4 = Peng \| first4 = Y. \| last5 = Wang \| first5 = H. \| last6 = Gu \| first6 = WL. \| last7 = Gao \| first7 = FH. \| title = DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. \| journal = Pathol Res Pract \| volume = 211 \| issue = 4 \| pages = 303-7 \| month = Apr \| year = 2015 \| doi = 10.1016/j.prp.2014.12.014 \| PMID = 25596994 }}</ref> 32 +ve of 32 cases).
	**Useful in ChRCC versus clear cell RCC.		**Useful in ChRCC versus clear cell RCC.

			A panel:
			*CK7, [[PAX8]], CD117, CD10, [[Mueller-Mowry stain]].

	==Molecular==		==Molecular==

Michael: +HOCT

2016-08-01T21:42:38Z

+HOCT

← Older revision		Revision as of 21:42, 1 August 2016
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	\| Micro = pale/clear (or eosinophilic) cytoplasm with wisps of eosinophilic material, perinuclear clearing (a pale halo surrounds the nucleus), periphery of cell distinct (cell membrane is easy to discern -- plant cell-like)		\| Micro = pale/clear (or eosinophilic) cytoplasm with wisps of eosinophilic material, perinuclear clearing (a pale halo surrounds the nucleus), periphery of cell distinct (cell membrane is easy to discern -- plant cell-like)
	\| Subtypes = classic, eosinophilic variant		\| Subtypes = classic, eosinophilic variant
	\| LMDDx = [[clear cell renal cell carcinoma]] (classic), [[renal oncocytoma]], [[clear cell renal cell carcinoma]] eosinophilic variant		\| LMDDx = [[clear cell renal cell carcinoma]] (classic), [[renal oncocytoma]], [[clear cell renal cell carcinoma]] eosinophilic variant, [[renal hybrid oncocytic/chromophobe tumour]], other [[renal tumours with eosinophilic cytoplasm]]
	\| Stains = [[Hale's colloidal iron]] ([[Mueller-Mowry stain]]) +ve		\| Stains = [[Hale's colloidal iron]] ([[Mueller-Mowry stain]]) +ve
	\| IHC = CK7 +ve cell membrane, CD117 +ve, vimentin -ve		\| IHC = CK7 +ve cell membrane, CD117 +ve, vimentin -ve

Michael: /* Eosinophilic variant */

2016-08-01T21:41:07Z

Eosinophilic variant

← Older revision		Revision as of 21:41, 1 August 2016
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	#*Perinuclear clearing is ''not'' seen in clear cell RCC.		#*Perinuclear clearing is ''not'' seen in clear cell RCC.
	#*ChRCC has wisps in the cytoplasm.		#*ChRCC has wisps in the cytoplasm.
			#[[Renal hybrid oncocytic/chromophobe tumour]].
	#Other [[renal tumours with eosinophilic cytoplasm]].		#Other [[renal tumours with eosinophilic cytoplasm]].
	====Images====		====Images====

Michael: /* IHC */

2016-08-01T21:36:20Z

IHC

← Older revision		Revision as of 21:36, 1 August 2016
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	==IHC==		==IHC==
	*CK7 +ve cell membrane.<ref name=Ref_GUP293>{{Ref GUP\|293}}</ref>		*[[CK7]] +ve cell membrane.<ref name=Ref_GUP293>{{Ref GUP\|293}}</ref>
	**Useful for differentiating from oncocytoma.		**Useful for differentiating from oncocytoma.
	*CD117 +ve.		*[[CD117]] +ve.
	*Vimentin -ve.<ref name=pmid22455881>{{Cite journal \| last1 = Zhang \| first1 = W. \| last2 = Yu \| first2 = WJ. \| last3 = Jiang \| first3 = YX. \| last4 = Li \| first4 = YJ. \| last5 = Han \| first5 = F. \| last6 = Liu \| first6 = Y. \| last7 = Han \| first7 = ZL. \| title = [Chromophobe renal cell carcinoma: a clinicopathologic study and immunophenotypes of 42 cases]. \| journal = Zhonghua Bing Li Xue Za Zhi \| volume = 41 \| issue = 2 \| pages = 76-80 \| month = Feb \| year = 2012 \| doi = \| PMID = 22455881 }}</ref><ref name=pmid24095630>{{Cite journal \| last1 = Din \| first1 = NU. \| last2 = Fatima \| first2 = S. \| last3 = Ahmad \| first3 = Z. \| title = Chromophobe renal cell carcinoma: a morphologic and immunohistochemical study of 45 cases. \| journal = Ann Diagn Pathol \| volume = 17 \| issue = 6 \| pages = 508-13 \| month = Dec \| year = 2013 \| doi = 10.1016/j.anndiagpath.2013.06.005 \| PMID = 24095630 }}</ref>		*Vimentin -ve.<ref name=pmid22455881>{{Cite journal \| last1 = Zhang \| first1 = W. \| last2 = Yu \| first2 = WJ. \| last3 = Jiang \| first3 = YX. \| last4 = Li \| first4 = YJ. \| last5 = Han \| first5 = F. \| last6 = Liu \| first6 = Y. \| last7 = Han \| first7 = ZL. \| title = [Chromophobe renal cell carcinoma: a clinicopathologic study and immunophenotypes of 42 cases]. \| journal = Zhonghua Bing Li Xue Za Zhi \| volume = 41 \| issue = 2 \| pages = 76-80 \| month = Feb \| year = 2012 \| doi = \| PMID = 22455881 }}</ref><ref name=pmid24095630>{{Cite journal \| last1 = Din \| first1 = NU. \| last2 = Fatima \| first2 = S. \| last3 = Ahmad \| first3 = Z. \| title = Chromophobe renal cell carcinoma: a morphologic and immunohistochemical study of 45 cases. \| journal = Ann Diagn Pathol \| volume = 17 \| issue = 6 \| pages = 508-13 \| month = Dec \| year = 2013 \| doi = 10.1016/j.anndiagpath.2013.06.005 \| PMID = 24095630 }}</ref>

Michael: /* ChRCC versus clear cell RCC */

2016-05-27T17:10:40Z

ChRCC versus clear cell RCC

← Older revision		Revision as of 17:10, 27 May 2016
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	Others:		Others:
	*DOG1 +ve (32 +ve of 32 cases).<ref name=pmid25596994>{{Cite journal \| last1 = Zhao \| first1 = W. \| last2 = Tian \| first2 = B. \| last3 = Wu \| first3 = C. \| last4 = Peng \| first4 = Y. \| last5 = Wang \| first5 = H. \| last6 = Gu \| first6 = WL. \| last7 = Gao \| first7 = FH. \| title = DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. \| journal = Pathol Res Pract \| volume = 211 \| issue = 4 \| pages = 303-7 \| month = Apr \| year = 2015 \| doi = 10.1016/j.prp.2014.12.014 \| PMID = 25596994 }}</ref>		*[[DOG1]] +ve (Swalchick ''et al.''<ref name=pmid26678977>{{Cite journal \| last1 = Swalchick \| first1 = W. \| last2 = Shamekh \| first2 = R. \| last3 = Bui \| first3 = MM. \| title = Is DOG1 Immunoreactivity Specific to Gastrointestinal Stromal Tumor? \| journal = Cancer Control \| volume = 22 \| issue = 4 \| pages = 498-504 \| month = Oct \| year = 2015 \| doi = \| PMID = 26678977 }}</ref> 32 +ve of 37 cases; Zhao ''et al.''<ref name=pmid25596994>{{Cite journal \| last1 = Zhao \| first1 = W. \| last2 = Tian \| first2 = B. \| last3 = Wu \| first3 = C. \| last4 = Peng \| first4 = Y. \| last5 = Wang \| first5 = H. \| last6 = Gu \| first6 = WL. \| last7 = Gao \| first7 = FH. \| title = DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. \| journal = Pathol Res Pract \| volume = 211 \| issue = 4 \| pages = 303-7 \| month = Apr \| year = 2015 \| doi = 10.1016/j.prp.2014.12.014 \| PMID = 25596994 }}</ref> 32 +ve of 32 cases).
	**Useful in ChRCC versus clear cell RCC.		**Useful in ChRCC versus clear cell RCC.