Chronic myeloid leukemia - Revision history

Michael: tweak

2018-05-27T23:57:29Z

tweak

← Older revision		Revision as of 23:57, 27 May 2018
Line 1:		Line 1:
	Chronic myeloid leukaemia (CML) is a type of [[myeloproliferative neoplasm~~,]] [[AKA~~]] ''chronic myelogenous leukemia''. It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome. It is a [[leukemia]] in that the fusion protein drives granulopoiesis (and less commonly megakaryopoiesis), resulting in marked peripheral blood leucocytosis.		'''Chronic myeloid leukaemia''', abbreviated '''CML''', is a type of [[myeloproliferative neoplasm]]. It is also known as '''chronic myelogenous leukemia'''.

			It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome. It is a [[leukemia]] in that the fusion protein drives granulopoiesis (and less commonly megakaryopoiesis), resulting in marked peripheral blood leucocytosis.

	==General==		==General==
	*Adults - ~~usu.~~ 50s or 60s.		*Adults - usually 50s or 60s.

	Clinical - commonly:<ref>{{Ref PCPBoD8\|336}}</ref>		Clinical - commonly:<ref>{{Ref PCPBoD8\|336}}</ref>

Michael: tweak

2018-05-27T23:40:49Z

tweak

← Older revision		Revision as of 23:40, 27 May 2018
Line 1:		Line 1:
	Chronic myeloid leukaemia (CML) is a type of [[myeloproliferative neoplasm,]] [[AKA]] ''chronic myelogenous leukemia''. It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome. It is a [[leukemia]] in that the fusion protein drives granulopoiesis (and less commonly megakaryopoiesis), resulting in marked peripheral blood leucocytosis.		Chronic myeloid leukaemia (CML) is a type of [[myeloproliferative neoplasm,]] [[AKA]] ''chronic myelogenous leukemia''. It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome. It is a [[leukemia]] in that the fusion protein drives granulopoiesis (and less commonly megakaryopoiesis), resulting in marked peripheral blood leucocytosis.

	===General===		==General==
	*Adults - usu. 50s or 60s.		*Adults - usu. 50s or 60s.

Line 18:		Line 18:
	*Myeloblast (common granulocyte precursor) -> promyelocyte -> metamyelocyte -> myelocyte -> band -> mature myelocyte.<ref name=hemechart>URL: [http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png]. Accessed on: 14 January 2012.</ref>		*Myeloblast (common granulocyte precursor) -> promyelocyte -> metamyelocyte -> myelocyte -> band -> mature myelocyte.<ref name=hemechart>URL: [http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png]. Accessed on: 14 January 2012.</ref>

	===Microscopic===		==Microscopic==
	Features:		Features:
	*Bone marrow with too many granulocytes/granulocyte precursors.		*Bone marrow with too many granulocytes/granulocyte precursors.
Line 29:		Line 29:
	**#Band - dia. 1x mature, 30-40% nucleus - C shape/irregular, no nucleolus.		**#Band - dia. 1x mature, 30-40% nucleus - C shape/irregular, no nucleolus.

	===IHC===		==IHC==
	Rarely required. CML may transform into a blast phase, typically myeloid blasts, but lymphoblasts may also be seen. These blasts are typically CD34 and/or CD117 positive. The myeloid blasts will express myeloid markers and the lymphoblasts will shows lymphoid markers.		Rarely required. CML may transform into a blast phase, typically myeloid blasts, but lymphoblasts may also be seen. These blasts are typically CD34 and/or CD117 positive. The myeloid blasts will express myeloid markers and the lymphoblasts will shows lymphoid markers.

	===Molecular===		==Molecular==
	*t(9;22) BCR-ABL - '''required for diagnosis'''.		*t(9;22) BCR-ABL - '''required for diagnosis'''.
	**May be found in other leukemias.		**May be found in other leukemias.

			==See also==
			*[[Leukemia]].

			==References==
			{{Reflist\|1}}

	[[Category: Hematopathology]]		[[Category: Hematopathology]]

Mark: IHC not usually helpful other than to enumerate blasts

2018-05-26T20:10:21Z

IHC not usually helpful other than to enumerate blasts

← Older revision		Revision as of 20:10, 26 May 2018
Line 30:		Line 30:

	===IHC===		===IHC===
	~~Features:<ref>{{Cite journal \| last1 = Muñoz \| first1 = L~~. ~~\| last2 = Bellido \| first2 = M. \| last3 = Sierra \| first3 = J. \| last4 = Nomdedéu \| first4 = JF. \| title = Flow cytometric detection of B cell abnormal maturation in chronic~~ myeloid ~~leukemia. \| journal = Leukemia \| volume = 14 \| issue = 2 \| pages = 339-40 \| month = Feb \| year = 2000 \| doi = \| PMID = 10673756 \|URL = http://www.nature.com/leu/journal/v14/n2/full/2401549a~~.~~html }}</ref> (???)~~		Rarely required. CML may transform into a blast phase, typically myeloid blasts, but lymphoblasts may also be seen. These blasts are typically CD34 and/or CD117 positive. The myeloid blasts will express myeloid markers and the lymphoblasts will shows lymphoid markers.
	*Chronic:
	**CD20+ CD19+ CD10-.
	*Accelerated:
	**CD20+ CD19+ CD10+.
	*Blast:
	**CD20- CD19+ CD10+.
	**CD34~~+ TdT+.<ref>URL: [http:~~/~~/path~~.~~upmc~~.~~edu/cases/case271.html http://path.upmc.edu/cases/case271.html]. Accessed on: 14 January 2012.</ref>~~

	===Molecular===		===Molecular===

Mark: add to introduction

2018-05-26T16:53:29Z

add to introduction

← Older revision		Revision as of 16:53, 26 May 2018
Line 1:		Line 1:
	Chronic myeloid leukaemia (CML) is a type of [[myeloproliferative]] ~~neoplasm,~~ [[AKA]] ''chronic myelogenous leukemia''. It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome.		Chronic myeloid leukaemia (CML) is a type of [[myeloproliferative neoplasm,]] [[AKA]] ''chronic myelogenous leukemia''. It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome. It is a [[leukemia]] in that the fusion protein drives granulopoiesis (and less commonly megakaryopoiesis), resulting in marked peripheral blood leucocytosis.

	===General===		===General===

Mark: contents transferred from leukemia

2018-05-26T16:50:53Z

contents transferred from leukemia

← Older revision		Revision as of 16:50, 26 May 2018
Line 1:		Line 1:
	~~#redirect~~ [[~~Leukemia#Chronic_myeloid_leukemia~~]]		Chronic myeloid leukaemia (CML) is a type of [[myeloproliferative]] neoplasm, [[AKA]] ''chronic myelogenous leukemia''. It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome.

	[[Category:~~Diagnosis~~]]		===General===
			*Adults - usu. 50s or 60s.

			Clinical - commonly:<ref>{{Ref PCPBoD8\|336}}</ref>
			*Leukocytosis - neutrophils, myelocytes, metamyelocytes, +/-eosinophilia, +/-basophilia.

			Progression:
			#Chronic phase - potentially curable.
			#Accelerated phase.
			#Blast crisis.

			Treatment:
			*[[Imatinib]] and other [[tyrosine kinase inhibitors]]

			Notes:
			*Myeloblast (common granulocyte precursor) -> promyelocyte -> metamyelocyte -> myelocyte -> band -> mature myelocyte.<ref name=hemechart>URL: [http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png]. Accessed on: 14 January 2012.</ref>

			===Microscopic===
			Features:
			*Bone marrow with too many granulocytes/granulocyte precursors.
			**Granulocyte precursors:<ref name=hemechart>URL: [http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png]. Accessed on: 14 January 2012.</ref>
			**#Myeloblast (common granulocyte precursor) ~ 90% nucleus, multiple nucleoli.
			*#Should be less than 10%.
			**#Promyelocyte (committed to a specific linage ([[neutrophil]], basophil or [[eosinophil]])) - dia. 2x mature, 40-50% nucleus, one [[nucleolus]].
			**#Metamyelocyte - dia. 2x mature, 30-40% nucleus, no nucleolus.
			**#Myelocyte - dia. 1x mature, 50-60% nucleus - kidney bean shape, no nucleolus.
			**#Band - dia. 1x mature, 30-40% nucleus - C shape/irregular, no nucleolus.

			===IHC===
			Features:<ref>{{Cite journal \| last1 = Muñoz \| first1 = L. \| last2 = Bellido \| first2 = M. \| last3 = Sierra \| first3 = J. \| last4 = Nomdedéu \| first4 = JF. \| title = Flow cytometric detection of B cell abnormal maturation in chronic myeloid leukemia. \| journal = Leukemia \| volume = 14 \| issue = 2 \| pages = 339-40 \| month = Feb \| year = 2000 \| doi = \| PMID = 10673756 \|URL = http://www.nature.com/leu/journal/v14/n2/full/2401549a.html }}</ref> (???)
			*Chronic:
			**CD20+ CD19+ CD10-.
			*Accelerated:
			**CD20+ CD19+ CD10+.
			*Blast:
			**CD20- CD19+ CD10+.
			**CD34+ TdT+.<ref>URL: [http://path.upmc.edu/cases/case271.html http://path.upmc.edu/cases/case271.html]. Accessed on: 14 January 2012.</ref>

			===Molecular===
			*t(9;22) BCR-ABL - '''required for diagnosis'''.
			**May be found in other leukemias.

			[[Category: Hematopathology]]

Michael: redirect w/ diagnosis

2012-01-14T17:11:06Z

redirect w/ diagnosis

New page

#redirect [[Leukemia#Chronic_myeloid_leukemia]]

[[Category:Diagnosis]]