Chronic traumatic encephalopathy - Revision history

Jensflorian: CTE staging

2022-10-17T12:43:20Z

CTE staging

← Older revision		Revision as of 12:43, 17 October 2022
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	*Wall-to-wall neurofibrillary tangles.		*Wall-to-wall neurofibrillary tangles.
	**Common in olfactory bulb, mammillary bodies, hippocampus.		**Common in olfactory bulb, mammillary bodies, hippocampus.
	**Usually perivascular.		**Usually perivascular around small blood vessels.
	**Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci.		**Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci.
			*** But not restricted to superficial regions of sulci (also deep in parenchyma).
			**Staging according to Bienik et al.: NFT in <5 regions: low CTE, in 5 or more: high CTE.<ref>{{cite journal \|vauthors=Snijders RJ, De Courcy-Wheeler RH, Nicolaides KH \|title=Intrauterine growth retardation and fetal transverse cerebellar diameter \|journal=Prenat Diagn \|volume=14 \|issue=12 \|pages=1101–5 \|date=December 1994 \|pmid=7899277 \|doi=10.1002/pd.1970141202 \|url=}}</ref>

	==IHC==		==IHC==
	*Increased TDP-43 staining.		*Increased TDP-43 staining.
			*p-Tau neuronal aggregates.
			**+/. thron shaped-astrocytes.
			*Usu. absence of beta-amyloid.

	Note:		Note:

Michael: +image

2020-01-21T03:51:46Z

+image

← Older revision		Revision as of 03:51, 21 January 2020
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			[[Image:Chronic Traumatic Encephalopathy.png\|thumb\|right\|Gross images showing a brain with chronic traumatic encephalopathy (CTE) and a normal brain. (WC/BU)]]
	'''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases\|neurodegenerative disease]] due to repeated trauma.		'''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases\|neurodegenerative disease]] due to repeated trauma.

Michael: /* IHC */ gr.

2015-02-17T06:51:12Z

IHC: gr.

← Older revision		Revision as of 06:51, 17 February 2015
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	Note:		Note:
	*[[ALS]] associated with ~~trauma~~ brain injuries.<ref name=pmid21696410>{{Cite journal \| last1 = Costanza \| first1 = A. \| last2 = Weber \| first2 = K. \| last3 = Gandy \| first3 = S. \| last4 = Bouras \| first4 = C. \| last5 = Hof \| first5 = PR. \| last6 = Giannakopoulos \| first6 = P. \| last7 = Canuto \| first7 = A. \| title = Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. \| journal = Neuropathol Appl Neurobiol \| volume = 37 \| issue = 6 \| pages = 570-84 \| month = Oct \| year = 2011 \| doi = 10.1111/j.1365-2990.2011.01186.x \| PMID = 21696410 }}</ref>		*[[ALS]] associated with traumatic brain injuries.<ref name=pmid21696410>{{Cite journal \| last1 = Costanza \| first1 = A. \| last2 = Weber \| first2 = K. \| last3 = Gandy \| first3 = S. \| last4 = Bouras \| first4 = C. \| last5 = Hof \| first5 = PR. \| last6 = Giannakopoulos \| first6 = P. \| last7 = Canuto \| first7 = A. \| title = Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. \| journal = Neuropathol Appl Neurobiol \| volume = 37 \| issue = 6 \| pages = 570-84 \| month = Oct \| year = 2011 \| doi = 10.1111/j.1365-2990.2011.01186.x \| PMID = 21696410 }}</ref>

	==See also==		==See also==

Michael: re-order

2015-02-16T21:50:10Z

re-order

← Older revision		Revision as of 21:50, 16 February 2015
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	'''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases\|neurodegenerative disease]] due to repeated trauma.		'''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases\|neurodegenerative disease]] due to repeated trauma.

			The in the context of boxing it is known as '''dementia pugilistica'''; ''pugil'' is ''boxer'' in Latin.<ref>URL: [http://dictionary.reference.com/browse/pugilism http://dictionary.reference.com/browse/pugilism]. Accessed on: 21 November 2011.</ref>

	==General==		==General==
	*Due to head trauma - usually repetitive.		*Due to head trauma - usually repetitive.
	**Seen in ''American football'' and ''boxing''.		**Seen in ''American football'' and ''boxing''.
	***The in the context of boxing it is known as ''dementia pugilistica''; ''pugil'' is ''boxer'' in Latin.<ref>URL: [http://dictionary.reference.com/browse/pugilism http://dictionary.reference.com/browse/pugilism]. Accessed on: 21 November 2011.</ref>
	*May be associated with motor neuron disease.<ref name=pmid22050943>{{Cite journal \| last1 = Daneshvar \| first1 = DH. \| last2 = Riley \| first2 = DO. \| last3 = Nowinski \| first3 = CJ. \| last4 = McKee \| first4 = AC. \| last5 = Stern \| first5 = RA. \| last6 = Cantu \| first6 = RC. \| title = Long-term consequences: effects on normal development profile after concussion. \| journal = Phys Med Rehabil Clin N Am \| volume = 22 \| issue = 4 \| pages = 683-700 \| month = Nov \| year = 2011 \| doi = 10.1016/j.pmr.2011.08.009 \| PMID = 22050943 }}</ref>		*May be associated with motor neuron disease.<ref name=pmid22050943>{{Cite journal \| last1 = Daneshvar \| first1 = DH. \| last2 = Riley \| first2 = DO. \| last3 = Nowinski \| first3 = CJ. \| last4 = McKee \| first4 = AC. \| last5 = Stern \| first5 = RA. \| last6 = Cantu \| first6 = RC. \| title = Long-term consequences: effects on normal development profile after concussion. \| journal = Phys Med Rehabil Clin N Am \| volume = 22 \| issue = 4 \| pages = 683-700 \| month = Nov \| year = 2011 \| doi = 10.1016/j.pmr.2011.08.009 \| PMID = 22050943 }}</ref>

Michael: split out

2015-02-16T21:46:55Z

split out

← Older revision		Revision as of 21:46, 16 February 2015
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	~~#redirect~~ [[~~Neurodegenerative_diseases#Chronic_traumatic_encephalopathy~~]]		'''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases\|neurodegenerative disease]] due to repeated trauma.

			==General==
			*Due to head trauma - usually repetitive.
			**Seen in ''American football'' and ''boxing''.
			***The in the context of boxing it is known as ''dementia pugilistica''; ''pugil'' is ''boxer'' in Latin.<ref>URL: [http://dictionary.reference.com/browse/pugilism http://dictionary.reference.com/browse/pugilism]. Accessed on: 21 November 2011.</ref>
			*May be associated with motor neuron disease.<ref name=pmid22050943>{{Cite journal \| last1 = Daneshvar \| first1 = DH. \| last2 = Riley \| first2 = DO. \| last3 = Nowinski \| first3 = CJ. \| last4 = McKee \| first4 = AC. \| last5 = Stern \| first5 = RA. \| last6 = Cantu \| first6 = RC. \| title = Long-term consequences: effects on normal development profile after concussion. \| journal = Phys Med Rehabil Clin N Am \| volume = 22 \| issue = 4 \| pages = 683-700 \| month = Nov \| year = 2011 \| doi = 10.1016/j.pmr.2011.08.009 \| PMID = 22050943 }}</ref>

			==Microscopic==
			Features:<ref name=pmid22035690>{{Cite journal \| last1 = Stern \| first1 = RA. \| last2 = Riley \| first2 = DO. \| last3 = Daneshvar \| first3 = DH. \| last4 = Nowinski \| first4 = CJ. \| last5 = Cantu \| first5 = RC. \| last6 = McKee \| first6 = AC. \| title = Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy. \| journal = PM R \| volume = 3 \| issue = 10 Suppl 2 \| pages = S460-7 \| month = Oct \| year = 2011 \| doi = 10.1016/j.pmrj.2011.08.008 \| PMID = 22035690 }}</ref>
			*Wall-to-wall neurofibrillary tangles.
			**Common in olfactory bulb, mammillary bodies, hippocampus.
			**Usually perivascular.
			**Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci.

			==IHC==
			*Increased TDP-43 staining.

			Note:
			*[[ALS]] associated with trauma brain injuries.<ref name=pmid21696410>{{Cite journal \| last1 = Costanza \| first1 = A. \| last2 = Weber \| first2 = K. \| last3 = Gandy \| first3 = S. \| last4 = Bouras \| first4 = C. \| last5 = Hof \| first5 = PR. \| last6 = Giannakopoulos \| first6 = P. \| last7 = Canuto \| first7 = A. \| title = Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. \| journal = Neuropathol Appl Neurobiol \| volume = 37 \| issue = 6 \| pages = 570-84 \| month = Oct \| year = 2011 \| doi = 10.1111/j.1365-2990.2011.01186.x \| PMID = 21696410 }}</ref>

			==See also==
			*[[Neurodegenerative diseases]].
			*[[Neuropathology]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology]]

Michael: redirect

2011-11-21T22:08:36Z

redirect

New page

#redirect [[Neurodegenerative_diseases#Chronic_traumatic_encephalopathy]]

[[Category:Diagnosis]]