Clear cell papillary renal cell tumour - Revision history

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← Older revision		Revision as of 22:13, 22 May 2025
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	<pre>		<pre>
	A. Left Kidney Mass, Radical Nephrectomy:		A. Left Kidney Mass, Radical Nephrectomy:
	- CLEAR CELL PAPILLARY RENAL CELL TUMOUR, nucleolar grade 1 of 4, see comment.		- CLEAR CELL PAPILLARY RENAL CELL TUMOUR, nucleolar grade 1 of 4, see comment.
	-- Margins clear.		-- Margins clear.
	-- Please see synoptic report.		-- Please see synoptic report.
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	NEGATIVE: CD10, AMACR.		NEGATIVE: CD10, AMACR.

	The findings are in keeping with clear cell papillary renal cell tumour. These tumours were previously called "clear cell papillary renal cell carcinoma".		The findings are in keeping with clear cell papillary renal cell tumour. These tumours were previously called "clear cell papillary renal cell carcinoma".[1]

	These tumours have a highly favourable clinical behaviour.[1,2]		These tumours have a highly favourable clinical behaviour.[2,3]

	1. Am J Surg Pathol. 2015 Dec;39(12):1621-34. DOI: 10.1097/PAS.0000000000000513		1. Pathologica. 2022 Feb;115(1):8-22. doi: 10.32074/1591-951X-818. https://pmc.ncbi.nlm.nih.gov/articles/PMC10342217/
	2. Pathology. 2020 Nov 19;S0031-3025(20)30957-0. DOI: 10.1016/j.pathol.2020.10.002		2. Am J Surg Pathol. 2015 Dec;39(12):1621-34. DOI: 10.1097/PAS.0000000000000513
			3. Pathology. 2020 Nov 19;S0031-3025(20)30957-0. DOI: 10.1016/j.pathol.2020.10.002
	</pre>		</pre>

Michael: fix typo

2025-04-14T15:09:13Z

fix typo

← Older revision		Revision as of 15:09, 14 April 2025
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	<pre>		<pre>
	A. Left Kidney Mass, Radical Nephrectomy:		A. Left Kidney Mass, Radical Nephrectomy:
	- CLEAR CELL ~~PAPILARY~~ RENAL CELL TUMOUR, nucleolar grade 1 of 4, see comment.		- CLEAR CELL PAPILLARY RENAL CELL TUMOUR, nucleolar grade 1 of 4, see comment.
	-- Margins clear.		-- Margins clear.
	-- Please see synoptic report.		-- Please see synoptic report.

Michael: /* Biopsy */

2025-04-14T15:05:23Z

Biopsy

← Older revision		Revision as of 15:05, 14 April 2025
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	Diagnosing the this entity on biopsy should be done with caution as:		Diagnosing the this entity on biopsy should be done with caution as:
	*Overlaps are described between ''clear cell renal cell carcinoma'' and ''clear cell papillary renal cell tumour''.<ref name=pmid26752401>{{cite journal \|vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG \|title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution \|journal=Am J Surg Pathol \|volume=40 \|issue=2 \|pages=141–54 \|date=February 2016 \|pmid=26752401 \|doi=10.1097/PAS.0000000000000583 \|url=}}</ref>		*Overlaps are described between ''clear cell renal cell carcinoma'' and ''clear cell papillary renal cell tumour''.<ref name=pmid26752401>{{cite journal \|vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG \|title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution \|journal=Am J Surg Pathol \|volume=40 \|issue=2 \|pages=141–54 \|date=February 2016 \|pmid=26752401 \|doi=10.1097/PAS.0000000000000583 \|url=}}</ref>
	*''Clear cell papillary renal cell tumour'' may also be seen in conjunction with (other) renal cell ~~arcinoma~~(s).<ref name=pmid26857533>{{cite journal \|authors=Shao T, Yousef P, Shipilova I, Saleeb R, Lee JY, Krizova A \|title=Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature \|journal=Pathol Res Pract \|volume=212 \|issue=3 \|pages=229–33 \|date=March 2016 \|pmid=26857533 \|doi=10.1016/j.prp.2015.12.007 \|url=}}</ref>		*''Clear cell papillary renal cell tumour'' may also be seen in conjunction with (other) renal cell carcinoma(s).<ref name=pmid26857533>{{cite journal \|authors=Shao T, Yousef P, Shipilova I, Saleeb R, Lee JY, Krizova A \|title=Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature \|journal=Pathol Res Pract \|volume=212 \|issue=3 \|pages=229–33 \|date=March 2016 \|pmid=26857533 \|doi=10.1016/j.prp.2015.12.007 \|url=}}</ref>

	==See also==		==See also==

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2025-04-14T15:05:10Z

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← Older revision		Revision as of 15:05, 14 April 2025
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	===Biopsy===		===Biopsy===
	Diagnosing the this entity on biopsy should be done with caution as:		Diagnosing the this entity on biopsy should be done with caution as:
	*Overlaps are described between clear cell ~~RCC~~ and clear cell papillary renal cell tumour.<ref name=pmid26752401>{{cite journal \|vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG \|title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution \|journal=Am J Surg Pathol \|volume=40 \|issue=2 \|pages=141–54 \|date=February 2016 \|pmid=26752401 \|doi=10.1097/PAS.0000000000000583 \|url=}}</ref>		*Overlaps are described between ''clear cell renal cell carcinoma'' and ''clear cell papillary renal cell tumour''.<ref name=pmid26752401>{{cite journal \|vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG \|title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution \|journal=Am J Surg Pathol \|volume=40 \|issue=2 \|pages=141–54 \|date=February 2016 \|pmid=26752401 \|doi=10.1097/PAS.0000000000000583 \|url=}}</ref>
	*''Clear cell papillary renal cell tumour'' may also be seen in conjunction with ~~RCC~~.<ref name=pmid26857533>{{cite journal \|authors=Shao T, Yousef P, Shipilova I, Saleeb R, Lee JY, Krizova A \|title=Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature \|journal=Pathol Res Pract \|volume=212 \|issue=3 \|pages=229–33 \|date=March 2016 \|pmid=26857533 \|doi=10.1016/j.prp.2015.12.007 \|url=}}</ref>		*''Clear cell papillary renal cell tumour'' may also be seen in conjunction with (other) renal cell arcinoma(s).<ref name=pmid26857533>{{cite journal \|authors=Shao T, Yousef P, Shipilova I, Saleeb R, Lee JY, Krizova A \|title=Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature \|journal=Pathol Res Pract \|volume=212 \|issue=3 \|pages=229–33 \|date=March 2016 \|pmid=26857533 \|doi=10.1016/j.prp.2015.12.007 \|url=}}</ref>

	==See also==		==See also==

Michael: /* Biopsy */

2025-04-14T15:03:54Z

Biopsy

← Older revision		Revision as of 15:03, 14 April 2025
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	===Biopsy===		===Biopsy===
	Overlaps are described between clear cell RCC and clear cell papillary renal cell tumour.<ref name=pmid26752401>{{cite journal \|vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG \|title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution \|journal=Am J Surg Pathol \|volume=40 \|issue=2 \|pages=141–54 \|date=February 2016 \|pmid=26752401 \|doi=10.1097/PAS.0000000000000583 \|url=}}</ref> ''Clear cell papillary renal cell tumour'' may also be seen in conjunction with ~~other types of~~ RCC.<ref name=pmid26857533>{{cite journal \|authors=Shao T, Yousef P, Shipilova I, Saleeb R, Lee JY, Krizova A \|title=Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature \|journal=Pathol Res Pract \|volume=212 \|issue=3 \|pages=229–33 \|date=March 2016 \|pmid=26857533 \|doi=10.1016/j.prp.2015.12.007 \|url=}}</ref>		Diagnosing the this entity on biopsy should be done with caution as:
			*Overlaps are described between clear cell RCC and clear cell papillary renal cell tumour.<ref name=pmid26752401>{{cite journal \|vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG \|title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution \|journal=Am J Surg Pathol \|volume=40 \|issue=2 \|pages=141–54 \|date=February 2016 \|pmid=26752401 \|doi=10.1097/PAS.0000000000000583 \|url=}}</ref>
			*''Clear cell papillary renal cell tumour'' may also be seen in conjunction with RCC.<ref name=pmid26857533>{{cite journal \|authors=Shao T, Yousef P, Shipilova I, Saleeb R, Lee JY, Krizova A \|title=Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature \|journal=Pathol Res Pract \|volume=212 \|issue=3 \|pages=229–33 \|date=March 2016 \|pmid=26857533 \|doi=10.1016/j.prp.2015.12.007 \|url=}}</ref>

	==See also==		==See also==

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2025-04-14T15:02:31Z

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← Older revision		Revision as of 15:02, 14 April 2025
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	<pre>		<pre>
	Left Kidney Mass, ~~Core Biopsy~~:		A. Left Kidney Mass, Radical Nephrectomy:
	- CLEAR CELL PAPILARY RENAL CELL TUMOUR, ~~preliminary ISUP~~ nucleolar grade 1 of 4, see comment.		- CLEAR CELL PAPILARY RENAL CELL TUMOUR, nucleolar grade 1 of 4, see comment.
			-- Margins clear.
			-- Please see synoptic report.

	Comment:		Comment:
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	The tumour stains as follows:		The tumour stains as follows:
	POSITIVE: PAX8 (diffuse), CK7 (strong, diffuse), ~~CK34betaE12~~ (strong, diffuse), ~~vimentin~~ (diffuse~~, strong~~), ~~EMA~~ (moderate, diffuse).		POSITIVE: PAX8 (strong, diffuse), CK7 (strong, diffuse), MA903 (strong, diffuse), CAIX (moderate, patchy cup-like), AE1/AE3 (moderate, diffuse), GATA3 (moderate, diffuse).
	NEGATIVE: CD10.		NEGATIVE: CD10, AMACR.

	~~The findings are in keeping with clear cell tubulopapillary renal cell tumour. These tumours were previously called "clear cell papillary renal cell carcinoma"~~.

			The findings are in keeping with clear cell papillary renal cell tumour. These tumours were previously called "clear cell papillary renal cell carcinoma".

	These tumours have a highly favourable clinical behaviour.[1,2]		These tumours have a highly favourable clinical behaviour.[1,2]
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	2. Pathology. 2020 Nov 19;S0031-3025(20)30957-0. DOI: 10.1016/j.pathol.2020.10.002		2. Pathology. 2020 Nov 19;S0031-3025(20)30957-0. DOI: 10.1016/j.pathol.2020.10.002
	</pre>		</pre>

			===Biopsy===
			Overlaps are described between clear cell RCC and clear cell papillary renal cell tumour.<ref name=pmid26752401>{{cite journal \|vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG \|title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution \|journal=Am J Surg Pathol \|volume=40 \|issue=2 \|pages=141–54 \|date=February 2016 \|pmid=26752401 \|doi=10.1097/PAS.0000000000000583 \|url=}}</ref> ''Clear cell papillary renal cell tumour'' may also be seen in conjunction with other types of RCC.<ref name=pmid26857533>{{cite journal \|authors=Shao T, Yousef P, Shipilova I, Saleeb R, Lee JY, Krizova A \|title=Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature \|journal=Pathol Res Pract \|volume=212 \|issue=3 \|pages=229–33 \|date=March 2016 \|pmid=26857533 \|doi=10.1016/j.prp.2015.12.007 \|url=}}</ref>

	==See also==		==See also==

Michael at 02:55, 20 March 2024

2024-03-20T02:55:45Z

← Older revision		Revision as of 02:55, 20 March 2024
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	</ref> seen in [[clear cell renal cell carcinoma]].		</ref> seen in [[clear cell renal cell carcinoma]].
	*Good prognosis.		*Good prognosis.
	**On the basis of 268 cases: it has ~~been~~ suggested that ''clear cell papillary renal cell carcinoma'' be renamed ''clear cell papillary neoplasm of low malignant potential''.<ref name=pmid26426379>{{Cite journal \| last1 = Diolombi \| first1 = ML. \| last2 = Cheng \| first2 = L. \| last3 = Argani \| first3 = P. \| last4 = Epstein \| first4 = JI. \| title = Do Clear Cell Papillary Renal Cell Carcinomas Have Malignant Potential? \| journal = Am J Surg Pathol \| volume = 39 \| issue = 12 \| pages = 1621-34 \| month = Dec \| year = 2015 \| doi = 10.1097/PAS.0000000000000513 \| PMID = 26426379 }}</ref>		*Previously classified as ''carcinoma''.
	**The name ''clear cell papillary (cyst)adenoma'' ~~has~~ also ~~been~~ proposed.<ref name=pmid33223139>{{cite journal \|authors=Williamson SR \|title=Clear cell papillary renal cell carcinoma: an update after 15 years \|journal=Pathology \|volume=53 \|issue=1 \|pages=109–119 \|date=January 2021 \|pmid=33223139 \|doi=10.1016/j.pathol.2020.10.002 \|url=}}</ref>		**On the basis of 268 cases: it has was suggested that ''clear cell papillary renal cell carcinoma'' be renamed ''clear cell papillary neoplasm of low malignant potential''.<ref name=pmid26426379>{{Cite journal \| last1 = Diolombi \| first1 = ML. \| last2 = Cheng \| first2 = L. \| last3 = Argani \| first3 = P. \| last4 = Epstein \| first4 = JI. \| title = Do Clear Cell Papillary Renal Cell Carcinomas Have Malignant Potential? \| journal = Am J Surg Pathol \| volume = 39 \| issue = 12 \| pages = 1621-34 \| month = Dec \| year = 2015 \| doi = 10.1097/PAS.0000000000000513 \| PMID = 26426379 }}</ref>
	*~~Fourth~~ most common type ~~of RCC is a recent series~~.<ref name=pmid24182559>{{Cite journal \| last1 = Zhou \| first1 = H. \| last2 = Zheng \| first2 = S. \| last3 = Truong \| first3 = LD. \| last4 = Ro \| first4 = JY. \| last5 = Ayala \| first5 = AG. \| last6 = Shen \| first6 = SS. \| title = Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma. \| journal = Hum Pathol \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.humpath.2013.08.004 \| PMID = 24182559 }}</ref>		**The name ''clear cell papillary (cyst)adenoma'' was also proposed.<ref name=pmid33223139>{{cite journal \|authors=Williamson SR \|title=Clear cell papillary renal cell carcinoma: an update after 15 years \|journal=Pathology \|volume=53 \|issue=1 \|pages=109–119 \|date=January 2021 \|pmid=33223139 \|doi=10.1016/j.pathol.2020.10.002 \|url=}}</ref>
			*Relatively common - if one considers it a RCC: it is the fourth most common type.<ref name=pmid24182559>{{Cite journal \| last1 = Zhou \| first1 = H. \| last2 = Zheng \| first2 = S. \| last3 = Truong \| first3 = LD. \| last4 = Ro \| first4 = JY. \| last5 = Ayala \| first5 = AG. \| last6 = Shen \| first6 = SS. \| title = Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma. \| journal = Hum Pathol \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.humpath.2013.08.004 \| PMID = 24182559 }}</ref>
	**Most common (in order): [[clear cell RCC]], [[papillary RCC]], [[chromophobe RCC]], clear cell papillary RCC.		**Most common (in order): [[clear cell RCC]], [[papillary RCC]], [[chromophobe RCC]], clear cell papillary RCC.

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2024-01-26T14:16:36Z

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← Older revision		Revision as of 14:16, 26 January 2024
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	NEGATIVE: CD10.		NEGATIVE: CD10.

	The findings are in keeping with clear cell tubulopapillary renal cell tumour.		The findings are in keeping with clear cell tubulopapillary renal cell tumour. These tumours were previously called "clear cell papillary renal cell carcinoma".


	These tumours have a highly favourable clinical behaviour.[1,2]		These tumours have a highly favourable clinical behaviour.[1,2]

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2022-10-11T22:20:23Z

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← Older revision		Revision as of 22:20, 11 October 2022
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	<pre>		<pre>
	Left Kidney Mass, Core Biopsy:		Left Kidney Mass, Core Biopsy:
	- CLEAR CELL PAPILARY RENAL CELL TUMOUR, preliminary ISUP nucleolar		- CLEAR CELL PAPILARY RENAL CELL TUMOUR, preliminary ISUP nucleolar grade 1 of 4, see comment.
	grade 1 of 4, see comment.

	Comment:		Comment:

← Older revision		Revision as of 22:20, 11 October 2022
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	*[[Kidney tumours]].		*[[Kidney tumours]].
	*[[Tubulocystic carcinoma of the kidney]].		*[[Tubulocystic carcinoma of the kidney]].
	*[[~~TCEB1~~-mutated renal cell carcinoma]].		*[[ELOC-mutated renal cell carcinoma]].

	==References==		==References==