Clear cell sugar tumour of the lung - Revision history

Michael: vauthors

2021-03-25T17:21:11Z

vauthors

← Older revision		Revision as of 17:21, 25 March 2021
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	==Molecular==		==Molecular==
	*TFE3 gene rearrangements - present in subset of cases.		*TFE3 gene rearrangements - present in subset of cases.
	**Typically younger patients.<ref name=pmid20871214>{{cite journal \|~~vauthors~~=Argani P, Aulmann S, Illei PB, Netto GJ, Ro J, Cho HY, Dogan S, Ladanyi M, Martignoni G, Goldblum JR, Weiss SW \|title=A distinctive subset of PEComas harbors TFE3 gene fusions \|journal=Am J Surg Pathol \|volume=34 \|issue=10 \|pages=1395–406 \|date=October 2010 \|pmid=20871214 \|doi=10.1097/PAS.0b013e3181f17ac0 \|url=}}</ref>		**Typically younger patients.<ref name=pmid20871214>{{cite journal \|authors=Argani P, Aulmann S, Illei PB, Netto GJ, Ro J, Cho HY, Dogan S, Ladanyi M, Martignoni G, Goldblum JR, Weiss SW \|title=A distinctive subset of PEComas harbors TFE3 gene fusions \|journal=Am J Surg Pathol \|volume=34 \|issue=10 \|pages=1395–406 \|date=October 2010 \|pmid=20871214 \|doi=10.1097/PAS.0b013e3181f17ac0 \|url=}}</ref>
	**Epithelioid morphology.<ref name=pmid20871214/>		**Epithelioid morphology.<ref name=pmid20871214/>
	**Minimal staining with muscle markers.<ref name=pmid20871214/>		**Minimal staining with muscle markers.<ref name=pmid20871214/>

Michael: more

2020-12-31T15:22:12Z

← Older revision		Revision as of 15:22, 31 December 2020
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	==Molecular==		==Molecular==
	*TFE3 gene ~~fusions~~ - subset of cases.<ref name=pmid20871214>{{cite journal \|vauthors=Argani P, Aulmann S, Illei PB, Netto GJ, Ro J, Cho HY, Dogan S, Ladanyi M, Martignoni G, Goldblum JR, Weiss SW \|title=A distinctive subset of PEComas harbors TFE3 gene fusions \|journal=Am J Surg Pathol \|volume=34 \|issue=10 \|pages=1395–406 \|date=October 2010 \|pmid=20871214 \|doi=10.1097/PAS.0b013e3181f17ac0 \|url=}}</ref>		*TFE3 gene rearrangements - present in subset of cases.
			**Typically younger patients.<ref name=pmid20871214>{{cite journal \|vauthors=Argani P, Aulmann S, Illei PB, Netto GJ, Ro J, Cho HY, Dogan S, Ladanyi M, Martignoni G, Goldblum JR, Weiss SW \|title=A distinctive subset of PEComas harbors TFE3 gene fusions \|journal=Am J Surg Pathol \|volume=34 \|issue=10 \|pages=1395–406 \|date=October 2010 \|pmid=20871214 \|doi=10.1097/PAS.0b013e3181f17ac0 \|url=}}</ref>
			**Epithelioid morphology.<ref name=pmid20871214/>
			**Minimal staining with muscle markers.<ref name=pmid20871214/>

	==See also==		==See also==

Michael: /* IHC */

2020-12-31T15:18:06Z

IHC

← Older revision		Revision as of 15:18, 31 December 2020
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	*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170404452 Clear cell sugar tumour of the lung (surgicalpathologyatlas.com)].		*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170404452 Clear cell sugar tumour of the lung (surgicalpathologyatlas.com)].
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/figure/F3/ CCST (nih.gov)].<ref name=pmid19119463/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/figure/F3/ CCST (nih.gov)].<ref name=pmid19119463/>

			==stains==
			*[[PAS]] +ve.<ref name=pmid29276673>{{cite journal \|authors=Tsilimigras DI, Bakopoulos A, Ntanasis-Stathopoulos I, Gavriatopoulou M, Moris D, Karaolanis G, Spartalis E, Vagios S, Kalfa M, Salla C, Avgerinos DV \|title=Clear cell "sugar tumor" of the lung: Diagnostic features of a rare pulmonary tumor \|journal=Respir Med Case Rep \|volume=23 \|issue= \|pages=52–54 \|date=2018 \|pmid=29276673 \|pmc=5734796 \|doi=10.1016/j.rmcr.2017.12.001 \|url=}}</ref>

	==IHC==		==IHC==
	*HMB-45 +ve (nuclear & cytoplasmic).		*HMB-45 +ve (nuclear & cytoplasmic).

			==Molecular==
			*TFE3 gene fusions - subset of cases.<ref name=pmid20871214>{{cite journal \|vauthors=Argani P, Aulmann S, Illei PB, Netto GJ, Ro J, Cho HY, Dogan S, Ladanyi M, Martignoni G, Goldblum JR, Weiss SW \|title=A distinctive subset of PEComas harbors TFE3 gene fusions \|journal=Am J Surg Pathol \|volume=34 \|issue=10 \|pages=1395–406 \|date=October 2010 \|pmid=20871214 \|doi=10.1097/PAS.0b013e3181f17ac0 \|url=}}</ref>

	==See also==		==See also==

Michael: /* General */

2020-12-31T15:16:30Z

General

← Older revision		Revision as of 15:16, 31 December 2020
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	*A [[PEComa]].		*A [[PEComa]].
	*Benign.<ref name=pmid19119463>{{Cite journal \| last1 = Kim \| first1 = WJ. \| last2 = Kim \| first2 = SR. \| last3 = Choe \| first3 = YH. \| last4 = Lee \| first4 = KY. \| last5 = Park \| first5 = SJ. \| last6 = Lee \| first6 = HB. \| last7 = Chung \| first7 = MJ. \| last8 = Jin \| first8 = GY. \| last9 = Lee \| first9 = YC. \| title = Clear cell "sugar" tumor of the lung: a well-enhanced mass with an early washout pattern on dynamic contrast-enhanced computed tomography. \| journal = J Korean Med Sci \| volume = 23 \| issue = 6 \| pages = 1121-4 \| month = Dec \| year = 2008 \| doi = 10.3346/jkms.2008.23.6.1121 \| PMID = 19119463 \| PMC = 2610653 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/?tool=pubmed }}</ref>		*Benign.<ref name=pmid19119463>{{Cite journal \| last1 = Kim \| first1 = WJ. \| last2 = Kim \| first2 = SR. \| last3 = Choe \| first3 = YH. \| last4 = Lee \| first4 = KY. \| last5 = Park \| first5 = SJ. \| last6 = Lee \| first6 = HB. \| last7 = Chung \| first7 = MJ. \| last8 = Jin \| first8 = GY. \| last9 = Lee \| first9 = YC. \| title = Clear cell "sugar" tumor of the lung: a well-enhanced mass with an early washout pattern on dynamic contrast-enhanced computed tomography. \| journal = J Korean Med Sci \| volume = 23 \| issue = 6 \| pages = 1121-4 \| month = Dec \| year = 2008 \| doi = 10.3346/jkms.2008.23.6.1121 \| PMID = 19119463 \| PMC = 2610653 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/?tool=pubmed }}</ref>
			*The ''sugar'' part in the name ''clear cell sugar tumour'' comes from the presence of glycogen; the tumour is [[PAS]] positive.<ref name=pmid29276673>{{cite journal \|authors=Tsilimigras DI, Bakopoulos A, Ntanasis-Stathopoulos I, Gavriatopoulou M, Moris D, Karaolanis G, Spartalis E, Vagios S, Kalfa M, Salla C, Avgerinos DV \|title=Clear cell "sugar tumor" of the lung: Diagnostic features of a rare pulmonary tumor \|journal=Respir Med Case Rep \|volume=23 \|issue= \|pages=52–54 \|date=2018 \|pmid=29276673 \|pmc=5734796 \|doi=10.1016/j.rmcr.2017.12.001 \|url=}}</ref>

	==Microscopic==		==Microscopic==

Michael: tweak

2017-10-23T18:07:41Z

tweak

← Older revision		Revision as of 18:07, 23 October 2017
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	'''Clear cell sugar tumour of the lung''' is a very rare [[lung tumour]].		'''Clear cell sugar tumour of the lung''' is a very rare benign [[lung tumour]].

	==General==		==General==
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	*Irregular epithelioid cells with:		*Irregular epithelioid cells with:
	**Focally clear cytoplasm.		**Focally clear cytoplasm.

			DDx:
			*[[Clear cell tumours]].

	===Images===		===Images===

Michael: split out

2017-10-23T18:05:56Z

split out

← Older revision		Revision as of 18:05, 23 October 2017
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	~~#redirect~~ [[~~Lung_tumours#Clear_cell_sugar_tumour_of_the_lung~~]]		'''Clear cell sugar tumour of the lung''' is a very rare [[lung tumour]].

			==General==
			*A [[PEComa]].
			*Benign.<ref name=pmid19119463>{{Cite journal \| last1 = Kim \| first1 = WJ. \| last2 = Kim \| first2 = SR. \| last3 = Choe \| first3 = YH. \| last4 = Lee \| first4 = KY. \| last5 = Park \| first5 = SJ. \| last6 = Lee \| first6 = HB. \| last7 = Chung \| first7 = MJ. \| last8 = Jin \| first8 = GY. \| last9 = Lee \| first9 = YC. \| title = Clear cell "sugar" tumor of the lung: a well-enhanced mass with an early washout pattern on dynamic contrast-enhanced computed tomography. \| journal = J Korean Med Sci \| volume = 23 \| issue = 6 \| pages = 1121-4 \| month = Dec \| year = 2008 \| doi = 10.3346/jkms.2008.23.6.1121 \| PMID = 19119463 \| PMC = 2610653 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/?tool=pubmed }}</ref>

			==Microscopic==
			Features:<ref name=pmid19119463/>
			*Sheets or trabeculae.
			*Irregular epithelioid cells with:
			**Focally clear cytoplasm.

			===Images===
			*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170404452 Clear cell sugar tumour of the lung (surgicalpathologyatlas.com)].
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/figure/F3/ CCST (nih.gov)].<ref name=pmid19119463/>

			==IHC==
			*HMB-45 +ve (nuclear & cytoplasmic).

			==See also==
			*[[Lung tumours]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect w/ cat.

2012-01-29T18:48:48Z

redirect w/ cat.

New page

#redirect [[Lung_tumours#Clear_cell_sugar_tumour_of_the_lung]]

[[Category:Diagnosis]]