Collagenous spherulosis - Revision history

Michael: tweak

2014-02-16T20:56:44Z

tweak

← Older revision		Revision as of 20:56, 16 February 2014
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	Note:		Note:
	* ‡ The opposite pattern is seen in ''adenoid cystic carcinoma''.		* ‡ The opposite pattern is seen in ''adenoid cystic carcinoma''.



	==See also==		==See also==
	*[[Breast pathology]].		*[[Breast pathology]].
			*[[Adenoid cystic carcinoma]].

	==References==		==References==

Michael: more

2014-02-16T20:55:42Z

← Older revision		Revision as of 20:55, 16 February 2014
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	\| LMDDx = [[atypical ductal hyperplasia]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast]]		\| LMDDx = [[atypical ductal hyperplasia]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = CD10 +ve, ER +ve, PR +ve, p63 +ve, SMA +ve, CD117 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	www:		www:
	*[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)].		*[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)].

			==IHC==
			Features:<ref name=pmid22658481>{{Cite journal \| last1 = Cabibi \| first1 = D. \| last2 = Giannone \| first2 = AG. \| last3 = Belmonte \| first3 = B. \| last4 = Aragona \| first4 = F. \| last5 = Aragona \| first5 = F. \| title = CD10 and HHF35 actin in the differential diagnosis between Collagenous spherulosis and adenoid-cystic carcinoma of the breast. \| journal = Pathol Res Pract \| volume = 208 \| issue = 7 \| pages = 405-9 \| month = Jul \| year = 2012 \| doi = 10.1016/j.prp.2012.05.002 \| PMID = 22658481 }}</ref>
			*CD10 +ve. ‡
			*Muscle-specific actin +ve. ‡
			*ER +ve. ‡
			*PR +ve. ‡
			*CD117 -ve. ‡

			Others:<ref name=pmid22658481/>
			*SMA +ve.
			*p63 +ve.
			*CK 5/6 +ve.

			Note:
			* ‡ The opposite pattern is seen in ''adenoid cystic carcinoma''.



	==See also==		==See also==

Michael: +infobox

2014-02-16T20:49:02Z

+infobox

← Older revision		Revision as of 20:49, 16 February 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Collagenous_spherulosis_-_very_high_mag.jpg
			\| Width =
			\| Caption = Collagenous spherulosis. [[H&E stain]].
			\| Synonyms = mucinous spherulosis, spherulosis
			\| Micro = tubular/cribriform architecture with intratubular eosinophilic material (classical arranged like the spokes of a wheel ("radial spikes"), granules ~ 1-2 micrometers),
			no mitotic activity, epithelial & myoepithelial - like benign breast
			\| Subtypes =
			\| LMDDx = [[atypical ductal hyperplasia]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[breast]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms = usu. asymptomatic
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx = none required, usu. incidental finding
			}}
	'''Collagenous spherulosis''' is a benign change of the [[breast]] that can be confused for a malignancy.		'''Collagenous spherulosis''' is a benign change of the [[breast]] that can be confused for a malignancy.

Michael: /* Gross */

2014-02-16T20:43:45Z

Gross

← Older revision		Revision as of 20:43, 16 February 2014
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	==Gross==		==Gross==
	*Usually small.		*Usually small, typically 1-3 mm.<ref name=pmid16330938/>

	Note:		Note:

Michael: /* General */

2014-02-16T20:42:27Z

General

← Older revision		Revision as of 20:42, 16 February 2014
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	==General==		==General==
	*Benign.		*Benign.
	*Usually an incidental (microscopic) finding.<ref name=pmid12523815/>		*Usually an incidental (microscopic) finding.<ref name=pmid12523815>{{Cite journal \| last1 = Jan \| first1 = YJ. \| last2 = Li \| first2 = MC. \| last3 = Ho \| first3 = WL. \| title = Collagenous spherulosis presenting as a mass of the breast. \| journal = Zhonghua Yi Xue Za Zhi (Taipei) \| volume = 65 \| issue = 10 \| pages = 494-7 \| month = Oct \| year = 2002 \| doi = \| PMID = 12523815 }}</ref>
	*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast\|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal \| last1 = Resetkova \| first1 = E. \| last2 = Albarracin \| first2 = C. \| last3 = Sneige \| first3 = N. \| title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. \| journal = Am J Surg Pathol \| volume = 30 \| issue = 1 \| pages = 20-7 \| month = Jan \| year = 2006 \| doi = \| PMID = 16330938 }}</ref>		*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast\|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal \| last1 = Resetkova \| first1 = E. \| last2 = Albarracin \| first2 = C. \| last3 = Sneige \| first3 = N. \| title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. \| journal = Am J Surg Pathol \| volume = 30 \| issue = 1 \| pages = 20-7 \| month = Jan \| year = 2006 \| doi = \| PMID = 16330938 }}</ref>
	**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/>		**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/>

Michael at 20:41, 16 February 2014

2014-02-16T20:41:32Z

← Older revision		Revision as of 20:41, 16 February 2014
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	==General==		==General==
	*Benign.		*Benign.
	*~~Almost always~~ an incidental finding.		*Usually an incidental (microscopic) finding.<ref name=pmid12523815/>
	*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast\|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal \| last1 = Resetkova \| first1 = E. \| last2 = Albarracin \| first2 = C. \| last3 = Sneige \| first3 = N. \| title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. \| journal = Am J Surg Pathol \| volume = 30 \| issue = 1 \| pages = 20-7 \| month = Jan \| year = 2006 \| doi = \| PMID = 16330938 }}</ref>		*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast\|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal \| last1 = Resetkova \| first1 = E. \| last2 = Albarracin \| first2 = C. \| last3 = Sneige \| first3 = N. \| title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. \| journal = Am J Surg Pathol \| volume = 30 \| issue = 1 \| pages = 20-7 \| month = Jan \| year = 2006 \| doi = \| PMID = 16330938 }}</ref>
	**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/>		**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/>

			==Gross==
			*Usually small.

			Note:
			*May present as a larger mass.<ref name=pmid18476887>{{Cite journal \| last1 = Hill \| first1 = P. \| last2 = Cawson \| first2 = J. \| title = Collagenous spherulosis presenting as a mass lesion on imaging. \| journal = Breast J \| volume = 14 \| issue = 3 \| pages = 301-3 \| month = \| year = \| doi = 10.1111/j.1524-4741.2008.00580.x \| PMID = 18476887 }}</ref><ref>{{Cite journal \| last1 = Jan \| first1 = YJ. \| last2 = Li \| first2 = MC. \| last3 = Ho \| first3 = WL. \| title = Collagenous spherulosis presenting as a mass of the breast. \| journal = Zhonghua Yi Xue Za Zhi (Taipei) \| volume = 65 \| issue = 10 \| pages = 494-7 \| month = Oct \| year = 2002 \| doi = \| PMID = 12523815 }}</ref>

	==Microscopic==		==Microscopic==

Michael: split out

2014-02-16T20:35:24Z

split out

← Older revision		Revision as of 20:35, 16 February 2014
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	~~#redirect~~ [[~~Breast_pathology#Collagenous_spherulosis~~]]		'''Collagenous spherulosis''' is a benign change of the [[breast]] that can be confused for a malignancy.

			It is also known as '''mucinous spherulosis''', and '''spherulosis'''.<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref>

			==General==
			*Benign.
			*Almost always an incidental finding.
			*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast\|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal \| last1 = Resetkova \| first1 = E. \| last2 = Albarracin \| first2 = C. \| last3 = Sneige \| first3 = N. \| title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. \| journal = Am J Surg Pathol \| volume = 30 \| issue = 1 \| pages = 20-7 \| month = Jan \| year = 2006 \| doi = \| PMID = 16330938 }}</ref>
			**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/>

			==Microscopic==
			Features:<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref><ref>URL: [http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm]. Accessed on: 31 August 2011.</ref>
			*Tubular/cribriform architecture.
			*Intratubular eosinophilic material - '''key feature'''.
			**Classical: Arranged like the spokes of a wheel ("radial spikes").
			**Atypical: Granules ~ 1-2 micrometers.
			*No mitotic activity.
			*Two cells populations (epithelial & myoepithelial) - like a well-behaved breast gland.

			Notes:
			*Usually small lesions: < 50 spherules per lesion, <100 micrometers.
			*May be multifocal.
			*+/-Calcifications - may prompt biopsy.

			DDx:
			*[[Atypical ductal hyperplasia]].
			*[[Cribriform DCIS]].
			*[[Adenoid cystic carcinoma of the breast]].

			===Images===
			<gallery>
			Image:Collagenous_spherulosis_-_intermed_mag.jpg \| Collagenous spherulosis - intermed. mag. (WC/Nephron)
			Image:Collagenous_spherulosis_-_high_mag.jpg \| Collagenous spherulosis - high mag. (WC/Nephron)
			Image:Collagenous_spherulosis_-_very_high_mag.jpg \| Collagenous spherulosis - very high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)].

			==See also==
			*[[Breast pathology]].

			==References==
			{{Reflist\|2}}

			[[Category:Diagnosis]]
			[[Category:Breast pathology]]

Michael: redirect

2011-09-01T02:21:13Z

redirect

New page

#redirect [[Breast_pathology#Collagenous_spherulosis]]