Complex sclerosing lesion - Revision history

Michael: /* IHC */

2022-01-31T21:16:54Z

IHC

← Older revision		Revision as of 21:16, 31 January 2022
Line 79:		Line 79:
	Note:		Note:
	*HMWK +ve/-ve. (???)		*HMWK +ve/-ve. (???)

			==Sign out==
			<pre>
			Right Breast, Partial Mastectomy:
			- Complex sclerosing lesion / radial scar.
			- Background breast with proliferative fibrocystic changes and apocrine metaplasia.
			- NEGATIVE for malignancy.
			</pre>

	==See also==		==See also==

Michael: /* General */

2017-01-01T18:20:46Z

General

← Older revision		Revision as of 18:20, 1 January 2017
Line 39:		Line 39:
	*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>		*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>
	*Management - usually surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>		*Management - usually surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>
	**Risk of malignancy for biopsy diagnosed CSLs ~~on excision~~ very small ~1%.<ref name=pmid26772402>{{Cite journal \| last1 = Li \| first1 = Z. \| last2 = Ranade \| first2 = A. \| last3 = Zhao \| first3 = C. \| title = Pathologic findings of follow-up surgical excision for radial scar on breast core needle biopsy. \| journal = Hum Pathol \| volume = 48 \| issue = \| pages = 76-80 \| month = Feb \| year = 2016 \| doi = 10.1016/j.humpath.2015.06.028 \| PMID = 26772402 }}</ref>		**Risk of malignancy on surgical excision for biopsy diagnosed CSLs very small ~1%.<ref name=pmid26772402>{{Cite journal \| last1 = Li \| first1 = Z. \| last2 = Ranade \| first2 = A. \| last3 = Zhao \| first3 = C. \| title = Pathologic findings of follow-up surgical excision for radial scar on breast core needle biopsy. \| journal = Hum Pathol \| volume = 48 \| issue = \| pages = 76-80 \| month = Feb \| year = 2016 \| doi = 10.1016/j.humpath.2015.06.028 \| PMID = 26772402 }}</ref>
	*Rare - less than 0.1% of core needle biopsies.<ref name=pmid25578683>{{Cite journal \| last1 = Nassar \| first1 = A. \| last2 = Conners \| first2 = AL. \| last3 = Celik \| first3 = B. \| last4 = Jenkins \| first4 = SM. \| last5 = Smith \| first5 = CY. \| last6 = Hieken \| first6 = TJ. \| title = Radial scar/complex sclerosing lesions: a clinicopathologic correlation study from a single institution. \| journal = Ann Diagn Pathol \| volume = 19 \| issue = 1 \| pages = 24-8 \| month = Feb \| year = 2015 \| doi = 10.1016/j.anndiagpath.2014.12.003 \| PMID = 25578683 }}</ref>		*Rare - less than 0.1% of core needle biopsies.<ref name=pmid25578683>{{Cite journal \| last1 = Nassar \| first1 = A. \| last2 = Conners \| first2 = AL. \| last3 = Celik \| first3 = B. \| last4 = Jenkins \| first4 = SM. \| last5 = Smith \| first5 = CY. \| last6 = Hieken \| first6 = TJ. \| title = Radial scar/complex sclerosing lesions: a clinicopathologic correlation study from a single institution. \| journal = Ann Diagn Pathol \| volume = 19 \| issue = 1 \| pages = 24-8 \| month = Feb \| year = 2015 \| doi = 10.1016/j.anndiagpath.2014.12.003 \| PMID = 25578683 }}</ref>

Michael: /* General */

2017-01-01T18:19:53Z

General

← Older revision		Revision as of 18:19, 1 January 2017
Line 36:		Line 36:
	*The term ''radial scar'' is a misnomer. It isn't a ''scar''. It isn't associated with prior trauma or surgery.<ref name=Ref_PBoD8_1072>{{Ref PBoD8\|1072}}</ref>		*The term ''radial scar'' is a misnomer. It isn't a ''scar''. It isn't associated with prior trauma or surgery.<ref name=Ref_PBoD8_1072>{{Ref PBoD8\|1072}}</ref>
	*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal \|author=Ung OA, Lee WB, Greenberg ML, Bilous M \|title=Complex sclerosing lesion: the lesion is complex, the management is straightforward \|journal=ANZ J Surg \|volume=71 \|issue=1 \|pages=35–40 \|year=2001 \|month=January \|pmid=11167596 \|doi= \|url=}}</ref>		*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal \|author=Ung OA, Lee WB, Greenberg ML, Bilous M \|title=Complex sclerosing lesion: the lesion is complex, the management is straightforward \|journal=ANZ J Surg \|volume=71 \|issue=1 \|pages=35–40 \|year=2001 \|month=January \|pmid=11167596 \|doi= \|url=}}</ref>
			**Typically [[BI-RADS]] 4 - but may be BI-RADS 5.<ref name=pmid24936496>{{Cite journal \| last1 = Myong \| first1 = JH. \| last2 = Choi \| first2 = BG. \| last3 = Kim \| first3 = SH. \| last4 = Kang \| first4 = BJ. \| last5 = Lee \| first5 = A. \| last6 = Song \| first6 = BJ. \| title = Imaging features of complex sclerosing lesions of the breast. \| journal = Ultrasonography \| volume = 33 \| issue = 1 \| pages = 58-64 \| month = Jan \| year = 2014 \| doi = 10.14366/usg.13015 \| PMID = 24936496 }}</ref>
	*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>		*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>
	**Typically [[BI-~~RADS]] 4 - but may be BI-RADS 5~~.<ref name=~~pmid24936496~~>{{~~Cite~~ journal \| ~~last1~~ = ~~Myong~~ \| ~~first1~~ = ~~JH.~~ \| ~~last2~~ = ~~Choi \| first2 = BG~~. ~~\| last3 = Kim \| first3 = SH~~. ~~\| last4 = Kang \| first4 = BJ~~. \| ~~last5~~ = ~~Lee~~ \| ~~first5~~ = A. \| ~~last6~~ = ~~Song~~ \| ~~first6~~ = ~~BJ.~~ \| ~~title~~ = ~~Imaging features of complex sclerosing lesions of the breast.~~ \| ~~journal~~ = ~~Ultrasonography~~ \| ~~volume~~ = ~~33 \| issue = 1 \| pages = 58-64 \| month = Jan \| year = 2014~~ \| doi = ~~10.14366/usg.13015~~ \| ~~PMID~~ = ~~24936496~~ }}</ref>		*Management - usually surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>
	*~~Management - usu. surgical~~ excision.<ref name=~~pmid14514771~~>{{~~cite~~ journal \|~~author~~=~~Kennedy M, Masterson AV, Kerin M, Flanagan F~~ \|title=~~Pathology and clinical relevance~~ of radial ~~scars: a review~~ \|journal=~~J. Clin.~~ Pathol. \|volume=56 \|issue=10 \|pages=~~721–4 \|year=2003~~ \|month=~~October~~ \|~~pmid~~=~~14514771 \|pmc=1770086~~ \|doi= \|~~url~~=}}</ref>		**Risk of malignancy for biopsy diagnosed CSLs on excision very small ~1%.<ref name=pmid26772402>{{Cite journal \| last1 = Li \| first1 = Z. \| last2 = Ranade \| first2 = A. \| last3 = Zhao \| first3 = C. \| title = Pathologic findings of follow-up surgical excision for radial scar on breast core needle biopsy. \| journal = Hum Pathol \| volume = 48 \| issue = \| pages = 76-80 \| month = Feb \| year = 2016 \| doi = 10.1016/j.humpath.2015.06.028 \| PMID = 26772402 }}</ref>
	*Rare - less than 0.1% of core needle biopsies.<ref name=pmid25578683>{{Cite journal \| last1 = Nassar \| first1 = A. \| last2 = Conners \| first2 = AL. \| last3 = Celik \| first3 = B. \| last4 = Jenkins \| first4 = SM. \| last5 = Smith \| first5 = CY. \| last6 = Hieken \| first6 = TJ. \| title = Radial scar/complex sclerosing lesions: a clinicopathologic correlation study from a single institution. \| journal = Ann Diagn Pathol \| volume = 19 \| issue = 1 \| pages = 24-8 \| month = Feb \| year = 2015 \| doi = 10.1016/j.anndiagpath.2014.12.003 \| PMID = 25578683 }}</ref>		*Rare - less than 0.1% of core needle biopsies.<ref name=pmid25578683>{{Cite journal \| last1 = Nassar \| first1 = A. \| last2 = Conners \| first2 = AL. \| last3 = Celik \| first3 = B. \| last4 = Jenkins \| first4 = SM. \| last5 = Smith \| first5 = CY. \| last6 = Hieken \| first6 = TJ. \| title = Radial scar/complex sclerosing lesions: a clinicopathologic correlation study from a single institution. \| journal = Ann Diagn Pathol \| volume = 19 \| issue = 1 \| pages = 24-8 \| month = Feb \| year = 2015 \| doi = 10.1016/j.anndiagpath.2014.12.003 \| PMID = 25578683 }}</ref>

	==Gross==		==Gross==
	*Spiculated mass.		*Spiculated mass.

Michael at 18:16, 1 January 2017

2017-01-01T18:16:51Z

← Older revision		Revision as of 18:16, 1 January 2017
Line 39:		Line 39:
	**Typically [[BI-RADS]] 4 - but may be BI-RADS 5.<ref name=pmid24936496>{{Cite journal \| last1 = Myong \| first1 = JH. \| last2 = Choi \| first2 = BG. \| last3 = Kim \| first3 = SH. \| last4 = Kang \| first4 = BJ. \| last5 = Lee \| first5 = A. \| last6 = Song \| first6 = BJ. \| title = Imaging features of complex sclerosing lesions of the breast. \| journal = Ultrasonography \| volume = 33 \| issue = 1 \| pages = 58-64 \| month = Jan \| year = 2014 \| doi = 10.14366/usg.13015 \| PMID = 24936496 }}</ref>		**Typically [[BI-RADS]] 4 - but may be BI-RADS 5.<ref name=pmid24936496>{{Cite journal \| last1 = Myong \| first1 = JH. \| last2 = Choi \| first2 = BG. \| last3 = Kim \| first3 = SH. \| last4 = Kang \| first4 = BJ. \| last5 = Lee \| first5 = A. \| last6 = Song \| first6 = BJ. \| title = Imaging features of complex sclerosing lesions of the breast. \| journal = Ultrasonography \| volume = 33 \| issue = 1 \| pages = 58-64 \| month = Jan \| year = 2014 \| doi = 10.14366/usg.13015 \| PMID = 24936496 }}</ref>
	*Management - usu. surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>		*Management - usu. surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>
			*Rare - less than 0.1% of core needle biopsies.<ref name=pmid25578683>{{Cite journal \| last1 = Nassar \| first1 = A. \| last2 = Conners \| first2 = AL. \| last3 = Celik \| first3 = B. \| last4 = Jenkins \| first4 = SM. \| last5 = Smith \| first5 = CY. \| last6 = Hieken \| first6 = TJ. \| title = Radial scar/complex sclerosing lesions: a clinicopathologic correlation study from a single institution. \| journal = Ann Diagn Pathol \| volume = 19 \| issue = 1 \| pages = 24-8 \| month = Feb \| year = 2015 \| doi = 10.1016/j.anndiagpath.2014.12.003 \| PMID = 25578683 }}</ref>
	==Gross==		==Gross==
	*Spiculated mass.		*Spiculated mass.

Michael at 18:12, 1 January 2017

2017-01-01T18:12:48Z

← Older revision		Revision as of 18:12, 1 January 2017
Line 37:		Line 37:
	*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal \|author=Ung OA, Lee WB, Greenberg ML, Bilous M \|title=Complex sclerosing lesion: the lesion is complex, the management is straightforward \|journal=ANZ J Surg \|volume=71 \|issue=1 \|pages=35–40 \|year=2001 \|month=January \|pmid=11167596 \|doi= \|url=}}</ref>		*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal \|author=Ung OA, Lee WB, Greenberg ML, Bilous M \|title=Complex sclerosing lesion: the lesion is complex, the management is straightforward \|journal=ANZ J Surg \|volume=71 \|issue=1 \|pages=35–40 \|year=2001 \|month=January \|pmid=11167596 \|doi= \|url=}}</ref>
	*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>		*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>
			**Typically [[BI-RADS]] 4 - but may be BI-RADS 5.<ref name=pmid24936496>{{Cite journal \| last1 = Myong \| first1 = JH. \| last2 = Choi \| first2 = BG. \| last3 = Kim \| first3 = SH. \| last4 = Kang \| first4 = BJ. \| last5 = Lee \| first5 = A. \| last6 = Song \| first6 = BJ. \| title = Imaging features of complex sclerosing lesions of the breast. \| journal = Ultrasonography \| volume = 33 \| issue = 1 \| pages = 58-64 \| month = Jan \| year = 2014 \| doi = 10.14366/usg.13015 \| PMID = 24936496 }}</ref>
	*Management - usu. surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>		*Management - usu. surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>
	==Gross==		==Gross==

Michael: +images

2017-01-01T18:02:27Z

+images

← Older revision		Revision as of 18:02, 1 January 2017
Line 1:		Line 1:
	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Radial scar of breast - intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Complex sclerosing lesion of breast. [[H&E stain]]. (WC)
	\| Synonyms = radial scar		\| Synonyms = radial scar
	\| Micro = stellate lesion (low magnification), center of lesion has fibroelastosis (stroma light pink on H&E), scar like stroma with entrapped normal breast ducts and lobules - glands appear to enlarge with distance from center of lesion		\| Micro = stellate lesion (low magnification), center of lesion has fibroelastosis (stroma light pink on H&E), scar like stroma with entrapped normal breast ducts and lobules - glands appear to enlarge with distance from center of lesion
Line 61:		Line 61:

	===Images===		===Images===
			<gallery>
			Image: Radial scar of breast - low mag.jpg \| RS - low mag. (WC)
			Image: Radial scar of breast - intermed mag.jpg \| RS - intermed. mag. (WC)
			</gallery>
			====www====
	*[http://www.breastpathology.info/Images/Benign/Radial_scar/rs3a_700.jpg Radial scar (breastpathology.info)].		*[http://www.breastpathology.info/Images/Benign/Radial_scar/rs3a_700.jpg Radial scar (breastpathology.info)].

Michael: +infobox

2017-01-01T18:00:50Z

+infobox

← Older revision		Revision as of 18:00, 1 January 2017
Line 1:		Line 1:
			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms = radial scar
			\| Micro = stellate lesion (low magnification), center of lesion has fibroelastosis (stroma light pink on H&E), scar like stroma with entrapped normal breast ducts and lobules - glands appear to enlarge with distance from center of lesion
			\| Subtypes =
			\| LMDDx = [[invasive ductal carcinoma]]
			\| Stains =
			\| IHC = myoepithelial cells preset (p63 +ve, calponin +ve)
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = spiculated mass
			\| Grossing =
			\| Staging =
			\| Site = [[breast]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign, increased risk of malignancy
			\| Other =
			\| ClinDDx = [[breast cancer]]
			\| Tx = excision
			}}
	'''Complex sclerosing lesion''' (abbreviated '''CSL'''), also '''radial scar''', is a benign [[breast pathology\|lesion of the breast]] that is associated with an increased risk of subsequent [[breast cancer]].		'''Complex sclerosing lesion''' (abbreviated '''CSL'''), also '''radial scar''', is a benign [[breast pathology\|lesion of the breast]] that is associated with an increased risk of subsequent [[breast cancer]].

Michael: +csl

2016-10-11T20:10:05Z

+csl

← Older revision		Revision as of 20:10, 11 October 2016
Line 1:		Line 1:
	'''Complex sclerosing lesion''', also '''radial scar''', is a benign [[breast pathology\|lesion of the breast]] that is associated with an increased risk of subsequent [[breast cancer]].		'''Complex sclerosing lesion''' (abbreviated '''CSL'''), also '''radial scar''', is a benign [[breast pathology\|lesion of the breast]] that is associated with an increased risk of subsequent [[breast cancer]].

	==General==		==General==

Michael at 04:31, 1 May 2016

2016-05-01T04:31:20Z

← Older revision		Revision as of 04:31, 1 May 2016
Line 1:		Line 1:
	'''Complex sclerosing lesion''', also '''radial scar''', is a benign [[breast pathology\|lesion of the breast]] that is associated with an increased risk of ~~malignancy~~.		'''Complex sclerosing lesion''', also '''radial scar''', is a benign [[breast pathology\|lesion of the breast]] that is associated with an increased risk of subsequent [[breast cancer]].

	==General==		==General==

Michael: split out

2016-05-01T04:23:31Z

split out

← Older revision		Revision as of 04:23, 1 May 2016
Line 1:		Line 1:
	~~#redirect~~ [[~~Breast_pathology#Complex_sclerosing_lesion~~]]		'''Complex sclerosing lesion''', also '''radial scar''', is a benign [[breast pathology\|lesion of the breast]] that is associated with an increased risk of malignancy.

			==General==
			*The term ''radial scar'' is a misnomer. It isn't a ''scar''. It isn't associated with prior trauma or surgery.<ref name=Ref_PBoD8_1072>{{Ref PBoD8\|1072}}</ref>
			*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal \|author=Ung OA, Lee WB, Greenberg ML, Bilous M \|title=Complex sclerosing lesion: the lesion is complex, the management is straightforward \|journal=ANZ J Surg \|volume=71 \|issue=1 \|pages=35–40 \|year=2001 \|month=January \|pmid=11167596 \|doi= \|url=}}</ref>
			*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>
			*Management - usu. surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>
			==Gross==
			*Spiculated mass.
			*Usually small - 3-7 mm.

			===Image===
			<gallery>
			Image:Radial_scar.jpg \| Radial scar - gross. (WC)
			</gallery>
			==Microscopic==
			Features:<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref><ref name=Ref_BP91>{{Ref BP\|91}}</ref>
			*Stellate appearance (low magnification).
			*Center of lesion has "fibroelastosis" - stroma light pink (on H&E) - '''key feature'''.
			**Scar like stroma with entrapped normal breast ducts and lobules.
			**Glands appear to enlarge with distance from center of lesion.

			Notes:
			*Histomorphologic appearance may mimic a [[desmoplastic reaction]] of the stroma - leading to a misdiagnosis of malignancy.
			*"[[Hyaline]] - pink stuff on H&E - is the key."

			DDx:
			*[[Invasive ductal carcinoma]] - should be considered if the lesion is asymmetrical ''or'' glands are dilated centrally.

			===Images===
			*[http://www.breastpathology.info/Images/Benign/Radial_scar/rs3a_700.jpg Radial scar (breastpathology.info)].

			==IHC==
			Features:
			*p63 +ve.
			*Calponin +ve.

			Note:
			*HMWK +ve/-ve. (???)

			==See also==
			*[[Breast pathology]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Breast_pathology]]

← Older revision		Revision as of 18:19, 1 January 2017
Line 36:		Line 36:
	*The term ''radial scar'' is a misnomer. It isn't a ''scar''. It isn't associated with prior trauma or surgery.<ref name=Ref_PBoD8_1072>{{Ref PBoD8\|1072}}</ref>		*The term ''radial scar'' is a misnomer. It isn't a ''scar''. It isn't associated with prior trauma or surgery.<ref name=Ref_PBoD8_1072>{{Ref PBoD8\|1072}}</ref>
	*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal \|author=Ung OA, Lee WB, Greenberg ML, Bilous M \|title=Complex sclerosing lesion: the lesion is complex, the management is straightforward \|journal=ANZ J Surg \|volume=71 \|issue=1 \|pages=35–40 \|year=2001 \|month=January \|pmid=11167596 \|doi= \|url=}}</ref>		*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal \|author=Ung OA, Lee WB, Greenberg ML, Bilous M \|title=Complex sclerosing lesion: the lesion is complex, the management is straightforward \|journal=ANZ J Surg \|volume=71 \|issue=1 \|pages=35–40 \|year=2001 \|month=January \|pmid=11167596 \|doi= \|url=}}</ref>
			**Typically [[BI-RADS]] 4 - but may be BI-RADS 5.<ref name=pmid24936496>{{Cite journal \| last1 = Myong \| first1 = JH. \| last2 = Choi \| first2 = BG. \| last3 = Kim \| first3 = SH. \| last4 = Kang \| first4 = BJ. \| last5 = Lee \| first5 = A. \| last6 = Song \| first6 = BJ. \| title = Imaging features of complex sclerosing lesions of the breast. \| journal = Ultrasonography \| volume = 33 \| issue = 1 \| pages = 58-64 \| month = Jan \| year = 2014 \| doi = 10.14366/usg.13015 \| PMID = 24936496 }}</ref>
	*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>		*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref>
	**Typically [[BI-~~RADS]] 4 - but may be BI-RADS 5~~.<ref name=~~pmid24936496~~>{{~~Cite~~ journal \| ~~last1~~ = ~~Myong~~ \| ~~first1~~ = ~~JH.~~ \| ~~last2~~ = ~~Choi \| first2 = BG~~. ~~\| last3 = Kim \| first3 = SH~~. ~~\| last4 = Kang \| first4 = BJ~~. \| ~~last5~~ = ~~Lee~~ \| ~~first5~~ = A. \| ~~last6~~ = ~~Song~~ \| ~~first6~~ = ~~BJ.~~ \| ~~title~~ = ~~Imaging features of complex sclerosing lesions of the breast.~~ \| ~~journal~~ = ~~Ultrasonography~~ \| ~~volume~~ = ~~33 \| issue = 1 \| pages = 58-64 \| month = Jan \| year = 2014~~ \| doi = ~~10.14366/usg.13015~~ \| ~~PMID~~ = ~~24936496~~ }}</ref>		*Management - usually surgical excision.<ref name=pmid14514771>{{cite journal \|author=Kennedy M, Masterson AV, Kerin M, Flanagan F \|title=Pathology and clinical relevance of radial scars: a review \|journal=J. Clin. Pathol. \|volume=56 \|issue=10 \|pages=721–4 \|year=2003 \|month=October \|pmid=14514771 \|pmc=1770086 \|doi= \|url=}}</ref>
	*~~Management - usu. surgical~~ excision.<ref name=~~pmid14514771~~>{{~~cite~~ journal \|~~author~~=~~Kennedy M, Masterson AV, Kerin M, Flanagan F~~ \|title=~~Pathology and clinical relevance~~ of radial ~~scars: a review~~ \|journal=~~J. Clin.~~ Pathol. \|volume=56 \|issue=10 \|pages=~~721–4 \|year=2003~~ \|month=~~October~~ \|~~pmid~~=~~14514771 \|pmc=1770086~~ \|doi= \|~~url~~=}}</ref>		**Risk of malignancy for biopsy diagnosed CSLs on excision very small ~1%.<ref name=pmid26772402>{{Cite journal \| last1 = Li \| first1 = Z. \| last2 = Ranade \| first2 = A. \| last3 = Zhao \| first3 = C. \| title = Pathologic findings of follow-up surgical excision for radial scar on breast core needle biopsy. \| journal = Hum Pathol \| volume = 48 \| issue = \| pages = 76-80 \| month = Feb \| year = 2016 \| doi = 10.1016/j.humpath.2015.06.028 \| PMID = 26772402 }}</ref>
	*Rare - less than 0.1% of core needle biopsies.<ref name=pmid25578683>{{Cite journal \| last1 = Nassar \| first1 = A. \| last2 = Conners \| first2 = AL. \| last3 = Celik \| first3 = B. \| last4 = Jenkins \| first4 = SM. \| last5 = Smith \| first5 = CY. \| last6 = Hieken \| first6 = TJ. \| title = Radial scar/complex sclerosing lesions: a clinicopathologic correlation study from a single institution. \| journal = Ann Diagn Pathol \| volume = 19 \| issue = 1 \| pages = 24-8 \| month = Feb \| year = 2015 \| doi = 10.1016/j.anndiagpath.2014.12.003 \| PMID = 25578683 }}</ref>		*Rare - less than 0.1% of core needle biopsies.<ref name=pmid25578683>{{Cite journal \| last1 = Nassar \| first1 = A. \| last2 = Conners \| first2 = AL. \| last3 = Celik \| first3 = B. \| last4 = Jenkins \| first4 = SM. \| last5 = Smith \| first5 = CY. \| last6 = Hieken \| first6 = TJ. \| title = Radial scar/complex sclerosing lesions: a clinicopathologic correlation study from a single institution. \| journal = Ann Diagn Pathol \| volume = 19 \| issue = 1 \| pages = 24-8 \| month = Feb \| year = 2015 \| doi = 10.1016/j.anndiagpath.2014.12.003 \| PMID = 25578683 }}</ref>

	==Gross==		==Gross==
	*Spiculated mass.		*Spiculated mass.