Cystic kidney diseases - Revision history

Michael at 16:45, 4 February 2025

2025-02-04T16:45:34Z

← Older revision		Revision as of 16:45, 4 February 2025
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	*[[Kidney tumours]].		*[[Kidney tumours]].
	*[[Bosniak classification]].		*[[Bosniak classification]].
			*[[Multicystic dysplastic kidney]].

	=References=		=References=

Michael: /* Autosomal dominant polycystic kidney disease */ split out

2016-06-21T14:43:56Z

Autosomal dominant polycystic kidney disease: split out

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	==Autosomal dominant polycystic kidney disease==		==Autosomal dominant polycystic kidney disease==
	*Abbreviated ''ADPKD''.		*Abbreviated ''ADPKD''.
	~~===General===~~		{{Main\|Autosomal dominant polycystic kidney disease}}
	~~====Etiology====~~
	*Mutation in ''PKD1'' gene or ''PKD2'' gene.
	*Is classified in a large group of diseases - ''ciliopathies''.

	~~PKD1 related disease:<ref name=Ref_MacSween174-5>{{Ref MacSween\|174-5}}</ref>~~
	*Encodes polycystin.
	*Death at ~53 years.
	*Assoc. with cerebral aneurysms.

	~~PKD2 related disease:<ref name=Ref_MacSween174-5>~~{{~~Ref MacSween~~\|~~174-5}}</ref>~~
	*Death at ~69 years.
	*Associated with colonic diverticula, [[aortic aneurysm]], [[mitral valve prolapse]].

	~~====Liver cysts and PKD====~~
	~~=====General=====~~
	~~Features:~~
	*Most common extra-renal manifestation of PKD; dependent on age, sex and renal function:<ref name=pmid9186898>{{cite journal \|author=Perrone RD \|title=Extrarenal manifestations of ADPKD \|journal=Kidney Int. \|volume=51 \|issue=6 \|pages=2022–36 \|year=1997 \|month=June \|pmid=9186898 \|doi= \|url=http://www.nature.com/ki/journal/v51/n6/pdf/ki1997276a.pdf}}</ref>
	**Age dependence:
	***10-17% <40 years old have liver cysts.
	***70-75% >60 years old have liver cysts.
	**Renal function:
	***60-70% of patients with [[end-stage renal disease]] (ESRD) and near-ESRD.
	**Females more often affected.
	*Hepatic function usu. preserved.

	~~Complications:<ref name=Ref_MacSween174-5>{{Ref MacSween\|174-5}}</ref>~~
	~~#Infected cyst.~~
	~~#[[Cholangiocarcinoma]].~~

	~~=====Microscopic=====~~
	~~Features:~~
	*''Von Meyenburg complexes'':
	**Cluster of dilated ducts with "altered" bile.
	**Surrounded by collagenous stroma.

	~~See: ''[[Medical liver disease]]''.~~

	~~===Gross===~~
	~~Features:~~
	*Thin walled cysts.
	**Number of cysts:
	***If you can count 'em it favours acquired renal cystic disease... if you can't it favours the genetic condition.

	~~===Microscopic===~~
	~~Features:<ref name=Ref_DARP426>{{Ref DARP\|426}}</ref>~~
	*Cysts lined by simple flattened epithelium.
	*Normal renal tubules interspersed between cysts.
	*+/-Fibrosis (late-stage).

	~~DDx:~~
	*[[Acquired renal cystic disease]] - rarely.<ref name=pmid1819219>{{cite journal \|author=Kessler M, Testevuide P, Aymard B, Huu TC \|title=Acquired renal cystic disease mimicking adult polycystic kidney disease ~~in a patient undergoing long-term hemodialysis \|journal=Am. J. Nephrol. \|volume=11 \|issue=6 \|pages=513–7 \|year=1991 \|pmid=1819219 \|doi= \|url=}}</ref>~~
	**Morphologically similar to acquired renal cystic disease.<ref name=rj_oct2010>RJ. 20 October 2010.</ref>
	**It is said that "... if you can count 'em it's simple cysts; if you can't it's polycystic (renal disease)."<ref name=rj_oct2010>RJ. 20 October 2010.</ref><ref>{{cite book \|author= Barbaric, Zoran L. \|title=[http://books.google.com/books?id=uABgezxjhYwC&pg=PA87&lpg=PA87&dq=cystic+renal+disease,+%22if+you+can+count+them%22&source=bl&ots=GYyIdR9YmS&sig=DBYzT8LO2MltLA-wwW-0QwnQ6Lk&hl=en&ei=0hF-Taz0IsG3twe5yfG6BQ&sa=X&oi=book_result&ct=result&resnum=1&ved=0CBoQ6AEwAA#v=onepage&q=cystic%20renal%20disease%2C%20%22if%20you%20can%20count%20them%22&f=false Principles of Genitourinary Radiology] \|publisher=Thieme \|location= \|year=1994 \|pages= 87 \|edition=2nd \|isbn=978-0865774933 \|oclc= \|doi= \|accessdate=}}~~</ref>~~

	~~===Sign out===~~
	~~<pre>~~
	~~Left Kidney, Nephrectomy:~~
	~~- Polycystic kidney with changes of chronic renal failure (thyroidization),~~
	~~consistent with polypcystic kidney disease.~~
	~~- NEGATIVE for malignancy.~~
	~~</pre>~~

	==Acquired renal cystic disease==		==Acquired renal cystic disease==

Michael: /* Acquired renal cystic disease */

2016-04-27T04:02:02Z

Acquired renal cystic disease

← Older revision		Revision as of 04:02, 27 April 2016
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	==Acquired renal cystic disease==		==Acquired renal cystic disease==
	{{Main\|Acquired ~~renal~~ cystic disease}}		{{Main\|Acquired cystic disease of the kidney}}

	==Autosomal recessive polycystic kidney disease==		==Autosomal recessive polycystic kidney disease==

Michael: /* Acquired renal cystic disease */ split out

2016-04-27T03:44:53Z

Acquired renal cystic disease: split out

← Older revision		Revision as of 03:44, 27 April 2016
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	==Acquired renal cystic disease==		==Acquired renal cystic disease==
	~~===General===~~		{{Main\|Acquired renal cystic disease}}
	*Thought to arise due to uremia,<ref name=pmid7861721>{{~~cite journal~~ \|author=Fick GM, Gabow PA \|title=Hereditary and acquired cystic disease of the kidney \|journal=Kidney Int. \|volume=46 \|issue=4 \|pages=951–64 \|year=1994 \|month=October \|pmid=7861721 \|doi= \|url=http://www.nature.com/ki/journal/v46/n4/pdf/ki1994354a.pdf}}</ref> not specific to the type of renal dialysis, i.e. hemodialysis vs. peritoneal dialysis.
	*Presence of cysts dependent on duration of dialysis:<ref name=pmid7861721/>
	**< 3 years ~44%.
	**>4 years ~80%.
	**>10 years ~90%.
	*Associated with [[papillary renal cell carcinoma]].<ref>{{Ref DARP\|438}}</ref>

	~~===Microscopic===~~
	Features:<ref name=pmid1819219>{{cite journal \|author=Kessler M, Testevuide P, Aymard B, Huu TC \|title=Acquired renal cystic disease mimicking adult polycystic kidney disease in a patient undergoing long-term hemodialysis \|journal=Am. J. Nephrol. \|volume=11 \|issue=6 \|pages=513–7 \|year=1991 \|pmid=1819219 \|doi= \|url=}}</ref>
	*Cysts - location: cortex and medulla.
	**Lined by simple flattened epithelium.

	~~DDx:~~
	*[[Autosomal dominant polycystic kidney disease]] rarely,<ref name=pmid1819219>{{cite journal \|author=Kessler M, Testevuide P, Aymard B, Huu TC \|title=Acquired renal cystic disease ~~mimicking adult polycystic kidney disease in a patient undergoing long-term hemodialysis \|journal=Am. J. Nephrol. \|volume=11 \|issue=6 \|pages=513–7 \|year=1991 \|pmid=1819219 \|doi= \|url=~~}}~~</ref> see ''Microscopic'' in [[ADPKD]].~~
	*[[Acquired cystic disease-associated renal cell carcinoma]].

	==Autosomal recessive polycystic kidney disease==		==Autosomal recessive polycystic kidney disease==

Michael: /* Benign cortical cyst of the kidney */

2015-10-23T17:48:11Z

Benign cortical cyst of the kidney

← Older revision		Revision as of 17:48, 23 October 2015
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	=Specific diseases=		=Specific diseases=
	==Benign cortical cyst of the kidney==		==Benign cortical cyst of the kidney==
			*[[AKA]] ''benign cortical cyst''.
	{{Main\|Benign cortical cyst of the kidney}}		{{Main\|Benign cortical cyst of the kidney}}

Michael: /* Benign cortical cyst of the kidney */

2015-10-23T17:46:34Z

Benign cortical cyst of the kidney

← Older revision		Revision as of 17:46, 23 October 2015
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	=Specific diseases=		=Specific diseases=
	==Benign cortical cyst of the kidney==		==Benign cortical cyst of the kidney==
	~~===General===~~		{{Main\|Benign cortical cyst of the kidney}}
	*Very common.
	*Benign.

	~~===Gross===~~
	*Thin-walled cyst ~~- usually filled with serous fluid.~~
	*Usually unilocular.

	~~===Microscopic===~~
	~~Features:~~
	*Simple epithelial lining without atypia.
	*May have clear cells.

	~~Note:~~
	*Do ''not'' have clear cells within the wall of the ~~cyst.<ref>{{Ref DDxSPGU\|197~~}}~~</ref>~~

	~~DDx:~~
	*Cystic [[clear cell renal cell carcinoma]].
	*[[Multicystic renal cell neoplasm of low malignant potential]].

	==Autosomal dominant polycystic kidney disease==		==Autosomal dominant polycystic kidney disease==

Michael: /* Benign cortical cysts of the kidney */

2015-10-23T17:43:35Z

Benign cortical cysts of the kidney

← Older revision		Revision as of 17:43, 23 October 2015
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	=Specific diseases=		=Specific diseases=
	==Benign cortical ~~cysts~~ of the kidney==		==Benign cortical cyst of the kidney==
	===General===		===General===
	*Very common.		*Very common.

Michael: /* Microscopic */

2015-10-23T17:36:42Z

Microscopic

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	Features:		Features:
	*Simple epithelial lining without atypia.		*Simple epithelial lining without atypia.
			*May have clear cells.

	Note:		Note:

Michael: /* Microscopic */ tweak

2015-10-23T17:36:20Z

Microscopic: tweak

← Older revision		Revision as of 17:36, 23 October 2015
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	Features:		Features:
	*Simple epithelial lining without atypia.		*Simple epithelial lining without atypia.

			Note:
			*Do ''not'' have clear cells within the wall of the cyst.<ref>{{Ref DDxSPGU\|197}}</ref>

			DDx:
			*Cystic [[clear cell renal cell carcinoma]].
			*[[Multicystic renal cell neoplasm of low malignant potential]].

	==Autosomal dominant polycystic kidney disease==		==Autosomal dominant polycystic kidney disease==

Michael: /* Microscopic */

2015-10-23T17:26:58Z

Microscopic

← Older revision		Revision as of 17:26, 23 October 2015
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	*Usually unilocular.		*Usually unilocular.

	==Microscopic==		===Microscopic===
	Features:		Features:
	*Simple epithelial lining without atypia.		*Simple epithelial lining without atypia.