Diffuse leptomeningeal glioneuronal tumour - Revision history

Michael: fix authors (vauthors)

2021-03-25T17:20:00Z

fix authors (vauthors)

← Older revision		Revision as of 17:20, 25 March 2021
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	==General==		==General==
	Features:		Features:
	*Currently no WHO grade assigned. Molecular class MC-1 corresponds to WHO I, class MC-2 to WHO II/III<ref name="pmid29766299">{{cite journal \|~~vauthors~~=Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW \|title=Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features \|journal=Acta Neuropathol \|volume=136 \|issue=2 \|pages=239–253 \|date=August 2018 \|pmid=29766299 \|doi=10.1007/s00401-018-1865-4 \|url=}}</ref>		*Currently no WHO grade assigned. Molecular class MC-1 corresponds to WHO I, class MC-2 to WHO II/III<ref name="pmid29766299">{{cite journal \|authors=Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW \|title=Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features \|journal=Acta Neuropathol \|volume=136 \|issue=2 \|pages=239–253 \|date=August 2018 \|pmid=29766299 \|doi=10.1007/s00401-018-1865-4 \|url=}}</ref>
	*Low-grade lesion but anaplastic progression reported.		*Low-grade lesion but anaplastic progression reported.
	* Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN)		* Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN)
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	==Molecular==		==Molecular==
	* Mixture of partially oligodendroglioma, partially pilocytic astrocytoma features.<ref name="pmid29766299">{{cite journal \|~~vauthors~~=Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW \|title=Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features \|journal=Acta Neuropathol \|volume=136 \|issue=2 \|pages=239–253 \|date=August 2018 \|pmid=29766299 \|doi=10.1007/s00401-018-1865-4 \|url=}}</ref>		* Mixture of partially oligodendroglioma, partially pilocytic astrocytoma features.<ref name="pmid29766299">{{cite journal \|authors=Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW \|title=Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features \|journal=Acta Neuropathol \|volume=136 \|issue=2 \|pages=239–253 \|date=August 2018 \|pmid=29766299 \|doi=10.1007/s00401-018-1865-4 \|url=}}</ref>
	* 1p loss in 100% (or combined 1p/19q loss in 15-50%)<ref>{{Cite journal \| last1 = Bourne \| first1 = TD. \| last2 = Mandell \| first2 = JW. \| last3 = Matsumoto \| first3 = JA. \| last4 = Jane \| first4 = JA. \| last5 = Lopes \| first5 = MB. \| title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. \| journal = J Neurosurg \| volume = 105 \| issue = 6 Suppl \| pages = 465-9 \| month = Dec \| year = 2006 \| doi = 10.3171/ped.2006.105.6.465 \| PMID = 17184079 }}</ref>		* 1p loss in 100% (or combined 1p/19q loss in 15-50%)<ref>{{Cite journal \| last1 = Bourne \| first1 = TD. \| last2 = Mandell \| first2 = JW. \| last3 = Matsumoto \| first3 = JA. \| last4 = Jane \| first4 = JA. \| last5 = Lopes \| first5 = MB. \| title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. \| journal = J Neurosurg \| volume = 105 \| issue = 6 Suppl \| pages = 465-9 \| month = Dec \| year = 2006 \| doi = 10.3171/ped.2006.105.6.465 \| PMID = 17184079 }}</ref>
	** 1p loss is usu. absent in [[pilocytic astrocytoma]]		** 1p loss is usu. absent in [[pilocytic astrocytoma]]

Jensflorian: /* Molecular */ fix error

2020-11-12T10:39:17Z

Molecular: fix error

← Older revision		Revision as of 10:39, 12 November 2020
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	* Two methylation class subgroups (DLGNT MC-1 and MC-2)		* Two methylation class subgroups (DLGNT MC-1 and MC-2)
	** 1p gain in all MC-2 class cases.		** 1p gain in all MC-2 class cases.
	** MC-1 class cases are younger and have ~~unfavourable~~ prognosis.		** MC-1 class cases are younger and have a more favourable prognosis.

	==Images==		==Images==

Jensflorian: /* General */ Prognosis

2020-11-12T10:38:57Z

General: Prognosis

← Older revision		Revision as of 10:38, 12 November 2020
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	==General==		==General==
	Features:		Features:
	*Currently no WHO grade assigned.		*Currently no WHO grade assigned. Molecular class MC-1 corresponds to WHO I, class MC-2 to WHO II/III<ref name="pmid29766299">{{cite journal \|vauthors=Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW \|title=Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features \|journal=Acta Neuropathol \|volume=136 \|issue=2 \|pages=239–253 \|date=August 2018 \|pmid=29766299 \|doi=10.1007/s00401-018-1865-4 \|url=}}</ref>
	*Low-grade lesion but anaplastic progression reported.		*Low-grade lesion but anaplastic progression reported.
	* Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN)		* Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN)

Jensflorian: /* Molecular */ Update

2020-11-12T10:37:51Z

Molecular: Update

← Older revision		Revision as of 10:37, 12 November 2020
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	==Molecular==		==Molecular==
			* Mixture of partially oligodendroglioma, partially pilocytic astrocytoma features.<ref name="pmid29766299">{{cite journal \|vauthors=Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW \|title=Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features \|journal=Acta Neuropathol \|volume=136 \|issue=2 \|pages=239–253 \|date=August 2018 \|pmid=29766299 \|doi=10.1007/s00401-018-1865-4 \|url=}}</ref>
	* 1p loss in 100% (or combined 1p/19q loss in 15-50%)<ref>{{Cite journal \| last1 = Bourne \| first1 = TD. \| last2 = Mandell \| first2 = JW. \| last3 = Matsumoto \| first3 = JA. \| last4 = Jane \| first4 = JA. \| last5 = Lopes \| first5 = MB. \| title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. \| journal = J Neurosurg \| volume = 105 \| issue = 6 Suppl \| pages = 465-9 \| month = Dec \| year = 2006 \| doi = 10.3171/ped.2006.105.6.465 \| PMID = 17184079 }}</ref>		* 1p loss in 100% (or combined 1p/19q loss in 15-50%)<ref>{{Cite journal \| last1 = Bourne \| first1 = TD. \| last2 = Mandell \| first2 = JW. \| last3 = Matsumoto \| first3 = JA. \| last4 = Jane \| first4 = JA. \| last5 = Lopes \| first5 = MB. \| title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. \| journal = J Neurosurg \| volume = 105 \| issue = 6 Suppl \| pages = 465-9 \| month = Dec \| year = 2006 \| doi = 10.3171/ped.2006.105.6.465 \| PMID = 17184079 }}</ref>
	* 1p gain (35-100% depending on subtype).
	** 1p loss is usu. absent in [[pilocytic astrocytoma]]		** 1p loss is usu. absent in [[pilocytic astrocytoma]]
	**Cases without 1p/19q loss reported.<ref>{{Cite journal \| last1 = Preuss \| first1 = M. \| last2 = Christiansen \| first2 = H. \| last3 = Merkenschlager \| first3 = A. \| last4 = Hirsch \| first4 = FW. \| last5 = Kiess \| first5 = W. \| last6 = Müller \| first6 = W. \| last7 = Kästner \| first7 = S. \| last8 = Henssler \| first8 = A. \| last9 = Pekrun \| first9 = A. \| title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. \| journal = J Neurooncol \| volume = 124 \| issue = 1 \| pages = 65-74 \| month = Aug \| year = 2015 \| doi = 10.1007/s11060-015-1735-z \| PMID = 25672644 }}</ref>		**Cases without 1p/19q loss reported.<ref>{{Cite journal \| last1 = Preuss \| first1 = M. \| last2 = Christiansen \| first2 = H. \| last3 = Merkenschlager \| first3 = A. \| last4 = Hirsch \| first4 = FW. \| last5 = Kiess \| first5 = W. \| last6 = Müller \| first6 = W. \| last7 = Kästner \| first7 = S. \| last8 = Henssler \| first8 = A. \| last9 = Pekrun \| first9 = A. \| title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. \| journal = J Neurooncol \| volume = 124 \| issue = 1 \| pages = 65-74 \| month = Aug \| year = 2015 \| doi = 10.1007/s11060-015-1735-z \| PMID = 25672644 }}</ref>
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	** BRAF-KIAA1549 fusions are usu. absent in [[oligodendroglioma]].<ref>{{Cite journal \| last1 = Gierke \| first1 = M. \| last2 = Sperveslage \| first2 = J. \| last3 = Schwab \| first3 = D. \| last4 = Beschorner \| first4 = R. \| last5 = Ebinger \| first5 = M. \| last6 = Schuhmann \| first6 = MU. \| last7 = Schittenhelm \| first7 = J. \| title = Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549-BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification. \| journal = J Cancer Res Clin Oncol \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00432-015-2006-2 \| PMID = 26115961 }}</ref>		** BRAF-KIAA1549 fusions are usu. absent in [[oligodendroglioma]].<ref>{{Cite journal \| last1 = Gierke \| first1 = M. \| last2 = Sperveslage \| first2 = J. \| last3 = Schwab \| first3 = D. \| last4 = Beschorner \| first4 = R. \| last5 = Ebinger \| first5 = M. \| last6 = Schuhmann \| first6 = MU. \| last7 = Schittenhelm \| first7 = J. \| title = Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549-BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification. \| journal = J Cancer Res Clin Oncol \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00432-015-2006-2 \| PMID = 26115961 }}</ref>
	*BRAF V600E-negative.		*BRAF V600E-negative.
			* IDH1/2-Wildtype.
			* Two methylation class subgroups (DLGNT MC-1 and MC-2)
			** 1p gain in all MC-2 class cases.
			** MC-1 class cases are younger and have unfavourable prognosis.

	==Images==		==Images==

Jensflorian: /* General */ sorting

2020-11-12T10:29:31Z

General: sorting

← Older revision		Revision as of 10:29, 12 November 2020
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	Features:		Features:
	*Currently no WHO grade assigned.		*Currently no WHO grade assigned.
			*Low-grade lesion but anaplastic progression reported.
	* Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN)		* Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN)
	*~~Low-grade lesion but anaplastic progression reported.~~		** AKA "disseminated oligodendroglial-like leptomeningeal tumor of childhood" (DOGLT).<ref>{{Cite journal \| last1 = Preuss \| first1 = M. \| last2 = Christiansen \| first2 = H. \| last3 = Merkenschlager \| first3 = A. \| last4 = Hirsch \| first4 = FW. \| last5 = Kiess \| first5 = W. \| last6 = Müller \| first6 = W. \| last7 = Kästner \| first7 = S. \| last8 = Henssler \| first8 = A. \| last9 = Pekrun \| first9 = A. \| title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. \| journal = J Neurooncol \| volume = 124 \| issue = 1 \| pages = 65-74 \| month = Aug \| year = 2015 \| doi = 10.1007/s11060-015-1735-z \| PMID = 25672644 }}</ref>
	*AKA ~~"diffuse leptomeningeal glioneural tumor" or~~ "disseminated oligodendroglial-like leptomeningeal tumor of childhood" (DOGLT).<ref>{{Cite journal \| last1 = Preuss \| first1 = M. \| last2 = Christiansen \| first2 = H. \| last3 = Merkenschlager \| first3 = A. \| last4 = Hirsch \| first4 = FW. \| last5 = Kiess \| first5 = W. \| last6 = Müller \| first6 = W. \| last7 = Kästner \| first7 = S. \| last8 = Henssler \| first8 = A. \| last9 = Pekrun \| first9 = A. \| title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. \| journal = J Neurooncol \| volume = 124 \| issue = 1 \| pages = 65-74 \| month = Aug \| year = 2015 \| doi = 10.1007/s11060-015-1735-z \| PMID = 25672644 }}</ref>
	*Intermediate prognosis.		*Intermediate prognosis.


	==Gross==		==Gross==

Jensflorian: /* Gross */ Update

2020-11-12T10:28:18Z

Gross: Update

← Older revision		Revision as of 10:28, 12 November 2020
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	==Gross==		==Gross==
	Features:		Features:
	*~~No solid tumour~~.		*Multiple tumor sites (60-85% spinal).
	*Diffuse leptomeningeal expansion.		*Diffuse leptomeningeal expansion.
	**Hydrocaphalus due to CSF occlusion.		**Hydrocaphalus due to CSF occlusion.

Jensflorian: /* Molecular */ Update

2020-11-12T10:20:58Z

Molecular: Update

← Older revision		Revision as of 10:20, 12 November 2020
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	==Molecular==		==Molecular==
	* 1p loss (or 1p/19q loss)<ref>{{Cite journal \| last1 = Bourne \| first1 = TD. \| last2 = Mandell \| first2 = JW. \| last3 = Matsumoto \| first3 = JA. \| last4 = Jane \| first4 = JA. \| last5 = Lopes \| first5 = MB. \| title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. \| journal = J Neurosurg \| volume = 105 \| issue = 6 Suppl \| pages = 465-9 \| month = Dec \| year = 2006 \| doi = 10.3171/ped.2006.105.6.465 \| PMID = 17184079 }}</ref>		* 1p loss in 100% (or combined 1p/19q loss in 15-50%)<ref>{{Cite journal \| last1 = Bourne \| first1 = TD. \| last2 = Mandell \| first2 = JW. \| last3 = Matsumoto \| first3 = JA. \| last4 = Jane \| first4 = JA. \| last5 = Lopes \| first5 = MB. \| title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. \| journal = J Neurosurg \| volume = 105 \| issue = 6 Suppl \| pages = 465-9 \| month = Dec \| year = 2006 \| doi = 10.3171/ped.2006.105.6.465 \| PMID = 17184079 }}</ref>
			* 1p gain (35-100% depending on subtype).
	** 1p loss is usu. absent in [[pilocytic astrocytoma]]		** 1p loss is usu. absent in [[pilocytic astrocytoma]]
	**Cases without 1p/19q loss reported.<ref>{{Cite journal \| last1 = Preuss \| first1 = M. \| last2 = Christiansen \| first2 = H. \| last3 = Merkenschlager \| first3 = A. \| last4 = Hirsch \| first4 = FW. \| last5 = Kiess \| first5 = W. \| last6 = Müller \| first6 = W. \| last7 = Kästner \| first7 = S. \| last8 = Henssler \| first8 = A. \| last9 = Pekrun \| first9 = A. \| title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. \| journal = J Neurooncol \| volume = 124 \| issue = 1 \| pages = 65-74 \| month = Aug \| year = 2015 \| doi = 10.1007/s11060-015-1735-z \| PMID = 25672644 }}</ref>		**Cases without 1p/19q loss reported.<ref>{{Cite journal \| last1 = Preuss \| first1 = M. \| last2 = Christiansen \| first2 = H. \| last3 = Merkenschlager \| first3 = A. \| last4 = Hirsch \| first4 = FW. \| last5 = Kiess \| first5 = W. \| last6 = Müller \| first6 = W. \| last7 = Kästner \| first7 = S. \| last8 = Henssler \| first8 = A. \| last9 = Pekrun \| first9 = A. \| title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. \| journal = J Neurooncol \| volume = 124 \| issue = 1 \| pages = 65-74 \| month = Aug \| year = 2015 \| doi = 10.1007/s11060-015-1735-z \| PMID = 25672644 }}</ref>

Jensflorian: move to new name

2020-11-12T10:16:12Z

move to new name

New page

'''Diffuse leptomeningeal glioneuronal tumour''' (abbreviated DLGNT) is a [[neuropathology tumour]] related to [[pilocytic astrocytoma]]. The future WHO classification of CNS tumours will include it as separate entity.

==General==
Features:
*Currently no WHO grade assigned.
* Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN)
*Low-grade lesion but anaplastic progression reported.
*AKA "diffuse leptomeningeal glioneural tumor" or "disseminated oligodendroglial-like leptomeningeal tumor of childhood" (DOGLT).<ref>{{Cite journal | last1 = Preuss | first1 = M. | last2 = Christiansen | first2 = H. | last3 = Merkenschlager | first3 = A. | last4 = Hirsch | first4 = FW. | last5 = Kiess | first5 = W. | last6 = Müller | first6 = W. | last7 = Kästner | first7 = S. | last8 = Henssler | first8 = A. | last9 = Pekrun | first9 = A. | title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. | journal = J Neurooncol | volume = 124 | issue = 1 | pages = 65-74 | month = Aug | year = 2015 | doi = 10.1007/s11060-015-1735-z | PMID = 25672644 }}</ref>
*Intermediate prognosis.

==Gross==
Features:
*No solid tumour.
*Diffuse leptomeningeal expansion.
**Hydrocaphalus due to CSF occlusion.
**May spread extraneural through shunts. <ref>{{Cite journal | last1 = Kessler | first1 = BA. | last2 = Bookhout | first2 = C. | last3 = Jaikumar | first3 = S. | last4 = Hipps | first4 = J. | last5 = Lee | first5 = YZ. | title = Disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural disease: case report. | journal = Clin Imaging | volume = 39 | issue = 2 | pages = 300-4 | month = | year = | doi = 10.1016/j.clinimag.2014.11.018 | PMID = 25518979 }}</ref>
**Rarely Cysts.<ref>{{Cite journal | last1 = Acar | first1 = NP. | last2 = Oguz | first2 = KK. | last3 = Kurne | first3 = AT. | last4 = Nurlu | first4 = G. | last5 = Ozer | first5 = H. | last6 = Soylemezoglu | first6 = F. | title = Disseminated cystic lesions: a case of disseminated oligodendroglial-like leptomeningeal tumor. | journal = Neurology | volume = 84 | issue = 13 | pages = 1382-3 | month = Mar | year = 2015 | doi = 10.1212/WNL.0000000000001410 | PMID = 25825464 }}</ref>

==Microscopic==
Features:
* [[Oligodendroglioma]]-like cells with low-mitotic activity.
* Rare ganglion/ganglioid cells.
* Ocassionally eosinophilic granular bodies and Rosenthal fibers.
* Infiltrative growth pattern.
* Variable mitotic activity.

==IHC==
Fetaures:<ref>{{Cite journal | last1 = Rodriguez | first1 = FJ. | last2 = Perry | first2 = A. | last3 = Rosenblum | first3 = MK. | last4 = Krawitz | first4 = S. | last5 = Cohen | first5 = KJ. | last6 = Lin | first6 = D. | last7 = Mosier | first7 = S. | last8 = Lin | first8 = MT. | last9 = Eberhart | first9 = CG. | title = Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. | journal = Acta Neuropathol | volume = 124 | issue = 5 | pages = 627-41 | month = Nov | year = 2012 | doi = 10.1007/s00401-012-1037-x | PMID = 22941225 }}</ref><ref>{{Cite journal | last1 = Preuss | first1 = M. | last2 = Christiansen | first2 = H. | last3 = Merkenschlager | first3 = A. | last4 = Hirsch | first4 = FW. | last5 = Kiess | first5 = W. | last6 = Müller | first6 = W. | last7 = Kästner | first7 = S. | last8 = Henssler | first8 = A. | last9 = Pekrun | first9 = A. | title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. | journal = J Neurooncol | volume = 124 | issue = 1 | pages = 65-74 | month = Aug | year = 2015 | doi = 10.1007/s11060-015-1735-z | PMID = 25672644 }}</ref>
* OLIG2 (7 of 9) (78 %).
* S100 (11 of 12) (92 %).
* [[GFAP]] (12 of 31) (39 %).
* Synaptophysin (19 of 27) (70 %).
* NeuN -ve.
* [[EMA]] -ve.
* [[IDH-1]] -ve.
* HuC/D +/-ve.
* CD99 -ve.

==Molecular==
* 1p loss (or 1p/19q loss)<ref>{{Cite journal | last1 = Bourne | first1 = TD. | last2 = Mandell | first2 = JW. | last3 = Matsumoto | first3 = JA. | last4 = Jane | first4 = JA. | last5 = Lopes | first5 = MB. | title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. | journal = J Neurosurg | volume = 105 | issue = 6 Suppl | pages = 465-9 | month = Dec | year = 2006 | doi = 10.3171/ped.2006.105.6.465 | PMID = 17184079 }}</ref>
** 1p loss is usu. absent in [[pilocytic astrocytoma]]
**Cases without 1p/19q loss reported.<ref>{{Cite journal | last1 = Preuss | first1 = M. | last2 = Christiansen | first2 = H. | last3 = Merkenschlager | first3 = A. | last4 = Hirsch | first4 = FW. | last5 = Kiess | first5 = W. | last6 = Müller | first6 = W. | last7 = Kästner | first7 = S. | last8 = Henssler | first8 = A. | last9 = Pekrun | first9 = A. | title = Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. | journal = J Neurooncol | volume = 124 | issue = 1 | pages = 65-74 | month = Aug | year = 2015 | doi = 10.1007/s11060-015-1735-z | PMID = 25672644 }}</ref>
*KIAA1549-BRAF fusions.<ref>{{Cite journal | last1 = Rodriguez | first1 = FJ. | last2 = Schniederjan | first2 = MJ. | last3 = Nicolaides | first3 = T. | last4 = Tihan | first4 = T. | last5 = Burger | first5 = PC. | last6 = Perry | first6 = A. | title = High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN). | journal = Acta Neuropathol | volume = 129 | issue = 4 | pages = 609-10 | month = Apr | year = 2015 | doi = 10.1007/s00401-015-1400-9 | PMID = 25720745 }}</ref>
** High frequency of co-occurence of BRAF-KIAA1549 fusions and 1p deletion.
** BRAF-KIAA1549 fusions are usu. absent in [[oligodendroglioma]].<ref>{{Cite journal | last1 = Gierke | first1 = M. | last2 = Sperveslage | first2 = J. | last3 = Schwab | first3 = D. | last4 = Beschorner | first4 = R. | last5 = Ebinger | first5 = M. | last6 = Schuhmann | first6 = MU. | last7 = Schittenhelm | first7 = J. | title = Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549-BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification. | journal = J Cancer Res Clin Oncol | volume = | issue = | pages = | month = Jun | year = 2015 | doi = 10.1007/s00432-015-2006-2 | PMID = 26115961 }}</ref>
*BRAF V600E-negative.

==Images==
* Radiopedia.org [[http://radiopaedia.org/cases/disseminated-oligodendroglial-like-leptomeningeal-tumour-of-childhood]]

<gallery>
File:Neuropathology case DOLN HE I.jpg | DOLN - HE low mag. (WC/jensflorian)
File:Neuropathology case DOLN HE II.jpg | DOLN - HE intermed mag. (WC/jensflorian)
File:Neuropathology case DOLN HE III.jpg | DOLN - HE high mag. (WC/jensflorian)
</gallery>

==DDx==
*[[Oligodendroglioma]]<ref>{{Cite journal | last1 = Bourne | first1 = TD. | last2 = Mandell | first2 = JW. | last3 = Matsumoto | first3 = JA. | last4 = Jane | first4 = JA. | last5 = Lopes | first5 = MB. | title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. | journal = J Neurosurg | volume = 105 | issue = 6 Suppl | pages = 465-9 | month = Dec | year = 2006 | doi = 10.3171/ped.2006.105.6.465 | PMID = 17184079 }}</ref>

==See also==
*[[Neuropathology tumours]].
*[[Pilocytic astrocytoma]].
*[[Oligodendroglioma]].

==References==
{{Reflist|2}}

[[Category:Diagnosis]]
[[Category:Neuropathology tumours]]