Embryonal carcinoma - Revision history

Michael at 13:41, 7 August 2024

2024-08-07T13:41:43Z

← Older revision		Revision as of 13:41, 7 August 2024
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	**Iczkowski ''et al.'' suggest it is useful for discriminating from [[seminoma]]. This is somewhat disputed by Lau ''et al.''<ref name=pmid17277761>{{Cite journal \| last1 = Lau \| first1 = SK. \| last2 = Weiss \| first2 = LM. \| last3 = Chu \| first3 = PG. \| title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. \| journal = Mod Pathol \| volume = 20 \| issue = 3 \| pages = 320-5 \| month = Mar \| year = 2007 \| doi = 10.1038/modpathol.3800749 \| PMID = 17277761 }}</ref>		**Iczkowski ''et al.'' suggest it is useful for discriminating from [[seminoma]]. This is somewhat disputed by Lau ''et al.''<ref name=pmid17277761>{{Cite journal \| last1 = Lau \| first1 = SK. \| last2 = Weiss \| first2 = LM. \| last3 = Chu \| first3 = PG. \| title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. \| journal = Mod Pathol \| volume = 20 \| issue = 3 \| pages = 320-5 \| month = Mar \| year = 2007 \| doi = 10.1038/modpathol.3800749 \| PMID = 17277761 }}</ref>
	*[[PLAP]] +ve.<ref name=pmid6209917>{{Cite journal \| last1 = Jacobsen \| first1 = GK. \| last2 = Nørgaard-Pedersen \| first2 = B. \| title = Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study. \| journal = Acta Pathol Microbiol Immunol Scand A \| volume = 92 \| issue = 5 \| pages = 323-9 \| month = Sep \| year = 1984 \| doi = \| PMID = 6209917 }}</ref>		*[[PLAP]] +ve.<ref name=pmid6209917>{{Cite journal \| last1 = Jacobsen \| first1 = GK. \| last2 = Nørgaard-Pedersen \| first2 = B. \| title = Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study. \| journal = Acta Pathol Microbiol Immunol Scand A \| volume = 92 \| issue = 5 \| pages = 323-9 \| month = Sep \| year = 1984 \| doi = \| PMID = 6209917 }}</ref>
			*CK7 +ve/-ve (~50% have weak staining).<ref name=pmid30359635>{{cite journal \|authors=Wegman SJ, Parwani AV, Zynger DL \|title=Cytokeratin 7, inhibin, and p63 in testicular germ cell tumor: superior markers of choriocarcinoma compared to β-human chorionic gonadotropin \|journal=Hum Pathol \|volume=84 \|issue= \|pages=254–261 \|date=February 2019 \|pmid=30359635 \|doi=10.1016/j.humpath.2018.10.007 \|url=}}</ref>
			**Seminoma -ve, choriocarcinoma +ve.

	==See also==		==See also==

Michael at 20:57, 26 April 2016

2016-04-26T20:57:01Z

← Older revision		Revision as of 20:57, 26 April 2016
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing = [[~~Orchiectomy~~ grossing]]		\| Grossing = [[orchiectomy grossing]]
	\| Staging = [[~~Testicular~~ cancer staging]]		\| Staging = [[testicular cancer staging]]
	\| Site = [[testis]], [[ovary]], [[mediastinum]]		\| Site = [[testis]], [[ovary]], [[mediastinum]]
	\| Assdx =		\| Assdx =

Michael at 20:55, 26 April 2016

2016-04-26T20:55:43Z

← Older revision		Revision as of 20:55, 26 April 2016
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing = [[~~orchiectomy~~ grossing]]		\| Grossing = [[Orchiectomy grossing]]
			\| Staging = [[Testicular cancer staging]]
	\| Site = [[testis]], [[ovary]], [[mediastinum]]		\| Site = [[testis]], [[ovary]], [[mediastinum]]
	\| Assdx =		\| Assdx =

Michael: fix terminology

2016-03-15T23:27:53Z

fix terminology

← Older revision		Revision as of 23:27, 15 March 2016
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	===Additional notes===		===Additional notes===
	*CK19 -ve.<ref>{{Cite journal \| last1 = Bremmer \| first1 = F. \| last2 = Ströbel \| first2 = P. \| last3 = Hubertus \| first3 = H. \| last4 = Strecker \| first4 = J. \| last5 = Gaisa \| first5 = N. \| last6 = Strauß \| first6 = A. \| last7 = Schweyer \| first7 = S. \| last8 = Radzun \| first8 = H-J. \| last9 = Behnes \| first9 = C-L \| title = CK19 is a sensitive marker for yolk sac tumours of the testis. \| journal = Diagnostic Pathology \| volume = 10 \| issue = 7 \| pages = \| month = \| year = 2015 \| doi = 10.1186/s13000-015-0243-y \| PMID = \| url = www.diagnosticpathology.org/content/10/1/7‎Cached }}</ref>		*CK19 -ve.<ref>{{Cite journal \| last1 = Bremmer \| first1 = F. \| last2 = Ströbel \| first2 = P. \| last3 = Hubertus \| first3 = H. \| last4 = Strecker \| first4 = J. \| last5 = Gaisa \| first5 = N. \| last6 = Strauß \| first6 = A. \| last7 = Schweyer \| first7 = S. \| last8 = Radzun \| first8 = H-J. \| last9 = Behnes \| first9 = C-L \| title = CK19 is a sensitive marker for yolk sac tumours of the testis. \| journal = Diagnostic Pathology \| volume = 10 \| issue = 7 \| pages = \| month = \| year = 2015 \| doi = 10.1186/s13000-015-0243-y \| PMID = \| url = www.diagnosticpathology.org/content/10/1/7‎Cached }}</ref>
	**[[Yolk sac tumour]] +ve, seminoma -ve, [[~~ITGCN~~]] -ve, normal testis -ve.		**[[Yolk sac tumour]] +ve, seminoma -ve, [[GCNIS]] (ITGCN) -ve, normal testis -ve.
	*AE1/AE3 +ve.		*AE1/AE3 +ve.
	*OCT3/4 +ve.<ref name=pmid18045648>{{Cite journal \| last1 = Iczkowski \| first1 = KA. \| last2 = Butler \| first2 = SL. \| last3 = Shanks \| first3 = JH. \| last4 = Hossain \| first4 = D. \| last5 = Schall \| first5 = A. \| last6 = Meiers \| first6 = I. \| last7 = Zhou \| first7 = M. \| last8 = Torkko \| first8 = KC. \| last9 = Kim \| first9 = SJ. \| title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. \| journal = Hum Pathol \| volume = 39 \| issue = 2 \| pages = 275-81 \| month = Feb \| year = 2008 \| doi = 10.1016/j.humpath.2007.07.002 \| PMID = 18045648 }}</ref>		*OCT3/4 +ve.<ref name=pmid18045648>{{Cite journal \| last1 = Iczkowski \| first1 = KA. \| last2 = Butler \| first2 = SL. \| last3 = Shanks \| first3 = JH. \| last4 = Hossain \| first4 = D. \| last5 = Schall \| first5 = A. \| last6 = Meiers \| first6 = I. \| last7 = Zhou \| first7 = M. \| last8 = Torkko \| first8 = KC. \| last9 = Kim \| first9 = SJ. \| title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. \| journal = Hum Pathol \| volume = 39 \| issue = 2 \| pages = 275-81 \| month = Feb \| year = 2008 \| doi = 10.1016/j.humpath.2007.07.002 \| PMID = 18045648 }}</ref>

Michael: wikify

2015-06-01T15:41:07Z

wikify

← Older revision		Revision as of 15:41, 1 June 2015
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	\| Width =		\| Width =
	\| Caption = Embryonal carcinoma. [[H&E stain]].		\| Caption = Embryonal carcinoma. [[H&E stain]].
	\| Micro = vesicular nuclei, nuclear overlap, necrosis (common), mitoses, variable architecture (tubulopapillary, glandular, solid, embryoid bodies)		\| Micro = [[vesicular nuclei]], nuclear overlap, necrosis (common), mitoses, variable architecture (tubulopapillary, glandular, solid, embryoid bodies)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[seminoma]], [[mixed germ cell tumour]], [[yolk sac tumour]], other carcinomas		\| LMDDx = [[seminoma]], [[mixed germ cell tumour]], [[yolk sac tumour]], other carcinomas
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	Features:<ref name=Ref_GUP549>{{Ref GUP\|549}}</ref>		Features:<ref name=Ref_GUP549>{{Ref GUP\|549}}</ref>
	#Nucleoli - '''key feature'''.		#Nucleoli - '''key feature'''.
	#Vesicular nuclei (clear, empty appearing nuclei) - '''key feature'''.		#[[Vesicular nuclei]] (clear, empty appearing nuclei) - '''key feature'''.
	#Nuclei overlap.		#Nuclei overlap.
	#[[Necrosis]] - common.		#[[Necrosis]] - common.

Michael: /* Additional notes */

2015-04-09T18:43:40Z

Additional notes

← Older revision		Revision as of 18:43, 9 April 2015
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	===Additional notes===		===Additional notes===
			*CK19 -ve.<ref>{{Cite journal \| last1 = Bremmer \| first1 = F. \| last2 = Ströbel \| first2 = P. \| last3 = Hubertus \| first3 = H. \| last4 = Strecker \| first4 = J. \| last5 = Gaisa \| first5 = N. \| last6 = Strauß \| first6 = A. \| last7 = Schweyer \| first7 = S. \| last8 = Radzun \| first8 = H-J. \| last9 = Behnes \| first9 = C-L \| title = CK19 is a sensitive marker for yolk sac tumours of the testis. \| journal = Diagnostic Pathology \| volume = 10 \| issue = 7 \| pages = \| month = \| year = 2015 \| doi = 10.1186/s13000-015-0243-y \| PMID = \| url = www.diagnosticpathology.org/content/10/1/7‎Cached }}</ref>
			**[[Yolk sac tumour]] +ve, seminoma -ve, [[ITGCN]] -ve, normal testis -ve.
	*AE1/AE3 +ve.		*AE1/AE3 +ve.
	*OCT3/4 +ve.<ref name=pmid18045648>{{Cite journal \| last1 = Iczkowski \| first1 = KA. \| last2 = Butler \| first2 = SL. \| last3 = Shanks \| first3 = JH. \| last4 = Hossain \| first4 = D. \| last5 = Schall \| first5 = A. \| last6 = Meiers \| first6 = I. \| last7 = Zhou \| first7 = M. \| last8 = Torkko \| first8 = KC. \| last9 = Kim \| first9 = SJ. \| title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. \| journal = Hum Pathol \| volume = 39 \| issue = 2 \| pages = 275-81 \| month = Feb \| year = 2008 \| doi = 10.1016/j.humpath.2007.07.002 \| PMID = 18045648 }}</ref>		*OCT3/4 +ve.<ref name=pmid18045648>{{Cite journal \| last1 = Iczkowski \| first1 = KA. \| last2 = Butler \| first2 = SL. \| last3 = Shanks \| first3 = JH. \| last4 = Hossain \| first4 = D. \| last5 = Schall \| first5 = A. \| last6 = Meiers \| first6 = I. \| last7 = Zhou \| first7 = M. \| last8 = Torkko \| first8 = KC. \| last9 = Kim \| first9 = SJ. \| title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. \| journal = Hum Pathol \| volume = 39 \| issue = 2 \| pages = 275-81 \| month = Feb \| year = 2008 \| doi = 10.1016/j.humpath.2007.07.002 \| PMID = 18045648 }}</ref>

Michael at 16:00, 26 November 2014

2014-11-26T16:00:35Z

← Older revision		Revision as of 16:00, 26 November 2014
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing = [[~~Orchiectomy~~ grossing]]		\| Grossing = [[orchiectomy grossing]]
	\| Site = [[testis]], [[ovary]], [[mediastinum]]		\| Site = [[testis]], [[ovary]], [[mediastinum]]
	\| Assdx =		\| Assdx =

Michael at 15:56, 26 November 2014

2014-11-26T15:56:28Z

← Older revision		Revision as of 15:56, 26 November 2014
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing = [[Orchiectomy grossing]]
	\| Site = [[testis]], [[ovary]], [[mediastinum]]		\| Site = [[testis]], [[ovary]], [[mediastinum]]
	\| Assdx =		\| Assdx =
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	\| Signs = testicular mass, pelvic mass		\| Signs = testicular mass, pelvic mass
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = pure embryonal uncommon
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
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	\| Prognosis =		\| Prognosis =
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = typically other [[testicle\|testicular tumours]]
	}}		}}
	'''Embryonal carcinoma''' is a type of [[germ cell tumour]]. It is commonly as a component of [[mixed germ cell tumour]]s.		'''Embryonal carcinoma''' is a type of [[germ cell tumour]]. It is commonly as a component of [[mixed germ cell tumour]]s.
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	*Affects young adults.		*Affects young adults.
	**May be seen in women.		**May be seen in women.
	*Usually a component of [[mixed germ cell tumour]] - in the [[testicle]] 85% of cases are mixed - only 15% are pure <ref name=pmid24503753/>.		*Usually a component of a [[mixed germ cell tumour]] - in the [[testicle]] 85% of cases are mixed, only 15% are pure.<ref name=pmid24503753/>

	==Gross==		==Gross==

Michael: /* General */

2014-11-26T15:51:20Z

General

← Older revision		Revision as of 15:51, 26 November 2014
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	*Affects young adults.		*Affects young adults.
	**May be seen in women.		**May be seen in women.
			*Usually a component of [[mixed germ cell tumour]] - in the [[testicle]] 85% of cases are mixed - only 15% are pure <ref name=pmid24503753/>.

	==Gross==		==Gross==

Michael: /* Microscopic */

2014-11-26T15:48:57Z

Microscopic

← Older revision		Revision as of 15:48, 26 November 2014
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	#Indistinct cell borders		#Indistinct cell borders
	#Mitoses - common.		#Mitoses - common.
	#Variable architecture:		#Variable architecture:<ref name=pmid24503753>{{Cite journal \| last1 = Kao \| first1 = CS. \| last2 = Ulbright \| first2 = TM. \| last3 = Young \| first3 = RH. \| last4 = Idrees \| first4 = MT. \| title = Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 5 \| pages = 689-97 \| month = May \| year = 2014 \| doi = 10.1097/PAS.0000000000000171 \| PMID = 24503753 }}</ref>
	#*~~Tubulopapillary~~.		#*Solid (predominant in ~55% of cases).
	#*Glandular.		#*Glandular (predominant in ~17% of cases).
	#*~~Solid~~.		#*Papillary (predominant in ~11% of cases).
			#*Nested.
			#*Micropapillary.
			#*Anastomosing glandular.
			#*Sieve-like glandular.
			#*Pseudopapillary.
			#*Blastocyst-like.
	#*Embryoid bodies - ball of cells in surrounded by empty space on three sides.		#*Embryoid bodies - ball of cells in surrounded by empty space on three sides.

	Notes:		Notes:
	*Cytoplasmic staining variable (eosinophilic to basophilic).		*Cytoplasmic staining variable (eosinophilic to basophilic).
			*[[Syncytiotrophoblasts]] commonly seen (~40-50% of cases<ref name=pmid24503753/>).

	DDx:		DDx:
	*[[Mixed germ cell tumour]].		*[[Mixed germ cell tumour]].
	*[[Yolk sac tumour]].		*[[Yolk sac tumour]].
			*[[Seminoma]].

	===Images===		===Images===