Endometrial stromal sarcoma - Revision history

Michael at 17:41, 20 March 2015

2015-03-20T17:41:36Z

← Older revision		Revision as of 17:41, 20 March 2015
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	\| LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[uterine leiomyosarcoma]], [[uterine tumour resembling an ovarian sex cord stromal tumour]]		\| LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[uterine leiomyosarcoma]], [[uterine tumour resembling an ovarian sex cord stromal tumour]]
	\| Stains =		\| Stains =
	\| IHC = CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve		\| IHC = [[CD10]] +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve
	\| EM =		\| EM =
	\| Molecular = t(7;17)		\| Molecular = t(7;17)
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	==IHC==		==IHC==
	Features:<ref name=pmid14751141>{{Cite journal \| last1 = Zhu \| first1 = XQ. \| last2 = Shi \| first2 = YF. \| last3 = Cheng \| first3 = XD. \| last4 = Zhao \| first4 = CL. \| last5 = Wu \| first5 = YZ. \| title = Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. \| journal = Gynecol Oncol \| volume = 92 \| issue = 1 \| pages = 71-9 \| month = Jan \| year = 2004 \| doi = \| PMID = 14751141 }}</ref>		Features:<ref name=pmid14751141>{{Cite journal \| last1 = Zhu \| first1 = XQ. \| last2 = Shi \| first2 = YF. \| last3 = Cheng \| first3 = XD. \| last4 = Zhao \| first4 = CL. \| last5 = Wu \| first5 = YZ. \| title = Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. \| journal = Gynecol Oncol \| volume = 92 \| issue = 1 \| pages = 71-9 \| month = Jan \| year = 2004 \| doi = \| PMID = 14751141 }}</ref>
	*CD10 +ve.		*[[CD10]] +ve.
	*H-caldesmin -ve.		*H-caldesmin -ve.
	**[[Leiomyoma]]s +ve.		**[[Leiomyoma]]s +ve.

Michael at 17:51, 23 February 2015

2015-02-23T17:51:32Z

← Older revision		Revision as of 17:51, 23 February 2015
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	\| Micro = highly cellular islands of (tumour) cells with a wavy irregular border -- benign uterine smooth muscle between; tumour cells: high [[NC ratio]] and epithelioid, pallisade around thin blood vessels within the tumour		\| Micro = highly cellular islands of (tumour) cells with a wavy irregular border -- benign uterine smooth muscle between; tumour cells: high [[NC ratio]] and epithelioid, pallisade around thin blood vessels within the tumour
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[uterine leiomyosarcoma]]		\| LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[uterine leiomyosarcoma]], [[uterine tumour resembling an ovarian sex cord stromal tumour]]
	\| Stains =		\| Stains =
	\| IHC = CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve		\| IHC = CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve

Michael: /* Microscopic */

2015-02-23T17:51:15Z

Microscopic

← Older revision		Revision as of 17:51, 23 February 2015
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	*[[Uterine leiomyosarcoma]].		*[[Uterine leiomyosarcoma]].
	*[[Undifferentiated endometrial sarcoma]] (previously known as ''high-grade endometrial stromal sarcoma'') - necrosis and nuclear atypia.<ref name=pmid24146786/>		*[[Undifferentiated endometrial sarcoma]] (previously known as ''high-grade endometrial stromal sarcoma'') - necrosis and nuclear atypia.<ref name=pmid24146786/>
			*[[Uterine tumour resembling an ovarian sex cord stromal tumour]].

	===Images===		===Images===

Michael at 03:58, 17 November 2013

2013-11-17T03:58:57Z

← Older revision		Revision as of 03:58, 17 November 2013
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	'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours\|tumour of the uterus]].		'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours\|tumour of the uterus]].

	~~Previously, it was~~ known as '''low-grade endometrial stromal sarcoma''', abbreviated '''LGESS'''.		It is also known as '''low-grade endometrial stromal sarcoma''', abbreviated '''LGESS'''.

	==General==		==General==

Michael at 03:58, 17 November 2013

2013-11-17T03:58:26Z

← Older revision		Revision as of 03:58, 17 November 2013
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	'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours\|tumour of the uterus]].		'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours\|tumour of the uterus]].

	~~It is also~~ known as '''low-grade endometrial stromal sarcoma''', abbreviated '''LGESS'''.		Previously, it was known as '''low-grade endometrial stromal sarcoma''', abbreviated '''LGESS'''.

	==General==		==General==

Michael: /* General */ fix ref

2013-11-17T03:57:54Z

General: fix ref

← Older revision		Revision as of 03:57, 17 November 2013
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	==General==		==General==
	*Uncommon.<ref name=pmid20179433> {{Cite journal \| last1 = Chew \| first1 = I. \| last2 = Oliva \| first2 = E. \| title = Endometrial stromal sarcomas: a review of potential prognostic factors. \| journal = Adv Anat Pathol \| volume = 17 \| issue = 2 \| pages = 113-21 \| month = Mar \| year = 2010 \| doi = 10.1097/PAP.0b013e3181cfb7c2 \| PMID = 20179433 }}</ref>		*Uncommon.<ref name=pmid20179433> {{Cite journal \| last1 = Chew \| first1 = I. \| last2 = Oliva \| first2 = E. \| title = Endometrial stromal sarcomas: a review of potential prognostic factors. \| journal = Adv Anat Pathol \| volume = 17 \| issue = 2 \| pages = 113-21 \| month = Mar \| year = 2010 \| doi = 10.1097/PAP.0b013e3181cfb7c2 \| PMID = 20179433 }}</ref>
	*Prognosis good<ref name=pmid24146786></ref> > 90% five year survival and > 85% ten year survival.<ref name=pmid24184602>{{Cite journal \| last1 = Yoon \| first1 = A. \| last2 = Park \| first2 = JY. \| last3 = Park \| first3 = JY. \| last4 = Lee \| first4 = YY. \| last5 = Kim \| first5 = TJ. \| last6 = Choi \| first6 = CH. \| last7 = Bae \| first7 = DS. \| last8 = Kim \| first8 = BG. \| last9 = Lee \| first9 = JW. \| title = Prognostic factors and outcomes in endometrial stromal sarcoma with the 2009 FIGO staging system: A multicenter review of 114 cases. \| journal = Gynecol Oncol \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.ygyno.2013.10.029 \| PMID = 24184602 }}</ref>		*Prognosis good<ref name=pmid24146786>{{Cite journal \| last1 = Feng \| first1 = W. \| last2 = Malpica \| first2 = A. \| last3 = Skaland \| first3 = I. \| last4 = Gudlaugsson \| first4 = E. \| last5 = Robboy \| first5 = SJ. \| last6 = Dalen \| first6 = I. \| last7 = Hua \| first7 = K. \| last8 = Zhou \| first8 = X. \| last9 = Baak \| first9 = JP. \| title = Can proliferation biomarkers reliably predict recurrence in world health organization 2003 defined endometrial stromal sarcoma, low grade? \| journal = PLoS One \| volume = 8 \| issue = 10 \| pages = e75899 \| month = \| year = 2013 \| doi = 10.1371/journal.pone.0075899 \| PMID = 24146786 }}</ref> > 90% five year survival and > 85% ten year survival.<ref name=pmid24184602>{{Cite journal \| last1 = Yoon \| first1 = A. \| last2 = Park \| first2 = JY. \| last3 = Park \| first3 = JY. \| last4 = Lee \| first4 = YY. \| last5 = Kim \| first5 = TJ. \| last6 = Choi \| first6 = CH. \| last7 = Bae \| first7 = DS. \| last8 = Kim \| first8 = BG. \| last9 = Lee \| first9 = JW. \| title = Prognostic factors and outcomes in endometrial stromal sarcoma with the 2009 FIGO staging system: A multicenter review of 114 cases. \| journal = Gynecol Oncol \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.ygyno.2013.10.029 \| PMID = 24184602 }}</ref>

	Note:		Note:

Michael: +abbrev

2013-11-17T03:55:48Z

+abbrev

← Older revision		Revision as of 03:55, 17 November 2013
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	'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours\|tumour of the uterus]].		'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours\|tumour of the uterus]].

	It is also known as '''low-grade endometrial stromal sarcoma'''		It is also known as '''low-grade endometrial stromal sarcoma''', abbreviated '''LGESS'''.

	==General==		==General==

Michael: /* General */ more

2013-11-17T03:55:22Z

General: more

← Older revision		Revision as of 03:55, 17 November 2013
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	==General==		==General==
	*Uncommon.<ref name=pmid20179433> {{Cite journal \| last1 = Chew \| first1 = I. \| last2 = Oliva \| first2 = E. \| title = Endometrial stromal sarcomas: a review of potential prognostic factors. \| journal = Adv Anat Pathol \| volume = 17 \| issue = 2 \| pages = 113-21 \| month = Mar \| year = 2010 \| doi = 10.1097/PAP.0b013e3181cfb7c2 \| PMID = 20179433 }}</ref>		*Uncommon.<ref name=pmid20179433> {{Cite journal \| last1 = Chew \| first1 = I. \| last2 = Oliva \| first2 = E. \| title = Endometrial stromal sarcomas: a review of potential prognostic factors. \| journal = Adv Anat Pathol \| volume = 17 \| issue = 2 \| pages = 113-21 \| month = Mar \| year = 2010 \| doi = 10.1097/PAP.0b013e3181cfb7c2 \| PMID = 20179433 }}</ref>
	*Prognosis good<ref name=pmid24146786></ref> > 90% five year survival and > 85% ten year survival<ref name=pmid24184602>{{Cite journal \| last1 = Yoon \| first1 = A. \| last2 = Park \| first2 = JY. \| last3 = Park \| first3 = JY. \| last4 = Lee \| first4 = YY. \| last5 = Kim \| first5 = TJ. \| last6 = Choi \| first6 = CH. \| last7 = Bae \| first7 = DS. \| last8 = Kim \| first8 = BG. \| last9 = Lee \| first9 = JW. \| title = Prognostic factors and outcomes in endometrial stromal sarcoma with the 2009 FIGO staging system: A multicenter review of 114 cases. \| journal = Gynecol Oncol \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.ygyno.2013.10.029 \| PMID = 24184602 }}</ref>		*Prognosis good<ref name=pmid24146786></ref> > 90% five year survival and > 85% ten year survival.<ref name=pmid24184602>{{Cite journal \| last1 = Yoon \| first1 = A. \| last2 = Park \| first2 = JY. \| last3 = Park \| first3 = JY. \| last4 = Lee \| first4 = YY. \| last5 = Kim \| first5 = TJ. \| last6 = Choi \| first6 = CH. \| last7 = Bae \| first7 = DS. \| last8 = Kim \| first8 = BG. \| last9 = Lee \| first9 = JW. \| title = Prognostic factors and outcomes in endometrial stromal sarcoma with the 2009 FIGO staging system: A multicenter review of 114 cases. \| journal = Gynecol Oncol \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.ygyno.2013.10.029 \| PMID = 24184602 }}</ref>

			Note:
			*''Extrauterine endometrial stromal sarcoma'' is known as ''endometrioid stromal sarcoma''.<ref name=pmid24121169>{{Cite journal \| last1 = Masand \| first1 = RP. \| last2 = Euscher \| first2 = ED. \| last3 = Deavers \| first3 = MT. \| last4 = Malpica \| first4 = A. \| title = Endometrioid stromal sarcoma: a clinicopathologic study of 63 cases. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 11 \| pages = 1635-47 \| month = Nov \| year = 2013 \| doi = 10.1097/PAS.0000000000000083 \| PMID = 24121169 }}</ref>

	==Microscopic==		==Microscopic==

Michael at 03:52, 17 November 2013

2013-11-17T03:52:04Z

← Older revision		Revision as of 03:52, 17 November 2013
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	\| Micro = highly cellular islands of (tumour) cells with a wavy irregular border -- benign uterine smooth muscle between; tumour cells: high [[NC ratio]] and epithelioid, pallisade around thin blood vessels within the tumour		\| Micro = highly cellular islands of (tumour) cells with a wavy irregular border -- benign uterine smooth muscle between; tumour cells: high [[NC ratio]] and epithelioid, pallisade around thin blood vessels within the tumour
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[~~Uterine~~ leiomyosarcoma]].		\| LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[uterine leiomyosarcoma]]
	\| Stains =		\| Stains =
	\| IHC = CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve		\| IHC = CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve
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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = good
	\| Other =		\| Other =
	\| ClinDDx = other [[uterine tumours]]		\| ClinDDx = other [[uterine tumours]]
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	==General==		==General==
	*Uncommon.<ref name=pmid20179433> {{Cite journal \| last1 = Chew \| first1 = I. \| last2 = Oliva \| first2 = E. \| title = Endometrial stromal sarcomas: a review of potential prognostic factors. \| journal = Adv Anat Pathol \| volume = 17 \| issue = 2 \| pages = 113-21 \| month = Mar \| year = 2010 \| doi = 10.1097/PAP.0b013e3181cfb7c2 \| PMID = 20179433 }}</ref>		*Uncommon.<ref name=pmid20179433> {{Cite journal \| last1 = Chew \| first1 = I. \| last2 = Oliva \| first2 = E. \| title = Endometrial stromal sarcomas: a review of potential prognostic factors. \| journal = Adv Anat Pathol \| volume = 17 \| issue = 2 \| pages = 113-21 \| month = Mar \| year = 2010 \| doi = 10.1097/PAP.0b013e3181cfb7c2 \| PMID = 20179433 }}</ref>
	*Prognosis good.<ref name=pmid24146786></ref>		*Prognosis good<ref name=pmid24146786></ref> > 90% five year survival and > 85% ten year survival<ref name=pmid24184602>{{Cite journal \| last1 = Yoon \| first1 = A. \| last2 = Park \| first2 = JY. \| last3 = Park \| first3 = JY. \| last4 = Lee \| first4 = YY. \| last5 = Kim \| first5 = TJ. \| last6 = Choi \| first6 = CH. \| last7 = Bae \| first7 = DS. \| last8 = Kim \| first8 = BG. \| last9 = Lee \| first9 = JW. \| title = Prognostic factors and outcomes in endometrial stromal sarcoma with the 2009 FIGO staging system: A multicenter review of 114 cases. \| journal = Gynecol Oncol \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.ygyno.2013.10.029 \| PMID = 24184602 }}</ref>

	==Microscopic==		==Microscopic==
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	*PR +/-ve.		*PR +/-ve.
	*ER +/-ve.		*ER +/-ve.
			*CD117 +ve (~80%).<ref>{{Cite journal \| last1 = Park \| first1 = JY. \| last2 = Kim \| first2 = KR. \| last3 = Nam \| first3 = JH. \| title = Immunohistochemical analysis for therapeutic targets and prognostic markers in low-grade endometrial stromal sarcoma. \| journal = Int J Gynecol Cancer \| volume = 23 \| issue = 1 \| pages = 81-9 \| month = Jan \| year = 2013 \| doi = 10.1097/IGC.0b013e3182738361 \| PMID = 23221606 }}</ref>

	==Molecular==		==Molecular==

Michael: /* Microscopic */ tweak some more

2013-11-17T03:42:25Z

Microscopic: tweak some more

← Older revision		Revision as of 03:42, 17 November 2013
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	*[[Endometrial stromal nodule]].		*[[Endometrial stromal nodule]].
	*[[Uterine leiomyosarcoma]].		*[[Uterine leiomyosarcoma]].
			*[[Undifferentiated endometrial sarcoma]] (previously known as ''high-grade endometrial stromal sarcoma'') - necrosis and nuclear atypia.<ref name=pmid24146786/>

	===Images===		===Images===