Endometrioid endometrial carcinoma - Revision history

Michael: touch

2023-02-22T21:40:09Z

touch

← Older revision		Revision as of 21:40, 22 February 2023
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Endometrioid endometrial adenocarcinoma high mag.jpg		\| Image = Endometrioid endometrial adenocarcinoma high mag.jpg

Michael: /* See also */

2018-03-05T18:17:10Z

Abraham: /* General */

2017-12-28T03:25:38Z

General

← Older revision		Revision as of 03:25, 28 December 2017
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	*Good prognosis - usually.		*Good prognosis - usually.
	*Women in 40s & 50s.		*Women in 40s & 50s.
	*Associated with estrogen excess.		*Associated with estrogen excess (unopossed estrogen stimulation).
	**Typical patient is [[obese]].		**Typical patient is [[obese]].

Mitchell: /* Micro */ added MELF as something to look for

2017-06-24T18:15:42Z

Micro: added MELF as something to look for

← Older revision		Revision as of 18:15, 24 June 2017
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	===Micro===		===Micro===
	The sections show endometrium with complex, fused and cribriform glands with scant intervening stroma over a region measuring greater than 2.1 millimetres. Focally, a desmoplastic stroma is also identified. No nuclear atypia is appreciated.		The sections show endometrium with complex, fused and cribriform glands with scant intervening stroma over a region measuring greater than 2.1 millimetres. Focally, a desmoplastic stroma is also identified. No nuclear atypia is appreciated.

			A subtle pattern of myoinvasion in low grade endometrial endometrioid carcinomas, microcystic, elongated and fragmented (MELF) should be searched for in the absence of frank invasion. At low power, microcystic tumor glands lie separated by muscle from non-invasive carcinoma in edematous stroma. At higher power lie microcystic glands with neutrophils, as well as elongated glands lined by flattened tumor cells. Eosinophilic tumor cells or squamous cells can often be seen within the lumens. <ref name=pmid14501811>{{cite journal \|author= Murray SK, Young RH, Scully RE \|title= Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinoma: a study of their frequency, associated diagnostic problems, and prognostic significance \|journal= Int J Gynecol Pathol \|volume=22 \|issue= \|pages=324-333 \|year=2003 \| pmid=14501811 \|doi=10.1097/01.pgp.0000092161.33490.a9 }}</ref>

	====Endocervical versus endometrial - biopsy====		====Endocervical versus endometrial - biopsy====

Michael: /* See also */

2016-02-09T03:19:57Z

Michael: /* Biopsy */

2015-12-01T13:21:50Z

Biopsy

← Older revision		Revision as of 13:21, 1 December 2015
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	- ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA, preliminary FIGO grade I.		- ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA, preliminary FIGO grade I.
	</pre>		</pre>

			<pre>
			Endometrium, Curettage:
			- ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA, preliminary FIGO grade II.

			Comment:
			The architecture is in keeping with FIGO I; however, nuclear atypia is
			present and therefore it is FIGO II.
			</pre>


	====Block letters====		====Block letters====

Michael: /* Grading */

2015-11-25T16:41:05Z

Grading

← Older revision		Revision as of 16:41, 25 November 2015
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	*High grade nuclei upgrades cancer by one.		*High grade nuclei upgrades cancer by one.
	**Tadrous says: high grade nuclei = increased size, irregular large nucleoli, irregular chromatin pattern (clumped, coarse).<ref>{{Ref DCHH\|240}}</ref>		**Tadrous says: high grade nuclei = increased size, irregular large nucleoli, irregular chromatin pattern (clumped, coarse).<ref>{{Ref DCHH\|240}}</ref>
	~~Winham~~
	**Winham ''et al''. describe it as: [[nuclear pleomorphism]] identifiable with the 10× objective or enlarged nuclei (1.5-2× normal) with [[prominent nucleoli]], irregular nuclear contours, and dispersed chromatin.<ref name=pmid24487465>{{Cite journal \| last1 = Winham \| first1 = WM. \| last2 = Lin \| first2 = D. \| last3 = Stone \| first3 = PJ. \| last4 = Nucci \| first4 = MR. \| last5 = Quick \| first5 = CM. \| title = Architectural versus nuclear atypia-defined FIGO grade 2 endometrial endometrioid adenocarcinoma (EEC): a clinicopathologic comparison of 154 cases with clinical follow-up. \| journal = Int J Gynecol Pathol \| volume = 33 \| issue = 2 \| pages = 120-6 \| month = Mar \| year = 2014 \| doi = 10.1097/PGP.0b013e31828bb4ed \| PMID = 24487465 }}</ref>		**Winham ''et al''. describe it as: [[nuclear pleomorphism]] identifiable with the 10× objective or enlarged nuclei (1.5-2× normal) with [[prominent nucleoli]], irregular nuclear contours, and dispersed chromatin.<ref name=pmid24487465>{{Cite journal \| last1 = Winham \| first1 = WM. \| last2 = Lin \| first2 = D. \| last3 = Stone \| first3 = PJ. \| last4 = Nucci \| first4 = MR. \| last5 = Quick \| first5 = CM. \| title = Architectural versus nuclear atypia-defined FIGO grade 2 endometrial endometrioid adenocarcinoma (EEC): a clinicopathologic comparison of 154 cases with clinical follow-up. \| journal = Int J Gynecol Pathol \| volume = 33 \| issue = 2 \| pages = 120-6 \| month = Mar \| year = 2014 \| doi = 10.1097/PGP.0b013e31828bb4ed \| PMID = 24487465 }}</ref>

Michael: /* Biopsy */

2015-11-25T16:38:27Z

Biopsy

← Older revision		Revision as of 16:38, 25 November 2015
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	==Sign out==		==Sign out==
	===Biopsy===		===Biopsy===
			<pre>
			Endometrium, Curettage:
			- ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA, preliminary FIGO grade I.
			</pre>

			====Block letters====
	<pre>		<pre>
	ENDOMETRIUM, BIOPSY:		ENDOMETRIUM, BIOPSY:

Michael at 16:35, 25 November 2015

2015-11-25T16:35:13Z

← Older revision		Revision as of 16:35, 25 November 2015
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	Modifiers/adjustment:		Modifiers/adjustment:
	*High grade nuclei upgrades cancer by one; high grade nuclei = increased size, irregular large nucleoli, irregular chromatin pattern (clumped, coarse).<ref>{{Ref DCHH\|240}}</ref>		*High grade nuclei upgrades cancer by one.
			**Tadrous says: high grade nuclei = increased size, irregular large nucleoli, irregular chromatin pattern (clumped, coarse).<ref>{{Ref DCHH\|240}}</ref>
			Winham
			**Winham ''et al''. describe it as: [[nuclear pleomorphism]] identifiable with the 10× objective or enlarged nuclei (1.5-2× normal) with [[prominent nucleoli]], irregular nuclear contours, and dispersed chromatin.<ref name=pmid24487465>{{Cite journal \| last1 = Winham \| first1 = WM. \| last2 = Lin \| first2 = D. \| last3 = Stone \| first3 = PJ. \| last4 = Nucci \| first4 = MR. \| last5 = Quick \| first5 = CM. \| title = Architectural versus nuclear atypia-defined FIGO grade 2 endometrial endometrioid adenocarcinoma (EEC): a clinicopathologic comparison of 154 cases with clinical follow-up. \| journal = Int J Gynecol Pathol \| volume = 33 \| issue = 2 \| pages = 120-6 \| month = Mar \| year = 2014 \| doi = 10.1097/PGP.0b013e31828bb4ed \| PMID = 24487465 }}</ref>

	===Images===		===Images===

Michael at 03:26, 24 September 2014

2014-09-24T03:26:36Z

← Older revision		Revision as of 03:26, 24 September 2014
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	\| IF =		\| IF =
	\| Gross = endometrial thickening		\| Gross = endometrial thickening
	\| Grossing =		\| Grossing = [[hysterectomy for endometrial cancer grossing]]
	\| Site = [[endometrium]] - see ''[[endometrial carcinoma]]''		\| Site = [[endometrium]] - see ''[[endometrial carcinoma]]''
	\| Assdx = [[obesity]]		\| Assdx = [[obesity]]

← Older revision		Revision as of 18:17, 5 March 2018
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	*[[Endometrial hyperplasia]].		*[[Endometrial hyperplasia]].
	*[[Ductal adenocarcinoma of the prostate gland]].		*[[Ductal adenocarcinoma of the prostate gland]].
			*[[Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma]] (MELF).

	==References==		==References==

← Older revision		Revision as of 03:19, 9 February 2016
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	*[[Endometrial carcinoma]].		*[[Endometrial carcinoma]].
	*[[Endometrial hyperplasia]].		*[[Endometrial hyperplasia]].
			*[[Ductal adenocarcinoma of the prostate gland]].

	==References==		==References==