Endometrium with squamous morules - Revision history

Michael: /* See also */

2014-06-18T12:35:29Z

Michael at 17:32, 19 March 2014

2014-03-19T17:32:13Z

← Older revision		Revision as of 17:32, 19 March 2014
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	\| Micro = well-circumscribed ball of squamoid cells -- cells have a whorled arrangement, moderate eosinophilic cytoplasm and a bland nucleus		\| Micro = well-circumscribed ball of squamoid cells -- cells have a whorled arrangement, moderate eosinophilic cytoplasm and a bland nucleus
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[endometrial hyperplasia]], [[endometrial carcinoma]] - esp. [[endometrioid endometrial carcinoma]], [[uterine leiomyoma]]		\| LMDDx = [[endometrial hyperplasia]], [[endometrial carcinoma]] - esp. [[endometrioid endometrial carcinoma]], [[uterine leiomyoma]], [[atypical polypoid adenomyoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael: /* Microscopic */

2014-03-19T17:31:43Z

Microscopic

← Older revision		Revision as of 17:31, 19 March 2014
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	*[[Endometrioid endometrial carcinoma]].		*[[Endometrioid endometrial carcinoma]].
	*[[Uterine leiomyoma]].		*[[Uterine leiomyoma]].
			*[[Atypical polypoid adenomyoma]] - squamous morules ''and'' proliferation of smooth muscle.

	===Images===		===Images===

Michael: /* Microscopic */

2014-01-09T13:20:08Z

Microscopic

← Older revision		Revision as of 13:20, 9 January 2014
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	www:		www:
	*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008146f1.html Squamous morules - several (nature.com)].		*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008146f1.html Squamous morules - several (nature.com)].
	*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008146f2.html Squamous morule (nature.com)].<ref name=pmid19180120>{{Cite journal \| last1 = Lin \| first1 = MC. \| last2 = Lomo \| first2 = L. \| last3 = Baak \| first3 = JP. \| last4 = Eng \| first4 = C. \| last5 = Ince \| first5 = TA. \| last6 = Crum \| first6 = CP. \| last7 = Mutter \| first7 = GL. \| title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. \| journal = Mod Pathol \| volume = 22 \| issue = 2 \| pages = 167-74 \| month = Feb \| year = 2009 \| doi = 10.1038/modpathol.2008.146 \| PMID = 19180120 }}</ref>		*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008146f2.html Squamous morule and IHC stains (nature.com)].<ref name=pmid19180120>{{Cite journal \| last1 = Lin \| first1 = MC. \| last2 = Lomo \| first2 = L. \| last3 = Baak \| first3 = JP. \| last4 = Eng \| first4 = C. \| last5 = Ince \| first5 = TA. \| last6 = Crum \| first6 = CP. \| last7 = Mutter \| first7 = GL. \| title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. \| journal = Mod Pathol \| volume = 22 \| issue = 2 \| pages = 167-74 \| month = Feb \| year = 2009 \| doi = 10.1038/modpathol.2008.146 \| PMID = 19180120 }}</ref>

			==IHC==
			Features:<ref name=pmid19180120>{{Cite journal \| last1 = Lin \| first1 = MC. \| last2 = Lomo \| first2 = L. \| last3 = Baak \| first3 = JP. \| last4 = Eng \| first4 = C. \| last5 = Ince \| first5 = TA. \| last6 = Crum \| first6 = CP. \| last7 = Mutter \| first7 = GL. \| title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. \| journal = Mod Pathol \| volume = 22 \| issue = 2 \| pages = 167-74 \| month = Feb \| year = 2009 \| doi = 10.1038/modpathol.2008.146 \| PMID = 19180120 }}</ref>
			*ER -ve.
			*PR -ve.
			*Ki-67 low.

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Michael: /* Images */

2014-01-09T13:17:08Z

Images

← Older revision		Revision as of 13:17, 9 January 2014
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	</gallery>		</gallery>
	www:		www:
			*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008146f1.html Squamous morules - several (nature.com)].
	*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008146f2.html Squamous morule (nature.com)].<ref name=pmid19180120>{{Cite journal \| last1 = Lin \| first1 = MC. \| last2 = Lomo \| first2 = L. \| last3 = Baak \| first3 = JP. \| last4 = Eng \| first4 = C. \| last5 = Ince \| first5 = TA. \| last6 = Crum \| first6 = CP. \| last7 = Mutter \| first7 = GL. \| title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. \| journal = Mod Pathol \| volume = 22 \| issue = 2 \| pages = 167-74 \| month = Feb \| year = 2009 \| doi = 10.1038/modpathol.2008.146 \| PMID = 19180120 }}</ref>		*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008146f2.html Squamous morule (nature.com)].<ref name=pmid19180120>{{Cite journal \| last1 = Lin \| first1 = MC. \| last2 = Lomo \| first2 = L. \| last3 = Baak \| first3 = JP. \| last4 = Eng \| first4 = C. \| last5 = Ince \| first5 = TA. \| last6 = Crum \| first6 = CP. \| last7 = Mutter \| first7 = GL. \| title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. \| journal = Mod Pathol \| volume = 22 \| issue = 2 \| pages = 167-74 \| month = Feb \| year = 2009 \| doi = 10.1038/modpathol.2008.146 \| PMID = 19180120 }}</ref>

Michael: /* General */

2014-01-09T13:15:10Z

General

← Older revision		Revision as of 13:15, 9 January 2014
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	*Benign finding in itself.		*Benign finding in itself.
	*Strong association with malignancy.<ref name=pmid21126963>{{Cite journal \| last1 = Nicolae \| first1 = A. \| last2 = Preda \| first2 = O. \| last3 = Nogales \| first3 = FF. \| title = Endometrial metaplasias and reactive changes: a spectrum of altered differentiation. \| journal = J Clin Pathol \| volume = 64 \| issue = 2 \| pages = 97-106 \| month = Feb \| year = 2011 \| doi = 10.1136/jcp.2010.085555 \| PMID = 21126963 }}</ref>		*Strong association with malignancy.<ref name=pmid21126963>{{Cite journal \| last1 = Nicolae \| first1 = A. \| last2 = Preda \| first2 = O. \| last3 = Nogales \| first3 = FF. \| title = Endometrial metaplasias and reactive changes: a spectrum of altered differentiation. \| journal = J Clin Pathol \| volume = 64 \| issue = 2 \| pages = 97-106 \| month = Feb \| year = 2011 \| doi = 10.1136/jcp.2010.085555 \| PMID = 21126963 }}</ref>
	**Associated with glandular lesions, i.e. endometrial hyperplasia and adenocarcinoma, ''not'' neoplastic squamous lesions.<ref>{{Cite journal \| last1 = Lin \| first1 = MC. \| last2 = Lomo \| first2 = L. \| last3 = Baak \| first3 = JP. \| last4 = Eng \| first4 = C. \| last5 = Ince \| first5 = TA. \| last6 = Crum \| first6 = CP. \| last7 = Mutter \| first7 = GL. \| title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. \| journal = Mod Pathol \| volume = 22 \| issue = 2 \| pages = 167-74 \| month = Feb \| year = 2009 \| doi = 10.1038/modpathol.2008.146 \| PMID = 19180120 }}</ref>		**Associated with glandular lesions, i.e. endometrial hyperplasia and adenocarcinoma, ''not'' neoplastic squamous lesions.<ref name=pmid19180120>{{Cite journal \| last1 = Lin \| first1 = MC. \| last2 = Lomo \| first2 = L. \| last3 = Baak \| first3 = JP. \| last4 = Eng \| first4 = C. \| last5 = Ince \| first5 = TA. \| last6 = Crum \| first6 = CP. \| last7 = Mutter \| first7 = GL. \| title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. \| journal = Mod Pathol \| volume = 22 \| issue = 2 \| pages = 167-74 \| month = Feb \| year = 2009 \| doi = 10.1038/modpathol.2008.146 \| PMID = 19180120 }}</ref>

	==Microscopic==		==Microscopic==

Michael: /* Images */

2014-01-09T13:14:36Z

Images

← Older revision		Revision as of 13:14, 9 January 2014
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	Image: Squamous morule 2 - endometrium -- extremely high mag.jpg \| SM - extremely high mag.		Image: Squamous morule 2 - endometrium -- extremely high mag.jpg \| SM - extremely high mag.
	</gallery>		</gallery>
			www:
			*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008146f2.html Squamous morule (nature.com)].<ref name=pmid19180120>{{Cite journal \| last1 = Lin \| first1 = MC. \| last2 = Lomo \| first2 = L. \| last3 = Baak \| first3 = JP. \| last4 = Eng \| first4 = C. \| last5 = Ince \| first5 = TA. \| last6 = Crum \| first6 = CP. \| last7 = Mutter \| first7 = GL. \| title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. \| journal = Mod Pathol \| volume = 22 \| issue = 2 \| pages = 167-74 \| month = Feb \| year = 2009 \| doi = 10.1038/modpathol.2008.146 \| PMID = 19180120 }}</ref>

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Michael: /* Sign out */

2013-12-23T20:21:22Z

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← Older revision		Revision as of 20:21, 23 December 2013
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	are associated with hyperplasia and malignancy. Close follow-up and a re-biopsy (when		are associated with hyperplasia and malignancy. Close follow-up and a re-biopsy (when
	clinically indicated) are recommended.		clinically indicated) are recommended.
			</pre>

			<pre>
			ENDOMETRIUM, BIOPSY:
			- EXTENSIVELY FRAGMENTED ENDOMETRIUM WITH ABUNDANT SQUAMOUS MORULES, SEE COMMENT.
			- FOCAL STROMAL CONDENSATION SUGGESTIVE OF SHEDDING.

			COMMENT:
			The fragmentation makes it difficult to assess for hyperplasia. The squamous morules have
			degenerative changes centrally. There is no evidence of malignancy in this biopsy.

			Squamous morules are associated with hyperplasia and malignancy. Close follow-up and a
			re-biopsy (when clinically indicated) are recommended.
	</pre>		</pre>

Michael: /* Sign out */

2013-12-20T14:16:36Z

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← Older revision		Revision as of 14:16, 20 December 2013
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	<pre>		<pre>
	ENDOMETRIUM, BIOPSY:		ENDOMETRIUM, BIOPSY:
	- PROLIFERATIVE PHASE ENDOMETRIUM WITH SQUAMOUS MORULES, SEE COMMENT.		- PROLIFERATIVE PHASE ENDOMETRIUM WITH A FOCUS OF SQUAMOUS MORULES, SEE COMMENT.

	COMMENT:		COMMENT:
	~~Squamous~~ morules are ~~strongly~~ associated with hyperplasia and malignancy.		There is no evidence of hyperplasia or malignancy in this biopsy; however, squamous morules
	Close follow-up and ~~rebiopsy is suggested~~.		are associated with hyperplasia and malignancy. Close follow-up and a re-biopsy (when
			clinically indicated) are recommended.
	</pre>		</pre>

Michael at 19:46, 18 December 2013

2013-12-18T19:46:18Z

← Older revision		Revision as of 19:46, 18 December 2013
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	Image: Squamous morule 2 - endometrium -- extremely high mag.jpg \| SM - extremely high mag.		Image: Squamous morule 2 - endometrium -- extremely high mag.jpg \| SM - extremely high mag.
	</gallery>		</gallery>

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			<pre>
			ENDOMETRIUM, BIOPSY:
			- PROLIFERATIVE PHASE ENDOMETRIUM WITH SQUAMOUS MORULES, SEE COMMENT.

			COMMENT:
			Squamous morules are strongly associated with hyperplasia and malignancy.
			Close follow-up and rebiopsy is suggested.
			</pre>

	==See also==		==See also==

← Older revision		Revision as of 12:35, 18 June 2014
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	*[[Endometrial hyperplasia]].		*[[Endometrial hyperplasia]].
	*[[Metaplasias of the endometrium]].		*[[Metaplasias of the endometrium]].
			*[[Endometrium with psammoma bodies]].

	==References==		==References==