Epithelial-myoepithelial carcinoma - Revision history

Michael at 02:13, 19 March 2019

2019-03-19T02:13:02Z

← Older revision		Revision as of 02:13, 19 March 2019
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	Epithelial-myoepithelial carcinoma, abbreviated '''EMCa''', is a rare malignant [[salivary gland]] tumour.		Epithelial-myoepithelial carcinoma, abbreviated '''EMCa''', is a rare malignant [[salivary gland]] tumour.

	Should '''not''' be confused with ''[[~~epithelial~~ carcinoma]]''.		Should '''not''' be confused with ''[[myoepithelial carcinoma]]''.

	==General==		==General==

Michael at 02:12, 19 March 2019

2019-03-19T02:12:47Z

← Older revision		Revision as of 02:12, 19 March 2019
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	}}		}}
	Epithelial-myoepithelial carcinoma, abbreviated '''EMCa''', is a rare malignant [[salivary gland]] tumour.		Epithelial-myoepithelial carcinoma, abbreviated '''EMCa''', is a rare malignant [[salivary gland]] tumour.

			Should '''not''' be confused with ''[[epithelial carcinoma]]''.

	==General==		==General==

Michael: /* General */

2019-03-18T00:20:19Z

General

← Older revision		Revision as of 00:20, 18 March 2019
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	*Usually older people - 50s or 60s.		*Usually older people - 50s or 60s.
	*Usually parotid gland ~ 60% of cases.<ref name=pmid17197918/>		*Usually parotid gland ~ 60% of cases.<ref name=pmid17197918/>
	**An analogous lung tumour exists - see ''[[epithelial-myoepithelial carcinoma of lung]].<ref>{{Cite journal \| last1 = Nakashima \| first1 = Y. \| last2 = Morita \| first2 = R. \| last3 = Ui \| first3 = A. \| last4 = Iihara \| first4 = K. \| last5 = Yazawa \| first5 = T. \| title = Epithelial-myoepithelial carcinoma of the lung: a case report. \| journal = Surg Case Rep \| volume = 4 \| issue = 1 \| pages = 74 \| month = Jul \| year = 2018 \| doi = 10.1186/s40792-018-0482-8 \| PMID = 29987577 }}</ref>
	*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/>		*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/>

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	*Most common malignant component in ''[[carcinoma ex pleomorphic adenoma]]''.		*Most common malignant component in ''[[carcinoma ex pleomorphic adenoma]]''.
	*May be the same tumour as ''[[adenomyoepithelioma]] of the breast''.<ref name=pmid9769134>{{Cite journal \| last1 = Seifert \| first1 = G. \| title = Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? \| journal = Virchows Arch \| volume = 433 \| issue = 3 \| pages = 285-8 \| month = Sep \| year = 1998 \| doi = \| PMID = 9769134 }}</ref>		*May be the same tumour as ''[[adenomyoepithelioma]] of the breast''.<ref name=pmid9769134>{{Cite journal \| last1 = Seifert \| first1 = G. \| title = Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? \| journal = Virchows Arch \| volume = 433 \| issue = 3 \| pages = 285-8 \| month = Sep \| year = 1998 \| doi = \| PMID = 9769134 }}</ref>
			*An analogous [[lung tumour]] exists - see ''[[epithelial-myoepithelial carcinoma of lung]].<ref>{{Cite journal \| last1 = Nakashima \| first1 = Y. \| last2 = Morita \| first2 = R. \| last3 = Ui \| first3 = A. \| last4 = Iihara \| first4 = K. \| last5 = Yazawa \| first5 = T. \| title = Epithelial-myoepithelial carcinoma of the lung: a case report. \| journal = Surg Case Rep \| volume = 4 \| issue = 1 \| pages = 74 \| month = Jul \| year = 2018 \| doi = 10.1186/s40792-018-0482-8 \| PMID = 29987577 }}</ref>

	==Microscopic==		==Microscopic==

Michael: /* General */ weak

2019-03-18T00:16:09Z

General: weak

← Older revision		Revision as of 00:16, 18 March 2019
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	*Rare ~1% of salivary gland tumours.<ref name=pmid9568184>{{Cite journal \| last1 = Tralongo \| first1 = V. \| last2 = Daniele \| first2 = E. \| title = Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. \| journal = Anticancer Res \| volume = 18 \| issue = 1B \| pages = 603-8 \| month = \| year = \| doi = \| PMID = 9568184 }}</ref>		*Rare ~1% of salivary gland tumours.<ref name=pmid9568184>{{Cite journal \| last1 = Tralongo \| first1 = V. \| last2 = Daniele \| first2 = E. \| title = Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. \| journal = Anticancer Res \| volume = 18 \| issue = 1B \| pages = 603-8 \| month = \| year = \| doi = \| PMID = 9568184 }}</ref>
	*Female:male = 1.5:1.<ref name=pmid17197918>{{Cite journal \| last1 = Seethala \| first1 = RR. \| last2 = Barnes \| first2 = EL. \| last3 = Hunt \| first3 = JL. \| title = Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 1 \| pages = 44-57 \| month = Jan \| year = 2007 \| doi = 10.1097/01.pas.0000213314.74423.d8 \| PMID = 17197918 }}</ref>		*Female:male = 1.5:1.<ref name=pmid17197918>{{Cite journal \| last1 = Seethala \| first1 = RR. \| last2 = Barnes \| first2 = EL. \| last3 = Hunt \| first3 = JL. \| title = Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 1 \| pages = 44-57 \| month = Jan \| year = 2007 \| doi = 10.1097/01.pas.0000213314.74423.d8 \| PMID = 17197918 }}</ref>
	*~~Usu.~~ older people - 50s or 60s.		*Usually older people - 50s or 60s.
	*~~Usu.~~ parotid gland ~ 60% of cases.<ref name=pmid17197918/>		*Usually parotid gland ~ 60% of cases.<ref name=pmid17197918/>
			**An analogous lung tumour exists - see ''[[epithelial-myoepithelial carcinoma of lung]].<ref>{{Cite journal \| last1 = Nakashima \| first1 = Y. \| last2 = Morita \| first2 = R. \| last3 = Ui \| first3 = A. \| last4 = Iihara \| first4 = K. \| last5 = Yazawa \| first5 = T. \| title = Epithelial-myoepithelial carcinoma of the lung: a case report. \| journal = Surg Case Rep \| volume = 4 \| issue = 1 \| pages = 74 \| month = Jul \| year = 2018 \| doi = 10.1186/s40792-018-0482-8 \| PMID = 29987577 }}</ref>
	*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/>		*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/>

Michael: +infobox

2013-07-30T13:11:28Z

+infobox

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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Epithelial-myoepithelial carcinoma - very high mag.jpg
			\| Width =
			\| Caption = Epithelial-myoepithelial carcinoma. [[H&E stain]].
			\| Micro = biphasic tumour with (1) epithelial layer, and (2) myoepithelial layer; variable architecture (solid, cystic, tubular, papillary); +/- spindle cells
			\| Subtypes =
			\| LMDDx = [[adenoid cystic carcinoma]] (tubular variant), [[pleomorphic adenoma]], tubular variant.
			\| Stains =
			\| IHC = CAM5.2 +ve (epithelial comp.), p63 +ve (myoepithelial comp.)
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[salivary gland]] - usually parotid gland
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = salivary gland mass
			\| Symptoms =
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = other [[salivary gland]] masses
			}}
	Epithelial-myoepithelial carcinoma, abbreviated '''EMCa''', is a rare malignant [[salivary gland]] tumour.		Epithelial-myoepithelial carcinoma, abbreviated '''EMCa''', is a rare malignant [[salivary gland]] tumour.

Michael: split out

2013-07-30T13:06:45Z

split out

← Older revision		Revision as of 13:06, 30 July 2013
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	#~~redirect~~ [[~~Salivary_glands#~~Epithelial-~~myoepithelial_carcinoma~~]]		Epithelial-myoepithelial carcinoma, abbreviated '''EMCa''', is a rare malignant [[salivary gland]] tumour.

			==General==
			*Rare ~1% of salivary gland tumours.<ref name=pmid9568184>{{Cite journal \| last1 = Tralongo \| first1 = V. \| last2 = Daniele \| first2 = E. \| title = Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. \| journal = Anticancer Res \| volume = 18 \| issue = 1B \| pages = 603-8 \| month = \| year = \| doi = \| PMID = 9568184 }}</ref>
			*Female:male = 1.5:1.<ref name=pmid17197918>{{Cite journal \| last1 = Seethala \| first1 = RR. \| last2 = Barnes \| first2 = EL. \| last3 = Hunt \| first3 = JL. \| title = Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 1 \| pages = 44-57 \| month = Jan \| year = 2007 \| doi = 10.1097/01.pas.0000213314.74423.d8 \| PMID = 17197918 }}</ref>
			*Usu. older people - 50s or 60s.
			*Usu. parotid gland ~ 60% of cases.<ref name=pmid17197918/>
			*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/>

			Notes:
			*Most common malignant component in ''[[carcinoma ex pleomorphic adenoma]]''.
			*May be the same tumour as ''[[adenomyoepithelioma]] of the breast''.<ref name=pmid9769134>{{Cite journal \| last1 = Seifert \| first1 = G. \| title = Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? \| journal = Virchows Arch \| volume = 433 \| issue = 3 \| pages = 285-8 \| month = Sep \| year = 1998 \| doi = \| PMID = 9769134 }}</ref>

			==Microscopic==
			Features:
			*Biphasic tumour:<ref name=pmid17197918/>
			*#Epithelial layer.
			*#Myoepithelial layer - '''key feature'''.
			*Architecture: variable (solid, cystic, tubular, papillary).
			*+/-Spindle cells.
			*Basement membrane-like material; may mimic adenoid cystic carcinoma.

			Notes:
			*Usually few mitoses.

			DDx:
			*[[Adenoid cystic carcinoma]] (tubular variant).
			*[[Pleomorphic adenoma]], tubular variant.
			**Has focal epithelial-myoepithelial carcinoma-like areas.

			===Images===
			<gallery>
			Image:Epithelial-myoepithelial_carcinoma_-_intermed_mag.jpg \| EMCa - intermed. mag. (WC/Nephron)
			Image:Epithelial-myoepithelial_carcinoma_-_high_mag.jpg \| EMCa - high mag. (WC/Nephron)
			Image:Epithelial-myoepithelial carcinoma - very high mag.jpg \| EMCa - very high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/images-features/emc-rev-cyto1-18.jpg EMCa (pathologyimagesinc.com)].<ref>{{cite web \|url=http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/fs-emc-cytopath-feat.html \|title=Cytopathologic Features of
			Epithelial-myoepithelial Carcinoma \|last1= \|first1= \|last2= \|first2= \|date= \|work= \|publisher= \|accessdate=January 18, 2011}}</ref>
			*[http://www.headandneckoncology.org/content/2/1/4 EMCa (headandneckoncology.org)].

			==IHC==
			*CAM5.2 +ve -- epithelial component.
			*p63 +ve -- myoepithelial component.

			==See also==
			*[[Salivary glands]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Salivary gland]]
			[[Category:Head and neck pathology]]

Michael: +cat.

2011-10-22T05:36:28Z

+cat.

← Older revision		Revision as of 05:36, 22 October 2011
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	#redirect [[Salivary_glands#Epithelial-myoepithelial_carcinoma]]		#redirect [[Salivary_glands#Epithelial-myoepithelial_carcinoma]]

			[[Category:Diagnosis]]

Michael: fix redirect

2011-07-24T16:27:29Z

fix redirect

← Older revision		Revision as of 16:27, 24 July 2011
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	#redirect [[~~Salivary_gland~~#Epithelial-myoepithelial_carcinoma]]		#redirect [[Salivary_glands#Epithelial-myoepithelial_carcinoma]]

Michael: redirect for now

2011-07-19T14:41:12Z

redirect for now

New page

#redirect [[Salivary_gland#Epithelial-myoepithelial_carcinoma]]