Epithelioid hemangioendothelioma - Revision history

Michael at 14:31, 5 April 2024

2024-04-05T14:31:58Z

← Older revision		Revision as of 14:31, 5 April 2024
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	==Gross==		==Gross==
	*Classically, a [[liver]] lesion - but found elsewhere.<ref>{{Cite journal \| last1 = Cardinal \| first1 = J. \| last2 = de Vera \| first2 = ME. \| last3 = Marsh \| first3 = JW. \| last4 = Steel \| first4 = JL. \| last5 = Geller \| first5 = DA. \| last6 = Fontes \| first6 = P. \| last7 = Nalesnik \| first7 = M. \| last8 = Gamblin \| first8 = TC. \| title = Treatment of hepatic epithelioid hemangioendothelioma: a single-institution experience with 25 cases. \| journal = Arch Surg \| volume = 144 \| issue = 11 \| pages = 1035-9 \| month = Nov \| year = 2009 \| doi = 10.1001/archsurg.2009.121 \| PMID = 19917940 }}</ref><ref name=pmid37541086>{{cite journal \|authors=Haughey AM, Moloney BM, O'Brien CM \|title=Epithelioid Haemangioendothelioma; Not simply a hepatic pathology \|journal=Clin Imaging \|volume=102 \|issue= \|pages=42–52 \|date=October 2023 \|pmid=37541086 \|doi=10.1016/j.clinimag.2023.07.003 \|url=}}</ref>		*Classically, a [[liver]] lesion - but found elsewhere.<ref>{{Cite journal \| last1 = Cardinal \| first1 = J. \| last2 = de Vera \| first2 = ME. \| last3 = Marsh \| first3 = JW. \| last4 = Steel \| first4 = JL. \| last5 = Geller \| first5 = DA. \| last6 = Fontes \| first6 = P. \| last7 = Nalesnik \| first7 = M. \| last8 = Gamblin \| first8 = TC. \| title = Treatment of hepatic epithelioid hemangioendothelioma: a single-institution experience with 25 cases. \| journal = Arch Surg \| volume = 144 \| issue = 11 \| pages = 1035-9 \| month = Nov \| year = 2009 \| doi = 10.1001/archsurg.2009.121 \| PMID = 19917940 }}</ref><ref name=pmid37541086>{{cite journal \|authors=Haughey AM, Moloney BM, O'Brien CM \|title=Epithelioid Haemangioendothelioma; Not simply a hepatic pathology \|journal=Clin Imaging \|volume=102 \|issue= \|pages=42–52 \|date=October 2023 \|pmid=37541086 \|doi=10.1016/j.clinimag.2023.07.003 \|url=}}</ref>

	~~Note:~~
	*Case reports of EHE in a wide number of anatomical sites (bowel,<ref name=pmid30238810>{{cite journal \|authors=Spasic S, Brcic I, Freire R, Garcia-Buitrago MT, Rosenberg AE \|title=Epithelioid Hemangioendothelioma of the Bowel in Crohn's Disease: The First Reported Case \|journal=Int J Surg Pathol \|volume=27 \|issue=4 \|pages=423–426 \|date=June 2019 \|pmid=30238810 \|doi=10.1177/1066896918801527 \|url=}}</ref>, parotid<ref name=pmid31530411>{{cite journal \|authors=Suarez-Zamora DA, Rodriguez-Urrego PA, Hakim-Tawil JA, Palau-Lazaro MA \|title=Epithelioid hemangioendothelioma of the parotid gland: A case report in an unusual location with a review of the literature \|journal=Rev Esp Patol \|volume=52 \|issue=4 \|pages=260–264 \|date=2019 \|pmid=31530411 \|doi=10.1016/j.patol.2019.04.002 \|url=}}</ref> mediastinum<ref>{{cite journal \|authors=Kim SH, Kim YS, Jang MH, Kwon HJ \|title=Mediastinal Epithelioid Hemangioendothelioma Invading Superior Vena Cava: A Case Report and Review of Literature \|journal=Curr Med Imaging Rev \|volume=15 \|issue=3 \|pages=349–352 \|date=2019 \|pmid=31989887 \|doi=10.2174/1573405614666180124141817 \|url=}}</ref>).		*Case reports of EHE in a wide number of anatomical sites (bowel,<ref name=pmid30238810>{{cite journal \|authors=Spasic S, Brcic I, Freire R, Garcia-Buitrago MT, Rosenberg AE \|title=Epithelioid Hemangioendothelioma of the Bowel in Crohn's Disease: The First Reported Case \|journal=Int J Surg Pathol \|volume=27 \|issue=4 \|pages=423–426 \|date=June 2019 \|pmid=30238810 \|doi=10.1177/1066896918801527 \|url=}}</ref>, parotid<ref name=pmid31530411>{{cite journal \|authors=Suarez-Zamora DA, Rodriguez-Urrego PA, Hakim-Tawil JA, Palau-Lazaro MA \|title=Epithelioid hemangioendothelioma of the parotid gland: A case report in an unusual location with a review of the literature \|journal=Rev Esp Patol \|volume=52 \|issue=4 \|pages=260–264 \|date=2019 \|pmid=31530411 \|doi=10.1016/j.patol.2019.04.002 \|url=}}</ref> mediastinum<ref>{{cite journal \|authors=Kim SH, Kim YS, Jang MH, Kwon HJ \|title=Mediastinal Epithelioid Hemangioendothelioma Invading Superior Vena Cava: A Case Report and Review of Literature \|journal=Curr Med Imaging Rev \|volume=15 \|issue=3 \|pages=349–352 \|date=2019 \|pmid=31989887 \|doi=10.2174/1573405614666180124141817 \|url=}}</ref>).

Michael at 14:31, 5 April 2024

2024-04-05T14:31:00Z

← Older revision		Revision as of 14:31, 5 April 2024
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	==Gross==		==Gross==
	*Classically, a [[liver]] lesion - but found elsewhere.<ref>{{Cite journal \| last1 = Cardinal \| first1 = J. \| last2 = de Vera \| first2 = ME. \| last3 = Marsh \| first3 = JW. \| last4 = Steel \| first4 = JL. \| last5 = Geller \| first5 = DA. \| last6 = Fontes \| first6 = P. \| last7 = Nalesnik \| first7 = M. \| last8 = Gamblin \| first8 = TC. \| title = Treatment of hepatic epithelioid hemangioendothelioma: a single-institution experience with 25 cases. \| journal = Arch Surg \| volume = 144 \| issue = 11 \| pages = 1035-9 \| month = Nov \| year = 2009 \| doi = 10.1001/archsurg.2009.121 \| PMID = 19917940 }}</ref>{{cite journal \|authors=Haughey AM, Moloney BM, O'Brien CM \|title=Epithelioid Haemangioendothelioma; Not simply a hepatic pathology \|journal=Clin Imaging \|volume=102 \|issue= \|pages=42–52 \|date=October 2023 \|pmid=37541086 \|doi=10.1016/j.clinimag.2023.07.003 \|url=}}~~<ref>~~</ref>		*Classically, a [[liver]] lesion - but found elsewhere.<ref>{{Cite journal \| last1 = Cardinal \| first1 = J. \| last2 = de Vera \| first2 = ME. \| last3 = Marsh \| first3 = JW. \| last4 = Steel \| first4 = JL. \| last5 = Geller \| first5 = DA. \| last6 = Fontes \| first6 = P. \| last7 = Nalesnik \| first7 = M. \| last8 = Gamblin \| first8 = TC. \| title = Treatment of hepatic epithelioid hemangioendothelioma: a single-institution experience with 25 cases. \| journal = Arch Surg \| volume = 144 \| issue = 11 \| pages = 1035-9 \| month = Nov \| year = 2009 \| doi = 10.1001/archsurg.2009.121 \| PMID = 19917940 }}</ref><ref name=pmid37541086>{{cite journal \|authors=Haughey AM, Moloney BM, O'Brien CM \|title=Epithelioid Haemangioendothelioma; Not simply a hepatic pathology \|journal=Clin Imaging \|volume=102 \|issue= \|pages=42–52 \|date=October 2023 \|pmid=37541086 \|doi=10.1016/j.clinimag.2023.07.003 \|url=}}</ref>

	Note:		Note:

Michael at 14:29, 5 April 2024

2024-04-05T14:29:54Z

← Older revision		Revision as of 14:29, 5 April 2024
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[soft tissue lesions\|soft tissue]] - see ''[[vascular tumours]]''		\| Site = [[soft tissue lesions\|soft tissue]] - see ''[[vascular tumours]]'', classically [[liver]] - but various sites reported
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
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	==Gross==		==Gross==
	*~~Relatively often in the~~ [[liver]].<ref>{{Cite journal \| last1 = Cardinal \| first1 = J. \| last2 = de Vera \| first2 = ME. \| last3 = Marsh \| first3 = JW. \| last4 = Steel \| first4 = JL. \| last5 = Geller \| first5 = DA. \| last6 = Fontes \| first6 = P. \| last7 = Nalesnik \| first7 = M. \| last8 = Gamblin \| first8 = TC. \| title = Treatment of hepatic epithelioid hemangioendothelioma: a single-institution experience with 25 cases. \| journal = Arch Surg \| volume = 144 \| issue = 11 \| pages = 1035-9 \| month = Nov \| year = 2009 \| doi = 10.1001/archsurg.2009.121 \| PMID = 19917940 }}</ref>		*Classically, a [[liver]] lesion - but found elsewhere.<ref>{{Cite journal \| last1 = Cardinal \| first1 = J. \| last2 = de Vera \| first2 = ME. \| last3 = Marsh \| first3 = JW. \| last4 = Steel \| first4 = JL. \| last5 = Geller \| first5 = DA. \| last6 = Fontes \| first6 = P. \| last7 = Nalesnik \| first7 = M. \| last8 = Gamblin \| first8 = TC. \| title = Treatment of hepatic epithelioid hemangioendothelioma: a single-institution experience with 25 cases. \| journal = Arch Surg \| volume = 144 \| issue = 11 \| pages = 1035-9 \| month = Nov \| year = 2009 \| doi = 10.1001/archsurg.2009.121 \| PMID = 19917940 }}</ref>{{cite journal \|authors=Haughey AM, Moloney BM, O'Brien CM \|title=Epithelioid Haemangioendothelioma; Not simply a hepatic pathology \|journal=Clin Imaging \|volume=102 \|issue= \|pages=42–52 \|date=October 2023 \|pmid=37541086 \|doi=10.1016/j.clinimag.2023.07.003 \|url=}}<ref></ref>

			Note:
			*Case reports of EHE in a wide number of anatomical sites (bowel,<ref name=pmid30238810>{{cite journal \|authors=Spasic S, Brcic I, Freire R, Garcia-Buitrago MT, Rosenberg AE \|title=Epithelioid Hemangioendothelioma of the Bowel in Crohn's Disease: The First Reported Case \|journal=Int J Surg Pathol \|volume=27 \|issue=4 \|pages=423–426 \|date=June 2019 \|pmid=30238810 \|doi=10.1177/1066896918801527 \|url=}}</ref>, parotid<ref name=pmid31530411>{{cite journal \|authors=Suarez-Zamora DA, Rodriguez-Urrego PA, Hakim-Tawil JA, Palau-Lazaro MA \|title=Epithelioid hemangioendothelioma of the parotid gland: A case report in an unusual location with a review of the literature \|journal=Rev Esp Patol \|volume=52 \|issue=4 \|pages=260–264 \|date=2019 \|pmid=31530411 \|doi=10.1016/j.patol.2019.04.002 \|url=}}</ref> mediastinum<ref>{{cite journal \|authors=Kim SH, Kim YS, Jang MH, Kwon HJ \|title=Mediastinal Epithelioid Hemangioendothelioma Invading Superior Vena Cava: A Case Report and Review of Literature \|journal=Curr Med Imaging Rev \|volume=15 \|issue=3 \|pages=349–352 \|date=2019 \|pmid=31989887 \|doi=10.2174/1573405614666180124141817 \|url=}}</ref>).

	==Microscopic==		==Microscopic==

Michael at 13:27, 4 April 2024

2024-04-04T13:27:15Z

← Older revision		Revision as of 13:27, 4 April 2024
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	==Molecular==		==Molecular==
	~~Fusions~~:<ref name=pmid26414223/>		Gene fusions:<ref name=pmid26414223/>
	*WWTR1-CAMTA1 - seen in approximately 90% of cases.		*WWTR1-CAMTA1 - seen in approximately 90% of cases.
	*YAP1-TFE3 fusion gene - <5% of cases.		*YAP1-TFE3 fusion gene - <5% of cases.

Michael at 13:25, 4 April 2024

2024-04-04T13:25:46Z

← Older revision		Revision as of 13:25, 4 April 2024
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	\| Micro = large epithelioid perivascular cells with abundant pale eosinophilic cytoplasm and cytoplasmic vacuolation ("blister cells") - may form lumen and have RBC within, vesicular nucleus +/-prominent nucleolus; tuft-like projections into capillaries; cells may be in well-circumscribed paucicellular nodules ''or'' poorly formed cellular aggregates		\| Micro = large epithelioid perivascular cells with abundant pale eosinophilic cytoplasm and cytoplasmic vacuolation ("blister cells") - may form lumen and have RBC within, vesicular nucleus +/-prominent nucleolus; tuft-like projections into capillaries; cells may be in well-circumscribed paucicellular nodules ''or'' poorly formed cellular aggregates
	\| Subtypes =		\| Subtypes =
	\| LMDDx = epithelioid [[angiosarcoma]], [[hemangioma]]		\| LMDDx = epithelioid [[angiosarcoma]], [[hemangioma]], [[epithelioid sarcoma]]
	\| Stains =		\| Stains =
	\| IHC = CD31 +ve, CD34 +ve, factor VIII +ve		\| IHC = CD31 +ve, CD34 +ve, factor VIII +ve, CAMTA1 +ve, TFE3 +ve/-ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = gene fusions: WWTR1-CAMTA1 (approximately 90% of cases), YAP1-TFE3 (small number of cases)
	\| IF =		\| IF =
	\| Gross =		\| Gross =
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	*[[Cholangiocarcinoma]].		*[[Cholangiocarcinoma]].
	*[[Fibrolamellar hepatocellular carcinoma]].		*[[Fibrolamellar hepatocellular carcinoma]].
			*[[Epithelioid sarcoma]].<ref name=pmid26414223/>

	===Images===		===Images===
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	*CD34 +ve.		*CD34 +ve.
	*Factor VIII +ve.		*Factor VIII +ve.
			*CAMTA1 +ve.<ref name=pmid26414223>{{cite journal \|authors=Doyle LA, Fletcher CD, Hornick JL \|title=Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics \|journal=Am J Surg Pathol \|volume=40 \|issue=1 \|pages=94–102 \|date=January 2016 \|pmid=26414223 \|doi=10.1097/PAS.0000000000000511 \|url=}}</ref>
			*TFE3 +ve - minority of cases.

			==Molecular==
			Fusions:<ref name=pmid26414223/>
			*WWTR1-CAMTA1 - seen in approximately 90% of cases.
			*YAP1-TFE3 fusion gene - <5% of cases.

	==See also==		==See also==

Michael: /* See also */

2015-10-19T13:40:28Z

Michael: /* See also */

2015-01-27T17:55:52Z

Michael: /* General */

2015-01-27T17:53:14Z

General

← Older revision		Revision as of 17:53, 27 January 2015
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	*Excision<ref name=pmid8941001/> if feasible.		*Excision<ref name=pmid8941001/> if feasible.
	*Chemotherapy - not standardized.<ref name=pmid23589078>{{Cite journal \| last1 = Chevreau \| first1 = C. \| last2 = Le Cesne \| first2 = A. \| last3 = Ray-Coquard \| first3 = I. \| last4 = Italiano \| first4 = A. \| last5 = Cioffi \| first5 = A. \| last6 = Isambert \| first6 = N. \| last7 = Robin \| first7 = YM. \| last8 = Fournier \| first8 = C. \| last9 = Clisant \| first9 = S. \| title = Sorafenib in patients with progressive epithelioid hemangioendothelioma: a phase 2 study by the French Sarcoma Group (GSF/GETO). \| journal = Cancer \| volume = 119 \| issue = 14 \| pages = 2639-44 \| month = Jul \| year = 2013 \| doi = 10.1002/cncr.28109 \| PMID = 23589078 }}</ref>		*Chemotherapy - not standardized.<ref name=pmid23589078>{{Cite journal \| last1 = Chevreau \| first1 = C. \| last2 = Le Cesne \| first2 = A. \| last3 = Ray-Coquard \| first3 = I. \| last4 = Italiano \| first4 = A. \| last5 = Cioffi \| first5 = A. \| last6 = Isambert \| first6 = N. \| last7 = Robin \| first7 = YM. \| last8 = Fournier \| first8 = C. \| last9 = Clisant \| first9 = S. \| title = Sorafenib in patients with progressive epithelioid hemangioendothelioma: a phase 2 study by the French Sarcoma Group (GSF/GETO). \| journal = Cancer \| volume = 119 \| issue = 14 \| pages = 2639-44 \| month = Jul \| year = 2013 \| doi = 10.1002/cncr.28109 \| PMID = 23589078 }}</ref>
			*[[Liver transplantation]].<ref>{{Cite journal \| last1 = Nudo \| first1 = CG. \| last2 = Yoshida \| first2 = EM. \| last3 = Bain \| first3 = VG. \| last4 = Marleau \| first4 = D. \| last5 = Wong \| first5 = P. \| last6 = Marotta \| first6 = PJ. \| last7 = Renner \| first7 = E. \| last8 = Watt \| first8 = KD. \| last9 = Deschênes \| first9 = M. \| title = Liver transplantation for hepatic epithelioid hemangioendothelioma: the Canadian multicentre experience. \| journal = Can J Gastroenterol \| volume = 22 \| issue = 10 \| pages = 821-4 \| month = Oct \| year = 2008 \| doi = \| PMID = 18925305 }}</ref>

	Prognosis - liver:		Prognosis - liver:

Michael: /* General */

2014-09-20T02:46:50Z

General

← Older revision		Revision as of 02:46, 20 September 2014
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	*Malignant.<ref name=Ref_WMSP603>{{Ref WMSP\|603}}</ref>		*Malignant.<ref name=Ref_WMSP603>{{Ref WMSP\|603}}</ref>
	*Adults - wide age range.		*Adults - wide age range.
	*Associated with oral contraceptives, vinyl chloride.<ref name=pmid20165548/>		*Associated with [[oral contraceptives]], vinyl chloride.<ref name=pmid20165548/>
	*Rare.<ref name=pmid23589078/>		*Rare.<ref name=pmid23589078/>

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	Prognosis - liver:		Prognosis - liver:
	*~55% five-year survival.<ref name=pmid8941001>{{Cite journal \| last1 = Läuffer \| first1 = JM. \| last2 = Zimmermann \| first2 = A. \| last3 = Krähenbühl \| first3 = L. \| last4 = Triller \| first4 = J. \| last5 = Baer \| first5 = HU. \| title = Epithelioid hemangioendothelioma of the liver. A rare hepatic tumor. \| journal = Cancer \| volume = 78 \| issue = 11 \| pages = 2318-27 \| month = Dec \| year = 1996 \| doi = \| PMID = 8941001 }}</ref>		*~55% five-year survival.<ref name=pmid8941001>{{Cite journal \| last1 = Läuffer \| first1 = JM. \| last2 = Zimmermann \| first2 = A. \| last3 = Krähenbühl \| first3 = L. \| last4 = Triller \| first4 = J. \| last5 = Baer \| first5 = HU. \| title = Epithelioid hemangioendothelioma of the liver. A rare hepatic tumor. \| journal = Cancer \| volume = 78 \| issue = 11 \| pages = 2318-27 \| month = Dec \| year = 1996 \| doi = \| PMID = 8941001 }}</ref>
	**Better than other liver tumours.		**Better than other [[liver tumours]].

	==Gross==		==Gross==

Michael: /* See also */

2014-04-03T00:42:50Z

← Older revision		Revision as of 13:40, 19 October 2015
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	*[[Kaposiform hemangioendothelioma]].		*[[Kaposiform hemangioendothelioma]].
	*[[Hemangioendothelioma]].		*[[Hemangioendothelioma]].
			*[[Liver hemangioma]].

	==References==		==References==

← Older revision		Revision as of 17:55, 27 January 2015
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	*[[Vascular tumours]].		*[[Vascular tumours]].
	*[[Kaposiform hemangioendothelioma]].		*[[Kaposiform hemangioendothelioma]].
			*[[Hemangioendothelioma]].

	==References==		==References==

← Older revision		Revision as of 00:42, 3 April 2014
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	==See also==		==See also==
	*[[Vascular tumours]].		*[[Vascular tumours]].
			*[[Kaposiform hemangioendothelioma]].

	==References==		==References==