Esophageal adenocarcinoma - Revision history

Michael at 16:29, 30 January 2024

2024-01-30T16:29:37Z

← Older revision		Revision as of 16:29, 30 January 2024
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	==IHC==		==IHC==
	*CK7 +ve.		Features:<ref name=pmid14631371>{{cite journal \|authors=Driessen A, Nafteux P, Lerut T, Van Raemdonck D, De Leyn P, Filez L, Penninckx F, Geboes K, Ectors N \|title=Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: etiopathological and clinical implications \|journal=Mod Pathol \|volume=17 \|issue=1 \|pages=49–55 \|date=January 2004 \|pmid=14631371 \|doi=10.1038/modpathol.3800011 \|url=}}</ref>
	*CK20 -ve.<ref name=pmid14631371>{{cite journal \|authors=Driessen A, Nafteux P, Lerut T, Van Raemdonck D, De Leyn P, Filez L, Penninckx F, Geboes K, Ectors N \|title=Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: etiopathological and clinical implications \|journal=Mod Pathol \|volume=17 \|issue=1 \|pages=49–55 \|date=January 2004 \|pmid=14631371 \|doi=10.1038/modpathol.3800011 \|url=}}</ref>		*CK7 +ve (54 of 66 cases).
			*CK20 -ve (14 of 66 cases).

			Note:
			*CK7 +ve and CK20 -ve is seen in ~67% cases (44/66).<ref name=pmid14631371/>

	To rule-out SCC:		To rule-out SCC:

Michael: usu CK20 -ve

2024-01-30T16:23:39Z

usu CK20 -ve

← Older revision		Revision as of 16:23, 30 January 2024
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	\| LMDDx = [[high-grade columnar dysplasia of the esophagus]], [[squamous cell carcinoma of the esophagus]],[[gastric adenocarcinoma]]		\| LMDDx = [[high-grade columnar dysplasia of the esophagus]], [[squamous cell carcinoma of the esophagus]],[[gastric adenocarcinoma]]
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve, CK20 +ve, p63 -ve		\| IHC = CK7 +ve, CK20 -ve, p63 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	==IHC==		==IHC==
	*CK7 +ve.		*CK7 +ve.
	*CK20 +ve.		*CK20 -ve.<ref name=pmid14631371>{{cite journal \|authors=Driessen A, Nafteux P, Lerut T, Van Raemdonck D, De Leyn P, Filez L, Penninckx F, Geboes K, Ectors N \|title=Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: etiopathological and clinical implications \|journal=Mod Pathol \|volume=17 \|issue=1 \|pages=49–55 \|date=January 2004 \|pmid=14631371 \|doi=10.1038/modpathol.3800011 \|url=}}</ref>

	To rule-out SCC:		To rule-out SCC:

Michael at 16:53, 28 October 2021

2021-10-28T16:53:48Z

← Older revision		Revision as of 16:53, 28 October 2021
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[esophagus]]		\| Site = [[esophagus]] - classically distal esophagus
	\| Assdx = [[Barrett's esophagus]], [[high-grade columnar dysplasia of the esophagus]]		\| Assdx = [[Barrett's esophagus]], [[high-grade columnar dysplasia of the esophagus]]
	\| Syndromes =		\| Syndromes =

Michael: /* Staging */

2017-09-04T07:52:55Z

Staging

← Older revision		Revision as of 07:52, 4 September 2017
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	*M3 = submucosa.		*M3 = submucosa.
	*M4 = muscularis propria.		*M4 = muscularis propria.
			<!--
	Comment:		Comment:
	*Different staging systems exist; confusingly, they use the same terms (M1, M2, M3).<ref name=pmid15557945>{{Cite journal \| last1 = Buskens \| first1 = CJ. \| last2 = Westerterp \| first2 = M. \| last3 = Lagarde \| first3 = SM. \| last4 = Bergman \| first4 = JJ. \| last5 = ten Kate \| first5 = FJ. \| last6 = van Lanschot \| first6 = JJ. \| title = Prediction of appropriateness of local endoscopic treatment for high-grade dysplasia and early adenocarcinoma by EUS and histopathologic features. \| journal = Gastrointest Endosc \| volume = 60 \| issue = 5 \| pages = 703-10 \| month = Nov \| year = 2004 \| doi = \| PMID = 15557945 }}</ref>		*Different staging systems exist; confusingly, they use the same terms (M1, M2, M3).<ref name=pmid15557945>{{Cite journal \| last1 = Buskens \| first1 = CJ. \| last2 = Westerterp \| first2 = M. \| last3 = Lagarde \| first3 = SM. \| last4 = Bergman \| first4 = JJ. \| last5 = ten Kate \| first5 = FJ. \| last6 = van Lanschot \| first6 = JJ. \| title = Prediction of appropriateness of local endoscopic treatment for high-grade dysplasia and early adenocarcinoma by EUS and histopathologic features. \| journal = Gastrointest Endosc \| volume = 60 \| issue = 5 \| pages = 703-10 \| month = Nov \| year = 2004 \| doi = \| PMID = 15557945 }}</ref> -->

	==IHC==		==IHC==

Michael: /* Staging */

2017-09-04T07:47:25Z

Staging

← Older revision		Revision as of 07:47, 4 September 2017
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	Comment:		Comment:
	*Different staging systems exist~~. Confusingly~~, they use the same terms.		*Different staging systems exist; confusingly, they use the same terms (M1, M2, M3).<ref name=pmid15557945>{{Cite journal \| last1 = Buskens \| first1 = CJ. \| last2 = Westerterp \| first2 = M. \| last3 = Lagarde \| first3 = SM. \| last4 = Bergman \| first4 = JJ. \| last5 = ten Kate \| first5 = FJ. \| last6 = van Lanschot \| first6 = JJ. \| title = Prediction of appropriateness of local endoscopic treatment for high-grade dysplasia and early adenocarcinoma by EUS and histopathologic features. \| journal = Gastrointest Endosc \| volume = 60 \| issue = 5 \| pages = 703-10 \| month = Nov \| year = 2004 \| doi = \| PMID = 15557945 }}</ref>

	==IHC==		==IHC==

Michael: /* Staging */

2017-09-04T07:40:30Z

Staging

← Older revision		Revision as of 07:40, 4 September 2017
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	====Staging====		====Staging====
	Early esophageal adenocarcinoma has its own staging system:<ref>{{Cite journal \| last1 = Pech \| first1 = O. \| last2 = May \| first2 = A. \| last3 = Rabenstein \| first3 = T. \| last4 = Ell \| first4 = C. \| title = Endoscopic resection of early oesophageal cancer. \| journal = Gut \| volume = 56 \| issue = 11 \| pages = 1625-34 \| month = Nov \| year = 2007 \| doi = 10.1136/gut.2006.112110 \| PMID = 17938435 \| PMC = 2095648 }}</ref><ref>{{Cite journal \| last1 = Thosani \| first1 = N. \| last2 = Singh \| first2 = H. \| last3 = Kapadia \| first3 = A. \| last4 = Ochi \| first4 = N. \| last5 = Lee \| first5 = JH. \| last6 = Ajani \| first6 = J. \| last7 = Swisher \| first7 = SG. \| last8 = Hofstetter \| first8 = WL. \| last9 = Guha \| first9 = S. \| title = Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis. \| journal = Gastrointest Endosc \| volume = \| issue = \| pages = \| month = Nov \| year = 2011 \| doi = 10.1016/j.gie.2011.09.016 \| PMID = 22115605 \| URL = http://www.sciencedirect.com/science/article/pii/S0016510711022048 }}</ref>		Early esophageal adenocarcinoma has its own staging system:<ref name=pmid17938435 >{{Cite journal \| last1 = Pech \| first1 = O. \| last2 = May \| first2 = A. \| last3 = Rabenstein \| first3 = T. \| last4 = Ell \| first4 = C. \| title = Endoscopic resection of early oesophageal cancer. \| journal = Gut \| volume = 56 \| issue = 11 \| pages = 1625-34 \| month = Nov \| year = 2007 \| doi = 10.1136/gut.2006.112110 \| PMID = 17938435 \| PMC = 2095648 }}</ref><ref name=pmid22115605>{{Cite journal \| last1 = Thosani \| first1 = N. \| last2 = Singh \| first2 = H. \| last3 = Kapadia \| first3 = A. \| last4 = Ochi \| first4 = N. \| last5 = Lee \| first5 = JH. \| last6 = Ajani \| first6 = J. \| last7 = Swisher \| first7 = SG. \| last8 = Hofstetter \| first8 = WL. \| last9 = Guha \| first9 = S. \| title = Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis. \| journal = Gastrointest Endosc \| volume = \| issue = \| pages = \| month = Nov \| year = 2011 \| doi = 10.1016/j.gie.2011.09.016 \| PMID = 22115605 \| URL = http://www.sciencedirect.com/science/article/pii/S0016510711022048 }}</ref>
	*M1 = lamina propria.		*M1 = lamina propria.
	*M2 = superficial muscularis mucosae.		*M2 = superficial muscularis mucosae.

Michael: /* Staging */

2017-09-04T07:39:30Z

Staging

← Older revision		Revision as of 07:39, 4 September 2017
Line 91:		Line 91:
	*M3 = submucosa.		*M3 = submucosa.
	*M4 = muscularis propria.		*M4 = muscularis propria.

			Comment:
			*Different staging systems exist. Confusingly, they use the same terms.

	==IHC==		==IHC==

Michael: +bx

2016-04-11T18:14:54Z

+bx

← Older revision		Revision as of 18:14, 11 April 2016
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	==Sign out==		==Sign out==
			===Biopsy===
			<pre>
			Esophagus, Biopsy:
			- INVASIVE ADENOCARCINOMA, poorly differentiated.

			Comment:
			Pending IHC (CK7, CK20) and HER2 testing; results of these will be reported in an addendum.
			</pre>

			===Resection===
	<pre>		<pre>
	GASTROESOPHAGEAL JUNCTION, RESECTION:		GASTROESOPHAGEAL JUNCTION, RESECTION:

Michael: /* Staging */

2016-01-12T12:42:58Z

Staging

← Older revision		Revision as of 12:42, 12 January 2016
Line 107:		Line 107:
	==Staging==		==Staging==
	*The number of lymph nodes is important for [[staging]], as a small number may lead to stage migration (Will Rogers phenomenon).		*The number of lymph nodes is important for [[staging]], as a small number may lead to stage migration (Will Rogers phenomenon).
	*There is no established standard for esophageal cancer (as per UICC/AJCC staging - based on Li ''et al.''<ref name=pmid23124992/>), several studies give different numbers (18 lymph nodes Greenstein ''et al.'',<ref name=pmid18224663>{{Cite journal \| last1 = Greenstein \| first1 = AJ. \| last2 = Litle \| first2 = VR. \| last3 = Swanson \| first3 = SJ. \| last4 = Divino \| first4 = CM. \| last5 = Packer \| first5 = S. \| last6 = Wisnivesky \| first6 = JP. \| title = Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer. \| journal = Cancer \| volume = 112 \| issue = 6 \| pages = 1239-46 \| month = Mar \| year = 2008 \| doi = 10.1002/cncr.23309 \| PMID = 18224663 }}</ref> 23 lymph nodes Peyre ''et al.''<ref name=pmid18936567>{{Cite journal \| last1 = Peyre \| first1 = CG. \| last2 = Hagen \| first2 = JA. \| last3 = DeMeester \| first3 = SR. \| last4 = Altorki \| first4 = NK. \| last5 = Ancona \| first5 = E. \| last6 = Griffin \| first6 = SM. \| last7 = Hölscher \| first7 = A. \| last8 = Lerut \| first8 = T. \| last9 = Law \| first9 = S. \| title = The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. \| journal = Ann Surg \| volume = 248 \| issue = 4 \| pages = 549-56 \| month = Oct \| year = 2008 \| doi = 10.1097/SLA.0b013e318188c474 \| PMID = 18936567 }}</ref>).		*There is no established standard for esophageal cancer (as per UICC/AJCC staging - based on Li ''et al.''<ref name=pmid23124992>{{Cite journal \| last1 = Li \| first1 = Q. \| last2 = Wu \| first2 = SG. \| last3 = Gao \| first3 = JM. \| last4 = Xu \| first4 = JJ. \| last5 = Hu \| first5 = LY. \| last6 = Xu \| first6 = T. \| title = Impact of esophageal cancer staging on overall survival and disease-free survival based on the 2010 AJCC classification by lymph nodes. \| journal = J Radiat Res \| volume = 54 \| issue = 2 \| pages = 307-14 \| month = Mar \| year = 2013 \| doi = 10.1093/jrr/rrs096 \| PMID = 23124992 }}</ref>), several studies give different numbers (18 lymph nodes Greenstein ''et al.'',<ref name=pmid18224663>{{Cite journal \| last1 = Greenstein \| first1 = AJ. \| last2 = Litle \| first2 = VR. \| last3 = Swanson \| first3 = SJ. \| last4 = Divino \| first4 = CM. \| last5 = Packer \| first5 = S. \| last6 = Wisnivesky \| first6 = JP. \| title = Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer. \| journal = Cancer \| volume = 112 \| issue = 6 \| pages = 1239-46 \| month = Mar \| year = 2008 \| doi = 10.1002/cncr.23309 \| PMID = 18224663 }}</ref> 23 lymph nodes Peyre ''et al.''<ref name=pmid18936567>{{Cite journal \| last1 = Peyre \| first1 = CG. \| last2 = Hagen \| first2 = JA. \| last3 = DeMeester \| first3 = SR. \| last4 = Altorki \| first4 = NK. \| last5 = Ancona \| first5 = E. \| last6 = Griffin \| first6 = SM. \| last7 = Hölscher \| first7 = A. \| last8 = Lerut \| first8 = T. \| last9 = Law \| first9 = S. \| title = The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. \| journal = Ann Surg \| volume = 248 \| issue = 4 \| pages = 549-56 \| month = Oct \| year = 2008 \| doi = 10.1097/SLA.0b013e318188c474 \| PMID = 18936567 }}</ref>).

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Michael: /* Staging */

2016-01-11T18:29:16Z

Staging

← Older revision		Revision as of 18:29, 11 January 2016
Line 107:		Line 107:
	==Staging==		==Staging==
	*The number of lymph nodes is important for [[staging]], as a small number may lead to stage migration (Will Rogers phenomenon).		*The number of lymph nodes is important for [[staging]], as a small number may lead to stage migration (Will Rogers phenomenon).
	*There is no established standard for esophageal cancer (as per UICC/AJCC staging - based on Li ''et al.''<ref name=pmid23124992/>), several studies give different numbers (18 lymph nodes Li ''et al.'',<ref name=~~pmid23124992~~>{{Cite journal \| last1 = Li \| first1 = Q. \| last2 = Wu \| first2 = SG. \| last3 = ~~Gao~~ \| first3 = JM. \| last4 = Xu \| first4 = JJ. \| last5 = Hu \| first5 = LY. \| last6 = Xu \| first6 = T. \| title = ~~Impact~~ of ~~esophageal cancer staging~~ on ~~overall~~ survival ~~and disease~~-~~free survival based on the 2010 AJCC classification by lymph nodes~~. \| journal = ~~J Radiat Res~~ \| volume = 54 \| issue = 2 \| pages = ~~307~~-14 \| month = Mar \| year = ~~2013~~ \| doi = 10.~~1093~~/~~jrr/rrs096~~ \| PMID = ~~23124992~~ }}</ref> 23 lymph nodes Peyre ''et al.''<ref name=pmid18936567>{{Cite journal \| last1 = Peyre \| first1 = CG. \| last2 = Hagen \| first2 = JA. \| last3 = DeMeester \| first3 = SR. \| last4 = Altorki \| first4 = NK. \| last5 = Ancona \| first5 = E. \| last6 = Griffin \| first6 = SM. \| last7 = Hölscher \| first7 = A. \| last8 = Lerut \| first8 = T. \| last9 = Law \| first9 = S. \| title = The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. \| journal = Ann Surg \| volume = 248 \| issue = 4 \| pages = 549-56 \| month = Oct \| year = 2008 \| doi = 10.1097/SLA.0b013e318188c474 \| PMID = 18936567 }}</ref>).		*There is no established standard for esophageal cancer (as per UICC/AJCC staging - based on Li ''et al.''<ref name=pmid23124992/>), several studies give different numbers (18 lymph nodes Greenstein ''et al.'',<ref name=pmid18224663>{{Cite journal \| last1 = Greenstein \| first1 = AJ. \| last2 = Litle \| first2 = VR. \| last3 = Swanson \| first3 = SJ. \| last4 = Divino \| first4 = CM. \| last5 = Packer \| first5 = S. \| last6 = Wisnivesky \| first6 = JP. \| title = Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer. \| journal = Cancer \| volume = 112 \| issue = 6 \| pages = 1239-46 \| month = Mar \| year = 2008 \| doi = 10.1002/cncr.23309 \| PMID = 18224663 }}</ref> 23 lymph nodes Peyre ''et al.''<ref name=pmid18936567>{{Cite journal \| last1 = Peyre \| first1 = CG. \| last2 = Hagen \| first2 = JA. \| last3 = DeMeester \| first3 = SR. \| last4 = Altorki \| first4 = NK. \| last5 = Ancona \| first5 = E. \| last6 = Griffin \| first6 = SM. \| last7 = Hölscher \| first7 = A. \| last8 = Lerut \| first8 = T. \| last9 = Law \| first9 = S. \| title = The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. \| journal = Ann Surg \| volume = 248 \| issue = 4 \| pages = 549-56 \| month = Oct \| year = 2008 \| doi = 10.1097/SLA.0b013e318188c474 \| PMID = 18936567 }}</ref>).

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