Eye - Revision history

Michael at 17:39, 17 November 2022

2022-11-17T17:39:06Z

← Older revision		Revision as of 17:39, 17 November 2022
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	*Lateral canthus.		*Lateral canthus.

	~~Most~~ common malignant canthus lesion is basal cell carcinoma.<ref>URL: [https://iovs.arvojournals.org/article.aspx?articleid=2372910 https://iovs.arvojournals.org/article.aspx?articleid=2372910]. Accessed on: 2022 Nov 17.</ref>		Note:
			*The most common malignant canthus lesion is [[basal cell carcinoma]].<ref>URL: [https://iovs.arvojournals.org/article.aspx?articleid=2372910 https://iovs.arvojournals.org/article.aspx?articleid=2372910]. Accessed on: 2022 Nov 17.</ref>

	=Histology=		=Histology=

Michael: canthi

2022-11-17T17:38:14Z

canthi

← Older revision		Revision as of 17:38, 17 November 2022
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	===Anterior angle===		===Anterior angle===
	*Angle between cornea and iris.		*Angle between cornea and iris.

			===Canthi===
			The canthi are where the upper and lower eyelids meet:
			*Medial canthus.
			*Lateral canthus.

			Most common malignant canthus lesion is basal cell carcinoma.<ref>URL: [https://iovs.arvojournals.org/article.aspx?articleid=2372910 https://iovs.arvojournals.org/article.aspx?articleid=2372910]. Accessed on: 2022 Nov 17.</ref>

	=Histology=		=Histology=

Michael: /* Papilloma of the caruncle */ split out

2017-01-23T04:14:40Z

Papilloma of the caruncle: split out

← Older revision		Revision as of 04:14, 23 January 2017
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	==Papilloma of the caruncle==		==Papilloma of the caruncle==
	*[[AKA]] ''caruncle papilloma''.		{{Main\|Eye papilloma}}
	~~===General===~~
	*Benign.
	*Second most common caruncle tumour ~ 15% of caruncle tumours.<ref name=pmid16935590>{{~~Cite journal~~ \| last1 = Kaeser \| first1 = PF. \| last2 = Uffer \| first2 = S. \| last3 = Zografos \| first3 = L. \| last4 = Hamédani \| first4 = M. \| title = Tumors of the caruncle: a clinicopathologic correlation. \| journal = Am J Ophthalmol \| volume = 142 \| issue = 3 \| pages = 448-55 \| month = Sep \| year = 2006 \| doi = 10.1016/j.ajo.2006.04.035 \| PMID = 16935590 }}~~</ref>~~
	**Most common is [[nevus]] ~ 50% of caruncle tumours.

	~~===Gross===~~
	*Frond-like lesion.

	~~Image:~~
	*[http://www.atlasophthalmology.com/atlas/photo.jsf?node=2748&locale=en Papilloma of caruncle (atlasophthalmology.com)].

	~~===Microscopic===~~
	~~Features:<ref name=pmid16935590/>~~
	*Fibrovascular fronds in a cauliflower-like arrangement.
	*No nuclear atypia.

	~~Image:~~
	*[http://www.atlasophthalmology.com/atlas/photo.jsf?node=4686&locale=en Papilloma of caruncle - crappy image (atlasophthalmology.com)].

	~~===Sign out===~~
	~~<pre>~~
	~~LESION, RIGHT CARUNCLE, EXCISION:~~
	~~- PAPILLOMA.~~
	~~- NEGATIVE FOR MALIGNANCY.~~
	~~</pre>~~

	~~====Micro====~~
	~~The sections show benign conjunctival mucosa and a lesion consisting of fibrovascular~~
	~~cores covered by a conjunctival epithelium with a cauliflower-like appearance at low~~
	~~power. Parakeratosis is present. No significant nuclear atypia is identified. No koilocytic~~
	~~change is seen. No mitotic activity is appreciated.~~

	~~===External links===~~
	*[http://eyewiki.aao.org/Conjunctival_Papilloma Conjunctival papilloma (eyewiki.aao.org)].

	==Corneal ulcer==		==Corneal ulcer==

Michael: /* Eccrine hidrocystoma */ split out

2017-01-18T15:45:16Z

Eccrine hidrocystoma: split out

← Older revision		Revision as of 15:45, 18 January 2017
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	==Eccrine hidrocystoma==		==Eccrine hidrocystoma==
	*Occasionally spelled ''eccrine hydrocystoma''.<ref name=pmid10065300/>		*Occasionally spelled ''eccrine hydrocystoma''.<ref name=pmid10065300/>
	~~===General===~~		{{Main\|Eccrine hidrocystoma}}
	*Benign.
	*Eyelid lesion.

	~~Clinical DDx:<ref name=pmid10065300/>~~
	*Cystic [[BCC]].

	~~===Microsopic===~~
	~~Features:<ref name=pmid15205675>~~{{~~Cite journal~~ \| ~~last1 = Singh \| first1 = AD. \| last2 = McCloskey \| first2 = L. \| last3 = Parsons \| first3 = MA. \| last4 = Slater \| first4 = DN. \| title =~~ Eccrine hidrocystoma ~~of the eyelid. \| journal = Eye (Lond) \| volume = 19 \| issue = 1 \| pages = 77-9 \| month = Jan \| year = 2005 \| doi = 10.1038/sj.eye.6701404 \| PMID = 15205675 }}</ref><ref>{{Ref Derm\|314~~}}~~</ref>~~
	*Cyst lined by a bland bilayer.
	**Inner lining cells have:
	***Small, round nuclei - usu. basal.
	***Moderate pale/greyish cytoplasm.
	***No apocrine snouts - flat surface.
	**Outer lining cells - spindled.
	***May be difficult to see.

	~~Note:~~
	*According to the CMAJ, it has the histology of an [[epidermal inclusion cyst]].<ref name=pmid10065300>{{Cite journal \| last1 = Adams \| first1 = SP. \| title = Dermacase. Eccrine hydrocystoma. \| journal = Can Fam Physician \| volume = 45 \| issue = \| pages = 297, 306 \| month = Feb \| year = 1999 \| doi = \| PMID = 10065300 \|PMC = 2328272 }}</ref>

	~~DDx:~~
	*[[Apocrine hidrocystoma]] - have apocrine snouts; surface is ''not'' flat.
	*Cystadenoma - has epithelial proliferation.

	~~====Image====~~
	~~<gallery>~~
	~~Image:SkinTumors-P7110453.JPG \| Apocrine hidrocystoma (AH). AH looks similar to ''eccrine hidrocystoma''. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.nature.com/eye/journal/v19/n1/fig_tab/6701404f1.html Eccrine hidrocystoma (nature.com)].
	*[http://www.dermnet.org.nz/pathology/apocrine-hidrocystoma-path.html Apocrine hidrocystoma (dermnet.org)].
	*[http://www.flickr.com/photos/42574434@N03/9519309216 Apocrine hidrocystoma (flickr.com)].

	~~===Sign out===~~
	~~<pre>~~
	~~SKIN LESION, ADJACENT TO RIGHT EYELID, EXCISION:~~
	~~- ECCRINE HIDROCYSTOMA.~~
	~~</pre>~~

	~~====Micro====~~
	~~The sections show hair bearing skin with a cyst lined by a bland bilayered epithelium. The predominant lining cell has moderate pale grey cytoplasm and a small round nucleus.~~

	~~The lesion is excised in the plane of section.~~

	==Chalazion==		==Chalazion==

Michael: /* Sign out */

2016-03-20T03:08:28Z

Sign out

← Older revision		Revision as of 03:08, 20 March 2016
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	- NEGATIVE for dysplasia.		- NEGATIVE for dysplasia.
	</pre>		</pre>

			==Conjunctival nevus==
			{{Main\|Conjunctival nevus}}

	=Tumours of the eye=		=Tumours of the eye=

Michael: /* Corneal ulcer */

2016-03-07T15:49:51Z

Corneal ulcer

← Older revision		Revision as of 15:49, 7 March 2016
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	==Corneal ulcer==		==Corneal ulcer==
	{{Main\|Corneal ulcer}}		{{Main\|Corneal ulcer}}

			==Keratoconus==
			{{Main\|Keratoconus}}

	==Corneal scar==		==Corneal scar==

Michael: /* Corneal ulcer */ split out

2016-02-09T14:55:04Z

Corneal ulcer: split out

← Older revision		Revision as of 14:55, 9 February 2016
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	==Corneal ulcer==		==Corneal ulcer==
	~~===General===~~		{{Main\|Corneal ulcer}}
	*Cause: trauma.<ref name=pmid26319343>{{~~Cite journal~~ \| ~~last1 = Ahmed \| first1 = F. \| last2 = House \| first2 = RJ. \| last3 = Feldman \| first3 = BH. \| title =~~ Corneal ~~Abrasions and Corneal Foreign Bodies. \| journal = Prim Care \| volume = 42 \| issue = 3 \| pages = 363-75 \| month = Sep \| year = 2015 \| doi = 10.1016/j.pop.2015.05.004 \| PMID = 26319343~~ }}~~</ref>~~
	*May threaten sight in the eye.<ref name=pmid26319343/>

	~~===Microscopic===~~
	~~Feature:~~
	*Ulceration of squamous epithelium.{{fact}}

	~~DDx:~~
	*[[Squamous dysplasia]].

	~~===Sign out===~~
	~~<pre>~~
	~~Corneal Button, Left Eye, Keratoplasty:~~
	~~- Corneal ulcer associated with neovascularization and chronic inflammation.~~
	~~- NEGATIVE for dysplasia.~~
	~~</pre>~~

	==Corneal scar==		==Corneal scar==

Michael: /* Retinoblastoma */ split out

2016-02-09T03:47:41Z

Retinoblastoma: split out

← Older revision		Revision as of 03:47, 9 February 2016
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	==Retinoblastoma==		==Retinoblastoma==
	~~===General===~~		{{Main\|Retinoblastoma}}
	*Rare.
	*Malignant.
	*May be familial.<ref name=pmid20687510>{{~~cite journal~~ \|~~author=Lohmann D \|title=~~Retinoblastoma ~~\|journal=Adv. Exp. Med. Biol. \|volume=685 \|issue= \|pages=220–7 \|year=2010 \|pmid=20687510 \|doi= \|url=}}</ref>~~

	~~===Gross===~~
	*White, solid.
	*Patterns:
	**Endophytic - grow into the vitreous cavity.
	**Exophytic - grow toward choroid.
	**Mixed - components of endophytic and exophytic.

	~~Image:~~
	*[http://radiopaedia.org/cases/retinoblastoma-gross-pathology Retinoblastoma (radiopaedia.org/AFIP)].

	~~Note:~~
	*Tumour is extremely friable.

	~~===Microscopic===~~
	~~Features:~~
	*[[Small round cell tumour]]:
	**Scant cytoplasm.
	*Flexner-Wintersteiner [[rosette]] - '''key feature'''.
	**Rosette with empty centre (donut hole).<ref name=pmid16551982>{{cite journal \|author=Wippold FJ, Perry A \|title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes \|journal=AJNR Am J Neuroradiol \|volume=27 \|issue=3 \|pages=488–92 \|year=2006 \|month=March \|pmid=16551982 \|doi= \|url=}}~~</ref>~~
	*+/-Homer-Wright rosette.<ref>WH. 14 March 2011.</ref>
	**Circular rosette with neuropil at the centre.<ref name=pmid16551982>{{cite journal \|author=Wippold FJ, Perry A \|title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes \|journal=AJNR Am J Neuroradiol \|volume=27 \|issue=3 \|pages=488–92 \|year=2006 \|month=March \|pmid=16551982 \|doi= \|url=}}</ref>
	*Mitoses - common.
	*+/-Necrosis.
	*+/-Calcification.

	~~DDx:~~
	*Retinocytoma (retinoma) - benign counterpart of retinoblastoma.

	~~Notes:~~
	*DDx of Flexner-Wintersteiner rosette includes:
	**Pineoblastoma.
	**Medulloepithelioma.

	~~Image:~~
	*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/O0A001-PQ01-M.htm Retinoblastoma (ouhsc.edu)].
	*[http://www.pathpedia.com/Education/eAtlas/Histopathology/eye_and_ocular_adnexa/retinoblastoma.aspx Retinoblastoma (pathpedia.com)].

	==Malignant melanoma==		==Malignant melanoma==

Michael: /* Corneal ulcer */

2015-12-11T22:47:00Z

Corneal ulcer

← Older revision		Revision as of 22:47, 11 December 2015
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	Corneal Button, Left Eye, Keratoplasty:		Corneal Button, Left Eye, Keratoplasty:
	- Corneal ulcer associated with neovascularization and chronic inflammation.		- Corneal ulcer associated with neovascularization and chronic inflammation.
			- NEGATIVE for dysplasia.
			</pre>

			==Corneal scar==
			===General===
			*Trauma to the cornea.

			===Microscopic===
			Features:
			*Compact hyaline tissue - darker staining.
			*Fibroblasts.

			DDx:
			*Squamous dysplasia.

			===Sign out===
			<pre>
			Corneal Button, Right Eye, Keratoplasty:
			- Consistent with corneal scar.
	- NEGATIVE for dysplasia.		- NEGATIVE for dysplasia.
	</pre>		</pre>

Michael: /* Corneal ulcer */

2015-12-11T15:30:12Z

Corneal ulcer

← Older revision		Revision as of 15:30, 11 December 2015
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	<pre>		<pre>
	Corneal Button, Left Eye, Keratoplasty:		Corneal Button, Left Eye, Keratoplasty:
	- Corneal ulcer with neovascularization and chronic inflammation.		- Corneal ulcer associated with neovascularization and chronic inflammation.
	- NEGATIVE for dysplasia.		- NEGATIVE for dysplasia.
	</pre>		</pre>