Familial adenomatous polyposis - Revision history

Jensflorian: /* Gardner syndrome */ Craniopharyngioma

2019-10-11T11:46:34Z

Gardner syndrome: Craniopharyngioma

← Older revision		Revision as of 11:46, 11 October 2019
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	**Considered useless for screening as they are so common otherwise. Multiple [[lipoma]]s are statistically more common; however, they are also useless.<ref name=pmid22135120>{{Cite journal \| last1 = Burger \| first1 = B. \| last2 = Cattani \| first2 = N. \| last3 = Trueb \| first3 = S. \| last4 = de Lorenzo \| first4 = R. \| last5 = Albertini \| first5 = M. \| last6 = Bontognali \| first6 = E. \| last7 = Itin \| first7 = C. \| last8 = Schaub \| first8 = N. \| last9 = Itin \| first9 = PH. \| title = Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? \| journal = Oncologist \| volume = 16 \| issue = 12 \| pages = 1698-705 \| month = \| year = 2011 \| doi = 10.1634/theoncologist.2011-0244 \| PMID = 22135120 }}</ref>		**Considered useless for screening as they are so common otherwise. Multiple [[lipoma]]s are statistically more common; however, they are also useless.<ref name=pmid22135120>{{Cite journal \| last1 = Burger \| first1 = B. \| last2 = Cattani \| first2 = N. \| last3 = Trueb \| first3 = S. \| last4 = de Lorenzo \| first4 = R. \| last5 = Albertini \| first5 = M. \| last6 = Bontognali \| first6 = E. \| last7 = Itin \| first7 = C. \| last8 = Schaub \| first8 = N. \| last9 = Itin \| first9 = PH. \| title = Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? \| journal = Oncologist \| volume = 16 \| issue = 12 \| pages = 1698-705 \| month = \| year = 2011 \| doi = 10.1634/theoncologist.2011-0244 \| PMID = 22135120 }}</ref>
	*Osteosclerotic jaw lesions.<ref name=omim175100>{{OMIM\|175100}}</ref>		*Osteosclerotic jaw lesions.<ref name=omim175100>{{OMIM\|175100}}</ref>
	*[[~~Craniopharyngeoma~~]].<ref>{{Cite journal \| last1 = Aquilina \| first1 = K. \| last2 = O'Brien \| first2 = DF. \| last3 = Farrell \| first3 = MA. \| last4 = Bolger \| first4 = C. \| title = Primary cerebellopontine angle craniopharyngioma in a patient with gardner syndrome. Case report and review of the literature. \| journal = J Neurosurg \| volume = 105 \| issue = 2 \| pages = 330-3 \| month = Aug \| year = 2006 \| doi = 10.3171/jns.2006.105.2.330 \| PMID = 17219843 }}</ref>		*[[Craniopharyngioma]].<ref>{{Cite journal \| last1 = Aquilina \| first1 = K. \| last2 = O'Brien \| first2 = DF. \| last3 = Farrell \| first3 = MA. \| last4 = Bolger \| first4 = C. \| title = Primary cerebellopontine angle craniopharyngioma in a patient with gardner syndrome. Case report and review of the literature. \| journal = J Neurosurg \| volume = 105 \| issue = 2 \| pages = 330-3 \| month = Aug \| year = 2006 \| doi = 10.3171/jns.2006.105.2.330 \| PMID = 17219843 }}</ref>

	Mneumonic ''DO STOP'' (modified):<ref name=pathologyexpert>URL: [http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm]. Accessed on: 26 November 2011.</ref>		Mneumonic ''DO STOP'' (modified):<ref name=pathologyexpert>URL: [http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm]. Accessed on: 26 November 2011.</ref>

Jensflorian: /* Gardner syndrome */ -> Craniopharyngioma

2019-10-11T11:46:04Z

Gardner syndrome: -> Craniopharyngioma

← Older revision		Revision as of 11:46, 11 October 2019
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	**Considered useless for screening as they are so common otherwise. Multiple [[lipoma]]s are statistically more common; however, they are also useless.<ref name=pmid22135120>{{Cite journal \| last1 = Burger \| first1 = B. \| last2 = Cattani \| first2 = N. \| last3 = Trueb \| first3 = S. \| last4 = de Lorenzo \| first4 = R. \| last5 = Albertini \| first5 = M. \| last6 = Bontognali \| first6 = E. \| last7 = Itin \| first7 = C. \| last8 = Schaub \| first8 = N. \| last9 = Itin \| first9 = PH. \| title = Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? \| journal = Oncologist \| volume = 16 \| issue = 12 \| pages = 1698-705 \| month = \| year = 2011 \| doi = 10.1634/theoncologist.2011-0244 \| PMID = 22135120 }}</ref>		**Considered useless for screening as they are so common otherwise. Multiple [[lipoma]]s are statistically more common; however, they are also useless.<ref name=pmid22135120>{{Cite journal \| last1 = Burger \| first1 = B. \| last2 = Cattani \| first2 = N. \| last3 = Trueb \| first3 = S. \| last4 = de Lorenzo \| first4 = R. \| last5 = Albertini \| first5 = M. \| last6 = Bontognali \| first6 = E. \| last7 = Itin \| first7 = C. \| last8 = Schaub \| first8 = N. \| last9 = Itin \| first9 = PH. \| title = Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? \| journal = Oncologist \| volume = 16 \| issue = 12 \| pages = 1698-705 \| month = \| year = 2011 \| doi = 10.1634/theoncologist.2011-0244 \| PMID = 22135120 }}</ref>
	*Osteosclerotic jaw lesions.<ref name=omim175100>{{OMIM\|175100}}</ref>		*Osteosclerotic jaw lesions.<ref name=omim175100>{{OMIM\|175100}}</ref>
			*[[Craniopharyngeoma]].<ref>{{Cite journal \| last1 = Aquilina \| first1 = K. \| last2 = O'Brien \| first2 = DF. \| last3 = Farrell \| first3 = MA. \| last4 = Bolger \| first4 = C. \| title = Primary cerebellopontine angle craniopharyngioma in a patient with gardner syndrome. Case report and review of the literature. \| journal = J Neurosurg \| volume = 105 \| issue = 2 \| pages = 330-3 \| month = Aug \| year = 2006 \| doi = 10.3171/jns.2006.105.2.330 \| PMID = 17219843 }}</ref>

	Mneumonic ''DO STOP'' (modified):<ref name=pathologyexpert>URL: [http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm]. Accessed on: 26 November 2011.</ref>		Mneumonic ''DO STOP'' (modified):<ref name=pathologyexpert>URL: [http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm]. Accessed on: 26 November 2011.</ref>

Michael: /* Prevalence */ +possible, SO

2017-06-02T20:29:10Z

Prevalence: +possible, SO

← Older revision		Revision as of 20:29, 2 June 2017
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	==Prevalence==		==Prevalence==
	1/11,300-37,600 in Europe.<ref name=pmid19822006>{{cite journal \|author=Half E, Bercovich D, Rozen P \|title=Familial adenomatous polyposis \|journal=Orphanet J Rare Dis \|volume=4 \|issue= \|pages=22 \|year=2009 \|pmid=19822006 \|pmc=2772987 \|doi=10.1186/1750-1172-4-22 \|url=}}</ref>		1/11,300-37,600 in Europe.<ref name=pmid19822006>{{cite journal \|author=Half E, Bercovich D, Rozen P \|title=Familial adenomatous polyposis \|journal=Orphanet J Rare Dis \|volume=4 \|issue= \|pages=22 \|year=2009 \|pmid=19822006 \|pmc=2772987 \|doi=10.1186/1750-1172-4-22 \|url=}}</ref>

			==Sign out==
			===Possible polyposis===
			*Numerous tubular adenoma (10+) in short time period (<1 year).

			<pre>
			Comment:
			The prior pathology is noted. The number of polyps raises the possibility of a polyposis syndrome.
			</pre>

	==See also==		==See also==

Michael: /* Gardner syndrome */ fix sp

2017-03-22T20:59:32Z

Gardner syndrome: fix sp

← Older revision		Revision as of 20:59, 22 March 2017
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	*[[Osteoma]].		*[[Osteoma]].
	*Skin lesions - multiple [[lipoma]]s.<ref name=pmid22135120>{{Cite journal \| last1 = Burger \| first1 = B. \| last2 = Cattani \| first2 = N. \| last3 = Trueb \| first3 = S. \| last4 = de Lorenzo \| first4 = R. \| last5 = Albertini \| first5 = M. \| last6 = Bontognali \| first6 = E. \| last7 = Itin \| first7 = C. \| last8 = Schaub \| first8 = N. \| last9 = Itin \| first9 = PH. \| title = Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? \| journal = Oncologist \| volume = 16 \| issue = 12 \| pages = 1698-705 \| month = \| year = 2011 \| doi = 10.1634/theoncologist.2011-0244 \| PMID = 22135120 }}</ref> ‡		*Skin lesions - multiple [[lipoma]]s.<ref name=pmid22135120>{{Cite journal \| last1 = Burger \| first1 = B. \| last2 = Cattani \| first2 = N. \| last3 = Trueb \| first3 = S. \| last4 = de Lorenzo \| first4 = R. \| last5 = Albertini \| first5 = M. \| last6 = Bontognali \| first6 = E. \| last7 = Itin \| first7 = C. \| last8 = Schaub \| first8 = N. \| last9 = Itin \| first9 = PH. \| title = Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? \| journal = Oncologist \| volume = 16 \| issue = 12 \| pages = 1698-705 \| month = \| year = 2011 \| doi = 10.1634/theoncologist.2011-0244 \| PMID = 22135120 }}</ref> ‡
	*Thyroid ~~carinoma~~ - [[papillary thyroid carcinoma cribriform morular variant]].<ref name=omim175100>{{OMIM\|175100}}</ref>		*Thyroid carcinoma - [[papillary thyroid carcinoma cribriform morular variant]].<ref name=omim175100>{{OMIM\|175100}}</ref>
	*Osteosclerotic jaw lesions.		*Osteosclerotic jaw lesions.
	*Polyps, adenomatous.		*Polyps, adenomatous.

Michael: fix ref.

2016-12-27T16:19:46Z

fix ref.

← Older revision		Revision as of 16:19, 27 December 2016
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	#*Many polyps - typically > 100.		#*Many polyps - typically > 100.
	#Attenuated FAP, abbreviated AFAP.		#Attenuated FAP, abbreviated AFAP.
	#*Less polyps - typically 10 to 100.<ref name=pmid19822006~~>{{cite journal \|author=Half E, Bercovich D, Rozen P \|title=Familial adenomatous polyposis \|journal=Orphanet J Rare Dis \|volume=4 \|issue= \|pages=22 \|year=2009 \|pmid=19822006 \|pmc=2772987 \|doi=10.1186~~/~~1750-1172-4-22 \|url=}}</ref~~>		#*Less polyps - typically 10 to 100.<ref name=pmid19822006/>
	#**As one may think... they tend to get cancer later than (the plain vanilla) FAP.		#**As one may think... they tend to get cancer later than (the plain vanilla) FAP.
	#**In a cohort of 190 individuals, median number of polyps = 25.<ref name=pmid20105204>{{Cite journal \| last1 = Knudsen \| first1 = AL. \| last2 = Bülow \| first2 = S. \| last3 = Tomlinson \| first3 = I. \| last4 = Möslein \| first4 = G. \| last5 = Heinimann \| first5 = K. \| last6 = Christensen \| first6 = IJ. \| last7 = Aretz \| first7 = S. \| last8 = Berk \| first8 = T. \| last9 = Bertario \| first9 = L. \| title = Attenuated familial adenomatous polyposis: results from an international collaborative study. \| journal = Colorectal Dis \| volume = 12 \| issue = 10 Online \| pages = e243-9 \| month = Oct \| year = 2010 \| doi = 10.1111/j.1463-1318.2010.02218.x \| PMID = 20105204 }}</ref>		#**In a cohort of 190 individuals, median number of polyps = 25.<ref name=pmid20105204>{{Cite journal \| last1 = Knudsen \| first1 = AL. \| last2 = Bülow \| first2 = S. \| last3 = Tomlinson \| first3 = I. \| last4 = Möslein \| first4 = G. \| last5 = Heinimann \| first5 = K. \| last6 = Christensen \| first6 = IJ. \| last7 = Aretz \| first7 = S. \| last8 = Berk \| first8 = T. \| last9 = Bertario \| first9 = L. \| title = Attenuated familial adenomatous polyposis: results from an international collaborative study. \| journal = Colorectal Dis \| volume = 12 \| issue = 10 Online \| pages = e243-9 \| month = Oct \| year = 2010 \| doi = 10.1111/j.1463-1318.2010.02218.x \| PMID = 20105204 }}</ref>
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	===Turcot syndrome===		===Turcot syndrome===
	The term is somewhat ambiguous and probably ought to be avoided:		The term is somewhat ambiguous and probably ought to be avoided:
	*Half ''et al.''<ref name=pmid19822006>{{Cite journal \| last1 = Half \| first1 = E. \| last2 = Bercovich \| first2 = D. \| last3 = Rozen \| first3 = P. \| title = Familial adenomatous polyposis. \| journal = Orphanet J Rare Dis \| volume = 4 \| issue = \| pages = 22 \| month = \| year = 2009 \| doi = 10.1186/~~1750-1172-4-22 \| PMID = 19822006 \| PMC = 2772987}}</ref~~> says Turcot syndrome is FAP associated with a [[medulloblastoma]]... while OMIM says Turcot syndrome is tied to [[Lynch syndrome]] and autosomal recessive.<ref name=omim175100>{{OMIM\|175100}}</ref>		*Half ''et al.''<ref name=pmid19822006/> says Turcot syndrome is FAP associated with a [[medulloblastoma]]... while OMIM says Turcot syndrome is tied to [[Lynch syndrome]] and autosomal recessive.<ref name=omim175100>{{OMIM\|175100}}</ref>
	**The discussions by Half ''et al.''<ref name=pmid19822006/> and in [[OMIM]]<ref name=omim175100>{{OMIM\|175100}}</ref> are informative.		**The discussions by Half ''et al.''<ref name=pmid19822006/> and in [[OMIM]]<ref name=omim175100>{{OMIM\|175100}}</ref> are informative.

Michael: teweak

2016-12-27T16:18:30Z

teweak

← Older revision		Revision as of 16:18, 27 December 2016
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	#**In a cohort of 190 individuals, median number of polyps = 25.<ref name=pmid20105204>{{Cite journal \| last1 = Knudsen \| first1 = AL. \| last2 = Bülow \| first2 = S. \| last3 = Tomlinson \| first3 = I. \| last4 = Möslein \| first4 = G. \| last5 = Heinimann \| first5 = K. \| last6 = Christensen \| first6 = IJ. \| last7 = Aretz \| first7 = S. \| last8 = Berk \| first8 = T. \| last9 = Bertario \| first9 = L. \| title = Attenuated familial adenomatous polyposis: results from an international collaborative study. \| journal = Colorectal Dis \| volume = 12 \| issue = 10 Online \| pages = e243-9 \| month = Oct \| year = 2010 \| doi = 10.1111/j.1463-1318.2010.02218.x \| PMID = 20105204 }}</ref>		#**In a cohort of 190 individuals, median number of polyps = 25.<ref name=pmid20105204>{{Cite journal \| last1 = Knudsen \| first1 = AL. \| last2 = Bülow \| first2 = S. \| last3 = Tomlinson \| first3 = I. \| last4 = Möslein \| first4 = G. \| last5 = Heinimann \| first5 = K. \| last6 = Christensen \| first6 = IJ. \| last7 = Aretz \| first7 = S. \| last8 = Berk \| first8 = T. \| last9 = Bertario \| first9 = L. \| title = Attenuated familial adenomatous polyposis: results from an international collaborative study. \| journal = Colorectal Dis \| volume = 12 \| issue = 10 Online \| pages = e243-9 \| month = Oct \| year = 2010 \| doi = 10.1111/j.1463-1318.2010.02218.x \| PMID = 20105204 }}</ref>
	===Gardner syndrome===		===Gardner syndrome===
	FAP with prominent extraintestinal manifestations - including:<ref name=pmid19822006>{{~~Cite~~ journal \| ~~last1~~ = Half ~~\| first1 =~~ E~~. \| last2 =~~ Bercovich ~~\| first2 =~~ D~~. \| last3 =~~ Rozen ~~\| first3 =~~ P. \| title = Familial adenomatous polyposis. \| journal = Orphanet J Rare Dis \| volume = 4 \| issue = \| pages = 22 \| ~~month~~ = \| ~~year~~ = ~~2009~~ \| doi = 10.1186/1750-1172-4-22 \| ~~PMID = 19822006 \| PMC~~ = ~~2772987~~}}</ref>		FAP with prominent extraintestinal manifestations - including:<ref name=pmid19822006>{{cite journal \|author=Half E, Bercovich D, Rozen P \|title=Familial adenomatous polyposis \|journal=Orphanet J Rare Dis \|volume=4 \|issue= \|pages=22 \|year=2009 \|pmid=19822006 \|pmc=2772987 \|doi=10.1186/1750-1172-4-22 \|url=}}</ref>
	*[[Osteoma]]s.		*[[Osteoma]]s.
	*[[Desmoid tumour]]s.		*[[Desmoid tumour]]s.

Michael: APC gene... not FAP

2015-08-14T21:17:43Z

APC gene... not FAP

← Older revision		Revision as of 21:17, 14 August 2015
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	'''Familial adenomatous polyposis''', abbreviated '''FAP''' and also known as '''familial polyposis coli''' and '''adenomatous polyposis coli‎''', is a genetic condition that predisposes to [[adenomatous polyps]] and thus invariably results in [[colorectal cancer]].		'''Familial adenomatous polyposis''', abbreviated '''FAP''' and also known as '''familial polyposis coli''' and '''adenomatous polyposis coli‎''', is a genetic condition that predisposes to [[adenomatous polyps]] and thus invariably results in [[colorectal cancer]].

	'''Gardner syndrome'''<ref name=pmid14902760>{{Cite journal \| last1 = Gardner \| first1 = EJ. \| title = A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum. \| journal = Am J Hum Genet \| volume = 3 \| issue = 2 \| pages = 167-76 \| month = Jun \| year = 1951 \| doi = \| PMID = 14902760 }}</ref> is a subset of FAP. Both FAP and Gardner syndrome have a mutation in the ~~FAP~~ gene.<ref name=omim175100>{{OMIM\|175100}}</ref>		'''Gardner syndrome'''<ref name=pmid14902760>{{Cite journal \| last1 = Gardner \| first1 = EJ. \| title = A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum. \| journal = Am J Hum Genet \| volume = 3 \| issue = 2 \| pages = 167-76 \| month = Jun \| year = 1951 \| doi = \| PMID = 14902760 }}</ref> is a subset of FAP. Both FAP and Gardner syndrome have a mutation in the APC gene.<ref name=omim175100>{{OMIM\|175100}}</ref>

	==General==		==General==

Michael: +gross image

2014-11-24T01:54:38Z

+gross image

← Older revision		Revision as of 01:54, 24 November 2014
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	[[Image:FAP.jpg\|thumb\|right\|An endoscopic image showing abundant polyps, as seen in familial adenomatous polyposis.]]		[[Image:Familial Adenomatous Polyposes colon -2.jpg\|thumb\|right\|250px\|[[Colectomy]] specimen with familial adenomatous polyposis. (WC/Netha Hussain)]]
			[[Image:FAP.jpg\|thumb\|right\|An endoscopic image showing abundant polyps, as seen in familial adenomatous polyposis. (WC/Samir)]]
	'''Familial adenomatous polyposis''', abbreviated '''FAP''' and also known as '''familial polyposis coli''' and '''adenomatous polyposis coli‎''', is a genetic condition that predisposes to [[adenomatous polyps]] and thus invariably results in [[colorectal cancer]].		'''Familial adenomatous polyposis''', abbreviated '''FAP''' and also known as '''familial polyposis coli''' and '''adenomatous polyposis coli‎''', is a genetic condition that predisposes to [[adenomatous polyps]] and thus invariably results in [[colorectal cancer]].

Michael: +image

2014-07-15T18:28:13Z

+image

← Older revision		Revision as of 18:28, 15 July 2014
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			[[Image:FAP.jpg\|thumb\|right\|An endoscopic image showing abundant polyps, as seen in familial adenomatous polyposis.]]
	'''Familial adenomatous polyposis''', abbreviated '''FAP''' and also known as '''familial polyposis coli''' and '''adenomatous polyposis coli‎''', is a genetic condition that predisposes to [[adenomatous polyps]] and thus invariably results in [[colorectal cancer]].		'''Familial adenomatous polyposis''', abbreviated '''FAP''' and also known as '''familial polyposis coli''' and '''adenomatous polyposis coli‎''', is a genetic condition that predisposes to [[adenomatous polyps]] and thus invariably results in [[colorectal cancer]].

Michael: /* Variants */

2013-10-24T13:41:27Z

Variants

← Older revision		Revision as of 13:41, 24 October 2013
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	#*Less polyps - typically 10 to 100.<ref name=pmid19822006>{{cite journal \|author=Half E, Bercovich D, Rozen P \|title=Familial adenomatous polyposis \|journal=Orphanet J Rare Dis \|volume=4 \|issue= \|pages=22 \|year=2009 \|pmid=19822006 \|pmc=2772987 \|doi=10.1186/1750-1172-4-22 \|url=}}</ref>		#*Less polyps - typically 10 to 100.<ref name=pmid19822006>{{cite journal \|author=Half E, Bercovich D, Rozen P \|title=Familial adenomatous polyposis \|journal=Orphanet J Rare Dis \|volume=4 \|issue= \|pages=22 \|year=2009 \|pmid=19822006 \|pmc=2772987 \|doi=10.1186/1750-1172-4-22 \|url=}}</ref>
	#**As one may think... they tend to get cancer later than (the plain vanilla) FAP.		#**As one may think... they tend to get cancer later than (the plain vanilla) FAP.
	#**In a cohort of 190 individuals, median number of polyps 25.<ref name=pmid20105204>{{Cite journal \| last1 = Knudsen \| first1 = AL. \| last2 = Bülow \| first2 = S. \| last3 = Tomlinson \| first3 = I. \| last4 = Möslein \| first4 = G. \| last5 = Heinimann \| first5 = K. \| last6 = Christensen \| first6 = IJ. \| last7 = Aretz \| first7 = S. \| last8 = Berk \| first8 = T. \| last9 = Bertario \| first9 = L. \| title = Attenuated familial adenomatous polyposis: results from an international collaborative study. \| journal = Colorectal Dis \| volume = 12 \| issue = 10 Online \| pages = e243-9 \| month = Oct \| year = 2010 \| doi = 10.1111/j.1463-1318.2010.02218.x \| PMID = 20105204 }}</ref>		#**In a cohort of 190 individuals, median number of polyps = 25.<ref name=pmid20105204>{{Cite journal \| last1 = Knudsen \| first1 = AL. \| last2 = Bülow \| first2 = S. \| last3 = Tomlinson \| first3 = I. \| last4 = Möslein \| first4 = G. \| last5 = Heinimann \| first5 = K. \| last6 = Christensen \| first6 = IJ. \| last7 = Aretz \| first7 = S. \| last8 = Berk \| first8 = T. \| last9 = Bertario \| first9 = L. \| title = Attenuated familial adenomatous polyposis: results from an international collaborative study. \| journal = Colorectal Dis \| volume = 12 \| issue = 10 Online \| pages = e243-9 \| month = Oct \| year = 2010 \| doi = 10.1111/j.1463-1318.2010.02218.x \| PMID = 20105204 }}</ref>
	===Gardner syndrome===		===Gardner syndrome===
	FAP with prominent extraintestinal manifestations - including:<ref name=pmid19822006>{{Cite journal \| last1 = Half \| first1 = E. \| last2 = Bercovich \| first2 = D. \| last3 = Rozen \| first3 = P. \| title = Familial adenomatous polyposis. \| journal = Orphanet J Rare Dis \| volume = 4 \| issue = \| pages = 22 \| month = \| year = 2009 \| doi = 10.1186/1750-1172-4-22 \| PMID = 19822006 \| PMC = 2772987}}</ref>		FAP with prominent extraintestinal manifestations - including:<ref name=pmid19822006>{{Cite journal \| last1 = Half \| first1 = E. \| last2 = Bercovich \| first2 = D. \| last3 = Rozen \| first3 = P. \| title = Familial adenomatous polyposis. \| journal = Orphanet J Rare Dis \| volume = 4 \| issue = \| pages = 22 \| month = \| year = 2009 \| doi = 10.1186/1750-1172-4-22 \| PMID = 19822006 \| PMC = 2772987}}</ref>