Fibroblastic/myofibroblastic tumours - Revision history

Michael: split out

2019-03-24T18:58:13Z

split out

← Older revision		Revision as of 18:58, 24 March 2019
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	==Elastofibroma==		==Elastofibroma==
	~~===General===~~		{{Main\|Elastofibroma}}
	*Benign.
	*Classically, subscapular in elderly women.<ref>URL: [http://emedicine.medscape.com/article/1057113-overview http://emedicine.medscape.com/article/1057113-overview]. Accessed on: 26 October 2011.</ref><ref>{{~~Cite journal~~ \| last1 = Ben Hassouna \| first1 = J. \| last2 = Hamdi \| first2 = N. \| last3 = Ben Bachouche \| first3 = W. \| last4 = Bouzid \| first4 = T. \| last5 = Dhiab \| first5 = T. \| last6 = Rahal \| first6 = K. \| title = Elastofibroma ~~dorsi. \| journal = Orthop Traumatol Surg Res \| volume = 96 \| issue = 6 \| pages = 717-20 \| month = Oct \| year = 2010 \| doi = 10.1016/j.otsr.2010.03.019 \| PMID = 20708994 }}</ref>~~

	~~===Gross===~~
	~~Features:~~
	*Yellow-white, moderate demarcation to surrounding tissue.<ref name=Ref_AoGP592>{{Ref AoGP\|592}}~~</ref>~~

	~~DDx - shoulder lesions:~~
	*[[Desmoplastic fibroblastoma]].
	*[[Pleomorphic lipoma]].

	~~===Microscopic===~~
	~~Features:~~
	*Thick bundles of collagen.
	*Elastin fibres.

	~~Image:~~

	==Nodular fasciitis==		==Nodular fasciitis==

Michael: /* Molecular */

2018-09-11T05:59:29Z

Molecular

← Older revision		Revision as of 05:59, 11 September 2018
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	Characteristic [[translocation]]:<ref name=pmid11242790 >{{Cite journal \| last1 = Sheng \| first1 = WQ. \| last2 = Hisaoka \| first2 = M. \| last3 = Okamoto \| first3 = S. \| last4 = Tanaka \| first4 = A. \| last5 = Meis-Kindblom \| first5 = JM. \| last6 = Kindblom \| first6 = LG. \| last7 = Ishida \| first7 = T. \| last8 = Nojima \| first8 = T. \| last9 = Hashimoto \| first9 = H. \| title = Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. \| journal = Am J Clin Pathol \| volume = 115 \| issue = 3 \| pages = 348-55 \| month = Mar \| year = 2001 \| doi = 10.1309/3H24-E7T7-V37G-AKKQ \| PMID = 11242790 }}</ref>		Characteristic [[translocation]]:<ref name=pmid11242790 >{{Cite journal \| last1 = Sheng \| first1 = WQ. \| last2 = Hisaoka \| first2 = M. \| last3 = Okamoto \| first3 = S. \| last4 = Tanaka \| first4 = A. \| last5 = Meis-Kindblom \| first5 = JM. \| last6 = Kindblom \| first6 = LG. \| last7 = Ishida \| first7 = T. \| last8 = Nojima \| first8 = T. \| last9 = Hashimoto \| first9 = H. \| title = Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. \| journal = Am J Clin Pathol \| volume = 115 \| issue = 3 \| pages = 348-55 \| month = Mar \| year = 2001 \| doi = 10.1309/3H24-E7T7-V37G-AKKQ \| PMID = 11242790 }}</ref>
	*t(12;15)(p13;q25).		*t(12;15)(p13;q25).
	**Gene fusion ETV6-NTRK3.		**Gene fusion ETV6-[[NTRK3]].
	***Same translocation in [[mesoblastic nephroma]].		***Same translocation in [[mesoblastic nephroma]].

Michael: /* Molecular */

2018-09-11T05:58:32Z

Molecular

← Older revision		Revision as of 05:58, 11 September 2018
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	===Molecular===		===Molecular===
	Characteristic [[translocation]]:<ref>{{Cite journal \| last1 = Sheng \| first1 = WQ. \| last2 = Hisaoka \| first2 = M. \| last3 = Okamoto \| first3 = S. \| last4 = Tanaka \| first4 = A. \| last5 = Meis-Kindblom \| first5 = JM. \| last6 = Kindblom \| first6 = LG. \| last7 = Ishida \| first7 = T. \| last8 = Nojima \| first8 = T. \| last9 = Hashimoto \| first9 = H. \| title = Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. \| journal = Am J Clin Pathol \| volume = 115 \| issue = 3 \| pages = 348-55 \| month = Mar \| year = 2001 \| doi = 10.1309/3H24-E7T7-V37G-AKKQ \| PMID = 11242790 }}</ref>		Characteristic [[translocation]]:<ref name=pmid11242790 >{{Cite journal \| last1 = Sheng \| first1 = WQ. \| last2 = Hisaoka \| first2 = M. \| last3 = Okamoto \| first3 = S. \| last4 = Tanaka \| first4 = A. \| last5 = Meis-Kindblom \| first5 = JM. \| last6 = Kindblom \| first6 = LG. \| last7 = Ishida \| first7 = T. \| last8 = Nojima \| first8 = T. \| last9 = Hashimoto \| first9 = H. \| title = Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. \| journal = Am J Clin Pathol \| volume = 115 \| issue = 3 \| pages = 348-55 \| month = Mar \| year = 2001 \| doi = 10.1309/3H24-E7T7-V37G-AKKQ \| PMID = 11242790 }}</ref>
	*t(12;15)(p13;q25).		*t(12;15)(p13;q25).
	**Gene fusion ETV6-NTRK3.		**Gene fusion ETV6-NTRK3.

Brigitte: /* Microscopic */

2018-05-10T00:59:50Z

Microscopic

← Older revision		Revision as of 00:59, 10 May 2018
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	Image:		Image:
	*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802163630229 Elastofibroma (surgicalpathologyatlas.com)].

	==Nodular fasciitis==		==Nodular fasciitis==

Michael: /* Myxofibrosarcoma */ split out

2016-06-24T12:24:33Z

Myxofibrosarcoma: split out

← Older revision		Revision as of 12:24, 24 June 2016
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	*Should '''not''' be confused with ''[[low-grade fibromyxoid sarcoma]]''.<ref name=pmid8650138>{{Cite journal \| last1 = Mentzel \| first1 = T. \| last2 = Katenkamp \| first2 = D. \| last3 = Fletcher \| first3 = CD. \| title = [Low malignancy myxofibrosarcoma versus low malignancy fibromyxoid sarcoma. Distinct entities with similar names but different clinical course]. \| journal = Pathologe \| volume = 17 \| issue = 2 \| pages = 116-21 \| month = Mar \| year = 1996 \| doi = \| PMID = 8650138 }}</ref>		*Should '''not''' be confused with ''[[low-grade fibromyxoid sarcoma]]''.<ref name=pmid8650138>{{Cite journal \| last1 = Mentzel \| first1 = T. \| last2 = Katenkamp \| first2 = D. \| last3 = Fletcher \| first3 = CD. \| title = [Low malignancy myxofibrosarcoma versus low malignancy fibromyxoid sarcoma. Distinct entities with similar names but different clinical course]. \| journal = Pathologe \| volume = 17 \| issue = 2 \| pages = 116-21 \| month = Mar \| year = 1996 \| doi = \| PMID = 8650138 }}</ref>
	*[[AKA]] ''myxoid malignant fibrous histiocytoma'' or ''myxoid MFH''.<ref>{{Cite journal \| last1 = Fujimura \| first1 = T. \| last2 = Okuyama \| first2 = R. \| last3 = Terui \| first3 = T. \| last4 = Okuno \| first4 = K. \| last5 = Masu \| first5 = A. \| last6 = Masu \| first6 = T. \| last7 = Chiba \| first7 = S. \| last8 = Kunii \| first8 = T. \| last9 = Tagami \| first9 = H. \| title = Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. \| journal = J Cutan Pathol \| volume = 32 \| issue = 7 \| pages = 512-5 \| month = Aug \| year = 2005 \| doi = 10.1111/j.0303-6987.2005.00368.x \| PMID = 16008697 }}</ref>		*[[AKA]] ''myxoid malignant fibrous histiocytoma'' or ''myxoid MFH''.<ref>{{Cite journal \| last1 = Fujimura \| first1 = T. \| last2 = Okuyama \| first2 = R. \| last3 = Terui \| first3 = T. \| last4 = Okuno \| first4 = K. \| last5 = Masu \| first5 = A. \| last6 = Masu \| first6 = T. \| last7 = Chiba \| first7 = S. \| last8 = Kunii \| first8 = T. \| last9 = Tagami \| first9 = H. \| title = Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. \| journal = J Cutan Pathol \| volume = 32 \| issue = 7 \| pages = 512-5 \| month = Aug \| year = 2005 \| doi = 10.1111/j.0303-6987.2005.00368.x \| PMID = 16008697 }}</ref>
	~~===General===~~		{{Main\|Myxofibrosarcoma}}
	*Malignant.
	*Usually older people, superficial (skin/dermis) and extremities (arm, legs).<ref name=Ref_WMSP612-3>{{~~Ref WMSP~~\|~~612-3}}</ref><ref name=pmid17197925/>~~
	*Prognosis better than [[pleomorphic undifferentiated sarcoma]].
	**Metastatic potential inversely related to component/portion that is myxoid.<ref name=pmid192434>{{Cite journal \| last1 = Weiss \| first1 = SW. \| last2 = Enzinger \| first2 = FM. \| title = Myxoid variant of malignant fibrous histiocytoma. \| journal = Cancer \| volume = 39 \| issue = 4 \| pages = 1672-85 \| month = Apr \| year = 1977 \| doi = \| PMID = 192434 }}</ref>

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP612-3>{{Ref WMSP\|612-3}}</ref>~~
	*Discontinuous fibrous septae.
	*Myxoid background.
	*Variable cellularity and nuclear pleomorphism.
	*Spindle cells or epithelioid cells.<ref name=pmid17197925/>
	*Curvilinear vessels.<ref name=pmid17197925>{{Cite journal \| last1 = Nascimento \| first1 = AF. \| last2 = Bertoni \| first2 = F. \| last3 = Fletcher \| first3 = CD. \| title = Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 1 \| pages = 99-105 \| month = Jan \| year = 2007 \| doi = 10.1097/01.pas.0000213379.94547.e7 \| PMID = 17197925 }}</ref>

	~~DDx:~~
	*[[Liposarcoma\|Myxoid liposarcoma]].
	*[[Low-grade fibromyxoid sarcoma]] - alternating fibrous and myxoid areas.<ref name=pmid8650138/>
	*[[Myxoma]].

	~~Image:~~
	*[http://www.sarcomaimages.com/sub.php?v=sample-case&p=myxofibrosarcoma-myxoid-mfh Myxofibrosarcoma ~~(sarcomaimages.com)].~~

	~~===IHC===~~
	*Vimentin +ve -- otherwise non-distinctive.<ref name=Ref_WMSP612-3>{{Ref WMSP\|612-3}}~~</ref>~~

	=See also=		=See also=

Michael at 03:34, 31 October 2015

2015-10-31T03:34:50Z

← Older revision		Revision as of 03:34, 31 October 2015
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	Feature:<ref name=Ref_WMSP611>{{Ref WMSP\|611}}</ref>		Feature:<ref name=Ref_WMSP611>{{Ref WMSP\|611}}</ref>
	*Spindle cell lesion.		*Spindle cell lesion.
	*Herring bone pattern - '''key feature'''.		*[[Herring bone pattern]] - '''key feature'''.
	*Mitoses.		*Mitoses.

Jensflorian: /* Hemangiopericytoma */ images added

2015-09-24T10:35:26Z

Hemangiopericytoma: images added

← Older revision		Revision as of 10:35, 24 September 2015
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	* Vimentin +ve.		* Vimentin +ve.
	* CD34 +ve (often patchy, used to differentiate from SFT).		* CD34 +ve (often patchy, used to differentiate from SFT).
	* ~~Stat6~~ nuclear +ve.		* [[STAT6]] nuclear +ve.
	* EMA +/-ve.		* EMA +/-ve.

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	*EMA -ve.		*EMA -ve.
	*S100 -ve.		*S100 -ve.

			===Images===
			<gallery>
			Image:Neuropathology_case_VI_02.jpg \| Anaplastic hemangiopericytoma, low mag. (WC/jensflorian)
			Image:Neuropathology_case_VI_03.jpg \| Anaplastic hemangiopericytoma, intermed mag. (WC/jensflorian)
			Image:Neuropathology_case_VI_04.jpg \| Anaplastic hemangiopericytoma, high mag. (WC/jensflorian)
			Image:Neuropathology_case_VI_01.jpg \| Anaplastic hemangiopericytoma, [[STAT6]] immunostaining. (WC/jensflorian)
			</gallery>

	=Malignant=		=Malignant=

Jensflorian: /* Histology */ typo

2015-06-02T08:58:29Z

Histology: typo

← Older revision		Revision as of 08:58, 2 June 2015
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	*little fibrosis.		*little fibrosis.
	*plenty reticulin.		*plenty reticulin.
	*~~vasczlar~~ with slit-like channels ("staghorn-like vessels").		*vascular with slit-like channels ("staghorn-like vessels").

	====IHC====		====IHC====

Michael at 15:43, 1 June 2015

2015-06-01T15:43:52Z

← Older revision		Revision as of 15:43, 1 June 2015
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	Features:<ref name=pmid1566969>{{Cite journal \| last1 = Meis \| first1 = JM. \| last2 = Enzinger \| first2 = FM. \| title = Proliferative fasciitis and myositis of childhood. \| journal = Am J Surg Pathol \| volume = 16 \| issue = 4 \| pages = 364-72 \| month = Apr \| year = 1992 \| doi = \| PMID = 1566969 }}</ref>		Features:<ref name=pmid1566969>{{Cite journal \| last1 = Meis \| first1 = JM. \| last2 = Enzinger \| first2 = FM. \| title = Proliferative fasciitis and myositis of childhood. \| journal = Am J Surg Pathol \| volume = 16 \| issue = 4 \| pages = 364-72 \| month = Apr \| year = 1992 \| doi = \| PMID = 1566969 }}</ref>
	*Large polygonal (ganglion-like) and/or spindled cells with:		*Large polygonal (ganglion-like) and/or spindled cells with:
	**Vesicular (clear) nuclei.		**[[Vesicular nuclei\|Vesicular (clear) nuclei]].
	**Prominent nucleoli.		**Prominent nucleoli.
	*+/-Binucleation.		*+/-Binucleation.

Jensflorian: /* General */ update incl. NAB2/Stat6

2015-05-20T08:29:40Z

General: update incl. NAB2/Stat6

← Older revision		Revision as of 08:29, 20 May 2015
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	==Hemangiopericytoma==		==Hemangiopericytoma==
	===General===		===General===
	*Grouped with ''[[solitary fibrous tumour]]'' in the WHO classification; ~~possibly the~~ same ~~tumour (?)~~.<ref name=Ref_WMSP609>{{Ref WMSP\|609}}</ref>		*Grouped with ''[[solitary fibrous tumour]]'' in the WHO classification; share same genetic NAB2-STAT6 fusion.<ref name=Ref_WMSP609>{{Ref WMSP\|609}}</ref><ref>{{Cite journal \| last1 = Schweizer \| first1 = L. \| last2 = Koelsche \| first2 = C. \| last3 = Sahm \| first3 = F. \| last4 = Piro \| first4 = RM. \| last5 = Capper \| first5 = D. \| last6 = Reuss \| first6 = DE. \| last7 = Pusch \| first7 = S. \| last8 = Habel \| first8 = A. \| last9 = Meyer \| first9 = J. \| title = Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. \| journal = Acta Neuropathol \| volume = 125 \| issue = 5 \| pages = 651-8 \| month = May \| year = 2013 \| doi = 10.1007/s00401-013-1117-6 \| PMID = 23575898 }}</ref>
	*~~Arises~~ from the ''pericyte'', a connective tissue cell of small vessels that is thought to be involved in flow regulation.
			*Thought to arise from the ''pericyte'', a connective tissue cell of small vessels that is thought to be involved in flow regulation while others consider a fibroblastic nature.<ref>{{Cite journal \| last1 = Gengler \| first1 = C. \| last2 = Guillou \| first2 = L. \| title = Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. \| journal = Histopathology \| volume = 48 \| issue = 1 \| pages = 63-74 \| month = Jan \| year = 2006 \| doi = 10.1111/j.1365-2559.2005.02290.x \| PMID = 16359538 }}</ref>
	*Hematologic spread most common - to lungs.<ref name=emed1255879ov>URL: [http://emedicine.medscape.com/article/1255879-overview http://emedicine.medscape.com/article/1255879-overview]. Accessed on: 2 May 2010.</ref>		*Hematologic spread most common - to lungs.<ref name=emed1255879ov>URL: [http://emedicine.medscape.com/article/1255879-overview http://emedicine.medscape.com/article/1255879-overview]. Accessed on: 2 May 2010.</ref>
	*[[Oncogenic osteomalacia]] - assoc. with hemangiopericytoma.<ref name=emed1255879ov>URL: [http://emedicine.medscape.com/article/1255879-overview http://emedicine.medscape.com/article/1255879-overview]. Accessed on: 2 May 2010.</ref>		*[[Oncogenic osteomalacia]] - assoc. with hemangiopericytoma.<ref name=emed1255879ov>URL: [http://emedicine.medscape.com/article/1255879-overview http://emedicine.medscape.com/article/1255879-overview]. Accessed on: 2 May 2010.</ref>
			*WHO grade II hemangiopericytoma (ICD-O: 9150/1), WHO grade III anaplastic hemangiopericytoma (ICD-O: 9150/3)

	====Presentation====		====Presentation====
	*Usually painless mass, slow enlargement.		*Usually painless mass, slow enlargement.
			*May profusely bleed during resection.
			*May invade bone.

			====Histology====
			*high cellular density.
			*indistinct cell borders.
			*random tumor cell orientation.
			*little fibrosis.
			*plenty reticulin.
			*vasczlar with slit-like channels ("staghorn-like vessels").

			====IHC====
			* Vimentin +ve.
			* CD34 +ve (often patchy, used to differentiate from SFT).
			* Stat6 nuclear +ve.
			* EMA +/-ve.

	===Radiology===		===Radiology===