Fibrous dysplasia - Revision history

Michael: /* Images */ small fix

2014-11-30T01:34:43Z

Images: small fix

← Older revision		Revision as of 01:34, 30 November 2014
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	Image:Fibrous_dysplasia_-_intermed_mag.jpg \| Fibrous dysplasia - intermed. mag. (WC/Nephron)		Image:Fibrous_dysplasia_-_intermed_mag.jpg \| Fibrous dysplasia - intermed. mag. (WC/Nephron)
	Image:Fibrous_dysplasia_-_high_mag.jpg \| Fibrous dysplasia - high mag. (WC/Nephron)		Image:Fibrous_dysplasia_-_high_mag.jpg \| Fibrous dysplasia - high mag. (WC/Nephron)
	Image:Bone FibrousDysplasia LP CTR.jpg~~\|thumb~~\|Medium power shot with the classic 'Chinese character' bone spicules.		Image:Bone FibrousDysplasia LP CTR.jpg\|Medium power shot with the classic 'Chinese character' bone spicules.
	Image:Bone FibrousDysplasia Jaw MP3 PA.JPG~~\|thumb~~\|Immature bony trabeculae in a fibrous stroma.		Image:Bone FibrousDysplasia Jaw MP3 PA.JPG\|Immature bony trabeculae in a fibrous stroma.
	</gallery>		</gallery>
	www:		www:

Sarah: /* Microscopic */

2014-10-19T05:57:33Z

Microscopic

← Older revision		Revision as of 05:57, 19 October 2014
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	** Gnathic ossifying fibroma recurs and needs to be completely enucleated		** Gnathic ossifying fibroma recurs and needs to be completely enucleated
	** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.		** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.
	**~~Distinguishing~~ between these two is important		**S0, distinguishing between these two entities is important

	===Images===		===Images===

Sarah: /* Molecular */

2014-10-19T05:56:47Z

Molecular

← Older revision		Revision as of 05:56, 19 October 2014
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	*Postzygotic (somatic) activating mutations of the GNAS1 gene 10, which encodes the α-subunit of the stimulatory G-protein Gs<ref>{{Cite journal \| last1 = Weinstein \| first1 = LS. \| last2 = Shenker \| first2 = A. \| last3 = Gejman \| first3 = PV. \| last4 = Merino \| first4 = MJ. \| last5 = Friedman \| first5 = E. \| last6 = Spiegel \| first6 = AM. \| title = Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. \| journal = N Engl J Med \| volume = 325 \| issue = 24 \| pages = 1688-95 \| month = Dec \| year = 1991 \| doi = 10.1056/NEJM199112123252403 \| PMID = 1944469 }}</ref>		*Postzygotic (somatic) activating mutations of the GNAS1 gene 10, which encodes the α-subunit of the stimulatory G-protein Gs<ref>{{Cite journal \| last1 = Weinstein \| first1 = LS. \| last2 = Shenker \| first2 = A. \| last3 = Gejman \| first3 = PV. \| last4 = Merino \| first4 = MJ. \| last5 = Friedman \| first5 = E. \| last6 = Spiegel \| first6 = AM. \| title = Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. \| journal = N Engl J Med \| volume = 325 \| issue = 24 \| pages = 1688-95 \| month = Dec \| year = 1991 \| doi = 10.1056/NEJM199112123252403 \| PMID = 1944469 }}</ref>
	*Both mono and polyostatic cases.		*Both mono and polyostatic cases.
	*Causative molecular lesion of McCune-Albright and Mazzabraud syndrome		*Causative molecular lesion of McCune-Albright and Mazzabraud syndrome<ref>http://ghr.nlm.nih.gov/condition/mccune-albright-syndrome</ref>

	==See also==		==See also==

Sarah: /* Molecular */

2014-10-19T05:56:27Z

Molecular

← Older revision		Revision as of 05:56, 19 October 2014
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	==Molecular==		==Molecular==
	Postzygotic (somatic) activating mutations of the GNAS1 gene 10, which encodes the α-subunit of the stimulatory G-protein Gs<ref>{{Cite journal \| last1 = Weinstein \| first1 = LS. \| last2 = Shenker \| first2 = A. \| last3 = Gejman \| first3 = PV. \| last4 = Merino \| first4 = MJ. \| last5 = Friedman \| first5 = E. \| last6 = Spiegel \| first6 = AM. \| title = Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. \| journal = N Engl J Med \| volume = 325 \| issue = 24 \| pages = 1688-95 \| month = Dec \| year = 1991 \| doi = 10.1056/NEJM199112123252403 \| PMID = 1944469 }}</ref>		*Postzygotic (somatic) activating mutations of the GNAS1 gene 10, which encodes the α-subunit of the stimulatory G-protein Gs<ref>{{Cite journal \| last1 = Weinstein \| first1 = LS. \| last2 = Shenker \| first2 = A. \| last3 = Gejman \| first3 = PV. \| last4 = Merino \| first4 = MJ. \| last5 = Friedman \| first5 = E. \| last6 = Spiegel \| first6 = AM. \| title = Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. \| journal = N Engl J Med \| volume = 325 \| issue = 24 \| pages = 1688-95 \| month = Dec \| year = 1991 \| doi = 10.1056/NEJM199112123252403 \| PMID = 1944469 }}</ref>
			*Both mono and polyostatic cases.
			*Causative molecular lesion of McCune-Albright and Mazzabraud syndrome

	==See also==		==See also==
	*[[Bone]].		*[[Bone]].

Sarah: /* Images */

2014-10-19T05:52:32Z

Images

← Older revision		Revision as of 05:52, 19 October 2014
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	*[http://www.pathologypics.com/pictview.aspx?id=104 Fibrous dysplasia of bone - high mag. (pathologypics.com)].		*[http://www.pathologypics.com/pictview.aspx?id=104 Fibrous dysplasia of bone - high mag. (pathologypics.com)].
	*[http://www.pathologypics.com/BigPicViewer.aspx?PictureID=103 Fibrous dysplasia of bone - low mag. (pathologypics.com)].		*[http://www.pathologypics.com/BigPicViewer.aspx?PictureID=103 Fibrous dysplasia of bone - low mag. (pathologypics.com)].
	*Modern Pathology[http://www.nature.com/modpathol/journal/v20/n3/images/3800753f1.jpg]		*Modern Pathology- fibrous dysplasia (left) vs ossifying fibroma (right)[http://www.nature.com/modpathol/journal/v20/n3/images/3800753f1.jpg]

	==Molecular==		==Molecular==

Sarah at 05:51, 19 October 2014

2014-10-19T05:51:22Z

← Older revision		Revision as of 05:51, 19 October 2014
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	*Modern Pathology[http://www.nature.com/modpathol/journal/v20/n3/images/3800753f1.jpg]		*Modern Pathology[http://www.nature.com/modpathol/journal/v20/n3/images/3800753f1.jpg]

			==Molecular==
			Postzygotic (somatic) activating mutations of the GNAS1 gene 10, which encodes the α-subunit of the stimulatory G-protein Gs<ref>{{Cite journal \| last1 = Weinstein \| first1 = LS. \| last2 = Shenker \| first2 = A. \| last3 = Gejman \| first3 = PV. \| last4 = Merino \| first4 = MJ. \| last5 = Friedman \| first5 = E. \| last6 = Spiegel \| first6 = AM. \| title = Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. \| journal = N Engl J Med \| volume = 325 \| issue = 24 \| pages = 1688-95 \| month = Dec \| year = 1991 \| doi = 10.1056/NEJM199112123252403 \| PMID = 1944469 }}</ref>
	==See also==		==See also==
	*[[Bone]].		*[[Bone]].

Sarah: /* Microscopic */

2014-10-19T05:46:40Z

Microscopic

← Older revision		Revision as of 05:46, 19 October 2014
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	*Low grade [[fibrosarcoma]].		*Low grade [[fibrosarcoma]].
	*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal \|author=Inwards, CY \|title=Low-grade central osteosarcoma versus fibrous dysplasia \|journal=Pathology Case Reviews \|volume=6 \|issue=1 \|pages=22-27 \|year=2001 \|pmid= \|doi= \|url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>		*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal \|author=Inwards, CY \|title=Low-grade central osteosarcoma versus fibrous dysplasia \|journal=Pathology Case Reviews \|volume=6 \|issue=1 \|pages=22-27 \|year=2001 \|pmid= \|doi= \|url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>
	*Gnathic ossifying fibroma (Cemento-ossifying fibroma)<ref>http://www.nature.com/modpathol/journal/v20/n3/full/3800753a.html</ref><ref>{{Cite journal \| last1 = Patel \| first1 = MM. \| last2 = Wilkey \| first2 = JF. \| last3 = Abdelsayed \| first3 = R. \| last4 = D'Silva \| first4 = NJ. \| last5 = Malchoff \| first5 = C. \| last6 = Mallya \| first6 = SM. \| title = Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod \| volume = 109 \| issue = 5 \| pages = 739-43 \| month = May \| year = 2010 \| doi = 10.1016/j.tripleo.2009.12.016 \| PMID = 20346714 }}<r/ref> - Prominent calcified spherules, no associated GNAS mutation		*Gnathic ossifying fibroma (Cemento-ossifying fibroma)<ref>http://www.nature.com/modpathol/journal/v20/n3/full/3800753a.html</ref><ref>{{Cite journal \| last1 = Patel \| first1 = MM. \| last2 = Wilkey \| first2 = JF. \| last3 = Abdelsayed \| first3 = R. \| last4 = D'Silva \| first4 = NJ. \| last5 = Malchoff \| first5 = C. \| last6 = Mallya \| first6 = SM. \| title = Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod \| volume = 109 \| issue = 5 \| pages = 739-43 \| month = May \| year = 2010 \| doi = 10.1016/j.tripleo.2009.12.016 \| PMID = 20346714 }}</ref> - Prominent calcified spherules, no associated GNAS mutation
	** Gnathic ossifying fibroma recurs and needs to be completely enucleated		** Gnathic ossifying fibroma recurs and needs to be completely enucleated
	** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.		** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.

Sarah: /* Microscopic */

2014-10-19T05:46:05Z

Microscopic

← Older revision		Revision as of 05:46, 19 October 2014
Line 51:		Line 51:
	*Low grade [[fibrosarcoma]].		*Low grade [[fibrosarcoma]].
	*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal \|author=Inwards, CY \|title=Low-grade central osteosarcoma versus fibrous dysplasia \|journal=Pathology Case Reviews \|volume=6 \|issue=1 \|pages=22-27 \|year=2001 \|pmid= \|doi= \|url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>		*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal \|author=Inwards, CY \|title=Low-grade central osteosarcoma versus fibrous dysplasia \|journal=Pathology Case Reviews \|volume=6 \|issue=1 \|pages=22-27 \|year=2001 \|pmid= \|doi= \|url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>
	*Gnathic ossifying fibroma (Cemento-ossifying fibroma)<ref>http://www.nature.com/modpathol/journal/v20/n3/full/3800753a.html</ref> - Prominent calcified spherules, no associated GNAS mutation		*Gnathic ossifying fibroma (Cemento-ossifying fibroma)<ref>http://www.nature.com/modpathol/journal/v20/n3/full/3800753a.html</ref><ref>{{Cite journal \| last1 = Patel \| first1 = MM. \| last2 = Wilkey \| first2 = JF. \| last3 = Abdelsayed \| first3 = R. \| last4 = D'Silva \| first4 = NJ. \| last5 = Malchoff \| first5 = C. \| last6 = Mallya \| first6 = SM. \| title = Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod \| volume = 109 \| issue = 5 \| pages = 739-43 \| month = May \| year = 2010 \| doi = 10.1016/j.tripleo.2009.12.016 \| PMID = 20346714 }}<r/ref> - Prominent calcified spherules, no associated GNAS mutation
	** Gnathic ossifying fibroma recurs and needs to be completely enucleated		** Gnathic ossifying fibroma recurs and needs to be completely enucleated
	** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.		** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.

Sarah: /* Microscopic */

2014-10-19T05:41:36Z

Microscopic

← Older revision		Revision as of 05:41, 19 October 2014
Line 51:		Line 51:
	*Low grade [[fibrosarcoma]].		*Low grade [[fibrosarcoma]].
	*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal \|author=Inwards, CY \|title=Low-grade central osteosarcoma versus fibrous dysplasia \|journal=Pathology Case Reviews \|volume=6 \|issue=1 \|pages=22-27 \|year=2001 \|pmid= \|doi= \|url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>		*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal \|author=Inwards, CY \|title=Low-grade central osteosarcoma versus fibrous dysplasia \|journal=Pathology Case Reviews \|volume=6 \|issue=1 \|pages=22-27 \|year=2001 \|pmid= \|doi= \|url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>
	*Gnathic ossifying fibroma(Cemento-ossifying fibroma)<ref>http://www.nature.com/modpathol/journal/v20/n3/full/3800753a.html</ref> - Prominent calcified spherules, no associated GNAS mutation		*Gnathic ossifying fibroma (Cemento-ossifying fibroma)<ref>http://www.nature.com/modpathol/journal/v20/n3/full/3800753a.html</ref> - Prominent calcified spherules, no associated GNAS mutation
	** Gnathic ossifying fibroma recurs and needs to be completely enucleated		** Gnathic ossifying fibroma recurs and needs to be completely enucleated
	** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.		** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.

Sarah: /* Microscopic */

2014-10-19T05:40:25Z

Microscopic

← Older revision		Revision as of 05:40, 19 October 2014
Line 51:		Line 51:
	*Low grade [[fibrosarcoma]].		*Low grade [[fibrosarcoma]].
	*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal \|author=Inwards, CY \|title=Low-grade central osteosarcoma versus fibrous dysplasia \|journal=Pathology Case Reviews \|volume=6 \|issue=1 \|pages=22-27 \|year=2001 \|pmid= \|doi= \|url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>		*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal \|author=Inwards, CY \|title=Low-grade central osteosarcoma versus fibrous dysplasia \|journal=Pathology Case Reviews \|volume=6 \|issue=1 \|pages=22-27 \|year=2001 \|pmid= \|doi= \|url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>
	*Gnathic ossifying fibroma<ref>http://www.nature.com/modpathol/journal/v20/n3/full/3800753a.html</ref> - Prominent calcified spherules, no associated GNAS mutation		*Gnathic ossifying fibroma(Cemento-ossifying fibroma)<ref>http://www.nature.com/modpathol/journal/v20/n3/full/3800753a.html</ref> - Prominent calcified spherules, no associated GNAS mutation
	** ~~Ossifying~~ fibroma recurs and needs to be completely enucleated		** Gnathic ossifying fibroma recurs and needs to be completely enucleated
	** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option		** Fibrous dysplasia may be self limited and can be followed with observation or if symptomatic bisphosphonate therapy is an option.
			**Distinguishing between these two is important

	===Images===		===Images===