Florid epithelial hyperplasia - Revision history

Michael: /* Sign out */

2021-09-02T13:53:00Z

Sign out

← Older revision		Revision as of 13:53, 2 September 2021
Line 86:		Line 86:

	==Sign out==		==Sign out==
			<pre>
			A. Left Breast (795 grams), Reduction Mammoplasty:
			- Benign breast tissue with usual ductal hyperplasia and skin within normal limits.

			B. Right Breast (685 grams), Reduction Mammoplasty:
			- Benign breast tissue and skin within normal limits.
			</pre>

			===UDH with cystic changes===
	<pre>		<pre>
	A. Right Breast (570 grams), Reduction Mammoplasty:		A. Right Breast (570 grams), Reduction Mammoplasty:

Michael at 04:01, 31 October 2015

2015-10-31T04:01:12Z

← Older revision		Revision as of 04:01, 31 October 2015
Line 5:		Line 5:
	\| Caption = Proliferative fibrocystic changes (''florid epithelial hyperplasia'' together with ''fibrocystic breast changes''). [[H&E stain]].		\| Caption = Proliferative fibrocystic changes (''florid epithelial hyperplasia'' together with ''fibrocystic breast changes''). [[H&E stain]].
	\| Synonyms = florid epithelial hyperplasia of the usual type, usual ductal hyperplasia, moderate epithelial hyperplasia		\| Synonyms = florid epithelial hyperplasia of the usual type, usual ductal hyperplasia, moderate epithelial hyperplasia
	\| Micro = breast glands with more than four cell layers above the basement membrane with irregular cell spacing (e.g. streaming), slit-like lumina (esp. at the periphery of the duct), no [[DCIS]]-like architecture (not cribriform, not papillary, not micropapillary, not solid), no nuclear atypia - usually no [[nucleoli]]		\| Micro = breast glands with more than four cell layers above the basement membrane with irregular cell spacing (e.g. streaming), slit-like lumina (esp. at the periphery of the duct), no [[DCIS]]-like architecture (not [[cribriform]], not papillary, not micropapillary, not solid), no nuclear atypia - usually no [[nucleoli]]
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]		\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]
Line 51:		Line 51:
	*Irregular cell spacing; streaming.		*Irregular cell spacing; streaming.
	*Slit-like lumina, esp. at the periphery of the duct.		*Slit-like lumina, esp. at the periphery of the duct.
	*No [[DCIS]]-like architecture (not cribriform, not papillary, not micropapillary, not solid).		*No [[DCIS]]-like architecture (not [[cribriform]], not papillary, not micropapillary, not solid).
	*No nuclear atypia - usually no [[nucleoli]].		*No nuclear atypia - usually no [[nucleoli]].

Michael at 03:26, 30 October 2015

2015-10-30T03:26:14Z

← Older revision		Revision as of 03:26, 30 October 2015
Line 36:		Line 36:
	Confusingly, it may be referred to as ''epithelial hyperplasia'', term that is best avoided, as it could lead to confusion with ''[[mild epithelial hyperplasia]]''.		Confusingly, it may be referred to as ''epithelial hyperplasia'', term that is best avoided, as it could lead to confusion with ''[[mild epithelial hyperplasia]]''.

	'''Moderate epithelial hyperplasia''' redirects to this article, as it is usually lumped with FEH. '''Proliferative fibrocystic changes''' redirects to this article.		'''Moderate epithelial hyperplasia''' redirects to this article, as it is usually lumped with FEH. '''Proliferative fibrocystic changes''' (abbreviated '''PFCC''') redirects to this article.

	==General==		==General==

Michael: /* See also */

2015-10-30T03:24:50Z

Michael at 03:24, 30 October 2015

2015-10-30T03:24:17Z

← Older revision		Revision as of 03:24, 30 October 2015
Line 9:		Line 9:
	\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]		\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]
	\| Stains =		\| Stains =
	\| IHC = ER "low", CK5 "high"		\| IHC = ER "low" (see below), CK5 "high" (see below)
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 03:23, 30 October 2015

2015-10-30T03:23:53Z

← Older revision		Revision as of 03:23, 30 October 2015
Line 9:		Line 9:
	\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]		\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = ER "low", CK5 "high"
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: /* Sign out */

2015-10-30T03:23:14Z

Sign out

← Older revision		Revision as of 03:23, 30 October 2015
Line 69:		Line 69:
	Image: Proliferative fibrocystic changes -- very high mag.jpg\|PFCC - very high mag.		Image: Proliferative fibrocystic changes -- very high mag.jpg\|PFCC - very high mag.
	</gallery>		</gallery>

			==IHC==
			Features:<ref name=pmid19675450>{{Cite journal \| last1 = Grin \| first1 = A. \| last2 = O'Malley \| first2 = FP. \| last3 = Mulligan \| first3 = AM. \| title = Cytokeratin 5 and estrogen receptor immunohistochemistry as a useful adjunct in identifying atypical papillary lesions on breast needle core biopsy. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 11 \| pages = 1615-23 \| month = Nov \| year = 2009 \| doi = 10.1097/PAS.0b013e3181aec446 \| PMID = 19675450 }}</ref>
			*ER "low".
			*CK5 "high".

			Where:
			*ER "high" = diffuse strong staining in >90% of cells.
			*CK5 "high" = mosaic pattern of staining in >20% of cells
			*CK5 "low" = absent or staining in <20% of cells.

			Note:
			*ADH/DCIS:
			**ER "high"
			**CK5 "low".

	==Sign out==		==Sign out==

Michael: /* Images= */

2015-10-30T03:18:22Z

Images=

← Older revision		Revision as of 03:18, 30 October 2015
Line 62:		Line 62:
	*Cribriform [[ductal carcinoma in situ]]		*Cribriform [[ductal carcinoma in situ]]

	===Images====		===Images===
	<gallery>		<gallery>
	Image: Proliferative fibrocystic changes -- low mag.jpg \|PFCC - low mag.		Image: Proliferative fibrocystic changes -- low mag.jpg \|PFCC - low mag.
Line 69:		Line 69:
	Image: Proliferative fibrocystic changes -- very high mag.jpg\|PFCC - very high mag.		Image: Proliferative fibrocystic changes -- very high mag.jpg\|PFCC - very high mag.
	</gallery>		</gallery>

	==Sign out==		==Sign out==
	<pre>		<pre>

Michael at 03:18, 30 October 2015

2015-10-30T03:18:10Z

← Older revision		Revision as of 03:18, 30 October 2015
Line 5:		Line 5:
	\| Caption = Proliferative fibrocystic changes (''florid epithelial hyperplasia'' together with ''fibrocystic breast changes''). [[H&E stain]].		\| Caption = Proliferative fibrocystic changes (''florid epithelial hyperplasia'' together with ''fibrocystic breast changes''). [[H&E stain]].
	\| Synonyms = florid epithelial hyperplasia of the usual type, usual ductal hyperplasia, moderate epithelial hyperplasia		\| Synonyms = florid epithelial hyperplasia of the usual type, usual ductal hyperplasia, moderate epithelial hyperplasia
	\| Micro = breast glands with more than four cell layers above the basement membrane with irregular cell spacing (e.g. streaming), slit-like lumina (esp. at the periphery of the duct), no [[DCIS]]-like architecture (not cribriform, not papillary, not micropapillary, not solid), no nuclear atypia - usually no [[nucleoli]].		\| Micro = breast glands with more than four cell layers above the basement membrane with irregular cell spacing (e.g. streaming), slit-like lumina (esp. at the periphery of the duct), no [[DCIS]]-like architecture (not cribriform, not papillary, not micropapillary, not solid), no nuclear atypia - usually no [[nucleoli]]
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]		\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]

Michael: +image

2015-10-30T03:17:18Z

+image

← Older revision		Revision as of 03:17, 30 October 2015
Line 1:		Line 1:
			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Proliferative fibrocystic changes -- intermed mag.jpg
			\| Width =
			\| Caption = Proliferative fibrocystic changes (''florid epithelial hyperplasia'' together with ''fibrocystic breast changes''). [[H&E stain]].
			\| Synonyms = florid epithelial hyperplasia of the usual type, usual ductal hyperplasia, moderate epithelial hyperplasia
			\| Micro = breast glands with more than four cell layers above the basement membrane with irregular cell spacing (e.g. streaming), slit-like lumina (esp. at the periphery of the duct), no [[DCIS]]-like architecture (not cribriform, not papillary, not micropapillary, not solid), no nuclear atypia - usually no [[nucleoli]].
			\| Subtypes =
			\| LMDDx = [[mild epithelial hyperplasia]], [[atypical ductal hyperplasia]], cribriform [[ductal carcinoma in situ]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[breast]]
			\| Assdx = [[fibrocystic breast changes]] (FEH + FCC = ''proliferative fibrocystic changes'')
			\| Syndromes =
			\| Clinicalhx = usually an incidental finding
			\| Signs =
			\| Symptoms =
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign, increased risk of [[breast cancer]]
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Florid epithelial hyperplasia''', abbreviated '''FEH''', is a common benign [[breast pathology]] finding that is associated with a mild increased risk of [[breast cancer]].		'''Florid epithelial hyperplasia''', abbreviated '''FEH''', is a common benign [[breast pathology]] finding that is associated with a mild increased risk of [[breast cancer]].

Line 31:		Line 62:
	*Cribriform [[ductal carcinoma in situ]]		*Cribriform [[ductal carcinoma in situ]]

			===Images====
			<gallery>
			Image: Proliferative fibrocystic changes -- low mag.jpg \|PFCC - low mag.
			Image: Proliferative fibrocystic changes -- intermed mag.jpg \|PFCC - intermed. mag.
			Image: Proliferative fibrocystic changes -- high mag.jpg \|PFCC - high mag.
			Image: Proliferative fibrocystic changes -- very high mag.jpg\|PFCC - very high mag.
			</gallery>
	==Sign out==		==Sign out==
	<pre>		<pre>

← Older revision		Revision as of 03:24, 30 October 2015
Line 100:		Line 100:
	==See also==		==See also==
	*[[Breast pathology]].		*[[Breast pathology]].
			*[[Atypical ductal hyperplasia]].

	==References==		==References==