Fulminant hepatic necrosis - Revision history

Michael: /* General */

2017-06-20T18:29:54Z

General

← Older revision		Revision as of 18:29, 20 June 2017
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	==General==		==General==
	Etiology:		Etiology:
	*Viral, i.e. [[Hepatitis A]], [[Hepatitis B]]; [[Hepatitis C]]<ref name=pmid26430449>{{Cite journal \| last1 = Younis \| first1 = BB. \| last2 = Arshad \| first2 = R. \| last3 = Khurhsid \| first3 = S. \| last4 = Masood \| first4 = J. \| last5 = Nazir \| first5 = F. \| last6 = Tahira \| first6 = M. \| title = Fulminant hepatic failure (FHF) due to acute hepatitis C. \| journal = Pak J Med Sci \| volume = 31 \| issue = 4 \| pages = 1009-11 \| month = \| year = \| doi = 10.12669/pjms.314.7618 \| PMID = 26430449 }}</ref> - extremely rare.		*Viral, i.e. [[Hepatitis A]], [[Hepatitis B]],<ref name=pmid14614604>{{Cite journal \| last1 = Igaki \| first1 = N. \| last2 = Nakaji \| first2 = M. \| last3 = Moriguchi \| first3 = R. \| last4 = Akiyama \| first4 = H. \| last5 = Tamada \| first5 = F. \| last6 = Oimomi \| first6 = M. \| last7 = Goto \| first7 = T. \| title = An outbreak of fulminant hepatitis B in immunocompromised hemodialysis patients. \| journal = J Gastroenterol \| volume = 38 \| issue = 10 \| pages = 968-76 \| month = \| year = 2003 \| doi = 10.1007/s00535-003-1180-1 \| PMID = 14614604 }}</ref> [[Hepatitis C]]<ref name=pmid26430449>{{Cite journal \| last1 = Younis \| first1 = BB. \| last2 = Arshad \| first2 = R. \| last3 = Khurhsid \| first3 = S. \| last4 = Masood \| first4 = J. \| last5 = Nazir \| first5 = F. \| last6 = Tahira \| first6 = M. \| title = Fulminant hepatic failure (FHF) due to acute hepatitis C. \| journal = Pak J Med Sci \| volume = 31 \| issue = 4 \| pages = 1009-11 \| month = \| year = \| doi = 10.12669/pjms.314.7618 \| PMID = 26430449 }}</ref> - extremely rare.
	*Trauma.		*Trauma.
	*Shock.		*Shock.

Michael: /* Microscopic */

2017-06-20T18:26:58Z

Microscopic

← Older revision		Revision as of 18:26, 20 June 2017
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	==Microscopic==		==Microscopic==
	Features:		Features:<ref name=pmid18771870/>
	*Hepatocyte [[necrosis]].		*Hepatocyte [[necrosis]] - '''key feature'''.
	*Bile duct proliferation.		*Bile duct proliferation.
			*Inflammatory cell infiltrate.

	DDx:		DDx:
	*[[Cholangiocarcinoma]].		*[[Cholangiocarcinoma]].
	*[[Angiosarcoma]].		*[[Angiosarcoma]].
			*Necrotic [[metastasis\|metastatic]] tumour.

	===Images===		===Images===
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	F. [[File:6 Necrosis 2 680x512px.tif\| Submassive hepatic necrosis.]]		F. [[File:6 Necrosis 2 680x512px.tif\| Submassive hepatic necrosis.]]
	<br>		<br>
	Submassive hepatic necrosis. Patient had transaminases in the thousands that rapidly dropped to normal. A/ Pink preserved parenchyma strews empty necrotic spaces. B. Focus of necrosis with no apparent hepatocytes macrophages abuts apparently normal liver. C. Iron stain shows the macrophages bear hemosiderin. D. Reticulin stain highlights the recently dead liver cells. E. Reticulin stain shows a necrotic bridge forming; the multiple small black circles preclude diagnosis of a fibrous bridge. F. Trichrome shows the necrotic bridge (“collapse”) lacks much collagen deposition, as would be expected for bridging fibrosis.		Submassive hepatic necrosis. Patient had transaminases in the thousands that rapidly dropped to normal. A/ Pink preserved parenchyma strews empty necrotic spaces. B. Focus of necrosis with no apparent hepatocytes macrophages abuts apparently normal liver. C. Iron stain shows the macrophages bear hemosiderin. D. Reticulin stain highlights the recently dead liver cells. E. Reticulin stain shows a necrotic bridge forming; the multiple small black circles preclude diagnosis of a fibrous bridge. F. Trichrome shows the necrotic bridge (“collapse”) lacks much collagen deposition, as would be expected for bridging fibrosis.


	==See also==		==See also==

Michael: /* General */

2017-06-20T18:24:38Z

General

← Older revision		Revision as of 18:24, 20 June 2017
Line 3:		Line 3:
	==General==		==General==
	Etiology:		Etiology:
	*Viral, i.e. [[Hepatitis A]], [[Hepatitis B]]; [[Hepatitis C]] - extremely rare.		*Viral, i.e. [[Hepatitis A]], [[Hepatitis B]]; [[Hepatitis C]]<ref name=pmid26430449>{{Cite journal \| last1 = Younis \| first1 = BB. \| last2 = Arshad \| first2 = R. \| last3 = Khurhsid \| first3 = S. \| last4 = Masood \| first4 = J. \| last5 = Nazir \| first5 = F. \| last6 = Tahira \| first6 = M. \| title = Fulminant hepatic failure (FHF) due to acute hepatitis C. \| journal = Pak J Med Sci \| volume = 31 \| issue = 4 \| pages = 1009-11 \| month = \| year = \| doi = 10.12669/pjms.314.7618 \| PMID = 26430449 }}</ref> - extremely rare.
	*Trauma.		*Trauma.
	*Shock.		*Shock.
			*Poisoning, e.g. mushrooms.<ref name=pmid18771870>{{Cite journal \| last1 = Cakir \| first1 = B. \| last2 = Kirbas \| first2 = I. \| last3 = Demirhan \| first3 = B. \| last4 = Tarhan \| first4 = NC. \| last5 = Bozkurt \| first5 = A. \| last6 = Ozcay \| first6 = F. \| last7 = Coskun \| first7 = M. \| title = Fulminant hepatic failure in children: etiology, histopathology and MDCT findings. \| journal = Eur J Radiol \| volume = 72 \| issue = 2 \| pages = 327-34 \| month = Nov \| year = 2009 \| doi = 10.1016/j.ejrad.2008.07.020 \| PMID = 18771870 }}</ref>

	==Microscopic==		==Microscopic==

Michael at 14:46, 18 June 2017

2017-06-18T14:46:58Z

← Older revision		Revision as of 14:46, 18 June 2017
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	'''Fulminant hepatic necrosis''' is extensive cell death in the liver. It is classified as a [[medical liver disease]].		'''Fulminant hepatic necrosis''' is extensive cell death in the liver. It is classified as a [[medical liver disease]].

	===General===		==General==
	Etiology:		Etiology:
	*Viral, i.e. [[Hepatitis A]], [[Hepatitis B]]; [[Hepatitis C]] - extremely rare.		*Viral, i.e. [[Hepatitis A]], [[Hepatitis B]]; [[Hepatitis C]] - extremely rare.
Line 7:		Line 7:
	*Shock.		*Shock.

	===Microscopic===		==Microscopic==
	Features:		Features:
	*Hepatocyte [[necrosis]].		*Hepatocyte [[necrosis]].

Michael: split out

2017-06-18T14:46:44Z

split out

← Older revision		Revision as of 14:46, 18 June 2017
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	~~#redirect~~ [[~~Medical_liver_disease#Fulminant_hepatic_necrosis~~]]		'''Fulminant hepatic necrosis''' is extensive cell death in the liver. It is classified as a [[medical liver disease]].

			===General===
			Etiology:
			*Viral, i.e. [[Hepatitis A]], [[Hepatitis B]]; [[Hepatitis C]] - extremely rare.
			*Trauma.
			*Shock.

			===Microscopic===
			Features:
			*Hepatocyte [[necrosis]].
			*Bile duct proliferation.

			DDx:
			*[[Cholangiocarcinoma]].
			*[[Angiosarcoma]].

			===Images===
			A. [[File:1 Necrosis 2 680x512px.tif\| Submassive hepatic necrosis.]]
			<br>
			B. [[File:2 Necrosis 2 680x512px.tif\| Submassive hepatic necrosis.]]
			<br>
			C. [[File:3 Necrosis 2 680x512px.tif\| Submassive hepatic necrosis.]]
			<br>
			D. [[File:4 Necrosis 2 680x512px.tif\| Submassive hepatic necrosis.]]
			<br>
			E. [[File:5 Necrosis 2 680x512px.tif\| Submassive hepatic necrosis.]]
			<br>
			F. [[File:6 Necrosis 2 680x512px.tif\| Submassive hepatic necrosis.]]
			<br>
			Submassive hepatic necrosis. Patient had transaminases in the thousands that rapidly dropped to normal. A/ Pink preserved parenchyma strews empty necrotic spaces. B. Focus of necrosis with no apparent hepatocytes macrophages abuts apparently normal liver. C. Iron stain shows the macrophages bear hemosiderin. D. Reticulin stain highlights the recently dead liver cells. E. Reticulin stain shows a necrotic bridge forming; the multiple small black circles preclude diagnosis of a fibrous bridge. F. Trichrome shows the necrotic bridge (“collapse”) lacks much collagen deposition, as would be expected for bridging fibrosis.


			==See also==
			*[[Necrosis]].
			*[[Medical liver disease]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Medical liver disease]]

Michael: create

2012-01-24T20:01:07Z

create

New page

#redirect [[Medical_liver_disease#Fulminant_hepatic_necrosis]]

[[Category:Diagnosis]]